42461-84-7,MFCD01725419
Catalog No.:AA00I853

42461-84-7 | Flunixin meglumine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5g
98%
in stock  
$14.00   $10.00
- +
25g
98%
in stock  
$41.00   $29.00
- +
100g
98%
in stock  
$126.00   $89.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00I853
Chemical Name:
Flunixin meglumine
CAS Number:
42461-84-7
Molecular Formula:
C21H28F3N3O7
Molecular Weight:
491.4581
MDL Number:
MFCD01725419
SMILES:
OC(=O)c1cccnc1Nc1cccc(c1C)C(F)(F)F.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
NSC Number:
759583
Properties
Computed Properties
 
Complexity:
510  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
8  
Isotope Atom Count:
0  
Rotatable Bond Count:
9  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Synonyms
 
  
Downstream Synthesis Route

[1]CurrentPatentAssignee:CHINESEACADEMYOFSCIENCES;LONGYANTAIMAISANLUCKPHARMACEUTICAL-CN109206365,2019,ALocationinpatent:Paragraph0022;0025;0038-0041;0046-0053

[2]CurrentPatentAssignee:JIANGSUHANSYNPHARMACEUTICALCOLTD-CN115710217,2023,ALocationinpatent:Paragraph0049-0054

[1]Camargo,HernandoA.;Contreras,JinesE.;Dávila-Miliani,MaríaCecilia;DíazDeDelgado,Graciela;Delgado,JoséMiguel;Dugarte-Dugarte,Analio;Henao,JoséAntonio;Toro,RobertA.[CrystalGrowthandDesign,2020,vol.20,#7,p.4657-4666]

Literature

Title: Differential Gene Expression across Breed and Sex in Commercial Pigs Administered Fenbendazole and Flunixin Meglumine.

Journal: PloS one 20150101

Title: Stimulatory effect of PGF2α on PRL based on experimental inhibition of each hormone in mares.

Journal: Theriogenology 20121201

Title: Direct effect of PGF2α pulses on PRL pulses, based on inhibition of PRL or PGF2α secretion in heifers.

Journal: Theriogenology 20120801

Title: Inhibition of prostaglandin biosynthesis during postluteolysis and effects on CL regression, prolactin, and ovulation in heifers.

Journal: Theriogenology 20120715

Title: Comparison of the effects of IV administration of meloxicam, carprofen, and flunixin meglumine on prostaglandin E(2) concentration in aqueous humor of dogs with aqueocentesis-induced anterior uveitis.

Journal: American journal of veterinary research 20120501

Title: The effect of systemic administration of cloprostenol on ovulation in mares treated with a prostaglandin synthetase inhibitor.

Journal: Reproduction in domestic animals = Zuchthygiene 20120201

Title: Ultrasound characteristics of experimentally induced luteinized unruptured follicles (LUF) and naturally occurring hemorrhagic anovulatory follicles (HAF) in the mare.

Journal: Theriogenology 20120201

Title: Effects of adrenocorticotropic hormone and flunixin meglumine on pregnancy retention in beef cows.

Journal: Journal of animal science 20120101

Title: Anesthesia case of the month. EPAM.

Journal: Journal of the American Veterinary Medical Association 20120101

Title: [Determination of residual organic solvents in flunixin meglumine raw material by headspace gas chromatography].

Journal: Se pu = Chinese journal of chromatography 20120101

Title: Therapeutic and adverse effects of flunixin-meglumine in adult and young cats.

Journal: The Journal of veterinary medical science 20111201

Title: Effect of flunixin meglumine on the amelioration of lameness in dairy steers with amphotericin B-induced transient synovitis-arthritis.

Journal: American journal of veterinary research 20111101

Title: Phenylbutazone and flunixin meglumine used singly or in combination in experimental lameness in horses.

Journal: Equine veterinary journal. Supplement 20111101

Title: The effects of two analgesic regimes on behavior after abdominal surgery in Steller sea lions.

Journal: Veterinary journal (London, England : 1997) 20111001

Title: Evaluation of the brain, renal, and hepatic effects of flunixin meglumine, ketoprofen, and phenylbutazone administration in Iranian fat-tailed sheep.

Journal: Tropical animal health and production 20111001

Title: Effects of inhibition of prostaglandin F2α biosynthesis during preluteolysis and luteolysis in heifers.

Journal: Theriogenology 20110901

Title: Effects of flunixin meglumine, recombinant bovine somatotropin and/or human chorionic gonadotropin on pregnancy rates in Nelore cows.

Journal: Theriogenology 20110901

Title: The effects of a novel anti-inflammatory compound (AHI-805) on cyclooxygenase enzymes and the recovery of ischaemia injured equine jejunum ex vivo.

Journal: Equine veterinary journal. Supplement 20110801

Title: Effects of flunixin meglumine on the recovery of ischaemic equine colonic mucosa in vitro.

Journal: Equine veterinary journal. Supplement 20110801

Title: The effect of treatment with flunixin meglumine at different times relative to hCG administration on ovulation failure and luteal function in mares.

Journal: Animal reproduction science 20110801

Title: Follicle and systemic hormone interrelationships during induction of luteinized unruptured follicles with a prostaglandin inhibitor in mares.

Journal: Theriogenology 20110715

Title: Comparison of the immunosuppressive effects of dexamethasone, flunixin meglumine and meloxicam on the in vitro response of calf peripheral blood mononuclear cells.

Journal: The Journal of veterinary medical science 20110701

Title: The effect of intramuscular injection of dinoprost or gonadotropin-releasing hormone in dairy cows on beef quality.

