Home Deuterated Building Blocks 964-21-6
964-21-6,MFCD00058545
Catalog No.:AA00VRQE

964-21-6 | O6-Methyl-deoxyguanosine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
1 week  
$416.00   $291.00
- +
10mg
1 week  
$670.00   $469.00
- +
25mg
1 week  
$1,289.00   $902.00
- +
50mg
1 week  
$2,035.00   $1,424.00
- +
100mg
1 week  
$3,146.00   $2,202.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00VRQE
Chemical Name:
O6-Methyl-deoxyguanosine
CAS Number:
964-21-6
Molecular Formula:
C11H15N5O4
Molecular Weight:
281.2679
MDL Number:
MFCD00058545
SMILES:
OCC1OC(CC1O)n1cnc2c1nc(N)nc2OC
Properties
Computed Properties
 
Complexity:
349  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
0.1  

Literature

Title: An efficient and simple method for site-selective modification of O6-methyl-2'-deoxyguanosine in DNA.

Journal: Chemical communications (Cambridge, England) 20120425

Title: Tumor prevalence and biomarkers of genotoxicity in brown bullhead (Ameiurus nebulosus) in Chesapeake Bay tributaries.

Journal: The Science of the total environment 20111201

Title: Inhibition by resistant starch of red meat-induced promutagenic adducts in mouse colon.

Journal: Cancer prevention research (Philadelphia, Pa.) 20111101

Title: Is the tissue persistence of O(6)-methyl-2'-deoxyguanosine an indicator of tumour formation in the gastrointestinal tract?

Journal: Mutation research 20110403

Title: High activity of sequential low dose chemo-modulating Temozolomide in combination with Fotemustine in metastatic melanoma. A feasibility study.

Journal: Journal of translational medicine 20100101

Title: Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates.

Journal: PloS one 20100101

Title: Sources of extracellular, oxidatively-modified DNA lesions: implications for their measurement in urine.

Journal: Journal of clinical biochemistry and nutrition 20091101

Title: Cell cycle effects and increased adduct formation by temozolomide enhance the effect of cytotoxic and targeted agents in lung cancer cell lines.

Journal: Journal of chemotherapy (Florence, Italy) 20090601

Title: Biological significance of DNA adducts investigated by simultaneous analysis of different endpoints of genotoxicity in L5178Y mouse lymphoma cells treated with methyl methanesulfonate.

Journal: Mutation research 20071201

Title: Potassium diazoacetate-induced p53 mutations in vitro in relation to formation of O6-carboxymethyl- and O6-methyl-2'-deoxyguanosine DNA adducts: relevance for gastrointestinal cancer.

Journal: Carcinogenesis 20070201

Title: Development of a novel site-specific mutagenesis assay using MALDI-ToF MS (SSMA-MS).

Journal: Nucleic acids research 20061201

Title: Quantification of O6-methyl and O6-ethyl deoxyguanosine adducts in C57BL/6N/Tk+/- mice using LC/MS/MS.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061121

Title: Kinetics of O(6)-methyl-2'-deoxyguanosine repair by O(6)-alkylguanine DNA alkyltransferase within K-ras gene-derived DNA sequences.

Journal: Chemical research in toxicology 20060401

Title: Simultaneous determination of O6-methyl-2'-deoxyguanosine, 8-oxo-7,8-dihydro-2'-deoxyguanosine, and 1,N6-etheno-2'-deoxyadenosine in DNA using on-line sample preparation by HPLC column switching coupled to ESI-MS/MS.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060118

Title: A novel 14C-postlabeling assay using accelerator mass spectrometry for the detection of O6-methyldeoxy-guanosine adducts.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: Function of domains of human O6-alkylguanine-DNA alkyltransferase.

Journal: Biochemistry 20051122

Title: Effect of DNA polymerase beta loop variants on discrimination of O6-methyldeoxyguanosine modification present in the nucleotide versus template substrate.

Journal: Biochemistry 20050802

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Inhibition by allyl sulfides and crushed garlic of O6-methylguanine formation in liver DNA of dimethylnitrosamine-treated rats.

Journal: Nutrition and cancer 20050101

Title: Detection of O6-carboxymethyl-2'-deoxyguanosine in DNA following reaction of nitric oxide with glycine and in human blood DNA using a quantitative immunoslot blot assay.

Journal: Chemical research in toxicology 20040301

Title: Quantitative determination of N7-methyldeoxyguanosine and O6-methyldeoxyguanosine in DNA by LC-UV-MS-MS.

Journal: Analytical chemistry 20021015

Title: Chemopreventive effects of Aloe arborescens on N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters.

Journal: Cancer letters 20020425

Title: Lethal mutagenesis of HIV with mutagenic nucleoside analogs.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19990216

Title: Thermodynamic investigation of monoclonal antibody alkylated nucleoside interaction as a model for epitope recognition on nucleic acids.

Journal: Biochemistry 19870421

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:964-21-6 Molecular Formula|964-21-6 MDL|964-21-6 SMILES|964-21-6 O6-Methyl-deoxyguanosine