Home Imidazoles 2315-02-8
2315-02-8,MFCD00058147
Catalog No.:AA019D0S

2315-02-8 | 2-(3-Hydroxy-2,6-dimethyl-4-tert-butylbenzyl)-2-imidazoline

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA019D0S
Chemical Name:
2-(3-Hydroxy-2,6-dimethyl-4-tert-butylbenzyl)-2-imidazoline
CAS Number:
2315-02-8
Molecular Formula:
C16H25ClN2O
Molecular Weight:
296.8355
MDL Number:
MFCD00058147
SMILES:
Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C.Cl
NSC Number:
757254
Properties
Computed Properties
 
Complexity:
345  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  

Literature

Title: The cardiovascular effects and pharmacokinetics of intranasal tetracaine plus oxymetazoline: preliminary findings.

Journal: Journal of the American Dental Association (1939) 20120801

Title: Further evidence of oxymetazoline's safety in otologic surgery.

Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20120701

Title: Comparative evaluation of nasal blood flow and airflow in the decongestant response to oxymetazoline.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20120201

Title: Oxymetazoline ototoxicity in a chinchilla animal model.

Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20120101

Title: Regarding the novel drug OMS103HP.

Journal: Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 20120101

Title: Novel drug in arthroscopic meniscectomy.

Journal: Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 20120101

Title: Baseline differences explain the apparent benefits of combining oxymetazoline with intranasal corticosteroids.

Journal: The Journal of allergy and clinical immunology 20111101

Title: ['Of snakes and crocodiles': central side effects of nose drops and facts about rhinitis medicamentosa].

Journal: Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege 20111001

Title: Novel drug OMS103HP reduces pain and improves joint motion and function for 90 days after arthroscopic meniscectomy.

Journal: Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 20110801

Title: An outbreak of Burkholderia cepacia complex associated with intrinsically contaminated nasal spray.

Journal: Infection control and hospital epidemiology 20110801

Title: Topical vasoconstrictor use for nasal intubation during pregnancy complicated by cardiomyopathy and preeclampsia.

Journal: International journal of obstetric anesthesia 20110701

Title: In vitro metabolism of oxymetazoline: evidence for bioactivation to a reactive metabolite.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110401

Title: Oxymetazoline adds to the effectiveness of fluticasone furoate in the treatment of perennial allergic rhinitis.

Journal: The Journal of allergy and clinical immunology 20110401

Title: Identification and characterization of oxymetazoline glucuronidation in human liver microsomes: evidence for the involvement of UGT1A9.

Journal: Journal of pharmaceutical sciences 20110201

Title: A comparative analysis of the decongestive effect of oxymetazoline and xylometazoline in healthy subjects.

Journal: European journal of clinical pharmacology 20110101

Title: Acoustic rhinometry: impact of external nasal dilator on the two first notches of the rhinogram.

Journal: American journal of rhinology & allergy 20110101

Title: Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline.

Journal: Fundamental & clinical pharmacology 20101201

Title: Dopamine D₁-like receptors play only a minor role in the increase of striatal dopamine induced by striatally applied SKF38393.

Journal: European journal of pharmacology 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Evaluation of optical rhinometry for nasal provocation testing in allergic and nonallergic subjects.

Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20100801

Title: Fluticasone reverses oxymetazoline-induced tachyphylaxis of response and rebound congestion.

Journal: American journal of respiratory and critical care medicine 20100701

Title: [Rhinitis acuta: therapeutic approach with oxymetazoline].

Journal: MMW Fortschritte der Medizin 20100408

Title: Assessment of nasal spray deposition pattern in a silicone human nose model using a color-based method.

Journal: Pharmaceutical research 20100101

Title: Decreased rhinovirus shedding after intranasal oxymetazoline application in adults with induced colds compared with intranasal saline.

Journal: American journal of rhinology & allergy 20100101

Title: Are nasal decongestants safer than rhinitis? A case of oxymetazoline-induced syncope.

Journal: Cardiology in the young 20091201

Title: Apical ballooning syndrome secondary to nasal decongestant abuse.

Journal: Arquivos brasileiros de cardiologia 20091101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Best drugs for what ails you: the brands to buy--and those to skip.

Journal: Consumer reports 20090901

Title: Oxymetazoline inhibits and resolves inflammatory reactions in human neutrophils.

