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32385-11-8,MFCD00059734
Catalog No.:AA00C09C

32385-11-8 | Sisomicin

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100mg
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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00C09C
Chemical Name:
Sisomicin
CAS Number:
32385-11-8
Molecular Formula:
C19H37N5O7
Molecular Weight:
447.5264
MDL Number:
MFCD00059734
SMILES:
NCC1=CC[C@H]([C@H](O1)O[C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@H]1OC[C@]([C@@H]([C@H]1O)NC)(C)O)N)N
Properties
Computed Properties
 
Complexity:
643  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
11  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
6  
XLogP3:
-5.1  

Literature

Title: Simultaneous determination of 15 aminoglycoside(s) residues in animal derived foods by automated solid-phase extraction and liquid chromatography-tandem mass spectrometry.

Journal: Food chemistry 20121115

Title: Activity of plazomicin (ACHN-490) against MDR clinical isolates of Klebsiella pneumoniae, Escherichia coli, and Enterobacter spp. from Athens, Greece.

Journal: Journal of chemotherapy (Florence, Italy) 20120801

Title: A high pH based reversed-phase high performance liquid chromatographic method for the analysis of aminoglycoside plazomicin and its impurities.

Journal: Journal of pharmaceutical and biomedical analysis 20120701

Title: Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin.

Journal: Expert review of anti-infective therapy 20120401

Title: EPR studies of free radicals decay and survival in gamma irradiated aminoglycoside antibiotics: sisomicin, tobramycin and paromomycin.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120214

Title: Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient.

Journal: BMC genomics 20120101

Title: Impact of metal ions on netilmicin-melanin interaction.

Journal: Acta poloniae pharmaceutica 20120101

Title: Hybrid aminoglycoside antibiotics via Tsuji palladium-catalyzed allylic deoxygenation.

Journal: Organic letters 20111216

Title: Activity of ACHN-490 against meticillin-resistant Staphylococcus aureus (MRSA) isolates from patients in US hospitals.

Journal: International journal of antimicrobial agents 20111001

Title: Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble.

Journal: Nature chemical biology 20110626

Title: Antimicrobial activity of a novel aminoglycoside, ACHN-490, against Acinetobacter baumannii and Pseudomonas aeruginosa from New York City.

Journal: The Journal of antimicrobial chemotherapy 20110201

Title: Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates.

Journal: The Journal of antimicrobial chemotherapy 20110101

Title: Lack of the delta subunit of RNA polymerase increases virulence related traits of Streptococcus mutans.

Journal: PloS one 20110101

Title: Comparative genomics study of multi-drug-resistance mechanisms in the antibiotic-resistant Streptococcus suis R61 strain.

Journal: PloS one 20110101

Title: Acquired antibiotic resistance genes: an overview.

Journal: Frontiers in microbiology 20110101

Title: Activity of a novel aminoglycoside, ACHN-490, against clinical isolates of Escherichia coli and Klebsiella pneumoniae from New York City.

Journal: The Journal of antimicrobial chemotherapy 20101001

Title: Combating evolution with intelligent design: the neoglycoside ACHN-490.

Journal: Current opinion in microbiology 20101001

Title: Thermodynamics and kinetics of association of antibiotics with the aminoglycoside acetyltransferase (3)-IIIb, a resistance-causing enzyme.

Journal: Biochemistry 20100518

Title: Biomimetic synthesis and structural refinement of the macrocyclic dimer aminoglycoside 66-40C--the remarkably selective self-condensation of a putative aldehyde intermediate in the submerged culture medium producing sisomicin.

Journal: Chemical communications (Cambridge, England) 20100328

Title: Determination of aminoglycoside and macrolide antibiotics in meat by pressurized liquid extraction and LC-ESI-MS.

Journal: Journal of separation science 20100301

Title: Immunoassays for the rapid detection of gentamicin and micronomicin in swine muscle.

Journal: Journal of AOAC International 20100101

Title: Inactivation of the Ecs ABC transporter of Staphylococcus aureus attenuates virulence by altering composition and function of bacterial wall.

Journal: PloS one 20100101

Title: Identification of gentamicin impurities by liquid chromatography tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20091205

Title: Development of a non-derivatization high-performance liquid chromatography method with resonance Rayleigh scattering detection for the detection of sisomicin in rat serum.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091201

Title: Characterization of the enzyme aac(3)-Id in a clinical isolate of Salmonella enterica serovar Haifa causing traveler's diarrhea.

Journal: Enfermedades infecciosas y microbiologia clinica 20091001

Title: Genetic analysis of antimicrobial resistance in Escherichia coli isolated from diarrheic neonatal calves.

Journal: Veterinary microbiology 20090512

Title: [Antibiotics given subcutaneously to elderly].

Journal: Presse medicale (Paris, France : 1983) 20090301

Title: Molecular cloning and sequence analysis of the sisomicin biosynthetic gene cluster from Micromonospora inyoensis.

Journal: Biotechnology letters 20090301

Title: Synthesis and comparative antibacterial activity of verdamicin C2 and C2a. A new oxidation of primary allylic azides in dihydro[2H]pyrans.

