Home Amines 91832-40-5
91832-40-5,MFCD28900275
Catalog No.:AA00IGTM

91832-40-5 | (6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(N-hydroxyimino)acetamido]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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1g
≥ 94% (Assay on anhydrous basis)
in stock  
$65.00   $45.00
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5g
≥ 94% (Assay on anhydrous basis)
in stock  
$158.00   $110.00
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10g
95%
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$286.00   $200.00
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25g
≥ 94% (Assay on anhydrous basis)
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$515.00   $360.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IGTM
Chemical Name:
(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(N-hydroxyimino)acetamido]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS Number:
91832-40-5
Molecular Formula:
C14H13N5O5S2
Molecular Weight:
395.4135
MDL Number:
MFCD28900275
SMILES:
O/N=C(/c1csc(n1)N)\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)C=C
NSC Number:
758926
Properties
Computed Properties
 
Complexity:
739  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
5  

Literature

Title: Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.

Journal: Chemical research in toxicology 20150518

Title: Comparison of amoxicillin/clavulanic acid high dose with cefdinir in the treatment of acute otitis media.

Journal: Drugs 20121022

Title: Development and validation of a rapid HPLC method for the determination of cefdinir in beagle dog plasma integrated with an automatic on-line solid-phase extraction following protein precipitation in the 96-well plate format.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120501

Title: [Identification of impurity peaks in the HPLC chromatogram by LC-MS and two-dimensional chromatographic correlation spectroscopy].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120401

Title: Bioequivalence evaluation of cefdinir in healthy fasting subjects.

Journal: Arzneimittel-Forschung 20120101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Simultaneous determination of cefdinir and cefixime in human plasma by RP-HPLC/UV detection method: Method development, optimization, validation, and its application to a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110815

Title: Oral antibiotics for infections due to multidrug-resistant Gram-negative organisms.

Journal: Scandinavian journal of infectious diseases 20110801

Title: Prophylactic cefdinir for pediatric cases of complicated urinary tract infection.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20110201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Preparation and pharmaceutical characterization of amorphous cefdinir using spray-drying and SAS-process.

Journal: International journal of pharmaceutics 20100830

Title: Another vacation, another medical 'crisis'.

Journal: Nature reviews. Gastroenterology & hepatology 20100401

Title: In vitro antimicrobial activity of cefditoren and other oral antibiotics against Streptococcus pneumoniae, isolated from children with community acquired respiratory tract infections.

Journal: The Japanese journal of antibiotics 20100201

Title: Infant male with blood-colored stools.

Journal: Annals of emergency medicine 20090801

Title: Rate of eradication of group A beta-hemolytic streptococci in children with pharyngo-tonsillitis by amoxicillin and cefdinir.

Journal: International journal of pediatric otorhinolaryngology 20090501

Title: Visual diagnosis: four infants who have red, 'bloody' stools.

Journal: Pediatrics in review 20090401

Title: Cefdinir-induced hepatotoxicity: potential hazards of inappropriate antibiotic use.

Journal: Journal of general internal medicine 20081101

Title: Cidal activity of oral third-generation cephalosporins against Streptococcus pneumoniae in relation to cefotaxime intrinsic activity.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20080801

Title: Effect of beta-cyclodextrin and hydroxypropyl beta-cyclodextrin complexation on physicochemical properties and antimicrobial activity of cefdinir.

Journal: Journal of pharmaceutical and biomedical analysis 20080715

Title: Nonbloody, red stools from coadministration of cefdinir and iron-supplemented infant formulas.

Journal: Pharmacotherapy 20080501

Title: A favorable response to steroid therapy in a child with drug-associated acute vanishing bile duct syndrome and skin disorder.

Journal: Journal of paediatrics and child health 20080401

Title: Voltammetric behavior of cefdinir in solubilized system.

Journal: Journal of colloid and interface science 20080215

Title: Cefdinir-associated 'bloody stools' in an infant.

Journal: Journal of the American Board of Family Medicine : JABFM 20080101

Title: Comparative bioavailability of two cefdinir suspension formulations in Middle Eastern healthy volunteers after single oral administration.

Journal: Arzneimittel-Forschung 20080101

Title: Effect of L-phenylalanine supplementation and a high-protein diet on pharmacokinetics of cefdinir in healthy volunteers: an exploratory study.

Journal: Journal of clinical pharmacy and therapeutics 20070601

Title: Isolation, structural elucidation and characterization of impurities in Cefdinir.

