Home Other Building Blocks 80418-24-2
80418-24-2,MFCD00210535
Catalog No.:AA00ID1J

80418-24-2 | Notoginsenoside R1

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$103.00   $72.00
- +
10mg
98%(HPLC)
in stock  
$178.00   $125.00
- +
20mg
in stock  
$236.00   $165.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ID1J
Chemical Name:
Notoginsenoside R1
CAS Number:
80418-24-2
Molecular Formula:
C47H80O18
Molecular Weight:
933.1273
MDL Number:
MFCD00210535
SMILES:
OC[C@H]1O[C@@H](O[C@H]2C[C@]3(C)[C@@H]([C@@]4([C@@H]2C(C)(C)[C@@H](O)CC4)C)C[C@H]([C@H]2[C@@]3(C)CC[C@@H]2[C@@](O[C@@H]2O[C@H](CO)[C@H]([C@@H]([C@H]2O)O)O)(CCC=C(C)C)C)O)[C@@H]([C@H]([C@@H]1O)O)O[C@@H]1OC[C@H]([C@@H]([C@H]1O)O)O
Properties
Computed Properties
 
Complexity:
1670  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
25  
Heavy Atom Count:
65  
Hydrogen Bond Acceptor Count:
18  
Hydrogen Bond Donor Count:
12  
Rotatable Bond Count:
12  
XLogP3:
1.1  

Literature

Title: Role of Chinese herbal medicinal ingredients in secretion of cytokines by PCV2-induced endothelial cells.

Journal: Journal of immunotoxicology 20160101

Title: Effects of notoginsenoside R1 on CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 activities in rats by cocktail probe drugs.

Journal: Pharmaceutical biology 20160101

Title: Notoginsenoside R1 stimulates osteogenic function in primary osteoblasts via estrogen receptor signaling.

Journal: Biochemical and biophysical research communications 20151016

Title: Estrogen receptor α mediates the effects of notoginsenoside R1 on endotoxin-induced inflammatory and apoptotic responses in H9c2 cardiomyocytes.

Journal: Molecular medicine reports 20150701

Title: Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3.

Journal: British journal of pharmacology 20150201

Title: Notoginsenoside R1 attenuates experimental inflammatory bowel disease via pregnane X receptor activation.

Journal: The Journal of pharmacology and experimental therapeutics 20150201

Title: Protective Effect of Notoginsenoside R1 on an APP/PS1 Mouse Model of Alzheimer's Disease by Up-Regulating Insulin Degrading Enzyme and Inhibiting Aβ Accumulation.

Journal: CNS & neurological disorders drug targets 20150101

Title: Notoginsenoside R1 reduces blood pressure in spontaneously hypertensive rats through a long non-coding RNA AK094457.

Journal: International journal of clinical and experimental pathology 20150101

Title: ROCK-dependent ATP5D modulation contributes to the protection of notoginsenoside NR1 against ischemia-reperfusion-induced myocardial injury.

Journal: American journal of physiology. Heart and circulatory physiology 20141215

Title: Notoginsenoside R1 attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation.

Journal: International immunopharmacology 20140901

Title: Suppression of NADPH oxidase- and mitochondrion-derived superoxide by Notoginsenoside R1 protects against cerebral ischemia-reperfusion injury through estrogen receptor-dependent activation of Akt/Nrf2 pathways.

Journal: Free radical research 20140701

Title: Dissecting active ingredients of Chinese medicine by content-weighted ingredient-target network.

Journal: Molecular bioSystems 20140701

Title: Notoginsenoside R1-mediated neuroprotection involves estrogen receptor-dependent crosstalk between Akt and ERK1/2 pathways: a novel mechanism of Nrf2/ARE signaling activation.

Journal: Free radical research 20140401

Title: Protective effects of Notoginsenoside R1 on intestinal ischemia-reperfusion injury in rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20140101

Title: Notoginsenoside R1 attenuates atherosclerotic lesions in ApoE deficient mouse model.

Journal: PloS one 20140101

Title: Notoginsenoside R1 attenuates hypoxia and hypercapnia-induced vasoconstriction in isolated rat pulmonary arterial rings by reducing the expression of ERK.

Journal: The American journal of Chinese medicine 20140101

Title: Protective effects of panax notoginseng saponins on cardiovascular diseases: a comprehensive overview of experimental studies.

Journal: Evidence-based complementary and alternative medicine : eCAM 20140101

Title: Notoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation.

Journal: Scientific reports 20140101

Title: Effects of Astragaloside IV combined with the active components of Panax notoginseng on oxidative stress injury and nuclear factor-erythroid 2-related factor 2/heme oxygenase-1 signaling pathway after cerebral ischemia-reperfusion in mice.

Journal: Pharmacognosy magazine 20140101

Title: Notoginsenoside R1 ameliorates podocyte adhesion under diabetic condition through α3β1 integrin upregulation in vitro and in vivo.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20140101

Title: Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into oestrogen receptor activation and PI3K/Akt signalling.

Journal: British journal of pharmacology 20130401

Title: The effects of notoginsenoside R₁ on the intestinal absorption of geniposide by the everted rat gut sac model.

Journal: Journal of ethnopharmacology 20120626

Title: Antioxidant, antiproliferative, and pro-apoptotic activities of a saponin extract derived from the roots of Panax notoginseng (Burk.) F.H. Chen.

Journal: Journal of medicinal food 20120401

Title: New triterpenoid saponins from fruits specimens of Panax japonicus collected in Kumamoto and Miyazaki prefectures (1).

