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532-11-6,MFCD00129751
Catalog No.:AA00I9F2

532-11-6 | Anethole trithione

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1g
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in stock  
$16.00   $11.00
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5g
98%
in stock  
$37.00   $26.00
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10g
98%
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$57.00   $40.00
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25g
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$110.00   $77.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I9F2
Chemical Name:
Anethole trithione
CAS Number:
532-11-6
Molecular Formula:
C10H8OS3
Molecular Weight:
240.3649
MDL Number:
MFCD00129751
SMILES:
COc1ccc(cc1)c1ssc(=S)c1
Properties
Properties
 
BP:
398.1°C at 760 mmHg  
Form:
Solid  
MP:
111°  
Refractive Index:
1.5080 (estimate)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
254  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
2.8  

Literature

Title: An examination of the potential effect of lipids on the first-pass metabolism of the lipophilic drug anethol trithione.

Journal: Journal of pharmaceutical sciences 20111101

Title: An HPLC-MS/MS method for the quantitative determination of 4-hydroxy-anethole trithione in human plasma and its application to a pharmacokinetic study.

Journal: Journal of pharmaceutical and biomedical analysis 20110220

Title: Inactivation of protein tyrosine phosphatases by oltipraz and other cancer chemopreventive 1,2-dithiole-3-thiones.

Journal: Bioorganic & medicinal chemistry 20100815

Title: Design, synthesis, and pharmacological evaluation of the aqueous prodrugs of desmethyl anethole trithione with hepatoprotective activity.

Journal: European journal of medicinal chemistry 20100701

Title: Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells.

Journal: Lung cancer (Amsterdam, Netherlands) 20100501

Title: Modulation of thiol homeostasis induced by H2S-releasing aspirin.

Journal: Free radical biology & medicine 20100501

Title: Quantitative morphometry of respiratory tract epithelial cells as a tool for testing chemopreventive agent efficacy.

Journal: Anticancer research 20100301

Title: Lipid-based formulations to enhance oral bioavailability of the poorly water-soluble drug anethol trithione: effects of lipid composition and formulation.

Journal: International journal of pharmaceutics 20090908

Title: [The clinical therapic efficiency of anethol trithione on dry eye].

Journal: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20090601

Title: Cancer is a preventable disease that requires major lifestyle changes.

Journal: Pharmaceutical research 20080901

Title: HPLC determination of 4-hydroxy-anethole trithione in plasma via enzymatic hydrolysis and its application to bioequivalence study.

Journal: Journal of pharmaceutical and biomedical analysis 20080715

Title: New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity.

Journal: Bioorganic & medicinal chemistry letters 20080315

Title: Determination of anethole trithione in human plasma using high performance liquid chromatography coupled with tandem mass spectrometric detection.

Journal: Analytica chimica acta 20070702

Title: Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein.

Journal: Life sciences 20070606

Title: Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid.

Journal: British journal of pharmacology 20070501

Title: HPLC determination of anethole trithione and its application to pharmacokinetics in rabbits.

Journal: Journal of pharmaceutical and biomedical analysis 20061116

Title: The antioxidant anethole dithiolethione inhibits monoamine oxidase-B but not monoamine oxidase A activity in extracts of cultured astrocytes.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20060501

Title: [A case of pneumatosis cystoides intestinalis developed in a patient with Sjogren syndrome during administration of anetholetrithion].

Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20050701

Title: QSAR studies on 1,2-dithiole-3-thiones: modeling of lipophilicity, quinone reductase specific activity, and production of growth hormone.

Journal: Bioorganic & medicinal chemistry letters 20050215

Title: [Anethole dithiolethione: an antioxidant agent against tenotoxicity induced by fluoroquinolones].

Journal: Pathologie-biologie 20040701

Title: Seizures in the developing brain.

Journal: Epilepsia 20040101

Title: [Radiation protectants of the crystalline lens].

Journal: Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20031101

Title: A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia.

Journal: Journal of the National Cancer Institute 20020703

Title: Usefulness of basal and pilocarpine-stimulated salivary flow in primary Sjögren's syndrome. Correlation with clinical, immunological and histological features.

Journal: Rheumatology (Oxford, England) 20020601

Title: The neuroprotective antioxidant alpha-lipoic acid induces detoxication enzymes in cultured astroglial cells.

Journal: Free radical research 20020601

Title: Enhancement of salivary secretion and neuropeptide (substance P, alpha-calcitonin gene-related peptide) levels in saliva by chronic anethole trithione treatment.