Journal: Journal of pharmacological sciences 20090701

Title: Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity.

Journal: Molecular pharmacology 20090501

Title: Relationship between nasal cavity volume changes and nasalance.

Journal: The Journal of laryngology and otology 20090401

Title: Flow-injection chemiluminescence method for the determination of naphazoline hydrochloride and oxymetazoline hydrochloride.

Journal: Luminescence : the journal of biological and chemical luminescence 20090101

Title: Passive and oxymetazoline-enhanced delivery with a lens device: pharmacokinetics and efficacy studies with rabbits.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080801

Title: Dexmedetomidine enhances the local anesthetic action of lidocaine via an alpha-2A adrenoceptor.

Journal: Anesthesia and analgesia 20080701

Title: Effects of oxymetazoline on isolated rat's tracheal smooth muscle.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20080601

Title: Novel drug product to improve joint motion and function and reduce pain after arthroscopic anterior cruciate ligament reconstruction.

Journal: Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 20080601

Title: [Effects of oxymetazoline hydrochloride on ex vivo human nasal cilia movement measured with high-speed digital microscopy].

Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20080401

Title: Analysis of efficacy of chiral adrenergic agonists.

Journal: Chirality 20080301

Title: Effect of oxymetazoline on healthy human nasal ciliary beat frequency measured with high-speed digital microscopy and mucociliary transport time.

Journal: The Annals of otology, rhinology, and laryngology 20080201

Title: Mechanism of decongestant activity of alpha 2-adrenoceptor agonists.

Journal: Pulmonary pharmacology & therapeutics 20080101

Title: [The influence of different alpha-sympathomimetic drugs and benzalkoniumchlorid on the ciliary beat frequency of in vitro cultured human nasal mucosa cells].

Journal: Laryngo- rhino- otologie 20080101

Title: Is topical local anaesthesia necessary when performing paediatric flexible nasendoscopy? A double-blind randomized controlled trial.

Journal: International journal of pediatric otorhinolaryngology 20071101

Title: Successful treatment of the erythema and flushing of rosacea using a topically applied selective alpha1-adrenergic receptor agonist, oxymetazoline.

Journal: Archives of dermatology 20071101

Title: Pre- and postsynaptic mechanisms in the clonidine- and oxymetazoline-induced inhibition of gastric motility in the rat.

Journal: Neurochemistry international 20071001

Title: alpha1-Adrenoceptors in proximal segments of tail arteries from control and reserpinised rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20071001

Title: Autonomic involvement in the permanent metabolic programming of hyperinsulinemia in the high-carbohydrate rat model.

Journal: American journal of physiology. Endocrinology and metabolism 20070501

Title: Flash pulmonary edema: an unusual presentation during orthognathic surgery.

Journal: Plastic and reconstructive surgery 20070501

Title: Role of the autonomic nervous system in the development of hyperinsulinemia by high-carbohydrate formula feeding to neonatal rats.

Journal: American journal of physiology. Endocrinology and metabolism 20070401

Title: Oxymetazoline modulates proinflammatory cytokines and the T-cell stimulatory capacity of dendritic cells.

Journal: Experimental dermatology 20070301

Title: Reference values for acoustic rhinometry in decongested school children and adults: the most sensitive measurement for change in nasal patency.

Journal: Rhinology 20070301

Title: Two model system of the alpha1A-adrenoceptor docked with selected ligands.

Journal: Journal of chemical information and modeling 20070101

Title: Anti-rhinovirus-specific activity of the alpha-sympathomimetic oxymetazoline.

Journal: Arzneimittel-Forschung 20070101

Title: [Ultrastructural changes in human nasal mucosa in rhinitis medicamentosa].

Journal: HNO 20061001

Title: By the way, doctor. The air in my apartment gets exceedingly dry during the winter. I started using a nasal decongestant containing oxymetazoline hydrochloride. Now I'm hooked. Even when it's not winter, I can't breathe at night without it. How can I break this addiction?

Journal: Harvard health letter 20061001

Title: Pharmacological characterization and autoradiographic distribution of alpha2-adrenoceptor antagonist [3H]RX 821002 binding sites in the chicken brain.

Journal: Neuroscience 20060811

Title: Antagonism by imidazoline-type drugs of muscarinic and other receptors in the guinea-pig ileum.