Journal: Organic letters 20090115

Title: Characterization and identification of a novel marine Streptomyces sp. produced antibacterial substance.

Journal: Marine biotechnology (New York, N.Y.) 20090101

Title: Contact sensitization in venous eczema: preliminary results of patch testing with Indian standard series and topical medicaments.

Journal: Indian journal of dermatology, venereology and leprology 20090101

Title: Deep recurrent infection of the hip after tumoral resection in an 18-years old male--a case report.

Journal: Journal of medicine and life 20081115

Title: Evaluation of the stability of gentamicin in different antibiotic carriers using a validated MEKC method.

Journal: Journal of pharmaceutical and biomedical analysis 20081104

Title: Characterization of impurities in sisomicin and netilmicin by liquid chromatography/mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20081101

Title: Improved liquid chromatographic method with pulsed electrochemical detection for the analysis of gentamicin.

Journal: Journal of chromatography. A 20080502

Title: Micellar electrokinetic chromatography of aminoglycosides.

Journal: Methods in molecular biology (Clifton, N.J.) 20080101

Title: Inhibition of poly(A) polymerase by aminoglycosides.

Journal: Biochimie 20071001

Title: Evaluation of combined deactivators-supplemented agar medium (CDSAM) for recovery of dermatophytes from patients with tinea pedis.

Journal: Medical mycology 20070601

Title: 16S rRNA methylase-producing, gram-negative pathogens, Japan.

Journal: Emerging infectious diseases 20070401

Title: Aminoglycoside resistance in members of the Staphylococcus sciuri group.

Journal: Microbial drug resistance (Larchmont, N.Y.) 20070101

Title: Inhibition of the catalytic activity of trans-acting antigenomic delta ribozyme by selected antibiotics and their Cu2+ complexes.

Journal: Biochemical and biophysical research communications 20061103

Title: Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in community-acquired primary pyoderma.

Journal: Indian journal of dermatology, venereology and leprology 20060101

Title: [Study on cloning of sisomicin-resistant gene (sisR) from Micromonospora inyoensis].

Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20050101

Title: ATP, histidine or magnesium ions can protect DNA against sisomicin-induced damage, following stray Cu(II) binding.

Journal: Archives of biochemistry and biophysics 20041101

Title: [Electrospray ion trap mass spectrometry of eight aminoglycoside antibiotics].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20041001

Title: Acid-base versus structural properties of an aminoglycoside antibiotic--sisomicin: NMR and potentiometric approach.

Journal: Bioorganic & medicinal chemistry 20040801

Title: Effectiveness of short-term antibiotic prophylaxis on postoperative recovery course after pulmonary lobectomies.

Journal: Journal of the Chinese Medical Association : JCMA 20040601

Title: Voltage-dependent inhibition of rat skeletal muscle sodium channels by aminoglycoside antibiotics.

Journal: Pflugers Archiv : European journal of physiology 20040501

Title: Distribution and characterization of Campylobacter spp. from Russian poultry.

Journal: Journal of food protection 20040201

Title: Determination of tobramycin in serum using liquid chromatography-tandem mass spectrometry and comparison with a fluorescence polarisation assay.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030905

Title: A new micellar electrokinetic capillary chromatography method for separation of the components of the aminoglycoside antibiotics.

Journal: Electrophoresis 20030901

Title: Role of the acetyltransferase AAC(6')-Iz modifying enzyme in aminoglycoside resistance in Stenotrophomonas maltophilia.

Journal: The Journal of antimicrobial chemotherapy 20030401

Title: Inhibition of bacterial IF2 binding to fMet-tRNA((fMet)) by aminoglycosides.

Journal: Bioorganic & medicinal chemistry letters 20030324

Title: Novel antibiotic-resistance markers in pGK12-derived vectors for Borrelia burgdorferi.

Journal: Gene 20030116

Title: [Evaluation of outcomes of combined specific prophylaxis with the antibiotic resistant immunogenic plague pathogen strain and emergency prophylaxis with aminoglycosides in the experimental plague model in white mice].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20030101

Title: Transferable plasmid mediating resistance to multiple antimicrobial agents in Klebsiella pneumoniae isolates in Greece.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20020901

Title: [Analysis of the response factors of different aminoglycoside antibiotics detected by evaporative light-scattering detector].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020301

Title: A comparative clinical study of sisomicin cream versus mupirocin ointment in pyodermas.

Journal: Indian journal of dermatology, venereology and leprology 20020101

Title: Electrophoretically mediated microanalysis of gentamicin with in-capillary derivatization and UV detection.

Journal: Electrophoresis 20010801

Title: [Microbiological research for the Hungarian pharmaceutical industry].

Journal: Acta pharmaceutica Hungarica 20010101

Title: Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production.

Journal: Cell 19930924

Title: [Comparative ototoxicity of aminoglycoside antibiotics in a guinea pig model (author's transl)].

Journal: La Nouvelle presse medicale 19781129

Title: Hypocalcemia with hypoparathyroidism and renal tubular dysfunction associated with aminoglycoside therapy.

Journal: Cancer 19770401

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