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56391-57-2,MFCD26142629
Catalog No.:AA00IMGI

56391-57-2 | Netilmicin Sulfate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
>98.0%(HPLC)
in stock  
$19.00   $13.00
- +
100mg
>98.0%(HPLC)
in stock  
$55.00   $39.00
- +
250mg
in stock  
$100.00   $70.00
- +
1g
in stock  
$247.00   $173.00
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5g
in stock  
$715.00   $500.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00IMGI
Chemical Name:
Netilmicin Sulfate
CAS Number:
56391-57-2
Molecular Formula:
C21H43N5O11S
Molecular Weight:
573.6580
MDL Number:
MFCD26142629
SMILES:
OS(=O)(=O)O.CCN[C@@H]1C[C@H](N)[C@H]([C@@H]([C@H]1O[C@H]1OC[C@]([C@@H]([C@H]1O)NC)(C)O)O)O[C@H]1OC(=CC[C@H]1N)CN
Properties
Properties
 
BP:
684.3°C at 760 mmHg  
Form:
Solid  
MP:
>194°C(dec.);  
Solubility:
H2O: soluble10mg/mL  
Stability:
Light Sensitive & Hygroscopic  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
754  
Covalently-Bonded Unit Count:
7  
Defined Atom Stereocenter Count:
22  
Heavy Atom Count:
91  
Hydrogen Bond Acceptor Count:
44  
Hydrogen Bond Donor Count:
26  
Rotatable Bond Count:
16  

Downstream Synthesis Route

[1]Nam,Ghilsoo;Sung,HoonKim;Kim,Joong-Hyup;Shin,Jung-Hyu;Jang,Eun-Sook[OrganicProcessResearchandDevelopment,2002,vol.6,#1,p.78-81]

Literature

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Title: Impact of aminoglycoside cycling in six tertiary intensive care units: prospective longitudinal interventional study.

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Title: Relationship between the AdeABC efflux system gene content, netilmicin susceptibility and multidrug resistance in a genotypically diverse collection of Acinetobacter baumannii strains.

Journal: The Journal of antimicrobial chemotherapy 20070901

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Journal: Bulletin de la Societe de pathologie exotique (1990) 20070801

Title: Dexamethasone-netilmicin: a new ophthalmic steroid-antibiotic combination. Efficacy and safety after cataract surgery.

Journal: Eye (London, England) 20070101

Title: [Sudden cardiorespiratory arrest in adults with acute epiglottitis. Report of 2 cases].

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Title: [Pseudomonas and acute external otitis. Results of a microbiological study in patients without previous antibiotic treatment].

Journal: Anales otorrinolaringologicos ibero-americanos 20070101

Title: Effect of melanin on netilmicin-induced inhibition of collagen biosynthesis in human skin fibroblasts.

Journal: Bioorganic & medicinal chemistry 20061215

Title: Interindividual variability of aminoglycoside pharmacokinetics in preterm neonates at birth.

Journal: European journal of clinical pharmacology 20061201

Title: Pharmacokinetics of a netilmicin loading dose on the first postnatal day in preterm neonates with very low gestational age.

Journal: European journal of clinical pharmacology 20060901

Title: Adsorptive stripping voltammetric determination of netilmicin in the presence of formaldehyde.

Journal: Analytical and bioanalytical chemistry 20060501

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Title: High dose of intrathecal netilmicin in the treatment of nosocomial Acinetobacter baumannii meningitis.

Journal: The Journal of infection 20051201

Title: Cefazolin plus netilmicin versus cefazolin plus ceftazidime for treating CAPD peritonitis: effect on residual renal function.

Journal: Kidney international 20051101

Title: Molecular and phenotypic features for identification of the opportunistic pathogens Ochrobactrum spp.

Journal: Journal of medical microbiology 20051001

Title: In vivo toxicity of netilmicin and ofloxacin on intact and mechanically damaged eyes of rabbit.

Journal: Cornea 20050801

Title: Cortical allograft as a vehicle for antibiotic delivery.

Journal: Acta orthopaedica 20050801

Title: Comparative study of the disposition of levofloxacin, netilmicin and cefepime in the isolated rat lung.

Journal: The Journal of pharmacy and pharmacology 20050701

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Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20050701

Title: Capillary electrophoresis assay of netilmicin sulphate.

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Title: Amikacin as a replacement aminoglycoside for netilmicin for coagulase-negative staphylococcal sepsis in neonates.

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Journal: The Japanese journal of antibiotics 20021001

Title: Influence of the infusion rate on disposition of netilmicin in the isolated rat perfused kidney.

