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5300-03-8,MFCD00270072
Catalog No.:AA00I9E1

5300-03-8 | 9-cis-Retinoic acid

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1mg
≥90%
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5mg
≥90%
in stock  
$189.00   $132.00
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10mg
≥90%
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25mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I9E1
Chemical Name:
9-cis-Retinoic acid
CAS Number:
5300-03-8
Molecular Formula:
C20H28O2
Molecular Weight:
300.4351
MDL Number:
MFCD00270072
SMILES:
C/C(=C/C=C/C(=C/C(=O)O)/C)/C=C/C1=C(C)CCCC1(C)C
NSC Number:
659772
Properties
Computed Properties
 
Complexity:
567  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
4  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
6.3  

Literature

Title: Dose-dependent transcriptomic responses of zebrafish eleutheroembryos to Bisphenol A.

Journal: Environmental pollution (Barking, Essex : 1987) 20181201

Title: Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics.

Journal: Toxicology letters 20171105

Title: Comparison of phenotypic and global gene expression changes in Xenopus tropicalis embryos induced by agonists of RAR and RXR.

Journal: Toxicology and applied pharmacology 20170901

Title: Chlorination by-products of bisphenol A enhanced retinoid X receptor disrupting effects.

Journal: Journal of hazardous materials 20161215

Title: Arsenic trioxide suppresses liver X receptor β and enhances cholesteryl ester transfer protein expression without affecting the liver X receptor α in HepG2 cells.

Journal: Chemico-biological interactions 20161025

Title: Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages.

Journal: The Journal of biological chemistry 20160520

Title: Ligand Activity of Group 15 Compounds Possessing Triphenyl Substituent for the RXR and PPARγ Nuclear Receptors.

Journal: Biological & pharmaceutical bulletin 20160101

Title: Retinoids and rexinoids inhibit hepatitis C virus independently of retinoid receptor signaling.

Journal: Microbes and infection 20140201

Title: The acyclic retinoid Peretinoin inhibits hepatitis C virus replication and infectious virus release in vitro.

Journal: Scientific reports 20140101

Title: Tryptanthrin induces growth inhibition and neuronal differentiation in the human neuroblastoma LA-N-1 cells.

Journal: Chemico-biological interactions 20130425

Title: 9-cis retinoic acid is the ALDH1A1 product that stimulates melanogenesis.

Journal: Experimental dermatology 20130301

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Alitretinoin abrogates innate inflammation in palmoplantar pustular psoriasis.

Journal: The British journal of dermatology 20121101

Title: Combination treatment with a tumour necrosis factor antagonist and an oral retinoid: efficacy in severe acral psoriasis?

Journal: The British journal of dermatology 20121001

Title: Extended treatment with oral alitretinoin for patients with chronic hand eczema not fully responding to initial treatment.

Journal: Clinical and experimental dermatology 20121001

Title: Alitretinoin for cutaneous lupus erythematosus.

Journal: Journal of the American Academy of Dermatology 20120901

Title: Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARγ/RXRα in placentogenesis.

Journal: Journal of cellular biochemistry 20120701

Title: Oral alitretinoin: a review of the clinical pharmacokinetics and pharmacodynamics.

Journal: Expert review of clinical pharmacology 20120701

Title: High glucose-induced repression of RAR/RXR in cardiomyocytes is mediated through oxidative stress/JNK signaling.

Journal: Journal of cellular physiology 20120601

Title: 9-cis Retinoic acid inhibits cumulus cell apoptosis during the maturation of bovine cumulus-oocyte-complexes.

Journal: Journal of animal science 20120601

Title: Oral alitretinoin in congenital ichthyosis: a pilot study shows variable effects and a risk of central hypothyroidism.

Journal: Acta dermato-venereologica 20120501

Title: Efficacy and tolerability of alitretinoin for chronic hand eczema under daily practice conditions: results of the TOCCATA open study comprising 680 patients.

Journal: Acta dermato-venereologica 20120501

Title: [Chronic hand eczema, conventional and new treatments].

Journal: Revue medicale suisse 20120404

Title: The influence of 9-cis-retinoic acid on nuclear and cytoplasmic maturation and gene expression in canine oocytes during in vitro maturation.

Journal: Theriogenology 20120401

Title: Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes.

Journal: International immunopharmacology 20120401

Title: Retinoic acid/alpha-interferon combination inhibits growth and promotes apoptosis in mantle cell lymphoma through Akt-dependent modulation of critical targets.

Journal: Cancer research 20120401

Title: NR4A nuclear receptors mediate carnitine palmitoyltransferase 1A gene expression by the rexinoid HX600.

Journal: Biochemical and biophysical research communications 20120224

Title: Lymphangiogenesis: a potential new therapy for lymphedema?

Journal: Circulation 20120221

Title: 9-cis retinoic acid promotes lymphangiogenesis and enhances lymphatic vessel regeneration: therapeutic implications of 9-cis retinoic acid for secondary lymphedema.

Journal: Circulation 20120221

Title: Low concentrations of bisphenol a suppress thyroid hormone receptor transcription through a nongenomic mechanism.

Journal: Toxicology and applied pharmacology 20120215

Title: [Successful treatment of Darier disease with oral alitretinoin].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20120201

Title: Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA.

Journal: The EMBO journal 20120118

Title: Retinoid receptors trigger neuritogenesis in retinal degenerations.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120101

Title: Analysis, occurrence, and function of 9-cis-retinoic acid.

Journal: Biochimica et biophysica acta 20120101

Title: Retinoids regulate the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells.

Journal: PloS one 20120101

Title: Retinoic acid stability in stem cell cultures.

Journal: The International journal of developmental biology 20120101

Title: Effective treatment of chronic hand dermatitis with 36 continuous months of alitretinoin administration: report of three cases.

Journal: Journal of cutaneous medicine and surgery 20120101

Title: Lichen planus of nails - successful treatment with Alitretinoin.

Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20111201

Title: Role of ERK1/2 activation in microtubule stabilization and glucose transport in cardiomyocytes.

Journal: American journal of physiology. Endocrinology and metabolism 20111101

Title: Delayed translocation of NGFI-B/RXR in glutamate stimulated neurons allows late protection by 9-cis retinoic acid.

Journal: Biochemical and biophysical research communications 20111014

Title: [Response to treatment with oral alitretinoin in patients with chronic hand eczema that is refractory to treatment with potent topical corticosteroids: experience in 15 patients].

Journal: Actas dermo-sifiliograficas 20111001

Title: Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression.

Journal: Gastroenterology 20111001

Title: 9-cis retinoic acid improves developmental competence and embryo quality during in vitro maturation of bovine oocytes through the inhibition of oocyte tumor necrosis factor-α gene expression.

Journal: Journal of animal science 20110901

Title: Suppression of the pancreatic duodenal homeodomain transcription factor-1 (Pdx-1) promoter by sterol regulatory element-binding protein-1c (SREBP-1c).

Journal: The Journal of biological chemistry 20110812

Title: All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta.

Journal: Journal of leukocyte biology 20110801

Title: CrbpI modulates glucose homeostasis and pancreas 9-cis-retinoic acid concentrations.

Journal: Molecular and cellular biology 20110801

Title: Response of recalcitrant lichen planus to alitretinoin in 3 patients.

Journal: Journal of the American Academy of Dermatology 20110801

Title: Keratitis-ichthyosis-deafness syndrome: response to alitretinoin and review of literature.

Journal: Archives of dermatology 20110801

Title: Furocoumarin derivatives from radix Angelicae dahuricae and their effects on RXRα transcriptional regulation.

Journal: Molecules (Basel, Switzerland) 20110726

Title: Bid as a potential target of apoptotic effects exerted by low doses of PPARγ and RXR ligands in breast cancer cells.

Journal: Cell cycle (Georgetown, Tex.) 20110715

Title: Identification of ligand binding site on RXRγ using molecular docking and dynamics methods.

Journal: Journal of molecular modeling 20110601

Title: The 9-cis retinoic acid signaling pathway and its regulation of prostaglandin-endoperoxide synthase 2 during in vitro maturation of pig cumulus cell-oocyte complexes and effects on parthenogenetic embryo production.

Journal: Biology of reproduction 20110601

Title: Retinoids enhance glucocorticoid-induced apoptosis of T cells by facilitating glucocorticoid receptor-mediated transcription.

Journal: Cell death and differentiation 20110501

Title: Binding affinities of CRBPI and CRBPII for 9-cis-retinoids.

Journal: Biochimica et biophysica acta 20110501

Title: DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex.

Journal: Nature structural & molecular biology 20110501

Title: Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity.

Journal: Bioorganic & medicinal chemistry 20110501

Title: Small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26): synthesis and biological evaluation of imidazole methyl 3-(4-(aryl-2-ylamino)phenyl)propanoates.

Journal: Journal of medicinal chemistry 20110428

Title: Clinical pharmacology supplement: introduction.

Journal: Clinical and experimental dermatology 20110401

Title: Influence of alitretinoin on the pharmacokinetics of the oral contraceptive ethinyl estradiol/norgestimate.

Journal: Clinical and experimental dermatology 20110401

Title: Low levels of alitretinoin in seminal fluids after repeated oral doses in healthy men.

Journal: Clinical and experimental dermatology 20110401

Title: Influence of food on the pharmacokinetics of oral alitretinoin (9-cis retinoic acid).

Journal: Clinical and experimental dermatology 20110401

Title: Pharmacokinetic interactions between alitretinoin and ketoconazole or simvastatin or ciclosporin A.

Journal: Clinical and experimental dermatology 20110401

Title: Pharmacokinetics, efficacy and safety of alitretinoin in moderate or severe chronic hand eczema.

Journal: Clinical and experimental dermatology 20110401

Title: An open-label study assessing the safety and efficacy of alitretinoin in patients with severe chronic hand eczema unresponsive to topical corticosteroids.