Journal: Autonomic & autacoid pharmacology 20060701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Simultaneous determination of triamcinolone acetonide and oxymetazoline hydrochloride in nasal spray formulations by HPLC.

Journal: Journal of pharmaceutical and biomedical analysis 20060318

Title: Oxymetazoline inhibits proinflammatory reactions: effect on arachidonic acid-derived metabolites.

Journal: The Journal of pharmacology and experimental therapeutics 20060201

Title: Effect of oxymetazoline nasal spray on intraocular pressure and retrobulbar hemodynamics.

Journal: The Journal of otolaryngology 20060201

Title: Nasal wall compliance in vasomotor rhinitis.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20060101

Title: In situ gelling, bioadhesive nasal inserts for extended drug delivery: in vitro characterization of a new nasal dosage form.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060101

Title: Characterisation of alpha2-adrenoceptor subtypes involved in gastric emptying, gastric motility and gastric mucosal defence.

Journal: European journal of pharmacology 20051228

Title: [Investigation of the effect of oxymetazoline on the duration of rhinitis].

Journal: MMW Fortschritte der Medizin 20051013

Title: [Investigation of the effect of oxymetazoline on the duration of rhinitis. results of a placebo-controlled double-blind study in patients with acute rhinitis].

Journal: MMW Fortschritte der Medizin 20051006

Title: Clinical images: Afrin-induced central nervous system vasospasm and thunderclap headache.

Journal: Arthritis and rheumatism 20051001

Title: [The observation of the ciliotoxicity of nasal mucosa with nasal decongestant].

Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20050901

Title: Oxymetazoline solutions inhibit middle ear pathogens and are not ototoxic.

Journal: The Annals of otology, rhinology, and laryngology 20050801

Title: Is oxymetazoline really safe for middle ear use.

Journal: The Laryngoscope 20050701

Title: [Usefulness of fenspiride in the treatment of acute otitis media in children].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20050601

Title: Use of mometasone furoate aqueous nasal spray in the treatment of rhinitis medicamentosa: an experimental study.

Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20050401

Title: Oxymetazoline is equivalent to ciprofloxacin in preventing postoperative otorrhea or tympanostomy tube obstruction.

Journal: The Laryngoscope 20050201

Title: Early changes in insulin secretion and action induced by high-fat diet are related to a decreased sympathetic tone.

Journal: American journal of physiology. Endocrinology and metabolism 20050101

Title: Pharmacological characterization of postjunctional alpha-adrenoceptors in human nasal mucosa.

Journal: American journal of rhinology 20050101

Title: Controlling bleeding from superficial wounds by the use of topical alpha adrenoreceptor agonists spray. A randomized, masked, controlled study.

Journal: Injury 20041101

Title: Thunderclap headache and reversible segmental cerebral vasoconstriction associated with use of oxymetazoline nasal spray.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20040914

Title: [Ethyl-3H]RS-79948-197 alpha2-adrenoceptor autoradiography validation in alpha2-adrenoceptor knockout mice.

Journal: European journal of pharmacology 20040830

Title: Antimuscarinic action of oxymetazoline on human intraocular muscles.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040801

Title: Intranasal drug delivery: an alternative to intravenous administration in selected emergency cases.

Journal: Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association 20040401

Title: Synthesis and identification of two potential oxidation degradants of oxymetazoline.

Journal: Rapid communications in mass spectrometry : RCM 20040101

Title: Bulk is a determinant of oxymetazoline affinity for the alpha1A-adrenergic receptor.

Journal: Receptors & channels 20040101

Title: Sympathomimetic drug allergy: cross-reactivity study by patch test.

Journal: American journal of clinical dermatology 20040101

Title: Effects of acute, repeated and chronic variable stress on in vivo tyrosine hydroxylase activity and on alpha(2)-adrenoceptor sensitivity in the rat brain.

Journal: Stress (Amsterdam, Netherlands) 20031201

Title: Alpha(2A)-adrenergic versus imidazoline receptor controversy in rilmenidine's action: alpha(2A)-antagonism in humans versus alpha(2A)-agonism in rabbits.

Journal: Annals of the New York Academy of Sciences 20031201

Title: [Tolerance and effectiveness of oxymetazoline and xylometazoline in treatment of acute rhinitis].