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Journal: Chemotherapy 20020701

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Journal: Journal of chemotherapy (Florence, Italy) 20020201

Title: Treatment of acute bacterial conjunctivitis with topical netilmicin.

Journal: Cornea 20020101

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Title: Influence of dose on the disposition kinetics of netilmicin in the isolated kidney of the rat.

Journal: European journal of drug metabolism and pharmacokinetics 20020101

Title: The effect of netilmicin and vancomycin on lipid peroxidation processes in cerebrospinal fluid in children with hydrocephalus.

Journal: Pathology, research and practice 20020101

Title: Comparative cochlear toxicities of streptomycin, gentamicin, amikacin and netilmicin in guinea-pigs.

Journal: The Journal of international medical research 20020101

Title: Once-daily aminoglycosides in patients with neutropenic fever.

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Title: [Evaluation of Emit netilmicin and amikacin assays on Dimension RXL HM (Dade Behring) open channels].

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Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] 20011001

Title: Cefepime versus vancomycin plus netilmicin therapy for continuous ambulatory peritoneal dialysis-associated peritonitis.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20010701

Title: Clinical course of peritonitis due to Pseudomonas species complicating peritoneal dialysis: a review of 104 cases.

Journal: Kidney international 20010601

Title: Pharmacokinetics of once-a-day netilmicin (4.5 mg/kg) in neonates.

Journal: Journal of chemotherapy (Florence, Italy) 20010601

Title: Cost-effectiveness of cefepime + netilmicin or ceftazidime + amikacin or meropenem monotherapy in febrile neutropenic children with malignancy in Turkey.

Journal: Journal of chemotherapy (Florence, Italy) 20010601

Title: Effect of different antibacterial agents and surfactant protein-A (SP-A) on adherence of some respiratory pathogens to bronchial epithelial cells.

Journal: International journal of antimicrobial agents 20010501

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Journal: Bioorganic & medicinal chemistry letters 20010423

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Journal: Indian pediatrics 20010401

Title: Prediction of gram-negative bacteremia in patients with cancer and febrile neutropenia by means of interleukin-8 levels in serum: targeting empirical monotherapy versus combination therapy.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010301

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Journal: European journal of obstetrics, gynecology, and reproductive biology 20010101

Title: Association between antibiotic resistance and the expression of Dr adhesin among uropathogenic Escherichia coli.

Journal: Chemotherapy 20010101

Title: Netilmicin: in vitro activity, time-kill evaluation and postantibiotic effect on microorganisms isolated from ocular infections.

Journal: Chemotherapy 20010101

Title: Postpneumonic empyema in childhood.

Journal: Indian journal of pediatrics 20010101

Title: [Antimicrobial activity of ciprofloxacin and netilmicin compared to various antibiotics in Lome, Togo].

Journal: Sante (Montrouge, France) 20010101

Title: [Netilmicin in the complex therapy of pneumonia in newborns].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20010101

Title: Neuromuscular blocking effects of the aminoglycoside antibiotics arbekacin, astromicin, isepamicin and netilmicin on the diaphragm and limb muscles in the rabbit.

Journal: Pharmacology 20010101

Title: [Antibiotic prophylaxis of postoperative complications in surgical treatment of pulmonary, tracheal and mediastinal tumors].

Journal: Anesteziologiia i reanimatologiia 20010101

Title: A prospective randomized trial of ceftazidime versus netilmicin plus mezlocillin in the empirical therapy of presumed sepsis in cirrhotic patients.

Journal: Hepatology (Baltimore, Md.) 19970401

Title: Effect of aminoglycoside therapy on renal function in full-term infants.

Journal: Pediatric nephrology (Berlin, Germany) 19961201

Title: Once-daily gentamicin versus once-daily netilmicin in patients with serious infections--a randomized clinical trial.

Journal: The Journal of antimicrobial chemotherapy 19940401

Title: Effects of diltiazem on netilmicin-induced nephrotoxicity in rabbits.

Journal: Antimicrobial agents and chemotherapy 19930901

Title: A comparison of netilmicin and tobramycin therapy in patients with renal impairment.

Journal: Scandinavian journal of infectious diseases 19920101

Title: Pharmacokinetic and toxicological evaluation of a once-daily regimen versus conventional schedules of netilmicin and amikacin.

Journal: The Journal of antimicrobial chemotherapy 19910501

Title: Pharmacodynamic parameters and toxicity of netilmicin (6 milligrams/kilogram/day) given once daily or in three divided doses to cancer patients with urinary tract infection.

Journal: Antimicrobial agents and chemotherapy 19910401

Title: Does administration of an aminoglycoside in a single daily dose affect its efficacy and toxicity?