Journal: Clinical and experimental dermatology 20110301

Title: Everyday clinical experience of alitretinoin in the treatment of severe chronic hand eczema: seven case studies.

Journal: Clinical and experimental dermatology 20110301

Title: Case study 1--A 54-year-old male gardener with chronic hand eczema.

Journal: Clinical and experimental dermatology 20110301

Title: Case study 2--A 33-year-old female horse trainer with long-standing hand and foot eczema.

Journal: Clinical and experimental dermatology 20110301

Title: Case study 3--A 41-year-old male with hyperkeratotic changes to the hands and feet.

Journal: Clinical and experimental dermatology 20110301

Title: Case study 4--A 35-year old male handyman with pompholyx blisters.

Journal: Clinical and experimental dermatology 20110301

Title: Case study 5--A 50-year-old female politician with long-standing chronic hand eczema affecting her quality of life.

Journal: Clinical and experimental dermatology 20110301

Title: Case study 6--A 56-year-old male civil engineer with chronic hand eczema presenting as fissures and inflammation.

Journal: Clinical and experimental dermatology 20110301

Title: Case study 7--A 39-year-old male IT worker with a 3 year history of chronic hand eczema.

Journal: Clinical and experimental dermatology 20110301

Title: All-trans- and 9-cis-retinoic acids activate the human cyclooxynase-2 gene: a role for DR1 as RARE or RXRE.

Journal: Molecular biology reports 20110201

Title: Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs.

Journal: Journal of cellular biochemistry 20110201

Title: Structure, energetics, and dynamics of binding coactivator peptide to the human retinoid X receptor α ligand binding domain complex with 9-cis-retinoic acid.

Journal: Biochemistry 20110111

Title: Retinoid X receptor gamma signaling accelerates CNS remyelination.

Journal: Nature neuroscience 20110101

Title: An RXR-γ Rx for white-matter damage.

Journal: Nature neuroscience 20110101

Title: Recent advances in the management of hand dermatitis: does alitretinoin work?

Journal: Clinics in dermatology 20110101

Title: Systemic therapy of atopic dermatitis in children and adults.

Journal: Current problems in dermatology 20110101

Title: Oral alitretinoin in chronic refractory hand eczema: a 'real life' case-series of 12 patients.

Journal: European journal of dermatology : EJD 20110101

Title: The thyroid hormone receptors modulate the skin response to retinoids.

Journal: PloS one 20110101

Title: Functional properties and substrate characterization of human CYP26A1, CYP26B1, and CYP26C1 expressed by recombinant baculovirus in insect cells.

Journal: Journal of pharmacological and toxicological methods 20110101

Title: Identification of 9-cis-retinoic acid as a pancreas-specific autacoid that attenuates glucose-stimulated insulin secretion.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20101214

Title: Changes in skin barrier during treatment with systemic alitretinoin: focus on skin susceptibility and stratum corneum ceramides.

Journal: Archives of dermatological research 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: [Alitretinoin in chronic hand eczema: summary of clinical trials].

Journal: Annales de dermatologie et de venereologie 20101101

Title: [Retinoids: mechanisms of action].

Journal: Annales de dermatologie et de venereologie 20101101

Title: Oral alitretinoin in lichen planus: two case reports.

Journal: Acta dermato-venereologica 20100901

Title: Treatment of refractory pityriasis rubra pilaris with oral alitretinoin: case report.

Journal: The British journal of dermatology 20100701

Title: Theoretical study of molecular mechanism of binding TRAP220 coactivator to Retinoid X Receptor alpha, activated by 9-cis retinoic acid.

Journal: The Journal of steroid biochemistry and molecular biology 20100701

Title: Effects of the aminophenol analogue p-Dodecylaminophenol on mouse skin.

Journal: The Journal of investigative dermatology 20100501

Title: Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid.

Journal: The Journal of investigative dermatology 20100501

Title: Redefining treatment options in chronic hand eczema (CHE).

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20100501

Title: Alitretinoin for the treatment of severe chronic hand eczema.

Journal: Health technology assessment (Winchester, England) 20100501

Title: [Alitretinoin: Toctino].

Journal: Annales de dermatologie et de venereologie 20100401

Title: Oral alitretinoin. Severe chronic hand eczema: this retinoid is too risky.

Journal: Prescrire international 20100401

Title: Synthesis and biological evaluation of 9Z-retinoic acid analogs having 2-substituted benzo[b]furan.

Journal: Chemical & pharmaceutical bulletin 20100301

Title: Acidic retinoids synergize with vitamin A to enhance retinol uptake and STRA6, LRAT, and CYP26B1 expression in neonatal lung.

Journal: Journal of lipid research 20100201

Title: Successful retreatment with alitretinoin in patients with relapsed chronic hand eczema.

Journal: The British journal of dermatology 20100201

Title: Managing chronic hand eczema.

Journal: The British journal of dermatology 20100201

Title: Retinoids activate RXR/CAR-mediated pathway and induce CYP3A.

Journal: Biochemical pharmacology 20100115

Title: Gene regulation of CYP4F11 in human keratinocyte HaCaT cells.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100101

Title: Treatment of atopic eczema with oral alitretinoin.

Journal: The British journal of dermatology 20100101

Title: Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms.

Journal: Molecular cancer 20100101

Title: Alitretinoin for severe chronic hand eczema: a NICE single technology appraisal.

Journal: PharmacoEconomics 20100101

Title: Characterization of a molecular switch system that regulates gene expression in mammalian cells through a small molecule.

Journal: BMC biotechnology 20100101

Title: Single technology appraisal at the UK National Institute for Health and clinical excellence: a source of evidence and analysis for decision making internationally.

Journal: PharmacoEconomics 20100101

Title: Cost-effectiveness of oral alitretinoin in patients with severe chronic hand eczema--a long-term analysis from a Swiss perspective.

Journal: BMC dermatology 20100101

Title: Anti-tumor effects of retinoids combined with trastuzumab or tamoxifen in breast cancer cells: induction of apoptosis by retinoid/trastuzumab combinations.

Journal: Breast cancer research : BCR 20100101

Title: p27(Kip1) deficiency promotes prostate carcinogenesis but does not affect the efficacy of retinoids in suppressing the neoplastic process.

Journal: BMC cancer 20100101

Title: Identification of retinoic acid in a high content screen for agents that overcome the anti-myogenic effect of TGF-beta-1.

Journal: PloS one 20100101

Title: Retinoic acids induce neurosteroid biosynthesis in human glial GI-1 Cells via the induction of steroidogenic genes.

Journal: Journal of biochemistry 20091201

Title: The effect of antagonists on the conformational exchange of the retinoid X receptor alpha ligand-binding domain.

Journal: Magnetic resonance in chemistry : MRC 20091201

Title: Possible benefit of oral alitretinoin in T-lymphoproliferative diseases: a report of two patients with palmoplantar hyperkeratotic-rhagadiform skin changes and mycosis fungoides or Sézary syndrome.

Journal: The British journal of dermatology 20091201

Title: Small discoidal pre-beta1 HDL particles are efficient acceptors of cell cholesterol via ABCA1 and ABCG1.

Journal: Biochemistry 20091124

Title: Statins, fibrates and retinoic acid upregulate mitochondrial acylcarnitine carrier gene expression.

Journal: Biochemical and biophysical research communications 20091030

Title: Retinoid X receptor-alpha mediates (R )-flurbiprofen's effect on the levels of Alzheimer's beta-amyloid.

Journal: Journal of neurochemistry 20091001

Title: Consensus statement on the management of chronic hand eczema.

Journal: Clinical and experimental dermatology 20091001

Title: Placental steroidogenesis in rats is independent of signaling pathways induced by retinoic acids.

Journal: General and comparative endocrinology 20090915

Title: Retinoic acid stimulates 17beta-estradiol and testosterone synthesis in rat hippocampal slice cultures.

Journal: Endocrinology 20090901

Title: Combined low doses of PPARgamma and RXR ligands trigger an intrinsic apoptotic pathway in human breast cancer cells.

Journal: The American journal of pathology 20090901

Title: Effects of cholesterol and nuclear hormone receptor agonists on the production of transforming growth factor-beta in macrophages.

Journal: Bulletin of experimental biology and medicine 20090901

Title: Alitretinoin: in severe chronic hand eczema.

Journal: Drugs 20090820

Title: Identification of a chromone-based retinoid containing a polyolefinic side chain via facile synthetic routes.

Journal: Bioorganic & medicinal chemistry letters 20090801

Title: Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles.

Journal: European journal of medicinal chemistry 20090601

Title: [Treatment for chronic hand eczema].

Journal: MMW Fortschritte der Medizin 20090507

Title: The vitamin A family can significantly decrease the expression of ERbeta of ERs positive breast cancer cells in the presence or absence of ER ligands and paclitaxel.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20090501

Title: Equilibrium unfolding of the retinoid X receptor ligand binding domain and characterization of an unfolding intermediate.

Journal: Biophysical chemistry 20090401

Title: Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor.

Journal: Digestive diseases and sciences 20090201

Title: 9-Cis-retinoic acid reduces ischemic brain injury in rodents via bone morphogenetic protein.

Journal: Journal of neuroscience research 20090201

Title: Low retinol levels differentially modulate bile salt-induced expression of human and mouse hepatic bile salt transporters.

Journal: Hepatology (Baltimore, Md.) 20090101

Title: Antiproliferative effects of CC-8062 and CC-8075 in pancreatic cancer cells.

Journal: Pancreas 20090101

Title: Potential new treatment for patients with severe chronic hand eczema.

Journal: Dermatology nursing 20090101

Title: 9-cis retinoic acid induces retinoid X receptor localized to the mitochondria for mediation of mitochondrial transcription.