Journal: HNO 20031001

Title: Oxymetazoline nasal spray three times daily for four weeks in normal subjects is not associated with rebound congestion or tachyphylaxis.

Journal: Rhinology 20030901

Title: Stroke associated with sympathomimetics contained in over-the-counter cough and cold drugs.

Journal: Stroke 20030701

Title: Central serous chorioretinopathy associated with administration of sympathomimetic agents.

Journal: American journal of ophthalmology 20030701

Title: Functional characterisation of alpha(1)-adrenoceptors in denervated rat vas deferens.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030701

Title: [The use of oxymetazoline in nasal endoscopic sinus surgery].

Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20030501

Title: Stimulation of interleukin-12 production in mouse macrophages via activation of p38 mitogen-activated protein kinase by alpha2-adrenoceptor agonists.

Journal: European journal of pharmacology 20030425

Title: Contractile actions of imidazoline alpha-adrenoceptor agonists and effects of noncompetitive alpha1-adrenoceptor antagonists in human vas deferens.

Journal: European journal of pharmacology 20030221

Title: Evidence for the role of alpha1D- and alpha1A-adrenoceptors in contraction of the rat mesenteric artery.

Journal: Vascular pharmacology 20030201

Title: Topical nasal anesthesia and laryngopharyngeal sensory testing: a prospective, double-blind crossover study.

Journal: The Annals of otology, rhinology, and laryngology 20030101

Title: [Acute exposure to imidazoline derivatives in children].

Journal: Jornal de pediatria 20030101

Title: Pertussis toxin converts hyperpolarizations caused by alpha(2)-adrenoceptor agonists containing an imidazoline moiety into depolarizations in MIN 6 cells.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020901

Title: Segmental analysis of nasal cavity compliance by acoustic rhinometry.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20020701

Title: Intracellular sodium modulates the state of protein kinase C phosphorylation of rat proximal tubule Na+,K+-ATPase.

Journal: Acta physiologica Scandinavica 20020601

Title: Improved strategies and new treatment options for allergic rhinitis.

Journal: The Journal of the American Osteopathic Association 20020601

Title: Desensitization of alpha(2)-adrenoceptors which regulate noradrenaline synthesis and release after chronic treatment with clorgyline in the rat brain.

Journal: Pharmacology 20020501

Title: Hypertonic saline nasal provocation and acoustic rhinometry.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20020401

Title: The effects of topical agents of fluticasone propionate, oxymetazoline, and 3% and 0.9% sodium chloride solutions on mucociliary clearance in the therapy of acute bacterial rhinosinusitis in vivo.

Journal: The Laryngoscope 20020201

Title: Involvement of central K(ATP) channels in the gastric antisecretory action of alpha2-adrenoceptor agonists and beta-endorphin in rats.

Journal: European journal of pharmacology 20020125

Title: Acute exudative inflammation and nasally exhaled nitric oxide are two independent phenomena.

Journal: ORL; journal for oto-rhino-laryngology and its related specialties 20020101

Title: The stability of oxymetazoline hydrochloride in aqueous solution.

Journal: Acta poloniae pharmaceutica 20020101

Title: Effects of oxymetazoline on the ventilation of paranasal sinuses in healthy subjects.

Journal: American journal of rhinology 20020101

Title: [The relationship between ostial patency and medical treatment in acute maxillary sinusitis: an experimental study].

Journal: Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat 20020101

Title: Endothelial inhibitory modulation on the contractile responses to alpha 2-adrenergic agonists.

Journal: Proceedings of the Western Pharmacology Society 20020101

Title: Vasocontractile effects of alpha 2-adrenergic agonists associated with intracellular calcium release.

Journal: Proceedings of the Western Pharmacology Society 20020101

Title: The effect of inferior turbinate hypertrophy on nasal spray distribution to the middle meatus.

Journal: Clinical otolaryngology and allied sciences 20011201

Title: A study of the effect of nasal steroid sprays in perennial allergic rhinitis patients with rhinitis medicamentosa.

Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20010901

Title: Molecular cloning and functional expression of the guinea pig alpha(1a)-adrenoceptor.

Journal: European journal of pharmacology 20010831

Title: Potent alpha(2A)-adrenoceptor-mediated vasoconstriction by brimonidine in porcine ciliary arteries.