Journal: The Journal of pharmacy and pharmacology 20011201

Title: Kinetic constraints for the thiolysis of 4-methyl-5-(pyrazin-2-yl)-1,2-dithiole-3-thione (oltipraz) and related dithiole-3-thiones in aqueous solution.

Journal: Chemical research in toxicology 20010801

Title: Lens epithelial cell protection by aminothiol WR-1065 and anetholedithiolethione from ionizing radiation.

Journal: International journal of cancer 20010101

Title: Anethole dithiolethione regulates oxidant-induced tyrosine kinase activation in endothelial cells.

Journal: Antioxidants & redox signaling 20000101

Title: Treatment of xerostomia with the bile secretion-stimulating drug anethole trithione: a clinical trial.

Journal: The American journal of the medical sciences 19990901

Title: Protective effects of anethole dithiolethione against oxidative stress-induced cytotoxicity in human Jurkat T cells.

Journal: Biochemical pharmacology 19980701

Title: Chemopreventive efficacy of anethole trithione, N-acetyl-L-cysteine, miconazole and phenethylisothiocyanate in the DMBA-induced rat mammary cancer model.

Journal: International journal of cancer 19970703

Title: A comparative study of the effects of yohimbine and anetholtrithione on salivary secretion in depressed patients treated with psychotropic drugs.

Journal: European journal of clinical pharmacology 19970101

Title: Assessment of the role of glutathione conjugation in the protection afforded by anethol dithiolthione against hexachloro-1,3-butadiene-induced nephrotoxicity.

Journal: Toxicology and applied pharmacology 19960701

Title: Inhibition of NF-kappa B activation in human T-cell lines by anetholdithiolthione.

Journal: Biochemical and biophysical research communications 19960105

Title: Chemoprevention of colon carcinogenesis by organosulfur compounds.

Journal: Cancer research 19930801

Title: Effects of chronic anethole trithione and amitriptyline treatment on rat parotid gland signalling.

Journal: European journal of pharmacology 19920512

Title: Protective effect of anethol dithiolthione against acetaminophen hepatotoxicity in mice.

Journal: Pharmacology & toxicology 19890701

Title: Pharmacological studies on anethole trithione.

Journal: Arzneimittel-Forschung 19881001

Title: Synergistic effect of sialagogues in management of xerostomia after radiation therapy.

Journal: Oral surgery, oral medicine, and oral pathology 19870801

Title: Systemic therapy of salivary gland hypofunction.

Journal: Journal of dental research 19870201

Title: [Protective effect of malotilate (diisopropyl 1,3-dithiol-2-ylidenemalonate) on chemical-induced hepatotoxicity].

Journal: The Journal of toxicological sciences 19860801

Title: A new potent inhibitor of lipid peroxidation in vitro and in vivo, the hepatoprotective drug anisyldithiolthione.

Journal: Biochemical and biophysical research communications 19860328

Title: Effects of anethole dithiolthione and 2(3)-tert-butyl-4-hydroxyanisole on schistosome granuloma formation.

Journal: Parasite immunology 19851101

Title: Effect of Sialor in treatment of xerostomia in Sjögren's syndrome.

Journal: Oral surgery, oral medicine, and oral pathology 19831101

Title: Chemoprotective effects of two dithiolthiones and of butylhydroxyanisole against carbon tetrachloride and acetaminophen toxicity.

Journal: Hepatology (Baltimore, Md.) 19830101

Title: Contact allergy to toothpaste flavors.

Journal: Contact dermatitis 19780801

Title: T Nagano, et al. Enhancement of salivary secretion and neuropeptide (substance P, alpha-calcitonin gene-related peptide) levels in saliva by chronic anethole trithione treatment. J Pharm Pharmacol. 2001 Dec;53(12):1697-702.

Title: Sheng Huang, et al. Synthesis, Characterization, and In Vivo Evaluation of Desmethyl Anethole Trithione Phosphate Prodrug for Ameliorating Cerebral Ischemia-Reperfusion Injury in Rats. ACS Omega. 2020 Feb 24;5(9):4595-4602.

Title: Y Ukai, et al. Chronic anethole trithione treatment enhances the salivary secretion and increases the muscarinic acetylcholine receptors in the rat submaxillary gland. Arch Int Pharmacodyn Ther. 1984 Oct;271(2):206-12.

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