Journal: Biochemical and biophysical research communications 20081212

Title: Exposure to 9-cis retinoic acid induces penis and vas deferens development in the female rock shell, Thais clavigera.

Journal: Cell biology and toxicology 20081201

Title: Comparison of the in vitro and in vivo effects of retinoids either alone or in combination with cisplatin and 5-fluorouracil on tumor development and metastasis of melanoma.

Journal: Cancer chemotherapy and pharmacology 20081201

Title: RXR isoforms and endogenous retinoids in the fiddler crab, Uca pugilator.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20081201

Title: Detection of endogenous retinoids in the molluscan CNS and characterization of the trophic and tropic actions of 9-cis retinoic acid on isolated neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20081126

Title: New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists.

Journal: Bioorganic & medicinal chemistry 20081115

Title: RXR agonists inhibit oxidative stress-induced apoptosis in H9c2 rat ventricular cells.

Journal: Biochemical and biophysical research communications 20081031

Title: Cutting edge: Inhibition of NF-kappaB-mediated TSLP expression by retinoid X receptor.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20081015

Title: Selected natural and synthetic retinoids impair CCR7- and CXCR4-dependent cell migration in vitro and in vivo.

Journal: Journal of leukocyte biology 20080901

Title: Cytosporone B is an agonist for nuclear orphan receptor Nur77.

Journal: Nature chemical biology 20080901

Title: [Alitretinoin: a new treatment option for chronic refractory hand eczema].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20080901

Title: [Chronic hand dermatitis: a solution in sight].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20080901

Title: Expression of uncoupling proteins in human skin and skin-derived cells.

Journal: The Journal of investigative dermatology 20080801

Title: 9-Cis-retinoic acid exhibits antifibrotic activity via the induction of cyclooxygenase-2 expression and prostaglandin E2 production in scleroderma fibroblasts.

Journal: Clinical and experimental dermatology 20080701

Title: Farnesol decreases serum triglycerides in rats: identification of mechanisms including up-regulation of PPARalpha and down-regulation of fatty acid synthase in hepatocytes.

Journal: Lipids 20080701

Title: Crystal structures of substrate-free and retinoic acid-bound cyanobacterial cytochrome P450 CYP120A1.

Journal: Biochemistry 20080624

Title: Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.

Journal: The Journal of biological chemistry 20080620

Title: Retinoid X receptor alpha is highly phosphorylated in retinoic acid-resistant HL-60R cells and the combination of 9-cis retinoic acid plus MEK inhibitor induces apoptosis in the cells.

Journal: Leukemia research 20080601

Title: Retinoids induce cytochrome P450 3A4 through RXR/VDR-mediated pathway.

Journal: Biochemical pharmacology 20080601

Title: PPAR gamma regulates MITF and beta-catenin expression and promotes a differentiated phenotype in mouse melanoma S91.

Journal: Pigment cell & melanoma research 20080601

Title: Pompholyx: what's new?

Journal: Expert opinion on investigational drugs 20080601

Title: Hepatic biotransformation responses in Atlantic salmon exposed to retinoic acids and 3,3',4,4'-tetrachlorobiphenyl (PCB congener 77).

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20080501

Title: Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia.

Journal: Journal of lipid research 20080401

Title: Efficacy and safety of oral alitretinoin (9-cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo-controlled, multicentre trial.

Journal: The British journal of dermatology 20080401

Title: Effect of 9-cis retinoic acid on dopamine D2 receptor expression in pituitary adenoma cells.

Journal: Experimental biology and medicine (Maywood, N.J.) 20080401

Title: [Emodin induces apoptosis of cancer cells and inhibits retinoid X receptor transcriptional activity].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080401

Title: Ab initio fragment molecular orbital study of molecular interactions between liganded retinoid X receptor and its coactivator; part II: influence of mutations in transcriptional activation function 2 activating domain core on the molecular interactions.

Journal: The journal of physical chemistry. A 20080313

Title: Nuclear receptor agonists improve insulin responsiveness in cultured cardiomyocytes through enhanced signaling and preserved cytoskeletal architecture.

Journal: Endocrinology 20080301

Title: Alitretinoin: a comprehensive review.

Journal: Expert opinion on investigational drugs 20080301

Title: The RXRalpha C-terminus T462 is a NMR sensor for coactivator peptide binding.

Journal: Biochemical and biophysical research communications 20080222

Title: A two-hybrid yeast assay to quantify the effects of xenobiotics on retinoid X receptor-mediated gene expression.

Journal: Toxicology letters 20080215

Title: Effect of heterodimer partner RXRalpha on PPARgamma activation function-2 helix in solution.

Journal: Biochemical and biophysical research communications 20080104

Title: VKORC1: a warfarin-sensitive enzyme in vitamin K metabolism and biosynthesis of vitamin K-dependent blood coagulation factors.

Journal: Vitamins and hormones 20080101

Title: Effect of retinoids on UDP-glucuronosyltransferase 2B7 mRNA expression in Caco-2 cells.

Journal: Drug metabolism and pharmacokinetics 20080101

Title: Effect of 9-cis retinoic acid (RA) on progesterone and estradiol secretion and RA receptor expression in the chicken ovarian follicles.

Journal: Folia biologica 20080101

Title: Orphan receptor TR3 attenuates the p300-induced acetylation of retinoid X receptor-alpha.

Journal: Molecular endocrinology (Baltimore, Md.) 20071201

Title: Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity.

Journal: The FEBS journal 20071201

Title: Imposex induction is mediated through the Retinoid X Receptor signalling pathway in the neogastropod Nucella lapillus.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20071115

Title: Proliferative changes in chemoprevention trials: learning from secondary endpoints.

Journal: Journal of the National Cancer Institute 20071107

Title: Proliferative changes in the bronchial epithelium of former smokers treated with retinoids.

Journal: Journal of the National Cancer Institute 20071107

Title: Agonists of PPAR-alpha, PPAR-gamma, and RXR inhibit the formation of foam cells from macrophages in mice with inflammation.

Journal: Bulletin of experimental biology and medicine 20071101

Title: Combinational treatment with retinoic acid derivatives in non-small cell lung carcinoma in vitro.

Journal: Journal of Korean medical science 20070901

Title: [Effect of retinoid X receptor activation on oxidized low-density lipoprotein induced cell differentiation of murine macrophage cell line into dendritic like cells].

Journal: Zhonghua xin xue guan bing za zhi 20070901

Title: Vitamin A regulation of gene expression: molecular mechanism of a prototype gene.

Journal: The Journal of nutritional biochemistry 20070801

Title: Adipocyte fatty acid-binding protein (aP2), a newly identified LXR target gene, is induced by LXR agonists in human THP-1 cells.

Journal: Molecular and cellular biochemistry 20070801

Title: Ethanol induces cholesterol efflux and up-regulates ATP-binding cassette cholesterol transporters in fetal astrocytes.

Journal: The Journal of biological chemistry 20070629

Title: 9-cis-Retinoic acid (9cRA), a retinoid X receptor (RXR) ligand, exerts immunosuppressive effects on dendritic cells by RXR-dependent activation: inhibition of peroxisome proliferator-activated receptor gamma blocks some of the 9cRA activities, and precludes them to mature phenotype development.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20070515

Title: Peroxisome proliferator-activated receptor gamma activation relieves expression of behavioral sensitization to methamphetamine in mice.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070501

Title: Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains.

Journal: Investigative ophthalmology & visual science 20070501

Title: p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells.

Journal: Experimental & molecular medicine 20070430

Title: Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth.

Journal: British journal of cancer 20070423

Title: Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells.

Journal: Endocrinology 20070401

Title: Inhibition of lung carcinogenesis by 1alpha,25-dihydroxyvitamin D3 and 9-cis retinoic acid in the A/J mouse model: evidence of retinoid mitigation of vitamin D toxicity.

Journal: International journal of cancer 20070401

Title: Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element.

Journal: Atherosclerosis 20070301

Title: MEK blockade converts AML differentiating response to retinoids into extensive apoptosis.

Journal: Blood 20070301

Title: Accumulation of retinoid X receptor-alpha in uterine leiomyomas is associated with a delayed ligand-dependent proteasome-mediated degradation and an alteration of its transcriptional activity.

Journal: Molecular endocrinology (Baltimore, Md.) 20070301

Title: Vitamin B6 conjugation to nuclear corepressor RIP140 and its role in gene regulation.

Journal: Nature chemical biology 20070301

Title: Thermodynamic characterization of the interaction between CAR-RXR and SRC-1 peptide by isothermal titration calorimetry.

Journal: Biochemistry 20070123

Title: Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells.

Journal: Life sciences 20070109

Title: Nuclear localization of liver X receptor alpha and beta is differentially regulated.

Journal: Journal of cellular biochemistry 20070101

Title: Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid.

Journal: Haematologica 20070101

Title: [Kaposi's sarcoma treated with topical alitretinoin].

Journal: Actas dermo-sifiliograficas 20070101

Title: Molecular cloning and analysis of the human PCAN1 (GDEP) promoter.

Journal: Cellular & molecular biology letters 20070101

Title: RXRalpha regulates the pregnancy-specific glycoprotein 5 gene transcription through a functional retinoic acid responsive element.

Journal: Placenta 20070101

Title: Age-related change in the retinoid X receptor beta gene expression in peripheral blood mononuclear cells of healthy volunteers: effect of 13-cis retinoic acid supplementation.

Journal: Mechanisms of ageing and development 20070101

Title: Bidirectional CLOCK/BMAL1-dependent circadian gene regulation by retinoic acid in vitro.

Journal: Biochemical and biophysical research communications 20061215

Title: In vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR)alpha and PPARgamma and quantitative analysis of in vivo induction pathway.

Journal: Toxicology and applied pharmacology 20061215

Title: Regulation of type III iodothyronine deiodinase expression in human cell lines.