Journal: Chemical & pharmaceutical bulletin 20120101

Title: [In vivo distribution and pharmacokinetics of multiple effective components contained in Panax notoginseng saponins after intratympanic administration].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110701

Title: [Effects of combination of Salvia miltiorrhiza and Panax notoginseng on the pharmacokinetics of their major bioactive components in Beagle dog].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20101101

Title: Notoginsenoside R1 attenuates renal ischemia-reperfusion injury in rats.

Journal: Shock (Augusta, Ga.) 20100901

Title: [Study on preparation and quality standard of Xueshuantong Drop Pills].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100801

Title: Characterization of metabolism and in vitro permeability study of notoginsenoside R1 from Radix notoginseng.

Journal: Journal of agricultural and food chemistry 20100512

Title: [In vitro balanced sustained-release of Panax notoginseng saponins controlled with various matrix materials].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100401

Title: Possible protection by notoginsenoside R1 against glutamate neurotoxicity mediated by N-methyl-D-aspartate receptors composed of an NR1/NR2B subunit assembly.

Journal: Journal of neuroscience research 20090701

Title: Effect of notoginsenoside R1 on hepatic microcirculation disturbance induced by gut ischemia and reperfusion.

Journal: World journal of gastroenterology 20080107

Title: Chemopreventive effects of Panax notoginseng and its major constituents on SW480 human colorectal cancer cells.

Journal: International journal of oncology 20071101

Title: [Studies on chemical constituents from rhizomes of Panax notoginseng].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20071101

Title: Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery.

Journal: Life sciences 20070719

Title: Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea.

Journal: Journal of natural products 20070701

Title: [RP-HPLC characteristics of Panax notoginseng].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20061101

Title: [Determination of notoginsenoside R1 and ginsenoside Rg1 in Rupixiao tablets by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060701

Title: Ginsenoside Re and notoginsenoside R1: Immunologic adjuvants with low haemolytic effect.

Journal: Chemistry & biodiversity 20060701

Title: Notoginsenoside R1 inhibits TNF-alpha-induced fibronectin production in smooth muscle cells via the ROS/ERK pathway.

Journal: Free radical biology & medicine 20060501

Title: Simultaneous determination of nine saponins from Panax notoginseng using HPLC and pressurized liquid extraction.

Journal: Journal of pharmaceutical and biomedical analysis 20060411

Title: Notoginsenoside R1 from Panax notoginseng inhibits TNF-alpha-induced PAI-1 production in human aortic smooth muscle cells.

Journal: Vascular pharmacology 20060401

Title: Simultaneous determination of components in preparation Naodesheng injection by high performance liquid chromatograph-atmospheric pressure chemical ionization mass spectrometry (HPLC-MS/APCI).

Journal: Chemical & pharmaceutical bulletin 20060401

Title: [Cell proliferation inhibitive and apoptosis promoting effects of sanchi extract on GES-1 cell after being transformed by MNNG].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050801

Title: Orthogonal array design in optimizing the extraction efficiency of active constituents from roots of Panax notoginseng.

Journal: Phytotherapy research : PTR 20050801

Title: [Determination of notoginsenoside R1, ginsenoside Rg1 and Rb1 in Radix Notoginseng and its preparation by HPLC-ELSD].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050101

Title: Absorption profiles of sanchinoside R1 and ginsenoside Rg1 in the rat intestine.

Journal: European journal of drug metabolism and pharmacokinetics 20050101

Title: HPLC determination of four active saponins from Panax notoginseng in rat serum and its application to pharmacokinetic studies.

Journal: Biomedical chromatography : BMC 20041201

Title: [Up-regulation of transcription factors NF-E2, c-jun and c-fos of AP-1 family induced by Panax Notoginosides in hematopoietic cells].

Journal: Zhongguo shi yan xue ye xue za zhi 20040201

Title: [Identification of Panax notoginseng and its preparations by LC/MS].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040201

Title: [Effects of root rot on saponin content in Panax notoginseng].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040201

Title: [Effect of Panax notoginsenosides on the proliferation of hematopoietic progenitor cells in mice with immune-mediated aplastic anemia].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20030901

Title: Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins.

Journal: Journal of natural products 20030701

Title: Dammarane-type Saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells.

Journal: Journal of natural products 20020901

Title: Bioactive saponins and glycosides. XIX. Notoginseng (3): immunological adjuvant activity of notoginsenosides and related saponins: structures of notoginsenosides-L, -M, and -N from the roots of Panax notoginseng (Burk.) F. H. Chen.

Journal: Chemical & pharmaceutical bulletin 20011101

Title: Effect of notoginsenoside R1 on the synthesis of components of the fibrinolytic system in cultured smooth muscle cells of human pulmonary artery.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 19970601

Title: Notoginsenoside R1 counteracts endotoxin-induced activation of endothelial cells in vitro and endotoxin-induced lethality in mice in vivo.

Journal: Arteriosclerosis, thrombosis, and vascular biology 19970301

Title: Effect of notoginsenoside R1 on the synthesis of tissue-type plasminogen activator and plasminogen activator inhibitor-1 in cultured human umbilical vein endothelial cells.

Journal: Arteriosclerosis and thrombosis : a journal of vascular biology 19940701

Title: Yu Y, et, al. Cardioprotective effects of Notoginsenoside R1 against ischemia/reperfusion injuries by regulating oxidative stress- and endoplasmic reticulum stress- related signaling pathways. Sci Rep. 2016 Feb 18;6:21730.

Title: Ma B, et, al. Notoginsenoside R1 attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation. Int Immunopharmacol. 2014 Sep;22(1):151-9.

Title: Sun K, et, al. Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery. Life Sci. 2007 Jul 19;81(6):509-18.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:80418-24-2 Molecular Formula|80418-24-2 MDL|80418-24-2 SMILES|80418-24-2 Notoginsenoside R1