Journal: Investigative ophthalmology & visual science 20010801

Title: Phe-308 and Phe-312 in transmembrane domain 7 are major sites of alpha 1-adrenergic receptor antagonist binding. Imidazoline agonists bind like antagonists.

Journal: The Journal of biological chemistry 20010706

Title: Prejunctional actions of methylenedioxymethamphetamine in vas deferens from wild-type and alpha(2A/D)-adrenoceptor knockout mice.

Journal: European journal of pharmacology 20010706

Title: Inhibition of synovial plasma extravasation by preemptive administration of an antiinflammatory irrigation solution in the rat knee.

Journal: Anesthesia and analgesia 20010501

Title: Evidence for a non-adrenoceptor, imidazoline-mediated contractile response to oxymetazoline in the porcine isolated rectal artery.

Journal: British journal of pharmacology 20010401

Title: Effects of N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) on alpha2-adrenoceptors which regulate the synthesis and release of noradrenaline in the rat brain.

Journal: Pharmacology & toxicology 20010301

Title: Frequency dependent alpha(2)-adrenoceptor mediated modulation of excitatory junction potentials in guinea-pig mesenteric artery.

Journal: European journal of pharmacology 20010105

Title: Involvement of the opioid system in the central antisecretory action of alpha-2 adrenoceptor agonists in rat.

Journal: Journal of physiology, Paris 20010101

Title: Intranasal application of the alpha2-adrenoceptor agonist BHT-920 produces decongestion in the cat.

Journal: American journal of rhinology 20010101

Title: Anterior ischemic optic neuropathy following the use of a nasal decongestant.

Journal: American journal of ophthalmology 19990101

Title: Effects of sustained-release oral phenylpropanolamine on the nasal mucosa of healthy subjects.

Journal: Acta oto-laryngologica 19990101

Title: Benzylimidazolines as h5-HT1B/1D serotonin receptor ligands: a structure-affinity investigation.

Journal: Journal of medicinal chemistry 19980618

Title: Buffers differentially alter the binding of [3H]rauwolscine and [3H]RX821002 to the alpha-2 adrenergic receptor subtypes.

Journal: The Journal of pharmacology and experimental therapeutics 19960901

Title: NS-49, a novel alpha 1a-adrenoceptor-selective agonist characterization using recombinant human alpha 1-adrenoceptors.

Journal: European journal of pharmacology 19951130

Title: Cardiac arrest after oxymetazoline nasal spray.

Journal: Journal of clinical anesthesia 19950901

Title: Selectivity of the imidazoline alpha-adrenoceptor agonists (oxymetazoline and cirazoline) for human cloned alpha 1-adrenoceptor subtypes.

Journal: British journal of pharmacology 19950901

Title: Paranoid psychosis induced by oxymetazoline nasal spray.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 19940201

Title: Novel alpha 2-adrenoceptor antagonists show selectivity for alpha 2A- and alpha 2B-adrenoceptor subtypes.

Journal: European journal of pharmacology 19890922

Title: A case of secondary mania.

Journal: Psychosomatics 19880101

Title: A case of panic disorder precipitated by oxymetazoline withdrawal.

Journal: The Journal of clinical psychiatry 19870701

Title: Location of the mechanism of the clonidine withdrawal tachycardia in rats.

Journal: The Journal of pharmacy and pharmacology 19850801

Title: Bradycardia, hypotension, and near-syncope associated with Afrin (oxymetazoline) nasal spray.

Journal: The New England journal of medicine 19830922

Title: Urethane inhibits cardiovascular responses mediated by the stimulation of alpha-2 adrenoceptors in the rat.

Journal: The Journal of pharmacology and experimental therapeutics 19821101

Title: The inhibitory effects of presynaptic alpha-adrenoceptor agonists on contractions of guinea-pig ileum and mouse vas deferens in the morphine-dependent and withdrawn states produced in vitro.

Journal: British journal of pharmacology 19790801

Title: Pharmacology of AH 5158; a drug which blocks both - and -adrenoceptors.

Journal: British journal of pharmacology 19720801

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Tags:2315-02-8 Molecular Formula|2315-02-8 MDL|2315-02-8 SMILES|2315-02-8 2-(3-Hydroxy-2,6-dimethyl-4-tert-butylbenzyl)-2-imidazoline