Journal: Endocrinology 20061201

Title: Expression of the human ABCC6 gene is induced by retinoids through the retinoid X receptor.

Journal: Biochemical and biophysical research communications 20061201

Title: [Inducement effect of 9-cis retinoic acid on cell cycle arrest and apoptosis of gastric carcinoma cell line MGC803 and its mechanism].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20061201

Title: 9-cis-Retinoic acid inhibition of lung carcinogenesis in the A/J mouse model is accompanied by increased expression of RAR-beta but no change in cyclooxygenase-2.

Journal: Cancer letters 20061128

Title: Differentiation of rhabdomyosarcoma cell lines using retinoic acid.

Journal: Pediatric blood & cancer 20061101

Title: Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells.

Journal: Archives of biochemistry and biophysics 20061101

Title: Retinal pigment epithelium rescues vascular endothelium from retinoic acid-induced apoptosis.

Journal: Investigative ophthalmology & visual science 20061101

Title: 13-cis Retinoic acid induces apoptosis and cell cycle arrest in human SEB-1 sebocytes.

Journal: The Journal of investigative dermatology 20061001

Title: Mechanism of 4-HPR-induced apoptosis in glioma cells: evidences suggesting role of mitochondrial-mediated pathway and endoplasmic reticulum stress.

Journal: Carcinogenesis 20061001

Title: The retinoid X receptor ligand restores defective signalling by the vitamin D receptor.

Journal: EMBO reports 20061001

Title: Failure of topical 0.1% alitretinoin gel for classic Kaposi sarcoma: first European experience.

Journal: The British journal of dermatology 20061001

Title: Kinetic properties of chimeric class I aldehyde dehydrogenases for retinal isomers.

Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20061001

Title: Retinoic acid regulates the expression of photoreceptor transcription factor NRL.

Journal: The Journal of biological chemistry 20060915

Title: Molecular cloning of the rat beta-carotene 15,15'-monooxygenase gene and its regulation by retinoic acid.

Journal: European journal of nutrition 20060901

Title: Antitumoral activity of 13-demethyl or 13-substituted analogues of all-trans retinoic acid and 9-cis retinoic acid in the human myeloid leukemia cell line HL-60.

Journal: Biological & pharmaceutical bulletin 20060901

Title: Enhancement of sodium/iodide symporter expression in thyroid and breast cancer.

Journal: Endocrine-related cancer 20060901

Title: Differential regulation of CC chemokine receptors by 9-cis retinoic acid in the human mast cell line, HMC-1.

Journal: Life sciences 20060822

Title: Thrombomodulin induction in cultured human endothelial cells by 9-cis-locked retinoic acid analogues.

Journal: Bioorganic & medicinal chemistry 20060801

Title: A novel cytochrome P450, zebrafish Cyp26D1, is involved in metabolism of all-trans retinoic acid.

Journal: Molecular endocrinology (Baltimore, Md.) 20060701

Title: Peroxisome proliferator-activated receptor-gamma and retinoic acid X receptor alpha represses the TGFbeta1 gene via PTEN-mediated p70 ribosomal S6 kinase-1 inhibition: role for Zf9 dephosphorylation.

Journal: Molecular pharmacology 20060701

Title: Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060701

Title: Retinoic acids increase P2X2 receptor expression through the 5'-flanking region of P2rx2 gene in rat phaeochromocytoma PC-12 cells.

Journal: Molecular pharmacology 20060701

Title: Effects of 9-cis retinoic acid on human homeobox gene NKX3.1 expression in prostate cancer cell line LNCaP.

Journal: Asian journal of andrology 20060701

Title: [Mechanism of receptor for retinoids inducing apoptosis of human melanoma cell line A375].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20060701

Title: Co-resistance to retinoic acid and TRAIL by insertion mutagenesis into RAM.

Journal: Oncogene 20060622

Title: CYP4A11 is repressed by retinoic acid in human liver cells.

Journal: FEBS letters 20060612

Title: 9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway.

Journal: The Journal of biological chemistry 20060602

Title: Efficacy of new retinoids in the prevention of mammary cancers and correlations with short-term biomarkers.

Journal: Carcinogenesis 20060601

Title: Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1alpha gene transcription: an autoregulatory loop controls PGC-1alpha expression in adipocytes via peroxisome proliferator-activated receptor-gamma coactivation.

Journal: Endocrinology 20060601

Title: Retinoids, eye development, and maturation of visual function.

Journal: Journal of neurobiology 20060601

Title: 9-cis retinoic acid induces insulin-like growth factor binding protein-3 through DR-8 retinoic acid responsive elements.

Journal: Cancer biology & therapy 20060601

Title: The human kallikrein 10 promoter contains a functional retinoid response element.

Journal: Biological chemistry 20060601

Title: Retinoic acid exerts dual regulatory actions on the expression and nuclear localization of interferon regulatory factor-1.

Journal: Experimental biology and medicine (Maywood, N.J.) 20060501

Title: Organotin compounds enhance 17beta-hydroxysteroid dehydrogenase type I activity in human choriocarcinoma JAr cells: potential promotion of 17beta-estradiol biosynthesis in human placenta.

Journal: Biochemical pharmacology 20060428

Title: Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells.

Journal: International journal of oncology 20060401

Title: Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide.

Journal: Molecular cancer therapeutics 20060401

Title: The phosphoinositide 3-kinase/Akt pathway is essential for the retinoic acid-induced differentiation of F9 cells.

Journal: Oncogene 20060330

Title: Receptor-selective retinoids inhibit the growth of normal and malignant breast cells by inducing G1 cell cycle blockade.

Journal: Breast cancer research and treatment 20060301

Title: Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis.

Journal: Endocrinology 20060301

Title: Analysis of ligand binding and protein dynamics of human retinoid X receptor alpha ligand-binding domain by nuclear magnetic resonance.

Journal: Biochemistry 20060214

Title: Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.

Journal: Journal of cellular biochemistry 20060201

Title: Prostate cancer cell type-specific involvement of the VDR and RXR in regulation of the human PTHrP gene via a negative VDRE.

Journal: Steroids 20060201

Title: Nonclassical action of retinoic acid on the activation of the cAMP response element-binding protein in normal human bronchial epithelial cells.

Journal: Molecular biology of the cell 20060201

Title: 9-Cis-retinoic acid suppresses inflammatory responses of microglia and astrocytes.

Journal: Journal of neuroimmunology 20060201

Title: TGIF inhibits retinoid signaling.

Journal: Molecular and cellular biology 20060201

Title: Retinoic acid receptors and tissue-transglutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells.

Journal: Oncogene 20060112

Title: Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis.

Journal: Gut 20060101

Title: Retinoic acids increase expression of GLUT4 in dedifferentiated and hypertrophied cardiac myocytes.

Journal: Basic research in cardiology 20060101

Title: Investigation of the mechanisms by which EB1089 abrogates apoptosis induced by 9-cis retinoic acid in pancreatic cancer cells.

Journal: Pancreas 20060101

Title: Cyclic adenosine monophosphate-dependent cell type-specific modulation of mitogenic signaling by retinoids in normal and neoplastic lung cells.

Journal: Cancer detection and prevention 20060101

Title: Regulation of 5'-promoter activity of the rat growth hormone and growth hormone-releasing hormone receptor genes in the MtT/S and MtT/E cells.

Journal: Neuroendocrinology 20060101

Title: Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes.

Journal: BMC immunology 20060101

Title: Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytes.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20051215

Title: Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy.

Journal: Cancer research 20051215

Title: Nuclear import of the retinoid X receptor, the vitamin D receptor, and their mutual heterodimer.

Journal: The Journal of biological chemistry 20051202

Title: Retinoic acid is a potential negative regulator for differentiation of human periodontal ligament cells.

Journal: Journal of periodontal research 20051201

Title: Vitamin A status in mice affects the histone code of the phosphoenolpyruvate carboxykinase gene in liver.

Journal: The Journal of nutrition 20051201

Title: Retinoic acid induces VEGF gene expression in human retinal pigment epithelial cells (ARPE-19).

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20051201

Title: All-trans and 9-cis retinoic acids, retinol and beta-carotene chemopreventive activities during the initial phases of hepatocarcinogenesis involve distinct actions on glutathione S-transferase positive preneoplastic lesions remodeling and DNA damage.

Journal: Carcinogenesis 20051101

Title: Molecular brightness determined from a generalized form of Mandel's Q-parameter.

Journal: Biophysical journal 20051101

Title: Development of a versatile reporter assay for studies of retinol uptake and metabolism in vivo.

Journal: Experimental cell research 20051101

Title: Specificity of receptor-ligand interactions and their effect on dimerisation as observed by electrospray mass spectrometry: bile acids form stable adducts to the RXRalpha.

Journal: Journal of mass spectrometry : JMS 20051101

Title: Physiological and receptor-selective retinoids modulate interferon gamma signaling by increasing the expression, nuclear localization, and functional activity of interferon regulatory factor-1.

Journal: The Journal of biological chemistry 20051028

Title: Ligand recognition by RAR and RXR receptors: binding and selectivity.

Journal: Journal of medicinal chemistry 20051006

Title: Trialkyltin compounds bind retinoid X receptor to alter human placental endocrine functions.

Journal: Molecular endocrinology (Baltimore, Md.) 20051001

Title: The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver.

Journal: Journal of lipid research 20051001

Title: Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells.

Journal: International journal of molecular medicine 20051001

Title: Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXRalpha phosphorylation.

Journal: The Journal of clinical investigation 20051001

Title: Hepatocyte growth factor receptor signaling mediates the anti-fibrotic action of 9-cis-retinoic acid in glomerular mesangial cells.

Journal: The American journal of pathology 20051001

Title: Regulation of a highly specific retinoic acid-4-hydroxylase (CYP26A1) enzyme and all-trans-retinoic acid metabolism in human intestinal, liver, endothelial, and acute promyelocytic leukemia cells.

