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104145-95-1,MFCD00865118
Catalog No.:AA008SKY

104145-95-1 | Cefditoren

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1mg
2 weeks  
$3,000.00   $2,100.00
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5mg
2 weeks  
$5,654.00   $3,958.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008SKY
Chemical Name:
Cefditoren
CAS Number:
104145-95-1
Molecular Formula:
C19H18N6O5S3
Molecular Weight:
506.5784
MDL Number:
MFCD00865118
SMILES:
CC1=C(SC=N1)C=CC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)O
Properties
Computed Properties
 
Complexity:
928  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
7  
XLogP3:
0.7  

Literature

Title: Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.

Journal: Chemical research in toxicology 20150518

Title: In vitro activity of cefditoren and other comparators against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis causing community-acquired respiratory tract infections in China.

Journal: Diagnostic microbiology and infectious disease 20120601

Title: Serum sickness-like reaction in children due to cefditoren.

Journal: Pediatric dermatology 20120101

Title: Cefditoren and ceftriaxone enhance complement-mediated immunity in the presence of specific antibodies against antibiotic-resistant pneumococcal strains.

Journal: PloS one 20120101

Title: Cefditoren in upper and lower community-acquired respiratory tract infections.

Journal: Drug design, development and therapy 20110101

Title: Comparative in vitro activity of cefditoren and other antimicrobials against Enterobacteriaceae causing community-acquired uncomplicated urinary tract infections in women: a Spanish nationwide multicenter study.

Journal: Diagnostic microbiology and infectious disease 20100701

Title: Cefditoren versus ceftazidime in inducer-substrate combinations for the evaluation of AmpC production in a disc approximation test.

Journal: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20100601

Title: Antibiotic susceptibility of respiratory pathogens recently isolated in Italy: focus on cefditoren.

Journal: Journal of chemotherapy (Florence, Italy) 20100601

Title: In vitro antimicrobial activity of cefditoren and other oral antibiotics against Streptococcus pneumoniae, isolated from children with community acquired respiratory tract infections.

Journal: The Japanese journal of antibiotics 20100201

Title: Wegener's granulomatosis presented as recurrent breast abscess.

Journal: The breast journal 20100101

Title: Enhanced in vivo activity of cefditoren in pre-immunized mice against penicillin-resistant S. pneumoniae (serotypes 6B, 19F and 23F) in a sepsis model.

Journal: PloS one 20100101

Title: Molecular mechanisms of biliary excretion of cefditoren and the effects of cefditoren on the expression levels of hepatic transporters.

Journal: Drug metabolism and pharmacokinetics 20100101

Title: In vitro activity of cefditoren versus other antibiotics against S. pneumoniae clinical strains isolated in Italy.

Journal: International journal of immunopathology and pharmacology 20100101

Title: [Cefditoren and community-acquired lower respiratory tract infections (corrected)].

Journal: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20090901

Title: Cefditoren versus community-acquired respiratory pathogens: time-kill studies.

Journal: Journal of chemotherapy (Florence, Italy) 20090801

Title: PEPT1 involved in the uptake and transepithelial transport of cefditoren in vivo and in vitro.

Journal: European journal of pharmacology 20090610

Title: Influence of different resistance traits on the competitive growth of Haemophilus influenzae in antibiotic-free medium and selection of resistant populations by different {beta}-lactams: an in vitro pharmacodynamic approach.

Journal: The Journal of antimicrobial chemotherapy 20090601

Title: Update of cefditoren activity tested against community-acquired pathogens associated with infections of the respiratory tract and skin and skin structures, including recent pharmacodynamic considerations.

Journal: Diagnostic microbiology and infectious disease 20090601

Title: Safety profile of cefditoren. A pooled analysis of data from clinical trials in community-acquired respiratory tract infections.

Journal: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20090601

Title: New antimicrobial molecules and new antibiotic strategies.

Journal: Seminars in respiratory and critical care medicine 20090401

Title: In vitro activity of cefditoren and other antimicrobial agents against 288 Streptococcus pneumoniae and 220 Haemophilus influenzae clinical strains isolated in Zaragoza, Spain.

Journal: Diagnostic microbiology and infectious disease 20081001

Title: Antibacterial activity of cefditoren against major community-acquired respiratory pathogens recently isolated in Italy.

Journal: Journal of chemotherapy (Florence, Italy) 20081001

Title: Antimicrobial activity of cefditoren tested against contemporary (2004-2006) isolates of Haemophilus influenzae and Moraxella catarrhalis responsible for community-acquired respiratory tract infections in the United States.

Journal: Diagnostic microbiology and infectious disease 20080601

Title: Antimicrobial susceptibility of Haemophilus influenzae and Moraxella catarrhalis isolates in eight Central, East and Baltic European countries in 2005-06: results of the Cefditoren Surveillance Study.

Journal: The Journal of antimicrobial chemotherapy 20080501

Title: Monte Carlo simulation describing the pharmacodynamic profile of cefditoren in plasma from healthy volunteers.

Journal: International journal of antimicrobial agents 20080401

Title: Update of the activity of cefditoren and comparator oral beta-lactam agents tested against community-acquired Streptococcus pneumoniae isolates (USA, 2004-2006).

Journal: Journal of chemotherapy (Florence, Italy) 20080401

Title: Efficacy of cefditoren in the treatment of upper respiratory tract infections: a pooled analysis of six clinical trials.

Journal: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20080301

Title: High protein binding and cidal activity against penicillin-resistant S. pneumoniae: a cefditoren in vitro pharmacodynamic simulation.

Journal: PloS one 20080101

Title: In vitro activity of cefditoren against clinical isolates of Escherichia coli from a Korean hospital.

Journal: International journal of antimicrobial agents 20070901

Title: Influence of the beta-lactam resistance phenotype on the cefuroxime versus cefditoren susceptibility of Streptococcus pneumoniae and Haemophilus influenzae recovered from children with acute otitis media.

Journal: The Journal of antimicrobial chemotherapy 20070801

Title: Effects of human albumin and serum on the in vitro bactericidal activity of cefditoren against penicillin-resistant Streptococcus pneumoniae.

Journal: The Journal of antimicrobial chemotherapy 20070701

Title: Pharmacodynamics of simulated total versus free-drug serum concentrations of a low versus a high protein bound third-generation oral cephalosporin (Cefpodoxime versus cefditoren) against Streptococcus pneumoniae.

Journal: Journal of chemotherapy (Florence, Italy) 20070601

Title: In vitro susceptibility of Spanish isolates of Neisseria gonorrhoeae to cefditoren and five other antimicrobial agents.

Journal: International journal of antimicrobial agents 20070401

Title: Are beta-lactam breakpoints adequate to define non-susceptibility for all Haemophilus influenzae resistance phenotypes from a pharmacodynamic point of view?

Journal: The Journal of antimicrobial chemotherapy 20070401

Title: Pharmacokinetic/pharmacodynamic serum and urine profile of cefditoren following single-dose and multiple twice- and thrice-daily regimens in healthy volunteers: a phase I study.

Journal: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20070301

Title: Activity of cefditoren against clinical isolates of Streptococcus pneumoniae showing non-susceptibility to penicillins, cephalosporins, macrolides, ketolides or quinolones.

Journal: International journal of antimicrobial agents 20070201

Title: In vitro activities of oral cephem and telithromycin against clinical isolates of major respiratory pathogens in Japan.

Journal: Journal of Korean medical science 20070201

Title: [Influence of the displacement of protein binding by ibuprofen in the activity of a third-generation cephalosporin against Streptococcus pneumoniae].

Journal: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20061201

Title: [Relationship between protein binding and antimicrobial activities of antibiotics against Streptococcus pneumoniae and Haemophilus influenzae].

Journal: The Japanese journal of antibiotics 20061001

Title: In vitro activity of cefditoren: antimicrobial efficacy against major respiratory pathogens from Asian countries.

Journal: International journal of antimicrobial agents 20060701

Title: [Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (2004). I. Susceptibility distribution].

Journal: The Japanese journal of antibiotics 20060601

Title: [Clinical effect of ceftriaxone and cefditoren administration against oral and genital gonococcal infection].

Journal: The Japanese journal of antibiotics 20060201

Title: Quantification of the cephalosporin antibiotic cefditoren in human plasma by high-performance liquid chromatography.

Journal: Arzneimittel-Forschung 20060101

Title: Beta-lactam antibiotics: newer formulations and newer agents.

Journal: Infectious disease clinics of North America 20040901

Title: Antimicrobial susceptibility of respiratory Haemophilus influenzae strains isolated from pediatric respiratory tract infections.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20040801

Title: Myeloperoxidase in nasal secretion as a cell-activation marker in acute sinusitis.

Journal: American journal of rhinology 20040101

Title: Simultaneous intravenous and intramiddle-ear dosing to determine cefditoren influx and efflux clearances in middle ear fluid in freely moving chinchillas.

Journal: Journal of pharmaceutical sciences 20031001

Title: [Susceptibility of major pathogens of acute pharyngitis and tonsillitis to levofloxacin and other oral antimicrobial drugs].

Journal: The Japanese journal of antibiotics 20030601

Title: In vitro activity of cefditoren against a special collection of clinical isolates of Streptococcus pneumoniae from Hungary.

Journal: Acta microbiologica et immunologica Hungarica 20030101

Title: [Antibacterial activity of cefpodoxime against clinical isolates in 2000 and 2001].

Journal: The Japanese journal of antibiotics 20021201

Title: Cefditoren, a new aminothiazolyl cephalosporin.

Journal: Pharmacotherapy 20021001

Title: Activity of cefditoren against respiratory pathogens.

Journal: The Journal of antimicrobial chemotherapy 20020701

Title: Randomized, double-blind, multicenter comparison of oral cefditoren 200 or 400 mg BID with either cefuroxime 250 mg BID or cefadroxil 500 mg BID for the treatment of uncomplicated skin and skin-structure infections.

Journal: Clinical therapeutics 20020701

Title: Cefditoren (Spectracef)--a new cephalosporin.

Journal: The Medical letter on drugs and therapeutics 20020121

Title: Activity of cefditoren against beta-lactamase-positive and -negative Haemophilus influenzae and Moraxella catarrhalis.

Journal: Diagnostic microbiology and infectious disease 20020101

Title: In vitro susceptibility of recent clinical isolates of pneumococci to the investigational cephalosporin cefditoren.

Journal: Diagnostic microbiology and infectious disease 20020101

Title: Review of cefditoren, an advanced-generation, broad-spectrum oral cephalosporin.

Journal: Clinical therapeutics 20011201

Title: Oral prodrug enters cephalosporin market.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20011101

Title: In vitro activity of cefditoren against clinical isolates of penicillin-susceptible and penicillin-intermediate strains of Streptococcus pneumoniae isolated in Germany, 1992-1998.

Journal: The Journal of antimicrobial chemotherapy 20010801

Title: [Epidemiological study on patients with pneumococcal respiratory tract infection in a Japanese health facility during the past year].

Journal: The Japanese journal of antibiotics 20010501

Title: [Clinical isolates and treatment of acute otitis media].

Journal: The Japanese journal of antibiotics 20010501

Title: [Therapy for children with acute pneumococcal otitis media in an outpatient clinic].

Journal: The Japanese journal of antibiotics 20010501

Title: [High-dose cefditren therapy for children with acute otitis media that had Streptococcus pneumoniae and haemophilus influenzae isolated from the nasopharynx].

Journal: The Japanese journal of antibiotics 20010501

Title: [Eradication of bacteria in upper pharynx of children treated with antibiotics].

Journal: The Japanese journal of antibiotics 20010501

Title: [Mid term report of the CDTR clinical trial for PRSP and BLNAR infections].

Journal: The Japanese journal of antibiotics 20010501

Title: [Bacteriological aspects in the mid term report of the CDTR clinical trial for PRSP and BLNAR infections].

Journal: The Japanese journal of antibiotics 20010501

Title: [Comparative study on bacterial eradication rate and clinical efficacy of CDTR, CFPN, and FRPM for treatment of children with otitis media and lower respiratory tract infection due to Streptococcus pneumoniae and Haemophilus influenzae].

Journal: The Japanese journal of antibiotics 20010501

Title: [Isolation of bacteria and treatment of patients with pneumococcal and Haemophilus influenzae infections].

Journal: The Japanese journal of antibiotics 20010501

Title: [Efficacy and safety of twice-daily administration of CTDR].

Journal: The Japanese journal of antibiotics 20010501

Title: [Infant case of acute otitis media due to PISP not eradicated with double-dose of CDTR].

Journal: The Japanese journal of antibiotics 20010501

Title: [Mode of transmission and natural course of pneumococcal infection].

Journal: The Japanese journal of antibiotics 20010501

Title: [Study on Streptococcus pneumoniae isolated from infants in widely-separated primary care facilities in Japan].

Journal: The Japanese journal of antibiotics 20010501

Title: Quality control parameters for cefditoren susceptibility tests.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20010201

Title: Validation of cefditoren MIC quality control ranges by a multi-laboratory study (2001).

Journal: Diagnostic microbiology and infectious disease 20010101

Title: Comparative activity of cefditoren and other oral beta-lactams against nonpneumococcal streptococci.

Journal: Chemotherapy 20010101

Title: Cefditoren in vitro activity and spectrum: a review of international studies using reference methods.

Journal: Diagnostic microbiology and infectious disease 20010101

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