Home Other Building Blocks 477600-75-2
477600-75-2,MFCD11035919
Catalog No.:AA00I8MD

477600-75-2 | Tofacitinib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$8.00   $6.00
- +
5mg
98%
in stock  
$15.00   $11.00
- +
25mg
95%
in stock  
$40.00   $28.00
- +
50mg
98%
in stock  
$45.00   $32.00
- +
100mg
95%
in stock  
$88.00   $62.00
- +
250mg
98%
in stock  
$112.00   $78.00
- +
1g
98%
in stock  
$261.00   $183.00
- +
5g
98%
in stock  
$760.00   $532.00
- +
10g
98%
in stock  
$1,258.00   $881.00
- +
25g
98%
in stock  
$2,472.00   $1,731.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00I8MD
Chemical Name:
Tofacitinib
CAS Number:
477600-75-2
Molecular Formula:
C16H20N6O
Molecular Weight:
312.3696
MDL Number:
MFCD11035919
SMILES:
N#CCC(=O)N1CCC([C@H](C1)N(c1ncnc2c1cc[nH]2)C)C
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
488  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
1.5  

Downstream Synthesis Route

[1]CurrentPatentAssignee:CSPCPHARMACEUTICALGROUPLIMITED-CN110343111,2019,ALocationinpatent:Page/Pagecolumn5-10

[2]CurrentPatentAssignee:LUOXINPHARMACEUTICALSGROUPSTOCKCOLTD-CN105884781,2016,ALocationinpatent:Paragraph0063

[3]CurrentPatentAssignee:LUOXINPHARMACEUTICALSGROUPSTOCKCOLTD-CN108997355,2018,ALocationinpatent:Paragraph0020;0021;0022;0025;0028

[4]CurrentPatentAssignee:SHANDONGUNIVERSITY-CN106146517,2016,ALocationinpatent:Paragraph0045;0051;0052;0065;0066-0070

[5]CurrentPatentAssignee:ZHEJIANGHUAHAIPHARMACEUTICALCO.,LTD.-CN114685510,2022,ALocationinpatent:Paragraph0047;0056-0058;0067-0069;0078-0079

[6]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2010/123919,2010,A2Locationinpatent:Page/Pagecolumn54-55

[7]CurrentPatentAssignee:KYUNGDONGPHARM.CO.,LTD.-KR2019/90729,2019,ALocationinpatent:Paragraph0097-0101

[8]CurrentPatentAssignee:GLENMARKPHARMACEUTICALSLTD-WO2014/102826,2014,A1Locationinpatent:Paragraph0297

[9]CurrentPatentAssignee:MSNLABORATORIESPRIVATELIMITED;SAMSUNGELECTRONICSCO.,LTD.-US2016/122354,2016,A1Locationinpatent:Paragraph0171;0172

[10]CurrentPatentAssignee:NANTONGCHANGYOUPHARMACEUTICALTECH-CN105732641,2016,ALocationinpatent:Paragraph0020

[11]CurrentPatentAssignee:SUNPHARMACEUTICALINDUSTRIESLIMITED-WO2016/132341,2016,A1Locationinpatent:Page/Pagecolumn6;7

[12]CurrentPatentAssignee:P&RSPA-US2016/297825,2016,A1Locationinpatent:Paragraph0105-0108

[13]CurrentPatentAssignee:YANGTZERIVERPHARMACEUTICALGROUPCOLTD-CN107793418,2018,ALocationinpatent:Paragraph0083;0084;0085;0086;0089

[14]CurrentPatentAssignee:SINOBIOPHARMACEUTICALLIMITED-CN108948020,2018,ALocationinpatent:Paragraph0025;0030;0031

[15]CurrentPatentAssignee:LEADINGPHARMMEDICALTECH-CN109776547,2019,ALocationinpatent:Paragraph0045;0048-0049

[16]CurrentPatentAssignee:GUANGZHOUYIPINHONGPHARMACEUTICAL-CN110437234,2019,ALocationinpatent:Paragraph0063-0091

[17]CurrentPatentAssignee:SICHUANUNIVERSITY-CN110724146,2020,ALocationinpatent:Page/Pagecolumn8-14

[18]CurrentPatentAssignee:JIANGSUHYKMEDICALTECH-CN110668995,2020,ALocationinpatent:Paragraph0090-0093

[19]Siadati,SeyyedAmir;Soheilizad,Mehdi;Firoozpour,Loghman;Samadi,Marjan;Payab,Meghdad;Bagherpour,Saeed;Mousavi,SeyyedMehdi[JournalofChemistry,2022,vol.2022]

[1]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2013/90490,2013,A1Locationinpatent:Page/Pagecolumn8;9

[2]CurrentPatentAssignee:PFIZERINC-US2012/258976,2012,A1Locationinpatent:Page/Pagecolumn14

[3]CurrentPatentAssignee:PFIZERINC-US2013/303557,2013,A1Locationinpatent:Paragraph0099

[4]CurrentPatentAssignee:UNICELLAB-KR102209701,2021,B1Locationinpatent:Paragraph0061-0076

tasocitinib 
  5949-29-1   
Tofacitinibcitrate 

[1]Patent:CN108640921,2018,A.Locationinpatent:Paragraph0087;0091;0092

[1]CurrentPatentAssignee:SHANDONGKEXINGBIOPRODUCTS-CN108640921,2018,A

[2]CurrentPatentAssignee:SHANDONGKEXINGBIOPRODUCTS-CN108640921,2018,A

[3]CurrentPatentAssignee:SHANDONGKEXINGBIOPRODUCTS-CN108640921,2018,A

[1]CurrentPatentAssignee:SHANDONGKEXINGBIOPRODUCTS-CN108640921,2018,ALocationinpatent:Paragraph0099;0101

Literature

Title: Jiang JK, et al. Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo,3-dpyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550). J Med Chem. 2008 Dec 25;51(24):8012-8.

Title: Onda M, et al. Tofacitinib suppresses antibody responses to protein therapeutics in murine hosts. J Immunol. 2014 Jul 1;193(1):48-55.

Title: LaBranche TP, et al. JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production. Arthritis Rheum. 2012 Nov;64(11):3531-42.

Title: Calama E, et al. Tofacitinib ameliorates inflammation in a rat model of airway neutrophilia induced by inhaled LPS. Pulm Pharmacol Ther. 2017 Apr;43:60-67.

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