Journal: Journal of animal science 20110601

Title: Disruption of periovulatory FSH and LH surges during induced anovulation by an inhibitor of prostaglandin synthesis in mares.

Journal: Animal reproduction science 20110601

Title: Associations among behavioral and acute physiologic responses to lipopolysaccharide-induced clinical mastitis in lactating dairy cows.

Journal: American journal of veterinary research 20110501

Title: Analgesic effects of meloxicam, morphine sulfate, flunixin meglumine, and xylazine hydrochloride in African-clawed frogs (Xenopus laevis).

Journal: Journal of the American Association for Laboratory Animal Science : JAALAS 20110501

Title: Systemic treatment with high dose of flunixin-meglumine is able to block ovulation in mares by inducing hemorrhage and luteinisation of follicles.

Journal: Theriogenology 20110301

Title: Effects of buprenorphine, meloxicam, and flunixin meglumine as postoperative analgesia in mice.

Journal: Journal of the American Association for Laboratory Animal Science : JAALAS 20110301

Title: Effects of acute hepatic and renal failure on pharmacokinetics of flunixin meglumine in rats.

Journal: Experimental animals 20110101

Title: Distribution of flunixin meglumine and firocoxib into aqueous humor of horses.

Journal: Journal of veterinary internal medicine 20110101

Title: GABAergic regulation of auditory sensory gating in low- and high-anxiety rats submitted to a fear conditioning procedure.

Journal: Neuroscience 20101229

Title: Practical experience with the treatment of recipient mares with a non-steroidal anti-inflammatory drug in an equine embryo transfer programme.

Journal: Reproduction in domestic animals = Zuchthygiene 20101201

Title: Hepatic effects of flunixin-meglumin in LPS-induced sepsis.

Journal: Fundamental & clinical pharmacology 20101201

Title: Activation of mitogen-activated protein kinases cellular signal transduction pathway in mammalian cells induced by silicon carbide nanowires.

Journal: Biomaterials 20101101

Title: Effect of flunixin meglumine and carprofen on pregnancy rates in dairy cattle.

Journal: Journal of dairy science 20101101

Title: Efficacy of single-dose intravenous phenylbutazone and flunixin meglumine before, during and after exercise in an experimental reversible model of foot lameness in horses.

Journal: Equine veterinary journal. Supplement 20101101

Title: [Simultaneous analysis of 4 non-steroidal anti-inflammatory drug residues in mutton muscle using high performance liquid chromatography assisted by ultrasonic-microwave extraction].

Journal: Se pu = Chinese journal of chromatography 20101101

Title: Effects of enrofloxacin, flunixin meglumine and dexamethasone on disseminated intravascular coagulation, cytokine levels and adenosine deaminase activity in endotoxaemia in rats.

Journal: Acta veterinaria Hungarica 20100901

Title: Effects of ring castration with local anesthesia and analgesia in Holstein calves at 3 months of age on welfare indicators.

Journal: Journal of animal science 20100801

Title: Effect of analgesia during hoof trimming on gait, weight distribution, and activity of dairy cattle.

Journal: Journal of dairy science 20100701

Title: The effects of perioperative analgesia on litter size in Crl:CD1(ICR) mice undergoing embryo transfer.

Journal: Journal of the American Association for Laboratory Animal Science : JAALAS 20100701

Title: Use of a five-day progesterone-based timed AI protocol to determine if flunixin meglumine improves pregnancy per timed AI in dairy heifers.

Journal: Theriogenology 20100601

Title: Clinical efficacy of diclofenac sodium and flunixin meglumine as adjuncts to antibacterial treatment of respiratory disease of calves.

Journal: Australian veterinary journal 20100601

Title: Effects of drugs used in endotoxic shock on oxidative stress and organ damage markers.

Journal: Free radical research 20100401

Title: Effects of flunixin meglumine on pregnancy establishment in beef cattle.

Journal: Journal of animal science 20100301

Title: Randomized clinical trial of long-acting oxytetracycline, foot trimming, and flunixine meglumine on time to recovery in sheep with footrot.

Journal: Journal of veterinary internal medicine 20100101

Title: Evaluation of the influence of meloxicam and flunixin meglumine on the apoptosis of peripheral blood CD4+ and CD8+ T cells in calves.

Journal: Polish journal of veterinary sciences 20100101

Title: Exploring non-invasive methods to assess pain in sheep.

Journal: Physiology & behavior 20091207

Title: Effect of oxytocin and flunixin meglumine on uterine response to insemination in mares.

Journal: Theriogenology 20091201

Title: Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses.

Journal: American journal of veterinary research 20091001

Title: Treatment of pregnancy toxaemia in sheep with flunixin meglumine.

Journal: The Veterinary record 20090829

Title: Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum.

Journal: American journal of veterinary research 20090801

Title: Effects of flunixin meglumine on pyrexia and bioenergetic variables in postparturient dairy cows.

Journal: Journal of dairy science 20090501

Title: A physiologically based pharmacokinetic model linking plasma protein binding interactions with drug disposition.

Journal: Research in veterinary science 20090401

Title: The behavioral assessment and alleviation of pain associated with castration in beef calves treated with flunixin meglumine and caudal lidocaine epidural anesthesia with epinephrine.

Journal: The Canadian veterinary journal = La revue veterinaire canadienne 20090401

Title: Effects of nonselective and selective cyclooxygenase inhibitors on small intestinal motility in the horse.

Journal: Research in veterinary science 20090201

Title: Effects of flunixin meglumine on recovery of colonic mucosa from ischemia in horses.

