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945976-76-1,MFCD19443125
Catalog No.:AA00IIAV

945976-76-1 | Lx1031

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$174.00   $122.00
- +
5mg
≥98%
in stock  
$375.00   $263.00
- +
10mg
≥98%
in stock  
$613.00   $429.00
- +
25mg
≥98%
in stock  
$1,457.00   $1,020.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00IIAV
Chemical Name:
Lx1031
CAS Number:
945976-76-1
Molecular Formula:
C28H25F3N4O4
Molecular Weight:
538.5177
MDL Number:
MFCD19443125
SMILES:
COc1cccc(c1)c1ccc(cc1)[C@H](C(F)(F)F)Oc1nc(N)nc(c1)c1ccc(cc1)C[C@@H](C(=O)O)N
Properties
Computed Properties
 
Complexity:
774  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  
XLogP3:
2.7  

Literature

Title: The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel syndrome.

Journal: Gastroenterology 20110801

Title: Targeting serotonin synthesis to treat irritable bowel syndrome.

Journal: Gastroenterology 20110801

Title: LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20110301

Title: LX-1031, a tryptophan 5-hydroxylase inhibitor that reduces 5-HT levels for the potential treatment of irritable bowel syndrome.

Journal: IDrugs : the investigational drugs journal 20101201

Title: Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin. Neurogastroenterol Motil. 2011 Mar;23(3):193-200.

Title: Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor that reduces 5-HT levels for the potential treatment of irritable bowel syndrome. IDrugs. 2010 Dec;13(12):921-8.

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SDS
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Tags:945976-76-1 Molecular Formula|945976-76-1 MDL|945976-76-1 SMILES|945976-76-1 Lx1031
Catalog No.: AA00IIAV
945976-76-1,MFCD19443125
945976-76-1 | Lx1031
Pack Size： 1mg
Purity： ≥98%
in stock
$174.00 $122.00
Pack Size： 5mg
Purity： ≥98%
in stock
$375.00 $263.00
Pack Size： 10mg
Purity： ≥98%
in stock
$613.00 $429.00
Pack Size： 25mg
Purity： ≥98%
in stock
$1,457.00 $1,020.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00IIAV
Chemical Name: Lx1031
CAS Number: 945976-76-1
Molecular Formula: C28H25F3N4O4
Molecular Weight: 538.5177
MDL Number: MFCD19443125
SMILES: COc1cccc(c1)c1ccc(cc1)[C@H](C(F)(F)F)Oc1nc(N)nc(c1)c1ccc(cc1)C[C@@H](C(=O)O)N
Properties
Complexity: 774  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 2  
Heavy Atom Count: 39  
Hydrogen Bond Acceptor Count: 11  
Hydrogen Bond Donor Count: 3  
Rotatable Bond Count: 9  
XLogP3: 2.7  
Literature fold

Title: The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel syndrome.

Journal: Gastroenterology20110801

Title: Targeting serotonin synthesis to treat irritable bowel syndrome.

Journal: Gastroenterology20110801

Title: LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20110301

Title: LX-1031, a tryptophan 5-hydroxylase inhibitor that reduces 5-HT levels for the potential treatment of irritable bowel syndrome.

Journal: IDrugs : the investigational drugs journal20101201

Title: Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin. Neurogastroenterol Motil. 2011 Mar;23(3):193-200.

Title: Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor that reduces 5-HT levels for the potential treatment of irritable bowel syndrome. IDrugs. 2010 Dec;13(12):921-8.

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