Journal: Leukemia & lymphoma 20051001

Title: Effect of retinoic acid on murine preosteoblastic MC3T3-E1 cells.

Journal: Journal of nutritional science and vitaminology 20051001

Title: The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling.

Journal: Cell 20050923

Title: Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis-retinoic acid.

Journal: Cancer letters 20050908

Title: Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors.

Journal: Biochemical and biophysical research communications 20050902

Title: Overexpression of the Wnt5b gene in leiomyoma cells: implications for a role of the Wnt signaling pathway in the uterine benign tumor.

Journal: The Journal of clinical endocrinology and metabolism 20050901

Title: VPAC1 expression is regulated by FXR agonists in the human gallbladder epithelium.

Journal: Hepatology (Baltimore, Md.) 20050901

Title: A teleost in vitro reporter gene assay to screen for agonists of the peroxisome proliferator-activated receptors.

Journal: Environmental toxicology and chemistry 20050901

Title: Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome.

Journal: The Journal of clinical endocrinology and metabolism 20050801

Title: Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia.

Journal: Journal of neuroscience research 20050801

Title: [Receptor-related mechanism of proliferation inhibilion and apoptosis induetion of human tongue squamous cell line Tca8113 by retinoids].

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050801

Title: Sensitivity to DNA damage is a common component of hormone-based strategies for protection of the mammary gland.

Journal: Molecular cancer research : MCR 20050801

Title: Arginine methylation provides epigenetic transcription memory for retinoid-induced differentiation in myeloid cells.

Journal: Molecular and cellular biology 20050701

Title: Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro.

Journal: The Journal of investigative dermatology 20050701

Title: Effects of 9-cis-retinoic acid on the insulin-like growth factor axis in former smokers.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050701

Title: A new retinoid-like compound that activates peroxisome proliferator-activated receptors and lowers blood glucose in diabetic mice.

Journal: Biological & pharmaceutical bulletin 20050701

Title: Open-label pilot study of alitretinoin gel 0.1% in the treatment of photoaging.

Journal: Cutis 20050701

Title: Vitamin D receptor-dependent regulation of colon multidrug resistance-associated protein 3 gene expression by bile acids.

Journal: The Journal of biological chemistry 20050617

Title: Oxysterols inhibit phosphatidylcholine synthesis via ERK docking and phosphorylation of CTP:phosphocholine cytidylyltransferase.

Journal: The Journal of biological chemistry 20050603

Title: Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation.

Journal: The Journal of biological chemistry 20050603

Title: Quantification of endogenous retinoic acid in limited biological samples by LC/MS/MS.

Journal: The Biochemical journal 20050515

Title: Selective activation of PPARgamma in breast, colon, and lung cancer cell lines.

Journal: Molecular and cellular endocrinology 20050512

Title: 9-cis-retinoic acid inhibits androgen receptor activity through activation of retinoid X receptor.

Journal: Molecular endocrinology (Baltimore, Md.) 20050501

Title: Ligation of RARgamma inhibits proliferation of phytohaemagglutinin-stimulated T-cells via down-regulating JAK3 protein levels.

Journal: Immunology letters 20050415

Title: Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness.

Journal: Journal of neurochemistry 20050401

Title: Sensitization of cervical cancer cell lines to low-dose radiation by retinoic acid does not require functional p53.

Journal: Gynecologic oncology 20050401

Title: [Advances in studies on selective RXR ligands].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050401

Title: The detection of differentiation-inducing chemicals by using green fluorescent protein expression in genetically engineered teratocarcinoma cells.

Journal: Alternatives to laboratory animals : ATLA 20050401

Title: 9-cis-retinoic acid treatment increases serum concentrations of alpha-tocopherol in former smokers.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050315

Title: Expression of gastrointestinal glutathione peroxidase is inversely correlated to the presence of hepatitis C virus subgenomic RNA in human liver cells.

Journal: The Journal of biological chemistry 20050311

Title: Proteasome inhibitors induce peroxisome proliferator-activated receptor transactivation through RXR accumulation and a protein kinase C-dependent pathway.

Journal: Experimental cell research 20050310

Title: HX531, a retinoid X receptor antagonist, inhibited the 9-cis retinoic acid-induced binding with steroid receptor coactivator-1 as detected by surface plasmon resonance.

Journal: The Journal of steroid biochemistry and molecular biology 20050301

Title: Retinoids and pulmonary hypertension.

Journal: Circulation 20050215

Title: Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.

Journal: Archives of biochemistry and biophysics 20050201

Title: Therapeutic potential of thiazolidinediones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration.

Journal: European journal of pharmacology 20050131

Title: Activation of peroxisome proliferator-activated receptor alpha increases the expression and activity of microsomal triglyceride transfer protein in the liver.

Journal: The Journal of biological chemistry 20050114

Title: Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter.

Journal: American journal of physiology. Endocrinology and metabolism 20050101

Title: Retinoic acid isomers protect hippocampal neurons from amyloid-beta induced neurodegeneration.

Journal: Neurotoxicity research 20050101

Title: Cellular retinoic acid binding protein I: expression and functional influence in renal cell carcinoma.

Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20050101

Title: Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression.

Journal: Journal of biochemical and molecular toxicology 20050101

Title: Targacept active conformation search: a new method for predicting the conformation of a ligand bound to its protein target.

Journal: Journal of medicinal chemistry 20041230

Title: 9-cis-retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists.

Journal: Bioorganic & medicinal chemistry letters 20041220

Title: Oral alitretinoin (9-cis-retinoic acid) therapy for chronic hand dermatitis in patients refractory to standard therapy: results of a randomized, double-blind, placebo-controlled, multicenter trial.

Journal: Archives of dermatology 20041201

Title: RXRalpha acts as a carrier for TR3 nuclear export in a 9-cis retinoic acid-dependent manner in gastric cancer cells.

Journal: Journal of cell science 20041101

Title: Activity of MDI-301, a novel synthetic retinoid, in xenografts.

Journal: Anti-cancer drugs 20041101

Title: Interaction of nuclear receptor ligands with the Vitamin D signaling pathway in prostate cancer.

Journal: The Journal of steroid biochemistry and molecular biology 20041101

Title: Midkine and retinoic acid reduce cerebral infarction induced by middle cerebral artery ligation in rats.

Journal: Neuroscience letters 20041014

Title: Breast cancer progression in MCF10A series of cell lines is associated with alterations in retinoic acid and retinoid X receptors and with differential response to retinoids.

Journal: International journal of oncology 20041001

Title: The induction of prostaglandin E synthase and upregulation of cyclooxygenase-2 by 9-cis retinoic acid.

Journal: Prostaglandins & other lipid mediators 20041001

Title: Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-deoxy-Delta12,14-prostaglandin J2.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20040901

Title: Determinants of retinoid X receptor transcriptional antagonism.

Journal: Journal of medicinal chemistry 20040826

Title: Structure-activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells.

Journal: Bioorganic & medicinal chemistry letters 20040816

Title: Differential effects of 9-cis retinoic acid on expression of CC chemokine receptors in human monocytes.

Journal: Biochemical pharmacology 20040815

Title: Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20040801

Title: Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells.

Journal: Blood 20040701

Title: Spatiotemporal retinoid-X receptor activation detected in live vertebrate embryos.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20040615

Title: The combination of tamoxifen and 9cis retinoic acid exerts overadditive anti-tumoral efficacy in rat hepatocellular carcinoma.

Journal: Journal of hepatology 20040601

Title: Purification and crystallization of the heterodimeric complex of RARbeta and RXRalpha ligand-binding domains in the active conformation.

Journal: Acta crystallographica. Section D, Biological crystallography 20040601

Title: How retinoids regulate breast cancer cell proliferation and apoptosis.

Journal: Cellular and molecular life sciences : CMLS 20040601

Title: Early expression of thyroid hormone receptor beta and retinoid X receptor gamma in the Xenopus embryo.

Journal: Differentiation; research in biological diversity 20040601

Title: Retinoids increase alpha-1 acid glycoprotein expression at the transcriptional level through two distinct DR1 retinoic acid responsive elements.

Journal: Biochimica et biophysica acta 20040525

Title: In vivo activation of PPAR target genes by RXR homodimers.

Journal: The EMBO journal 20040519

Title: Transactivation of the PPAR-responsive enhancer module in chemopreventive glutathione S-transferase gene by the peroxisome proliferator-activated receptor-gamma and retinoid X receptor heterodimer.

Journal: Cancer research 20040515

Title: MAT1-modulated cyclin-dependent kinase-activating kinase activity cross-regulates neuroblastoma cell G1 arrest and neurite outgrowth.

Journal: Cancer research 20040501

Title: Oxidized LDL upregulated ATP binding cassette transporter-1 in THP-1 macrophages.

Journal: Acta pharmacologica Sinica 20040501

Title: Retinoic acid inhibits interleukin-4-induced eotaxin production in a human bronchial epithelial cell line.

Journal: American journal of physiology. Lung cellular and molecular physiology 20040401

Title: Modulation of resistin expression by retinoic acid and vitamin A status.

Journal: Diabetes 20040401

Title: Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter.

Journal: The Journal of biological chemistry 20040312

Title: Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis.

Journal: Journal of neuroimmunology 20040301

Title: Effect of LPS on basal and induced apo E secretion by 25-OH chol and 9cRA in differentiated CaCo-2.

Journal: Journal of cellular biochemistry 20040301

Title: Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1).

Journal: The Journal of biological chemistry 20040227

Title: Novel roles of retinoid X receptor (RXR) and RXR ligand in dynamically modulating the activity of the thyroid hormone receptor/RXR heterodimer.

Journal: The Journal of biological chemistry 20040227

Title: Dynamics and ligand-induced solvent accessibility changes in human retinoid X receptor homodimer determined by hydrogen deuterium exchange and mass spectrometry.