Journal: American journal of veterinary research 20090201

Title: A comparison of florfenicol-flunixin meglumine versus tulathromycin for the treatment of undifferentiated fever in fall-placed feedlot calves.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20090101

Title: Efficacy of a florfenicol-flunixin meglumine combination product versus tulathromycin or ceftiofur crystalline free acid for the treatment of undifferentiated fever in feedlot calves.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20090101

Title: Incomplete placentation after twin reduction in a mare.

Journal: The Veterinary record 20081201

Title: Embryo transfer induces a subclinical endometritis in recipient mares which can be prevented by treatment with non-steroid anti-inflammatory drugs.

Journal: Theriogenology 20081015

Title: Pharmacokinetics of enrofloxacin and flunixin meglumine and interactions between both drugs after intravenous co-administration in healthy and endotoxaemic rabbits.

Journal: Veterinary journal (London, England : 1997) 20080901

Title: Attenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaine.

Journal: Equine veterinary journal 20080601

Title: Effects of nonsteroidal anti-inflammatory drugs on long-term pain in calves castrated by use of an external clamping technique following epidural anesthesia.

Journal: American journal of veterinary research 20080601

Title: Extralabel use of nonsteroidal anti-inflammatory drugs in cattle.

Journal: Journal of the American Veterinary Medical Association 20080301

Title: Escherichia coli mastitis in cattle being treated for Staphylococcus aureus intramammary infection.

Journal: The Veterinary record 20080202

Title: Effectiveness of administration of phenylbutazone alone or concurrent administration of phenylbutazone and flunixin meglumine to alleviate lameness in horses.

Journal: American journal of veterinary research 20080201

Title: Effect of preoperative administration of erythromycin or flunixin meglumine on postoperative abomasal emptying rate in dairy cows undergoing surgical correction of left displacement of the abomasum.

Journal: Journal of the American Veterinary Medical Association 20080201

Title: Pharmacokinetics of flunixin in mature heifers following multiple intravenous administration.

Journal: Polish journal of veterinary sciences 20080101

Title: Outcome of medical and surgical treatment of cecal impaction in horses: 114 cases (1994-2004).

Journal: Journal of the American Veterinary Medical Association 20071101

Title: Effect of flunixin meglumine on cytokine levels in experimental endotoxemia in mice.

Journal: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20070901

Title: Treatment of acute puerperal metritis with flunixin meglumine in addition to antibiotic treatment.

Journal: Journal of dairy science 20070801

Title: Suspected panosteitis in a camel.

Journal: Journal of the American Veterinary Medical Association 20070801

Title: FDA issues reminder on correct use of flunixin meglumine.

Journal: Journal of the American Veterinary Medical Association 20070701

Title: Evaluation of the renal effects of flunixin meglumine, ketoprofen and meloxicam in budgerigars (Melopsittacus undulatus).

Journal: The Veterinary record 20070616

Title: Effects of flunixin meglumine and transportation on establishment of pregnancy in beef cows.

Journal: Journal of animal science 20070601

Title: Pharmacokinetic interactions of flunixin meglumine and enrofloxacin in ICR mice.

Journal: Experimental animals 20070401

Title: Effect of the administration of flunixin meglumine on pregnancy rates in Holstein heifers.

Journal: The Veterinary record 20070324

Title: Rapid method for the determination of non-steroidal anti-inflammatory drugs in animal tissue by liquid chromatography-mass spectrometry with ion-trap detector.

Journal: Analytica chimica acta 20070314

Title: Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs.

Journal: American journal of veterinary research 20070301

Title: In vitro effects of reactive oxygen metabolites, with and without flunixin meglumine, on equine colonic mucosa.

Journal: American journal of veterinary research 20070301

Title: Outbreak of neurologic disease caused by equine herpesvirus-1 at a university equestrian center.

Journal: Journal of veterinary internal medicine 20070101

Title: Pharmacokinetics of flunixin meglumine in swine after intravenous dosing.

Journal: Journal of veterinary pharmacology and therapeutics 20061001

Title: Effects of flunixin meglumine on selected clinicopathologic variables, and serum testosterone concentration in stallions after endotoxin administration.

Journal: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20060901

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Actinobacillus peritonitis in a Warmblood gelding.

Journal: The Veterinary clinics of North America. Equine practice 20060401

Title: Postpartum hemoperitoneum and septic peritonitis in a Thoroughbred mare.

Journal: The Veterinary clinics of North America. Equine practice 20060401

Title: Acute diarrhea in the adult horse: case example and review.

Journal: The Veterinary clinics of North America. Equine practice 20060401

Title: Malabsorptive maldigestive disorder with concurrent Salmonella in a 3-year-old quarter horse.

Journal: The Veterinary clinics of North America. Equine practice 20060401

Title: Equine herpes myeloencephalopathy in a 12-year-old American quarter horse.

Journal: The Veterinary clinics of North America. Equine practice 20060401

Title: Effects of phenylbutazone alone or in combination with flunixin meglumine on blood protein concentrations in horses.

Journal: American journal of veterinary research 20060301

Title: Pharmacokinetics of flunixin after intravenous administration in healthy and endotoxaemic rabbits.

Journal: Veterinary research communications 20060101

Title: Effect of a CIDR insert and flunixin meglumine, administered at the time of embryo transfer, on pregnancy rate and resynchronization of estrus in beef cattle.

Journal: Theriogenology 20050901

Title: Technical Note: Improved technique for fitting pigs with steered ileocecal valve cannulas.

Journal: Journal of animal science 20050701

Title: Pharmacokinetic interactions of flunixin meglumine and enrofloxacin in dogs.

Journal: American journal of veterinary research 20050701

Title: Investigation of the effect of black walnut extract on in vitro ion transport and structure of equine colonic mucosa.