Journal: Journal of pharmaceutical and biomedical analysis 20070312

Title: Cefdinir: an oral cephalosporin for the treatment of respiratory tract infections and skin and skin structure infections.

Journal: Expert review of anti-infective therapy 20070201

Title: Bayesian estimation of intervention effect with pre- and post-misclassified binomial data.

Journal: Journal of biopharmaceutical statistics 20070101

Title: Cefdinir vs. cephalexin for mild to moderate uncomplicated skin and skin structure infections in adolescents and adults.

Journal: Current medical research and opinion 20061201

Title: Therapeutic experience with cefdinir in the treatment of uSSSIs.

Journal: International journal of clinical practice 20061001

Title: Cefdinir: A comparative study of anhydrous vs. monohydrate form. Microstructure and tabletting behaviour.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20061001

Title: Efficacy, tolerability, and parent reported outcomes for cefdinir vs. high-dose amoxicillin/clavulanate oral suspension for acute otitis media in young children.

Journal: Current medical research and opinion 20060901

Title: Update on the cefdinir spectrum and potency against pathogens isolated from uncomplicated skin and soft tissue infections in North America: are we evaluating the orally administered cephalosporins correctly?

Journal: Diagnostic microbiology and infectious disease 20060801

Title: The efficacy of cefdinir in acute bacterial rhinosinusitis.

Journal: Expert opinion on pharmacotherapy 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Selective method for the determination of cefdinir in human plasma using liquid chromatography electrospray ionization tandam mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060413

Title: Cefdinir pharmacokinetics and tolerability in children receiving 25 mg/kg once daily.

Journal: The Pediatric infectious disease journal 20060301

Title: A multicenter, open label, double tympanocentesis study of high dose cefdinir in children with acute otitis media at high risk of persistent or recurrent infection.

Journal: The Pediatric infectious disease journal 20060301

Title: Susceptibility of recent bacterial isolates to cefdinir and selected antibiotics among children with urinary tract infections.

Journal: Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 20060101

Title: Microdialysis studies of the distribution of antibiotics into chinchilla middle ear fluid.

Journal: Pharmacotherapy 20051201

Title: A pooled analysis of seven randomized crossover studies of the palatability of cefdinir oral suspension versus amoxicillin/clavulanate potassium, cefprozil, azithromycin, and amoxicillin in children aged 4 to 8 years.

Journal: Clinical therapeutics 20051201

Title: Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1.

Journal: Biochemical pharmacology 20051001

Title: Effects of amoxicillin and cefdinir on nasopharyngeal bacterial flora.

Journal: Archives of otolaryngology--head & neck surgery 20050901

Title: A pooled comparison of cefdinir and penicillin in the treatment of group a beta-hemolytic streptococcal pharyngotonsillitis.

Journal: Clinical therapeutics 20050801

Title: Long-term effects on the nasopharyngeal flora of children following antimicrobial therapy of acute otitis media with cefdinir or amoxycillin-clavulanate.

Journal: Journal of medical microbiology 20050601

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: A comparison of 5 days of therapy with cefdinir or azithromycin in children with acute otitis media: a multicenter, prospective, single-blind study.

Journal: Clinical therapeutics 20050601

Title: Cefdinir: an oral alternative to parenteral cephems.

Journal: Diagnostic microbiology and infectious disease 20050401

Title: [Effects of cefdinir in pediatric infectious diseases].

Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20050301

Title: Estimation of the intervention effect in a non-randomized study with pre- and post-mismeasured binary responses.

Journal: Statistics in medicine 20050215

Title: Cefdinir activity against contemporary North American isolates from community-acquired urinary tract infections.

Journal: International journal of antimicrobial agents 20050101

Title: Determination of Cefdinir by a stability-indicating liquid chromatographic method.

Journal: Journal of AOAC International 20050101

Title: Cefdinir versus levofloxacin in patients with acute rhinosinusitis of presumed bacterial etiology: a multicenter, randomized, double-blind study.

Journal: Clinical therapeutics 20041201

Title: [Comparison of pharmacokinetics/pharmacodynamics of cefdinir, cefpodoxime proxetil and cefaclor against common bacteria of community acquired infections].

Journal: Zhonghua yi xue za zhi 20041117

Title: [Comparative study on cefdinir and cefaclor in the treatment of patients with mild to moderate bacterial community acquired pneumonia].