Journal: Biochemistry 20040203

Title: The transcription factor NGFI-B (Nur77) and retinoids play a critical role in acute neuroleptic-induced extrapyramidal effect and striatal neuropeptide gene expression.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040201

Title: Efficacy of 9-cis-retinoic acid and N-(4-hydroxyphenyl) retinamide alone and in combination in mammary cancer prevention.

Journal: Oncology reports 20040201

Title: RXR-induced TNF-alpha suppression is reversed by morphine in activated U937 cells.

Journal: Journal of neuroimmunology 20040201

Title: Retinoic acid induces corneal epithelial CYP4B1 gene expression and stimulates the synthesis of inflammatory 12-hydroxyeicosanoids.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040201

Title: [Effects of 9-cis-retinoic acid on cell cycle and expression of cyclin D1 and cdk4 in lung cancer cells].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040201

Title: A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid.

Journal: The Journal of biological chemistry 20040102

Title: Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids.

Journal: Hepatology (Baltimore, Md.) 20040101

Title: Retinoic acid increases insulin-like growth factor-binding protein-4 expression in cultured rat hepatocytes.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20040101

Title: Effects of hormones targeting nuclear receptors on transcriptional regulation of the growth hormone gene in the MtT/S rat somatotrope cell line.

Journal: Neuroendocrinology 20040101

Title: Effect of retinoic acid on leptin, glycerol, and glucose levels in mature rat adipocytes in vitro.

Journal: Journal of medicinal food 20040101

Title: Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid.

Journal: The Journal of biological chemistry 20031219

Title: Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells.

Journal: The Biochemical journal 20031201

Title: Functional specificity of two hormone response elements present on the human apoA-II promoter that bind retinoid X receptor alpha/thyroid receptor beta heterodimers for retinoids and thyroids: synergistic interactions between thyroid receptor beta and upstream stimulatory factor 2a.

Journal: The Biochemical journal 20031201

Title: The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro.

Journal: International journal of cancer 20031110

Title: 9-cis-retinoic acid during in vitro maturation improves development of the bovine oocyte and increases midkine but not IGF-I expression in cumulus-granulosa cells.

Journal: Molecular reproduction and development 20031101

Title: Separation of retinoid-induced epidermal and dermal thickening from skin irritation.

Journal: Archives of dermatological research 20031101

Title: Identification and characterization of rodent ABCA1 in isolated type II pneumocytes.

Journal: American journal of physiology. Lung cellular and molecular physiology 20031001

Title: Growth inhibition through activation of peroxisome proliferator-activated receptor gamma in human oesophageal squamous cell carcinoma.

Journal: European journal of cancer (Oxford, England : 1990) 20031001

Title: 9-cis-Retinoic acid regulation of four UGT isoforms in hepatocytes from rats with various thyroid states.

Journal: Pharmaceutical research 20031001

Title: Transcription suppression of thromboxane receptor gene expression by retinoids in vascular smooth muscle cells.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20031001

Title: Thiazolidinediones inhibit growth of gastrointestinal, biliary, and pancreatic adenocarcinoma cells through activation of the peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway.

Journal: Experimental cell research 20030910

Title: Overadditive anti-proliferative and pro-apoptotic effects of a combination therapy on colorectal carcinoma cells.

Journal: International journal of oncology 20030901

Title: 9-cis retinoic acid accelerates calcitriol-induced osteocalcin production and promotes degradation of both vitamin D receptor and retinoid X receptor in human osteoblastic cells.

Journal: Journal of cellular biochemistry 20030815

Title: Growth inhibition of pancreatic cancer cells through activation of peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway.

Journal: International journal of oncology 20030801

Title: Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors.

Journal: International immunology 20030801

Title: Combination treatment with 1alpha,25-dihydroxyvitamin D3 and 9-cis-retinoic acid directly inhibits human telomerase reverse transcriptase transcription in prostate cancer cells.

Journal: Molecular cancer therapeutics 20030801

Title: Neuroprotective effects of PPARgamma agonists against oxidative insults in HT-22 cells.

Journal: European journal of pharmacology 20030704

Title: Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II gene regulation by bile acids and retinoids.

Journal: The Biochemical journal 20030601

Title: 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion.

Journal: The Journal of biological chemistry 20030411

Title: All-trans and 9-cis retinoid acids inhibit proliferation, migration, and synthesis of extracellular matrix of human vascular smooth muscle cells by inducing differentiation in vitro.

Journal: Journal of cardiovascular pharmacology 20030401

Title: Dual activation of PPARalpha and PPARgamma by mono-(2-ethylhexyl) phthalate in rat ovarian granulosa cells.

Journal: Molecular and cellular endocrinology 20030328

Title: The lipidation by hepatocytes of human apolipoprotein A-I occurs by both ABCA1-dependent and -independent pathways.

Journal: The Journal of biological chemistry 20030321

Title: Mouse retinal dehydrogenase 4 (RALDH4), molecular cloning, cellular expression, and activity in 9-cis-retinoic acid biosynthesis in intact cells.

Journal: The Journal of biological chemistry 20030314

Title: Pregnancies and improved early embryonic development with bovine oocytes matured in vitro with 9-cis-retinoic acid.

Journal: Reproduction (Cambridge, England) 20030301

Title: Endocrine regulation of mitochondrial activity: involvement of truncated RXRalpha and c-Erb Aalpha1 proteins.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030301

Title: Characterization of mammary tumor cell lines from wild type and vitamin D3 receptor knockout mice.

Journal: Molecular and cellular endocrinology 20030227

Title: Predicting success in cancer prevention trials.

Journal: Journal of the National Cancer Institute 20030205

Title: Treatment of former smokers with 9-cis-retinoic acid reverses loss of retinoic acid receptor-beta expression in the bronchial epithelium: results from a randomized placebo-controlled trial.

Journal: Journal of the National Cancer Institute 20030205

Title: The efficacy of 9-cis-retinoic acid (aliretinoin) as a chemopreventive agent for cervical dysplasia: results of a randomized double-blind clinical trial.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20030201

Title: 9-cis-retinoic acid capsules in the treatment of AIDS-related Kaposi sarcoma: results of a phase 2 multicenter clinical trial.

Journal: Archives of dermatology 20030201

Title: Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid.

Journal: Bioorganic & medicinal chemistry letters 20030120

Title: Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes.

Journal: The Journal of biological chemistry 20030103

Title: p53 Is required for 1,25-dihydroxyvitamin D3-induced G0 arrest but is not required for G1 accumulation or apoptosis of LNCaP prostate cancer cells.

Journal: Endocrinology 20030101

Title: 9-cis retinoic acid enhances the antiviral effect of interferon on hepatitis C virus replication through increased expression of type I interferon receptor.

Journal: The Journal of laboratory and clinical medicine 20030101

Title: Clinically potential subclasses of retinoid synergists revealed by gene expression profiling.

Journal: Molecular cancer therapeutics 20030101

Title: Aberration in the expression of the retinoid receptor, RXRalpha, in prostate cancer.

Journal: Cancer biology & therapy 20030101

Title: Effect of a new derivative of retinoic acid on proliferation and differentiation in human neuroblastoma cells.

Journal: Anticancer research 20030101

Title: Treatment of Kaposi's sarcoma in HIV-1 infected individuals with emphasis on resource poor settings.

Journal: The Cochrane database of systematic reviews 20030101

Title: Alitretinoin gel to treat pyogenic granuloma.

Journal: Journal of the American Academy of Dermatology 20021201

Title: [A novel molecular target therapeutics for refractory prostate cancer].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20021201

Title: Retinoic acid stimulates the cell cycle machinery in normal T cells: involvement of retinoic acid receptor-mediated IL-2 secretion.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20021115

Title: Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol.

Journal: Journal of lipid research 20021101

Title: The regulation of the thyroid-stimulating hormone of the anterior pituitary gland by thyroid hormone and by 9-cis-retinoic acid.

Journal: Nutrition reviews 20021101

Title: Retinoid signaling controls mouse pancreatic exocrine lineage selection through epithelial-mesenchymal interactions.

Journal: Gastroenterology 20021001

Title: Isolation and functional analysis of the mouse RXRgamma1 gene promoter in anterior pituitary cells.

Journal: The Journal of biological chemistry 20020927

Title: Synthesis and characterization of a new RXR agonist based on the 6-tert-butyl-1,1-dimethylindanyl structure.

Journal: Bioorganic & medicinal chemistry letters 20020916

Title: 9-cis-retinoic acid but not 4-(hydroxyphenyl)retinamide inhibits prostate intraepithelial neoplasia in Noble rats.

Journal: Cancer research 20020915

Title: Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/Bax.

Journal: British journal of cancer 20020827

Title: Stereoselective synthesis of annular 9-cis-retinoids and binding characterization to the retinoid X receptor.

Journal: The Journal of organic chemistry 20020823

Title: Immunomodulatory effects of RXR rexinoids: modulation of high-affinity IL-2R expression enhances susceptibility to denileukin diftitox.

Journal: Blood 20020815

Title: Superior effect of 9-cis retinoic acid (RA) compared with all-trans RA and 13-cis RA on the inhibition of clonogenic cell growth and the induction of apoptosis in OCI/AML-2 subclones: is the p53 pathway involved?

Journal: British journal of haematology 20020801

Title: Preventive efficacy of receptor class selective retinoids on HER-2/neu oncogene expressing preneoplastic human mammary epithelial cells.

Journal: International journal of oncology 20020701

Title: LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells.

Journal: Journal of lipid research 20020701

Title: The expression of retinoic acid receptors and the effects in vitro by retinoids in human pancreatic cancer cell lines.

