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945976-43-2,MFCD19053188
Catalog No.:AA00JNOX

945976-43-2 | LP-533401 (free base)

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$100.00   $70.00
- +
5mg
≥98%
in stock  
$440.00   $308.00
- +
10mg
≥98%
in stock  
$779.00   $545.00
- +
25mg
≥98%
in stock  
$1,699.00   $1,189.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00JNOX
Chemical Name:
LP-533401 (free base)
CAS Number:
945976-43-2
Molecular Formula:
C27H22F4N4O3
Molecular Weight:
526.4822
MDL Number:
MFCD19053188
SMILES:
Nc1nc(cc(n1)c1ccc(cc1)C[C@@H](C(=O)O)N)OC(C(F)(F)F)c1ccc(cc1)c1cccc(c1)F
Properties
Computed Properties
 
Complexity:
759  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
1  
XLogP3:
2.9  

Literature

Title: Inhibition of gut- and lung-derived serotonin attenuates pulmonary hypertension in mice.

Journal: American journal of physiology. Lung cellular and molecular physiology 20120915

Title: Efficacy of serotonin inhibition in mouse models of bone loss.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20110901

Title: Regulation of bone mass by serotonin: molecular biology and therapeutic implications.

Journal: Annual review of medicine 20110101

Title: Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis.

Journal: Nature medicine 20100301

Title: Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders.

Journal: Journal of medicinal chemistry 20080710

Title: Yadav, V.K., et al. Inhibition of gut-derived serotonin synthesis: A potential bone anabolic treatment. Nat. Med. 16(3), 308-312 (2010).

Title: Abid S, et al. Inhibition of gut- and lung-derived serotonin attenuates pulmonary hypertension in mice. Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15;303(6):L500-8.

Title: Krevvata M, et al. Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts. Blood. 2014 Oct 30;124(18):2834-46.

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SDS
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