Journal: American journal of veterinary research 20050301

Title: Use of force plate analysis to compare the analgesic effects of intravenous administration of phenylbutazone and flunixin meglumine in horses with navicular syndrome.

Journal: American journal of veterinary research 20050201

Title: Evaluating postoperative analgesics in mice using telemetry.

Journal: Comparative medicine 20050201

Title: [Slaughter emergency].

Journal: Tijdschrift voor diergeneeskunde 20041101

Title: Field evaluation of flunixin meglumine in the supportive treatment of caprine mastitis.

Journal: Journal of veterinary pharmacology and therapeutics 20041001

Title: Disposition of flunixin meglumine injectable preparation administered orally to healthy horses.

Journal: Journal of veterinary pharmacology and therapeutics 20040601

Title: Effects of flunixin meglumine or etodolac treatment on mucosal recovery of equine jejunum after ischemia.

Journal: American journal of veterinary research 20040601

Title: Effect of morphine and flunixin meglumine on isoflurane minimum alveolar concentration in goats.

Journal: Veterinary anaesthesia and analgesia 20040401

Title: Pharmacokinetics of flunixin in the cat: enterohepatic circulation and active transport mechanism in the liver.

Journal: Journal of veterinary pharmacology and therapeutics 20040401

Title: Effects of two anti-inflammatory drugs on physiologic variables and milk production in cows with endotoxin-induced mastitis.

Journal: American journal of veterinary research 20040101

Title: Role of prostaglandins in the development of hyperthermia in heat-stressed, lactating Holstein cows.

Journal: Journal of veterinary pharmacology and therapeutics 20031201

Title: Evaluation of flunixin meglumine as an adjunct treatment for diarrhea in dairy calves.

Journal: Journal of the American Veterinary Medical Association 20031101

Title: Residue depletion study and withdrawal period for flunixin-N-methyl glucamine in bovine milk following intravenous administration.

Journal: Journal of agricultural and food chemistry 20030730

Title: Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B.

Journal: American journal of veterinary research 20030201

Title: A comparative study of the effects of meloxicam and flunixin meglumine (NSAIDs) as adjunctive therapy on interferon and tumor necrosis factor production in calves suffering from enzootic bronchopneumonia.

Journal: Polish journal of veterinary sciences 20030101

Title: Flunixin residues in milk after intravenous treatment of dairy cattle with (14)C-flunixin.

Journal: Journal of agricultural and food chemistry 20021204

Title: Kinetics of venom and antivenom serum and clinical parameters and treatment efficacy in Bothrops alternatus envenomed dogs.

Journal: Veterinary and human toxicology 20021201

Title: Efficacy and pharmacokinetics of enrofloxacin and flunixin meglumine for treatment of cows with experimentally induced Escherichia coli mastitis.

Journal: Journal of veterinary pharmacology and therapeutics 20020801

Title: In vitro investigation of the interaction between nitric oxide and cyclo-oxygenase activity in equine ventral colon smooth muscle.

Journal: Equine veterinary journal 20020701

Title: Non-surgical management of rectal tears in two mares.

Journal: Australian veterinary journal 20020301

Title: Effect of flunixin meglumine on selected physiologic and performance parameters of athletically conditioned thoroughbred horses subjected to an incremental exercise stress test.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20020101

Title: Investigation of factors affecting pregnancy rate after embryo transfer in the dromedary camel.

Journal: Reproduction, fertility, and development 20020101

Title: In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats.

Journal: American journal of veterinary research 20011101

Title: Pharmacokinetics of flunixin meglumine in llamas following a single intravenous dose.

Journal: Journal of veterinary pharmacology and therapeutics 20011001

Title: Flunixin meglumine accelerates uterine involution and shortens the calving-to-first-oestrus interval in cows with puerperal metritis.

Journal: Journal of veterinary pharmacology and therapeutics 20011001

Title: Possible active transport mechanism in pharmacokinetics of flunixin-meglumin in rabbits.

Journal: The Journal of veterinary medical science 20010801

Title: Effects of steroidal and non-steroidal antiphlogistic drugs on eicosanoid synthesis in irritated skin: studies with the isolated perfused bovine udder.

Journal: The Journal of pharmacy and pharmacology 20010501

Title: Role of prostaglandins in intrauterine migration of the equine conceptus.

Journal: Reproduction (Cambridge, England) 20010501

Title: Effect of finadyne on oestradiol-induced ovarian oxytocin and uterine PGF2alpha secretory systems on day 15 after oestrus in ovarian autotransplanted ewes.

Journal: Reproduction (Cambridge, England) 20010301

Title: Abdominal radiography in monitoring the resolution of sand accumulations from the large colon of horses treated medically.

Journal: Equine veterinary journal 20010101

Title: Effects of anti-inflammatory drugs on lipopolysaccharide-challenged and -unchallenged equine synovial explants.

Journal: American journal of veterinary research 20010101

Title: Effects of butorphanol, flunixin, levorphanol, morphine, and xylazine in ponies.

Journal: American journal of veterinary research 19840201

Title: Cheng Z, et al. Measurement of cyclooxygenase inhibition in vivo: a study of two non-steroidal anti-inflammatory drugs in sheep. Inflammation. 1998 Aug;22(4):353-66.

Title: Bryant, C.E., B.A. Farnfield, and H.J. Janicke, Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B. Am J Vet Res, 2003. 64(2): p. 211-5.