Journal: Pancreas 20020701

Title: Analysis of human cellular retinol-binding protein II promoter during enterocyte differentiation.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20020601

Title: Sterol regulatory element binding protein-1c expression and action in rat muscles: insulin-like effects on the control of glycolytic and lipogenic enzymes and UCP3 gene expression.

Journal: Diabetes 20020601

Title: Induction of human aquaporin-1 gene by retinoic acid in human erythroleukemia HEL cells.

Journal: Biochemical and biophysical research communications 20020510

Title: Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20020501

Title: Molecular recognition of agonist ligands by RXRs.

Journal: Molecular endocrinology (Baltimore, Md.) 20020501

Title: Acyclic retinoid induces partial differentiation, down-regulates telomerase reverse transcriptase mRNA expression and telomerase activity, and induces apoptosis in human hepatoma-derived cell lines.

Journal: Journal of hepatology 20020501

Title: Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020501

Title: Mechanism of protection induced by vitamin A in falciparum malaria.

Journal: Lancet (London, England) 20020420

Title: Photoaffinity labeling of human retinoid X receptor beta (RXRbeta) with 9-cis-retinoic acid: identification of phytanic acid, docosahexaenoic acid, and lithocholic acid as ligands for RXRbeta.

Journal: Biochemistry 20020416

Title: Retinoids induce the PAI-1 gene expression through tyrosine kinase-dependent pathways in vascular smooth muscle cells.

Journal: Journal of cardiovascular pharmacology 20020401

Title: A mathematical analysis using fractals for binding interactions of nuclear estrogen receptors occurring on biosensor surfaces.

Journal: Analytical biochemistry 20020401

Title: Targeted disruption of the mouse cis-retinol dehydrogenase gene: visual and nonvisual functions.

Journal: Journal of lipid research 20020401

Title: Retinoids enhance cisplatin-based chemoradiation in cervical cancer cells in vitro.

Journal: Gynecologic oncology 20020401

Title: Topical 0.1% alitretinoin gel for classic Kaposi sarcoma.

Journal: Archives of dermatology 20020401

Title: Kinetic analysis of mouse retinal dehydrogenase type-2 (RALDH2) for retinal substrates.

Journal: Biochimica et biophysica acta 20020401

Title: cis-Retinol/androgen dehydrogenase, isozyme 3 (CRAD3): a short-chain dehydrogenase active in a reconstituted path of 9-cis-retinoic acid biosynthesis in intact cells.

Journal: Biochemistry 20020312

Title: Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids.

Journal: Biochemical pharmacology 20020301

Title: Discovery and design of retinoic acid receptor and retinoid X receptor class- and subtype-selective synthetic analogs of all-trans-retinoic acid and 9-cis-retinoic acid.

Journal: Current medicinal chemistry 20020301

Title: Tumor prevention by 9-cis-retinoic acid in the N-nitroso-N-methylurea model of mammary carcinogenesis is potentiated by the pineal hormone melatonin.

Journal: Breast cancer research and treatment 20020301

Title: Synergistic effect of vitamin D derivatives and retinoids on C2C12 skeletal muscle cells.

Journal: IUBMB life 20020301

Title: Oxysterol activators of liver X receptor and 9-cis-retinoic acid promote sequential steps in the synthesis and secretion of tumor necrosis factor-alpha from human monocytes.

Journal: The Journal of biological chemistry 20020215

Title: Antitumor activity of oral 9-cis-retinoic acid in HIV-associated Kaposi's sarcoma.

Journal: AIDS (London, England) 20020215

Title: Alitretinoin.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020215

Title: Peroxisome proliferator-activated receptor gamma reduces the growth rate of pancreatic cancer cells through the reduction of cyclin D1.

Journal: Life sciences 20020215

Title: Macrophage cholesterol efflux to free apoprotein A-I in C3H and C57BL/6 mice.

Journal: Biochemical and biophysical research communications 20020208

Title: Retinoic acids repress constitutive active receptor-mediated induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene of the CYP2B10 gene in mouse primary hepatocytes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20020201

Title: Treatment of cutaneous T-cell lymphoma with alitretinoin gel.

Journal: International journal of dermatology 20020201

Title: Expression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency.

Journal: Biochemical and biophysical research communications 20020118

Title: Prevention of methylnitrosourea-induced mammary cancers by 9-cis-retinoic acid and/or vitamin D3.

Journal: Oncology reports 20020101

Title: Retinoid X receptors and retinoid response in neuroblastoma cells.

Journal: Journal of cellular biochemistry 20020101

Title: Retinoid signalling and gene expression in neuroblastoma cells: RXR agonist and antagonist effects on CRABP-II and RARbeta expression.

Journal: Journal of cellular biochemistry 20020101

Title: The Suzuki coupling reaction in the stereocontrolled synthesis of 9-cis-retinoic acid and its ring-demethylated analogues.

Journal: The Journal of organic chemistry 20011214

Title: Real time RT-PCR shows correlation between retinoid-induced apoptosis and NGF-R mRNA levels.

Journal: Biochemical and biophysical research communications 20011207

Title: Bioavailability and dose-dependent anti-tumour effects of 9-cis retinoic acid on human neuroblastoma xenografts in rat.

Journal: British journal of cancer 20011201

Title: Chemopreventive agents inhibit aberrant proliferation of the aneuploid phenotype in a colon epithelial cell line established from Apc 1638N [+/-] mouse.

Journal: Annals of the New York Academy of Sciences 20011201

Title: Engineering orthogonal ligand-receptor pairs from 'near drugs'.

Journal: Journal of the American Chemical Society 20011121

Title: DNase I hypersensitivity analysis of the human CCAAT enhancer binding protein epsilon (C/EBPepsilon) gene.

Journal: Leukemia research 20011101

Title: Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis retinoic acid only detected after all-trans-retinoic acid levels are super-elevated experimentally.

Journal: Developmental dynamics : an official publication of the American Association of Anatomists 20011101

Title: Activation of the peroxisome proliferator-activated receptor-alpha enhances cell death in cultured cerebellar granule cells.

Journal: Journal of neuroscience research 20011015

Title: Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins.

Journal: Oncogene 20011004

Title: Distinct retinoid X receptor activation function-2 residues mediate transactivation in homodimeric and vitamin D receptor heterodimeric contexts.

Journal: Journal of molecular endocrinology 20011001

Title: Retinoic acid enhances the cytotoxic effects of gemcitabine and cisplatin in pancreatic adenocarcinoma cells.

Journal: Pancreas 20011001

Title: Where to next with retinoids for cancer therapy?

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20011001

Title: A phase I trial and pharmacokinetic study of 9-cis-retinoic acid (ALRT1057) in pediatric patients with refractory cancer: a joint Pediatric Oncology Branch, National Cancer Institute, and Children's Cancer Group study.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20011001

Title: Expression of adipogenesis markers in a murine stromal cell line treated with 15-deoxy Delta(12,14)-prostaglandin J2, interleukin-11, 9-cis retinoic acid and vitamin K2.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20011001

Title: Stimulated release of arachidonic acid by agonists of the peroxisome proliferator-activated receptor and retinoic acid receptors.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20011001

Title: Metabolism of a physiological amount of all-trans-retinol in the vitamin A-deficient rat.

Journal: Archives of biochemistry and biophysics 20010915

Title: Effects of retinoids and thiazolidinediones on proliferation, insulin release, insulin mRNA, GLUT 2 transporter protein and mRNA of INS-1 cells.

Journal: Cell biochemistry and function 20010901

Title: Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells.

Journal: Carcinogenesis 20010901

Title: Development of a retinoic acid receptor-binding assay with rainbow trout tissue: characterization of retinoic acid binding, receptor tissue distribution, and developmental changes.

Journal: General and comparative endocrinology 20010901

Title: Sphingosine kinase regulates hepatoma cell differentiation: roles of hepatocyte nuclear factor and retinoid receptor.

Journal: Biochemical and biophysical research communications 20010831

Title: Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

Journal: The Journal of biological chemistry 20010803

Title: Regulation of stearoyl coenzyme A desaturase expression in human retinal pigment epithelial cells by retinoic acid.

Journal: The Journal of biological chemistry 20010803

Title: Regulation of p85alpha phosphatidylinositol-3-kinase expression by peroxisome proliferator-activated receptors (PPARs) in human muscle cells.

Journal: FEBS letters 20010803

Title: Simultaneous determination of all-trans, 9-cis, 13-cis retinoic acid and retinol in rat prostate using liquid chromatography-mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20010801

Title: Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid.

Journal: Cancer letters 20010726

Title: Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.

Journal: Journal of medicinal chemistry 20010705

Title: Heterocycle-containing retinoids. Discovery of a novel isoxazole arotinoid possessing potent apoptotic activity in multidrug and drug-induced apoptosis-resistant cells.

Journal: Journal of medicinal chemistry 20010705

Title: Effects of dietary N-(4-hydroxyphenyl)retinamide on N-nitrosomethylbenzylamine metabolism and esophageal tumorigenesis in the Fischer 344 rat.

Journal: Journal of the National Cancer Institute 20010704

Title: Characterization of a novel airway epithelial cell-specific short chain alcohol dehydrogenase/reductase gene whose expression is up-regulated by retinoids and is involved in the metabolism of retinol.

Journal: The Journal of biological chemistry 20010629

Title: Biosynthesis of 9-cis-retinoic acid in vivo. The roles of different retinol dehydrogenases and a structure-activity analysis of microsomal retinol dehydrogenases.

Journal: The Journal of biological chemistry 20010601

Title: Peroxisome proliferator-activated receptor gamma-retinoid X receptor agonists increase CD36-dependent phagocytosis of Plasmodium falciparum-parasitized erythrocytes and decrease malaria-induced TNF-alpha secretion by monocytes/macrophages.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20010601

Title: Low synthesis of retinoic acid due to impaired cytochrome P450 1a1 expression in mouse xeroderma pigmentosum fibroblasts.