Journal: The Journal of antimicrobial chemotherapy 19900101

Title: Comparison of once-daily and thrice-daily netilmicin regimens in serious systemic infections: a multicenter study in six Asian countries.

Journal: Clinical therapeutics 19890101

Title: [Habekacin: a new aminoglycoside. Study of nephrotoxicity in rats in comparison with gentamicin, netilmicin and amikacin].

Journal: Pathologie-biologie 19880601

Title: Neurological toxicity related to pefloxacin.

Journal: The Journal of antimicrobial chemotherapy 19880601

Title: Univariate and multivariate analyses of risk factors predisposing to auditory toxicity in patients receiving aminoglycosides.

Journal: Antimicrobial agents and chemotherapy 19870901

Title: [Localized cutaneous vasculitis induced by subcutaneous netilmicin].

Journal: Presse medicale (Paris, France : 1983) 19870516

Title: Relative efficacy and toxicity of netilmicin and tobramycin in oncology patients.

Journal: Archives of internal medicine 19861201

Title: Drug-induced hemorrhagic cystitis.

Journal: Clinical pharmacy 19860701

Title: [An early and specific indicator of aminoglycoside nephrotoxicity: isoenzyme B of urinary N-acetyl-beta-D-glucosaminidase (NAG)].

Journal: Pathologie-biologie 19860501

Title: Aminoglycoside ototoxicity.

Journal: American journal of otolaryngology 19860101

Title: Prospective controlled evaluation of auditory function in neonates given netilmicin or amikacin.

Journal: The Journal of pediatrics 19850101

Title: Prospective, randomized comparison of the efficacy and safety of netilmicin-clindamycin and tobramycin-clindamycin in the treatment of serious systemic infections.

Journal: Clinical therapeutics 19850101

Title: Prospective randomized double-blind comparison of nephrotoxicity and auditory toxicity of tobramycin and netilmicin.

Journal: Antimicrobial agents and chemotherapy 19841101

Title: Comparative nephrotoxicity of hydroxygentamicin and other aminoglycosides in rats.

Journal: Fundamental and applied toxicology : official journal of the Society of Toxicology 19840801

Title: Netilmicin versus tobramycin in multi-centre studies.

Journal: The Journal of antimicrobial chemotherapy 19840101

Title: Nephrotoxic effects of aminoglycoside treatment on renal protein reabsorption and accumulation.

Journal: Nephron 19840101

Title: Aminoglycosides induce a phospholipidosis in the renal cortex of the rat: an early manifestation of nephrotoxicity.

Journal: The Journal of pharmacology and experimental therapeutics 19820301

Title: Ototoxicity of netilmicin.

Journal: Acta oto-laryngologica 19820101

Title: Netilmicin therapy of gentamicin-sensitive and resistant gram-negative infections.

Journal: The American journal of the medical sciences 19810101

Title: Multicenter comparative evaluation of netilmicin and gentamicin in adult patients. Efficacy and safety.

Journal: Arzneimittel-Forschung 19810101

Title: Preclinical toxicologic studies of netilmicin.

Journal: Arzneimittel-Forschung 19810101

Title: Amikacin nephrotoxicity in the rat.

Journal: Journal of environmental pathology and toxicology 19801101

Title: Natural history of aminoglycoside nephrotoxicity in the dog.

Journal: The Journal of laboratory and clinical medicine 19800301

Title: Netilmicin therapy of patients with septicaemia and other severe infections.

Journal: Scandinavian journal of infectious diseases. Supplementum 19800101

Title: Netilmicin: chemical development and overview of clinical research.

Journal: Scandinavian journal of infectious diseases. Supplementum 19800101

Title: Course of gentamicin nephrotoxicity.

Journal: Toxicology 19800101

Title: Comparative nephrotoxicities of gentamicin, netilmicin and tobramycin in the rat.

Journal: The Journal of pharmacology and experimental therapeutics 19790901

Title: Comparative auditory toxicity of aminoglycoside antibiotics in leukopenic patients.

Journal: American journal of hospital pharmacy 19790801

Title: Netilmicin therapy of serious Gram-negative bacillary infections.

Journal: The Journal of antimicrobial chemotherapy 19781101

Title: Campoli-Richards DM, et al. Netilmicin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1989 Nov;38(5):703-56.

Title: Adams E, et al. Determination of netilmicin sulfate by liquid chromatography with pulsed electrochemical detection. J Chromatogr A. 1998 Jul 3;812(1-2):151-7.

Title: Ciftci M, et al. Effects of some drugs on rat erythrocyte 6-phosphogluconate dehydrogenase: an in vitro and in vivo study. Pol J Pharmacol. 2002 May-Jun;54(3):275-80.

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