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Tags:42461-84-7 Molecular Formula|42461-84-7 MDL|42461-84-7 SMILES|42461-84-7 Flunixin meglumine
Catalog No.: AA00I853
42461-84-7,MFCD01725419
42461-84-7 | Flunixin meglumine
Pack Size: 5g
Purity: 98%
in stock
$14.00 $10.00
Pack Size: 25g
Purity: 98%
in stock
$41.00 $29.00
Pack Size: 100g
Purity: 98%
in stock
$126.00 $89.00
Quantity
- +
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Technical Information
Catalog Number: AA00I853
Chemical Name: Flunixin meglumine
CAS Number: 42461-84-7
Molecular Formula: C21H28F3N3O7
Molecular Weight: 491.4581
MDL Number: MFCD01725419
SMILES: OC(=O)c1cccnc1Nc1cccc(c1C)C(F)(F)F.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
NSC Number: 759583
Properties
Complexity: 510  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 4  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 34  
Hydrogen Bond Acceptor Count: 13  
Hydrogen Bond Donor Count: 8  
Isotope Atom Count: 0  
Rotatable Bond Count: 9  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
93:   
Downstream Synthesis Route
6284-40-8    38677-85-9    42461-84-7 

[1]CurrentPatentAssignee:CHINESEACADEMYOFSCIENCES;LONGYANTAIMAISANLUCKPHARMACEUTICAL-CN109206365,2019,ALocationinpatent:Paragraph0022;0025;0038-0041;0046-0053

[2]CurrentPatentAssignee:JIANGSUHANSYNPHARMACEUTICALCOLTD-CN115710217,2023,ALocationinpatent:Paragraph0049-0054

42461-84-7    38677-85-9 

[1]Camargo,HernandoA.;Contreras,JinesE.;Dávila-Miliani,MaríaCecilia;DíazDeDelgado,Graciela;Delgado,JoséMiguel;Dugarte-Dugarte,Analio;Henao,JoséAntonio;Toro,RobertA.[CrystalGrowthandDesign,2020,vol.20,#7,p.4657-4666]

Literature fold

Title: Differential Gene Expression across Breed and Sex in Commercial Pigs Administered Fenbendazole and Flunixin Meglumine.

Journal: PloS one20150101

Title: Stimulatory effect of PGF2α on PRL based on experimental inhibition of each hormone in mares.

Journal: Theriogenology20121201

Title: Direct effect of PGF2α pulses on PRL pulses, based on inhibition of PRL or PGF2α secretion in heifers.

Journal: Theriogenology20120801

Title: Inhibition of prostaglandin biosynthesis during postluteolysis and effects on CL regression, prolactin, and ovulation in heifers.

Journal: Theriogenology20120715

Title: Comparison of the effects of IV administration of meloxicam, carprofen, and flunixin meglumine on prostaglandin E(2) concentration in aqueous humor of dogs with aqueocentesis-induced anterior uveitis.

Journal: American journal of veterinary research20120501

Title: The effect of systemic administration of cloprostenol on ovulation in mares treated with a prostaglandin synthetase inhibitor.

Journal: Reproduction in domestic animals = Zuchthygiene20120201

Title: Ultrasound characteristics of experimentally induced luteinized unruptured follicles (LUF) and naturally occurring hemorrhagic anovulatory follicles (HAF) in the mare.

Journal: Theriogenology20120201

Title: Effects of adrenocorticotropic hormone and flunixin meglumine on pregnancy retention in beef cows.

Journal: Journal of animal science20120101

Title: Anesthesia case of the month. EPAM.

Journal: Journal of the American Veterinary Medical Association20120101

Title: [Determination of residual organic solvents in flunixin meglumine raw material by headspace gas chromatography].

Journal: Se pu = Chinese journal of chromatography20120101

Title: Therapeutic and adverse effects of flunixin-meglumine in adult and young cats.

Journal: The Journal of veterinary medical science20111201

Title: Effect of flunixin meglumine on the amelioration of lameness in dairy steers with amphotericin B-induced transient synovitis-arthritis.

Journal: American journal of veterinary research20111101

Title: Phenylbutazone and flunixin meglumine used singly or in combination in experimental lameness in horses.

Journal: Equine veterinary journal. Supplement20111101

Title: The effects of two analgesic regimes on behavior after abdominal surgery in Steller sea lions.

Journal: Veterinary journal (London, England : 1997)20111001

Title: Evaluation of the brain, renal, and hepatic effects of flunixin meglumine, ketoprofen, and phenylbutazone administration in Iranian fat-tailed sheep.

Journal: Tropical animal health and production20111001

Title: Effects of inhibition of prostaglandin F2α biosynthesis during preluteolysis and luteolysis in heifers.

Journal: Theriogenology20110901

Title: Effects of flunixin meglumine, recombinant bovine somatotropin and/or human chorionic gonadotropin on pregnancy rates in Nelore cows.

Journal: Theriogenology20110901

Title: The effects of a novel anti-inflammatory compound (AHI-805) on cyclooxygenase enzymes and the recovery of ischaemia injured equine jejunum ex vivo.

Journal: Equine veterinary journal. Supplement20110801

Title: Effects of flunixin meglumine on the recovery of ischaemic equine colonic mucosa in vitro.

Journal: Equine veterinary journal. Supplement20110801

Title: The effect of treatment with flunixin meglumine at different times relative to hCG administration on ovulation failure and luteal function in mares.

Journal: Animal reproduction science20110801

Title: Follicle and systemic hormone interrelationships during induction of luteinized unruptured follicles with a prostaglandin inhibitor in mares.

Journal: Theriogenology20110715

Title: Comparison of the immunosuppressive effects of dexamethasone, flunixin meglumine and meloxicam on the in vitro response of calf peripheral blood mononuclear cells.

Journal: The Journal of veterinary medical science20110701

Title: The effect of intramuscular injection of dinoprost or gonadotropin-releasing hormone in dairy cows on beef quality.

Journal: Journal of animal science20110601

Title: Disruption of periovulatory FSH and LH surges during induced anovulation by an inhibitor of prostaglandin synthesis in mares.

Journal: Animal reproduction science20110601

Title: Associations among behavioral and acute physiologic responses to lipopolysaccharide-induced clinical mastitis in lactating dairy cows.

Journal: American journal of veterinary research20110501

Title: Analgesic effects of meloxicam, morphine sulfate, flunixin meglumine, and xylazine hydrochloride in African-clawed frogs (Xenopus laevis).

Journal: Journal of the American Association for Laboratory Animal Science : JAALAS20110501

Title: Systemic treatment with high dose of flunixin-meglumine is able to block ovulation in mares by inducing hemorrhage and luteinisation of follicles.

Journal: Theriogenology20110301

Title: Effects of buprenorphine, meloxicam, and flunixin meglumine as postoperative analgesia in mice.

Journal: Journal of the American Association for Laboratory Animal Science : JAALAS20110301

Title: Effects of acute hepatic and renal failure on pharmacokinetics of flunixin meglumine in rats.

Journal: Experimental animals20110101

Title: Distribution of flunixin meglumine and firocoxib into aqueous humor of horses.

Journal: Journal of veterinary internal medicine20110101

Title: GABAergic regulation of auditory sensory gating in low- and high-anxiety rats submitted to a fear conditioning procedure.

Journal: Neuroscience20101229

Title: Practical experience with the treatment of recipient mares with a non-steroidal anti-inflammatory drug in an equine embryo transfer programme.

Journal: Reproduction in domestic animals = Zuchthygiene20101201

Title: Hepatic effects of flunixin-meglumin in LPS-induced sepsis.

Journal: Fundamental & clinical pharmacology20101201

Title: Activation of mitogen-activated protein kinases cellular signal transduction pathway in mammalian cells induced by silicon carbide nanowires.

Journal: Biomaterials20101101

Title: Effect of flunixin meglumine and carprofen on pregnancy rates in dairy cattle.

Journal: Journal of dairy science20101101

Title: Efficacy of single-dose intravenous phenylbutazone and flunixin meglumine before, during and after exercise in an experimental reversible model of foot lameness in horses.

Journal: Equine veterinary journal. Supplement20101101

Title: [Simultaneous analysis of 4 non-steroidal anti-inflammatory drug residues in mutton muscle using high performance liquid chromatography assisted by ultrasonic-microwave extraction].

Journal: Se pu = Chinese journal of chromatography20101101

Title: Effects of enrofloxacin, flunixin meglumine and dexamethasone on disseminated intravascular coagulation, cytokine levels and adenosine deaminase activity in endotoxaemia in rats.

Journal: Acta veterinaria Hungarica20100901

Title: Effects of ring castration with local anesthesia and analgesia in Holstein calves at 3 months of age on welfare indicators.

Journal: Journal of animal science20100801

Title: Effect of analgesia during hoof trimming on gait, weight distribution, and activity of dairy cattle.

Journal: Journal of dairy science20100701

Title: The effects of perioperative analgesia on litter size in Crl:CD1(ICR) mice undergoing embryo transfer.

Journal: Journal of the American Association for Laboratory Animal Science : JAALAS20100701

Title: Use of a five-day progesterone-based timed AI protocol to determine if flunixin meglumine improves pregnancy per timed AI in dairy heifers.

Journal: Theriogenology20100601

Title: Clinical efficacy of diclofenac sodium and flunixin meglumine as adjuncts to antibacterial treatment of respiratory disease of calves.

Journal: Australian veterinary journal20100601

Title: Effects of drugs used in endotoxic shock on oxidative stress and organ damage markers.

Journal: Free radical research20100401

Title: Effects of flunixin meglumine on pregnancy establishment in beef cattle.

Journal: Journal of animal science20100301

Title: Randomized clinical trial of long-acting oxytetracycline, foot trimming, and flunixine meglumine on time to recovery in sheep with footrot.

Journal: Journal of veterinary internal medicine20100101

Title: Evaluation of the influence of meloxicam and flunixin meglumine on the apoptosis of peripheral blood CD4+ and CD8+ T cells in calves.

Journal: Polish journal of veterinary sciences20100101

Title: Exploring non-invasive methods to assess pain in sheep.

Journal: Physiology & behavior20091207

Title: Effect of oxytocin and flunixin meglumine on uterine response to insemination in mares.

Journal: Theriogenology20091201

Title: Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses.

Journal: American journal of veterinary research20091001

Title: Treatment of pregnancy toxaemia in sheep with flunixin meglumine.

Journal: The Veterinary record20090829

Title: Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum.

Journal: American journal of veterinary research20090801

Title: Effects of flunixin meglumine on pyrexia and bioenergetic variables in postparturient dairy cows.

Journal: Journal of dairy science20090501

Title: A physiologically based pharmacokinetic model linking plasma protein binding interactions with drug disposition.

Journal: Research in veterinary science20090401

Title: The behavioral assessment and alleviation of pain associated with castration in beef calves treated with flunixin meglumine and caudal lidocaine epidural anesthesia with epinephrine.

Journal: The Canadian veterinary journal = La revue veterinaire canadienne20090401

Title: Effects of nonselective and selective cyclooxygenase inhibitors on small intestinal motility in the horse.

Journal: Research in veterinary science20090201

Title: Effects of flunixin meglumine on recovery of colonic mucosa from ischemia in horses.

Journal: American journal of veterinary research20090201

Title: A comparison of florfenicol-flunixin meglumine versus tulathromycin for the treatment of undifferentiated fever in fall-placed feedlot calves.

Journal: Veterinary therapeutics : research in applied veterinary medicine20090101

Title: Efficacy of a florfenicol-flunixin meglumine combination product versus tulathromycin or ceftiofur crystalline free acid for the treatment of undifferentiated fever in feedlot calves.

Journal: Veterinary therapeutics : research in applied veterinary medicine20090101

Title: Incomplete placentation after twin reduction in a mare.

Journal: The Veterinary record20081201

Title: Embryo transfer induces a subclinical endometritis in recipient mares which can be prevented by treatment with non-steroid anti-inflammatory drugs.

Journal: Theriogenology20081015

Title: Pharmacokinetics of enrofloxacin and flunixin meglumine and interactions between both drugs after intravenous co-administration in healthy and endotoxaemic rabbits.

Journal: Veterinary journal (London, England : 1997)20080901

Title: Attenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaine.

Journal: Equine veterinary journal20080601

Title: Effects of nonsteroidal anti-inflammatory drugs on long-term pain in calves castrated by use of an external clamping technique following epidural anesthesia.

Journal: American journal of veterinary research20080601

Title: Extralabel use of nonsteroidal anti-inflammatory drugs in cattle.

Journal: Journal of the American Veterinary Medical Association20080301

Title: Escherichia coli mastitis in cattle being treated for Staphylococcus aureus intramammary infection.

Journal: The Veterinary record20080202

Title: Effectiveness of administration of phenylbutazone alone or concurrent administration of phenylbutazone and flunixin meglumine to alleviate lameness in horses.

Journal: American journal of veterinary research20080201

Title: Effect of preoperative administration of erythromycin or flunixin meglumine on postoperative abomasal emptying rate in dairy cows undergoing surgical correction of left displacement of the abomasum.

Journal: Journal of the American Veterinary Medical Association20080201

Title: Pharmacokinetics of flunixin in mature heifers following multiple intravenous administration.

Journal: Polish journal of veterinary sciences20080101

Title: Outcome of medical and surgical treatment of cecal impaction in horses: 114 cases (1994-2004).

Journal: Journal of the American Veterinary Medical Association20071101

Title: Effect of flunixin meglumine on cytokine levels in experimental endotoxemia in mice.

Journal: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine20070901

Title: Treatment of acute puerperal metritis with flunixin meglumine in addition to antibiotic treatment.

Journal: Journal of dairy science20070801

Title: Suspected panosteitis in a camel.

Journal: Journal of the American Veterinary Medical Association20070801

Title: FDA issues reminder on correct use of flunixin meglumine.

Journal: Journal of the American Veterinary Medical Association20070701

Title: Evaluation of the renal effects of flunixin meglumine, ketoprofen and meloxicam in budgerigars (Melopsittacus undulatus).

Journal: The Veterinary record20070616

Title: Effects of flunixin meglumine and transportation on establishment of pregnancy in beef cows.

Journal: Journal of animal science20070601

Title: Pharmacokinetic interactions of flunixin meglumine and enrofloxacin in ICR mice.

Journal: Experimental animals20070401

Title: Effect of the administration of flunixin meglumine on pregnancy rates in Holstein heifers.

Journal: The Veterinary record20070324

Title: Rapid method for the determination of non-steroidal anti-inflammatory drugs in animal tissue by liquid chromatography-mass spectrometry with ion-trap detector.

Journal: Analytica chimica acta20070314

Title: Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs.

Journal: American journal of veterinary research20070301

Title: In vitro effects of reactive oxygen metabolites, with and without flunixin meglumine, on equine colonic mucosa.

Journal: American journal of veterinary research20070301

Title: Outbreak of neurologic disease caused by equine herpesvirus-1 at a university equestrian center.

Journal: Journal of veterinary internal medicine20070101

Title: Pharmacokinetics of flunixin meglumine in swine after intravenous dosing.

Journal: Journal of veterinary pharmacology and therapeutics20061001

Title: Effects of flunixin meglumine on selected clinicopathologic variables, and serum testosterone concentration in stallions after endotoxin administration.

Journal: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine20060901

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Actinobacillus peritonitis in a Warmblood gelding.

Journal: The Veterinary clinics of North America. Equine practice20060401

Title: Postpartum hemoperitoneum and septic peritonitis in a Thoroughbred mare.

Journal: The Veterinary clinics of North America. Equine practice20060401

Title: Acute diarrhea in the adult horse: case example and review.

Journal: The Veterinary clinics of North America. Equine practice20060401

Title: Malabsorptive maldigestive disorder with concurrent Salmonella in a 3-year-old quarter horse.

Journal: The Veterinary clinics of North America. Equine practice20060401

Title: Equine herpes myeloencephalopathy in a 12-year-old American quarter horse.

Journal: The Veterinary clinics of North America. Equine practice20060401

Title: Effects of phenylbutazone alone or in combination with flunixin meglumine on blood protein concentrations in horses.

Journal: American journal of veterinary research20060301

Title: Pharmacokinetics of flunixin after intravenous administration in healthy and endotoxaemic rabbits.

Journal: Veterinary research communications20060101

Title: Effect of a CIDR insert and flunixin meglumine, administered at the time of embryo transfer, on pregnancy rate and resynchronization of estrus in beef cattle.

Journal: Theriogenology20050901

Title: Technical Note: Improved technique for fitting pigs with steered ileocecal valve cannulas.

Journal: Journal of animal science20050701

Title: Pharmacokinetic interactions of flunixin meglumine and enrofloxacin in dogs.

Journal: American journal of veterinary research20050701

Title: Investigation of the effect of black walnut extract on in vitro ion transport and structure of equine colonic mucosa.

Journal: American journal of veterinary research20050301

Title: Use of force plate analysis to compare the analgesic effects of intravenous administration of phenylbutazone and flunixin meglumine in horses with navicular syndrome.

Journal: American journal of veterinary research20050201

Title: Evaluating postoperative analgesics in mice using telemetry.

Journal: Comparative medicine20050201

Title: [Slaughter emergency].

Journal: Tijdschrift voor diergeneeskunde20041101

Title: Field evaluation of flunixin meglumine in the supportive treatment of caprine mastitis.

Journal: Journal of veterinary pharmacology and therapeutics20041001

Title: Disposition of flunixin meglumine injectable preparation administered orally to healthy horses.

Journal: Journal of veterinary pharmacology and therapeutics20040601

Title: Effects of flunixin meglumine or etodolac treatment on mucosal recovery of equine jejunum after ischemia.

Journal: American journal of veterinary research20040601

Title: Effect of morphine and flunixin meglumine on isoflurane minimum alveolar concentration in goats.

Journal: Veterinary anaesthesia and analgesia20040401

Title: Pharmacokinetics of flunixin in the cat: enterohepatic circulation and active transport mechanism in the liver.

Journal: Journal of veterinary pharmacology and therapeutics20040401

Title: Effects of two anti-inflammatory drugs on physiologic variables and milk production in cows with endotoxin-induced mastitis.

Journal: American journal of veterinary research20040101

Title: Role of prostaglandins in the development of hyperthermia in heat-stressed, lactating Holstein cows.

Journal: Journal of veterinary pharmacology and therapeutics20031201

Title: Evaluation of flunixin meglumine as an adjunct treatment for diarrhea in dairy calves.

Journal: Journal of the American Veterinary Medical Association20031101

Title: Residue depletion study and withdrawal period for flunixin-N-methyl glucamine in bovine milk following intravenous administration.

Journal: Journal of agricultural and food chemistry20030730

Title: Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B.

Journal: American journal of veterinary research20030201

Title: A comparative study of the effects of meloxicam and flunixin meglumine (NSAIDs) as adjunctive therapy on interferon and tumor necrosis factor production in calves suffering from enzootic bronchopneumonia.

Journal: Polish journal of veterinary sciences20030101

Title: Flunixin residues in milk after intravenous treatment of dairy cattle with (14)C-flunixin.

Journal: Journal of agricultural and food chemistry20021204

Title: Kinetics of venom and antivenom serum and clinical parameters and treatment efficacy in Bothrops alternatus envenomed dogs.

Journal: Veterinary and human toxicology20021201

Title: Efficacy and pharmacokinetics of enrofloxacin and flunixin meglumine for treatment of cows with experimentally induced Escherichia coli mastitis.

Journal: Journal of veterinary pharmacology and therapeutics20020801

Title: In vitro investigation of the interaction between nitric oxide and cyclo-oxygenase activity in equine ventral colon smooth muscle.

Journal: Equine veterinary journal20020701

Title: Non-surgical management of rectal tears in two mares.

Journal: Australian veterinary journal20020301

Title: Effect of flunixin meglumine on selected physiologic and performance parameters of athletically conditioned thoroughbred horses subjected to an incremental exercise stress test.

Journal: Veterinary therapeutics : research in applied veterinary medicine20020101

Title: Investigation of factors affecting pregnancy rate after embryo transfer in the dromedary camel.

Journal: Reproduction, fertility, and development20020101

Title: In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats.

Journal: American journal of veterinary research20011101

Title: Pharmacokinetics of flunixin meglumine in llamas following a single intravenous dose.

Journal: Journal of veterinary pharmacology and therapeutics20011001

Title: Flunixin meglumine accelerates uterine involution and shortens the calving-to-first-oestrus interval in cows with puerperal metritis.

Journal: Journal of veterinary pharmacology and therapeutics20011001

Title: Possible active transport mechanism in pharmacokinetics of flunixin-meglumin in rabbits.

Journal: The Journal of veterinary medical science20010801

Title: Effects of steroidal and non-steroidal antiphlogistic drugs on eicosanoid synthesis in irritated skin: studies with the isolated perfused bovine udder.

Journal: The Journal of pharmacy and pharmacology20010501

Title: Role of prostaglandins in intrauterine migration of the equine conceptus.

Journal: Reproduction (Cambridge, England)20010501

Title: Effect of finadyne on oestradiol-induced ovarian oxytocin and uterine PGF2alpha secretory systems on day 15 after oestrus in ovarian autotransplanted ewes.

Journal: Reproduction (Cambridge, England)20010301

Title: Abdominal radiography in monitoring the resolution of sand accumulations from the large colon of horses treated medically.

Journal: Equine veterinary journal20010101

Title: Effects of anti-inflammatory drugs on lipopolysaccharide-challenged and -unchallenged equine synovial explants.

Journal: American journal of veterinary research20010101

Title: Effects of butorphanol, flunixin, levorphanol, morphine, and xylazine in ponies.

Journal: American journal of veterinary research19840201

Title: Cheng Z, et al. Measurement of cyclooxygenase inhibition in vivo: a study of two non-steroidal anti-inflammatory drugs in sheep. Inflammation. 1998 Aug;22(4):353-66.

Title: Bryant, C.E., B.A. Farnfield, and H.J. Janicke, Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B. Am J Vet Res, 2003. 64(2): p. 211-5.

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