Journal: The international journal of biochemistry & cell biology 20010601

Title: Synergistic anti-proliferative effects of vitamin D derivatives and 9-cis retinoic acid in SH-SY5Y human neuroblastoma cells.

Journal: The Journal of steroid biochemistry and molecular biology 20010601

Title: Phase I clinical trial of alitretinoin and tamoxifen in breast cancer patients: toxicity, pharmacokinetic, and biomarker evaluations.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010515

Title: Retinoids inhibit proliferation of human coronary smooth muscle cells by modulating cell cycle regulators.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20010501

Title: Retinoic acids repress the expression of ETS-1 in endothelial cells.

Journal: The Tohoku journal of experimental medicine 20010501

Title: Up-regulation of uncoupling proteins by beta-adrenergic stimulation in L6 myotubes.

Journal: FEBS letters 20010413

Title: Suppression of constitutive but not Il-1beta-inducible expression of monocyte chemoattractant protein-1 in mesangial cells by retinoic acids: intervention in the activator protein-1 pathway.

Journal: Journal of the American Society of Nephrology : JASN 20010401

Title: Retinoids inhibit the actions of angiotensin II on vascular smooth muscle cells.

Journal: Circulation research 20010330

Title: 9-cis-Retinoic acid represses transcription of the gonadotropin-releasing hormone (GnRH) gene via proximal promoter region that is distinct from all-trans-retinoic acid response element.

Journal: Brain research. Molecular brain research 20010305

Title: Purification and crystallization of the human RXRalpha ligand-binding domain-9-cisRA complex.

Journal: Acta crystallographica. Section D, Biological crystallography 20010301

Title: Retinoic acid up-regulates myeloid ICAM-3 expression and function in a cell-specific fashion--evidence for retinoid signaling pathways in the mast cell lineage.

Journal: Journal of leukocyte biology 20010301

Title: Methoprene and 20-OH-ecdysone affect male production in Daphnia pulex.

Journal: Environmental toxicology and chemistry 20010301

Title: Agonists of the retinoic acid- and retinoid X-receptors inhibit hepatocyte growth factor secretion and expression in U87 human astrocytoma cells.

Journal: Brain research. Molecular brain research 20010219

Title: Induction of acyl-coenzyme A:cholesterol acyltransferase-1 by 1,25-dihydroxyvitamin D(3) or 9-cis-retinoic acid in undifferentiated THP-1 cells.

Journal: Journal of lipid research 20010201

Title: Downregulation of MLL-CBP fusion gene expression is associated with differentiation of SN-1 cells with t(11;16)(q23;p13).

Journal: Oncogene 20010118

Title: Regulation of prohormone convertase 1 (PC1) by thyroid hormone.

Journal: American journal of physiology. Endocrinology and metabolism 20010101

Title: Overexpression of retinoic acid receptor beta induces growth arrest and apoptosis in oral cancer cell lines.

Journal: Japanese journal of cancer research : Gann 20010101

Title: Effect of retinoids on growth inhibition of two canine melanoma cell lines.

Journal: The Journal of veterinary medical science 20010101

Title: Application of photoaffinity labeling with [(3)H] all trans- and 9-cis-retinoic acids for characterization of cellular retinoic acid--binding proteins I and II.

Journal: Protein science : a publication of the Protein Society 20010101

Title: The vitamin A analogues: 13-cis retinoic acid, 9-cis retinoic acid, and Ro 13-6307 inhibit neuroblastoma tumour growth in vivo.

Journal: Medical and pediatric oncology 20010101

Title: Differential gene regulation by 9-cis and all-trans retinoic acid in neuroblastoma cells.

Journal: Medical and pediatric oncology 20010101

Title: Alitretinoin (Panretin) gel 0.1%.

Journal: The Journal of the Association of Nurses in AIDS Care : JANAC 20010101

Title: Phase III vehicle-controlled, multi-centered study of topical alitretinoin gel 0.1% in cutaneous AIDS-related Kaposi's sarcoma.

Journal: American journal of clinical dermatology 20010101

Title: Vitamin A and all-trans and 9-cis retinoic acids inhibit cell proliferation during the progression phase of hepatocarcinogenesis in Wistar rats.

Journal: Nutrition and cancer 20010101

Title: Human renal mesangial cells are a target for the anti-inflammatory action of 9-cis retinoic acid.

Journal: British journal of pharmacology 20001201

Title: Biological effects and metabolism of 9-cis-retinoic acid and its metabolite 9,13-di-cis-retinoic acid in HaCaT keratinocytes in vitro: comparison with all-trans-retinoic acid.

Journal: Archives of dermatological research 20001201

Title: Structural basis for isotype selectivity of the human retinoic acid nuclear receptor.

Journal: Journal of molecular biology 20000908

Title: Fatty acid binding proteins from different tissues show distinct patterns of fatty acid interactions.

Journal: Biochemistry 20000620

Title: Characterization of retinoic acid receptor-deficient keratinocytes.

Journal: The Journal of biological chemistry 20000602

Title: Retinoic acid is a negative regulator for the differentiation of cord blood-derived human mast cell progenitors.

Journal: Blood 20000501

Title: Induction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective rexinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular target.

Journal: The Journal of biological chemistry 20000428

Title: Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.

Journal: Molecular cell 20000301

Title: Chelation of zinc amplifies induction of growth hormone mRNA levels in cultured rat pituitary tumor cells.

Journal: The Journal of nutrition 20000201

Title: Both retinoic-acid-receptor- and retinoid-X-receptor-dependent signalling pathways mediate the induction of the brown-adipose-tissue-uncoupling-protein-1 gene by retinoids.

Journal: The Biochemical journal 20000101

Title: Growth inhibition of myeloid leukemia cells by troglitazone, a ligand for peroxisome proliferator activated receptor gamma, and retinoids.

Journal: International journal of oncology 19991101

Title: PPARalpha activation by Wy 14643 induces transactivation of the rat UCP-1 promoter without increasing UCP-1 mRNA levels and attenuates PPARgamma-mediated increases in UCP-1 mRNA levels induced by rosiglitazone in fetal rat brown adipocytes.

Journal: Biochemical and biophysical research communications 19991022

Title: Pharmacology of warfarin and clinical implications.

Journal: Seminars in thrombosis and hemostasis 19990101

Title: Successful treatment of chronic hand eczema with oral 9-cis-retinoic acid.

Journal: Dermatology (Basel, Switzerland) 19990101

Title: Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -- role of the peroxisome proliferator-activated receptor-alpha.

Journal: Thrombosis and haemostasis 19981201

Title: Initial retinoid requirement for early avian development coincides with retinoid receptor coexpression in the precardiac fields and induction of normal cardiovascular development.

Journal: Developmental dynamics : an official publication of the American Association of Anatomists 19981001

Title: Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19980929

Title: Evidence for the involvement of both retinoic acid receptor- and retinoic X receptor-dependent signaling pathways in the induction of tissue transglutaminase and apoptosis in the human myeloma cell line RPMI 8226.

Journal: Blood 19980401

Title: Action mechanism of retinoid-synergistic dibenzodiazepines.

Journal: Biochemical and biophysical research communications 19970407

Title: The thyrotrope-restricted isoform of the retinoid-X receptor-gamma1 mediates 9-cis-retinoic acid suppression of thyrotropin-beta promoter activity.

Journal: Molecular endocrinology (Baltimore, Md.) 19970401

Title: Studies on the mechanism of fibrate-inhibited expression of plasminogen activator inhibitor-1 in cultured hepatocytes from cynomolgus monkey.

Journal: Arteriosclerosis, thrombosis, and vascular biology 19970101

Title: Regulation of keratinocyte proliferation and differentiation by all-trans-retinoic acid, 9-cis-retinoic acid and 1,25-dihydroxy vitamin D3.

Journal: Archives of dermatological research 19961101

Title: 9-cis-retinoic acid induces neuronal differentiation of retinoic acid-nonresponsive embryonal carcinoma cells.

Journal: Experimental cell research 19961010

Title: Activation of specific RXR heterodimers by an antagonist of RXR homodimers.

Journal: Nature 19961003

Title: Retinoic acid receptor- and retinoid X receptor-selective retinoids activate signaling pathways that converge on AP-1 and inhibit squamous differentiation in human bronchial epithelial cells.

Journal: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 19960801

Title: Retinoids increase human apolipoprotein A-11 expression through activation of the retinoid X receptor but not the retinoic acid receptor.

Journal: Molecular and cellular biology 19960701

Title: Sebum excretion rate in subjects treated with oral all-trans-retinoic acid.

Journal: Dermatology (Basel, Switzerland) 19960101

Title: New retinoid X receptor subtypes in zebra fish (Danio rerio) differentially modulate transcription and do not bind 9-cis retinoic acid.

Journal: Molecular and cellular biology 19951001

Title: Activation of retinoid X receptors induces apoptosis in HL-60 cell lines.

Journal: Molecular and cellular biology 19950701

Title: The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors.

Journal: AIDS (London, England) 19941201

Title: Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties.

Journal: Journal of medicinal chemistry 19940204

Title: 9-cis-retinoic acid: a direct-acting dysmorphogen.

Journal: Biochemical pharmacology 19930817

Title: Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19930101

Title: Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

Journal: Genes & development 19920301

Title: 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.

Journal: Cell 19920124

Title: 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXR alpha.

Journal: Nature 19920123

Title: Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity.

Journal: Journal of medicinal chemistry 19881101

Title: 9-Cis-retinoic acid induces growth inhibition in retinoid-sensitive breast cancer and sea urchin embryonic cells via retinoid X receptor α and replication factor C3.

Journal: Molecular endocrinology (Baltimore, Md.)

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Tags:5300-03-8 Molecular Formula|5300-03-8 MDL|5300-03-8 SMILES|5300-03-8 9-cis-Retinoic acid