Journal: Zhonghua yi xue za zhi 20041117

Title: Comparison of five-day cefdinir treatment with ten-day low dose amoxicillin/clavulanate treatment for acute otitis media.

Journal: The Pediatric infectious disease journal 20040901

Title: [In vitro antibacterial activity of cefdinir against isolates of respiratory tract pathogens in children].

Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20040901

Title: Fungal biofilm formation on cochlear implant hardware after antibiotic-induced fungal overgrowth within the middle ear.

Journal: The Pediatric infectious disease journal 20040801

Title: Potency and spectrum reevaluation of cefdinir tested against pathogens causing skin and soft tissue infections: a sample of North American isolates.

Journal: Diagnostic microbiology and infectious disease 20040801

Title: Overview of cefdinir: pharmacokinetics, safety, and efficacy in the treatment of uncomplicated skin and skin structure infections.

Journal: Cutis 20040501

Title: Effect of cefixime and cefdinir, oral cephalosporins, on cytochrome P450 activities in human hepatic microsomes.

Journal: Biological & pharmaceutical bulletin 20040101

Title: Cefdinir: a review of its use in the management of mild-to-moderate bacterial infections.

Journal: Drugs 20040101

Title: Parent-reported outcomes for treatment of acute otitis media with cefdinir or amoxicillin/clavulanate oral suspensions.

Journal: Paediatric drugs 20040101

Title: Contemporary evaluation of the in vitro activity and spectrum of cefdinir compared with other orally administered antimicrobials tested against common respiratory tract pathogens (2000-2002).

Journal: Diagnostic microbiology and infectious disease 20031101

Title: [Clinical efficacy and bacteriological studies of clarithromycin and cefdinir against group A beta-hemolytic streptococcal tonsillopharyngitis].

Journal: The Japanese journal of antibiotics 20030801

Title: An alternative procedure for preparation of cefdinir.

Journal: Farmaco (Societa chimica italiana : 1989) 20030601

Title: [Susceptibility of major pathogens of acute pharyngitis and tonsillitis to levofloxacin and other oral antimicrobial drugs].

Journal: The Japanese journal of antibiotics 20030601

Title: Management update of acute bacterial rhinosinusitis and the use of cefdinir.

Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20021201

Title: [Antibacterial activity of gatifloxacin against various fresh clinical isolates in 2002].

Journal: The Japanese journal of antibiotics 20021201

Title: [Antibacterial activity of cefpodoxime against clinical isolates in 2000 and 2001].

Journal: The Japanese journal of antibiotics 20021201

Title: Cefdinir: an advanced-generation, broad-spectrum oral cephalosporin.

Journal: Clinical therapeutics 20020401

Title: Transporter-mediated Drug Interactions.

Journal: Drug metabolism and pharmacokinetics 20020101

Title: Antibacterial action of several tannins against Staphylococcus aureus.

Journal: The Journal of antimicrobial chemotherapy 20011001

Title: Evaluation of oral antimicrobial agent levels in tooth extraction sites.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20010601

Title: [Toxicity study of cefmatilen hydrochloride hydrate (S-1090) (5)--Six-month repeated oral dose toxicity study and supplement study in rats].

Journal: The Journal of toxicological sciences 20010501

Title: Emergence of cephem- and aztreonam-high-resistant Neisseria gonorrhoeae that does not produce beta-lactamase.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20010301

Title: Successful steroid therapy for cefdinir-induced acute tubulointerstitial nephritis with progressive renal failure.

Journal: Internal medicine (Tokyo, Japan) 20010201

Title: beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter.

Journal: The Journal of biological chemistry 20000121

Title: Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells.

Journal: The American journal of physiology 19971101

Title: Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2.

Journal: Biochimica et biophysica acta 19970313

Title: Effect of estrogen administration on activities of testosterone 5alpha-reductase, alkaline phosphatase and arginase in the ventral and the dorsolateral prostates of rats.

Journal: Endocrinologia japonica 19750801

Title: Soejima R. Cefdinir. Jpn J Antibiot. 1992 Oct;45(10):1239-52.

Title: Labro MT, et al. Cefdinir (CI-983), a new oral amino-2-thiazolyl cephalosporin, inhibits human neutrophil myeloperoxidase in the extracellular medium but not the phagolysosome. J Immunol. 1994 Mar 1;152(5):2447-55.

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Tags:91832-40-5 Molecular Formula|91832-40-5 MDL|91832-40-5 SMILES|91832-40-5 (6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(N-hydroxyimino)acetamido]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid