Home Imidazoles 526-36-3
526-36-3,MFCD00242956
Catalog No.:AA019H09

526-36-3 | 2-(4-(tert-Butyl)-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole

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5mg
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$379.00   $265.00
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10mg
96%
in stock  
$570.00   $399.00
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25mg
96%
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$1,070.00   $749.00
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50mg
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100mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA019H09
Chemical Name:
2-(4-(tert-Butyl)-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole
CAS Number:
526-36-3
Molecular Formula:
C16H24N2
Molecular Weight:
244.3752
MDL Number:
MFCD00242956
SMILES:
Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C
Properties
Computed Properties
 
Complexity:
302  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
3.2  

Literature

Title: The development and application of a system for simultaneously determining anti-infectives and nasal decongestants using on-line solid-phase extraction and liquid chromatography-tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20120701

Title: Topical glucocorticoid reduces the topical decongestant-induced histologic changes in an animal model nasal mucosa.

Journal: The Laryngoscope 20120401

Title: The role of rhinomanometry after nasal decongestant test in the assessment of adenoid hypertrophy in children.

Journal: International journal of pediatric otorhinolaryngology 20120301

Title: A rare, potentially hazardous, malposition of the nasotracheal tube.

Journal: Indian journal of anaesthesia 20120101

Title: Perioperative concerns in transoral robotic surgery: Initial experience of four cases.

Journal: Journal of anaesthesiology, clinical pharmacology 20120101

Title: Anesthetic management of superior vena cava syndrome due to anterior mediastinal mass.

Journal: Journal of anaesthesiology, clinical pharmacology 20120101

Title: Hypertensive crisis and end-organ damage induced by over-the-counter nasal decongestant abuse.

Journal: European heart journal 20111201

Title: ['Of snakes and crocodiles': central side effects of nose drops and facts about rhinitis medicamentosa].

Journal: Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege 20111001

Title: The role of the nose in snoring and obstructive sleep apnoea: an update.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20110901

Title: Anesthesia and Intensive care implications for pituitary surgery: Recent trends and advancements.

Journal: Indian journal of endocrinology and metabolism 20110901

Title: Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

Journal: Journal of medicinal chemistry 20110714

Title: Rosacea (erythematotelangiectatic type) effectively improved by topical xylometazoline.

Journal: The Journal of dermatology 20110501

Title: Can we always trust rhinomanometry?

Journal: Rhinology 20110301

Title: Paradoxical increase in nasal airway resistance following a topical nasal decongestant spray.

Journal: Rhinology 20110301

Title: Xylometazoline pretreatment reduces nasotracheal intubation-related epistaxis in paediatric dental surgery.

Journal: British journal of anaesthesia 20110201

Title: Concha bullosa of the inferior turbinate: an unusual cause of nasal obstruction.

Journal: Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 20110201

Title: A comparative analysis of the decongestive effect of oxymetazoline and xylometazoline in healthy subjects.

Journal: European journal of clinical pharmacology 20110101

Title: Xylometazoline abuse induced ischemic stroke in a young adult.

Journal: The neurologist 20110101

Title: Preventing hospital admissions by reviewing medication (PHARM) in primary care: design of the cluster randomised, controlled, multi-centre PHARM-study.

Journal: BMC health services research 20110101

Title: Mucoadhesive drug delivery systems.

Journal: Journal of pharmacy & bioallied sciences 20110101

Title: Airway management in patients with maxillofacial trauma - A retrospective study of 177 cases.

Journal: Saudi journal of anaesthesia 20110101

Title: Study and development of reversed-phase HPLC systems for the determination of 2-imidazolines in the presence of preservatives in pharmaceutical preparations.

Journal: Journal of AOAC International 20110101

Title: Nasal leech infestation causing persistent epistaxis.

Journal: Journal of emergencies, trauma, and shock 20110101

Title: Failed nasal intubation after successful flexible bronchoscopy: Guide wire to the rescue.

Journal: Journal of anaesthesiology, clinical pharmacology 20110101

Title: Use of intubating laryngeal mask airway in a morbidly obese patient with chest trauma in an emergency setting.

Journal: Journal of anaesthesiology, clinical pharmacology 20110101

Title: Intubation in a pediatric difficult airway using an adult flexible fiber-optic bronchoscope and a j-tipped guidewire: An innovation in adversity.

Journal: Saudi journal of anaesthesia 20110101

Title: Sinusitis (acute).

Journal: BMJ clinical evidence 20110101

Title: Scientific rationale for the use of alpha-adrenergic agonists and glucocorticoids in the therapy of pediatric stridor.

Journal: International journal of otolaryngology 20110101

Title: Nasal inspiratory flow: at rest and sniffing.

Journal: International forum of allergy & rhinology 20110101

Title: Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline.

Journal: Fundamental & clinical pharmacology 20101201

Title: Case report: unilateral mydriasis following nasal cautery.

Journal: Orbit (Amsterdam, Netherlands) 20101201

Title: Xylometazoline pretreatment reduces nasotracheal intubation-related epistaxis in paediatric dental surgery.

Journal: British journal of anaesthesia 20101001

Title: Prognostic value of anterior rhinomanometry in diode laser turbinoplasty.

Journal: Archives of otolaryngology--head & neck surgery 20101001

Title: A randomized trial of topical anesthesia comparing lidocaine versus lidocaine plus xylometazoline for unsedated transnasal upper gastrointestinal endoscopy.

Journal: Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20100501

Title: Effects of intranasal xylometazoline, alone or in combination with ipratropium, in patients with common cold.

Journal: Current medical research and opinion 20100401

Title: Influence of intranasal sterile isotonic sea water applications on xylometazoline administration: an experimental study in pigs.

Journal: Auris, nasus, larynx 20100201

Title: Comments on: Central serous chorioretinopathy after dacryocystorhinostomy operation on the same side.

Journal: Indian journal of ophthalmology 20100101

Title: Treatment of congestion in upper respiratory diseases.

Journal: International journal of general medicine 20100101

Title: Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates.

Journal: PloS one 20100101

Title: Retrograde intubation in a case of ankylosing spondylitis posted for correction of deformity of spine.

Journal: Saudi journal of anaesthesia 20100101

Title: Physiology and pathophysiology of respiratory mucosa of the nose and the paranasal sinuses.

Journal: GMS current topics in otorhinolaryngology, head and neck surgery 20100101

Title: Numerical simulation and nasal air-conditioning.

Journal: GMS current topics in otorhinolaryngology, head and neck surgery 20100101

Title: OTC use of a topical nasal spray solution containing xylometazoline plus ipratropium in patients with common cold.

Journal: International journal of clinical pharmacology and therapeutics 20091201

Title: Effects of topical drops and sprays on mucociliary transport time and nasal air flow.

Journal: Acta oto-laryngologica 20091101

Title: Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment.

Journal: Molecular pharmacology 20091001

Title: A comparison of xylometazoline (Otrivine) and phenylephrine/lignocaine mixture (Cophenylcaine) for the purposes of rigid nasendoscopy: a prospective, double-blind, randomised trial.

Journal: The Journal of laryngology and otology 20090601

Title: Relation of nasal air flow to nasal cavity dimensions.

Journal: Archives of otolaryngology--head & neck surgery 20090601

Title: Efficacy and safety of intranasal xylometazoline and ipratropium in patients with common cold.

Journal: Expert opinion on pharmacotherapy 20090401

Title: Anaesthetic consideration in macroglossia due to lymphangioma of tongue: a case report.

Journal: Indian journal of anaesthesia 20090201

Title: Xylometazoline hydrochloride 0.1 per cent versus physiological saline in nasal surgical aftercare: a randomised, single-blinded, comparative clinical trial.

Journal: The Journal of laryngology and otology 20090101

Title: Central serous chorioretinopathy after dacryocystorhinostomy operation on the same side.

Journal: Indian journal of ophthalmology 20090101

Title: [Misuse of substances theoretically without abuse potential--case series].

Journal: Przeglad lekarski 20090101

Title: Does nasal decongestion improve obstructive sleep apnea?

Journal: Journal of sleep research 20081201

Title: Misuse of xylometazoline nasal drops by inhalation.

Journal: Substance use & misuse 20081201

Title: Oxymetazoline plus dexpanthenol in nasal congestion.

Journal: Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India 20081201

Title: The value of herbal medicines in the treatment of acute non-purulent rhinosinusitis. Results of a double-blind, randomised, controlled trial.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20081101

Title: Miscellaneous.

Journal: Indian journal of pharmacology 20081001

Title: Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.

Journal: Journal of medicinal chemistry 20080124

Title: [The influence of different alpha-sympathomimetic drugs and benzalkoniumchlorid on the ciliary beat frequency of in vitro cultured human nasal mucosa cells].

Journal: Laryngo- rhino- otologie 20080101

Title: The nasal decongestant effect of xylometazoline in the common cold.

Journal: American journal of rhinology 20080101

Title: Health-related quality of life in a trial of acupuncture, sham acupuncture and conventional treatment for chronic sinusitis.

Journal: BMC research notes 20080101

Title: Drug use in children: cohort study in three European countries.

Journal: BMJ (Clinical research ed.) 20080101

Title: Sinusitis (acute).

Journal: BMJ clinical evidence 20080101

Title: Trapping of adrenergic decongestant drugs into cellular endomembrane compartments: toxicological and pharmacological consequences.

Journal: International immunopharmacology 20071220

Title: Negative pressure pulmonary oedema.

Journal: European journal of anaesthesiology 20071201

Title: Effects of an external nasal dilator strip (ENDS) compared to xylometazolin nasal spray.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20071101

Title: Optical rhinometry: application on children and adolescents for nasal provocation tests.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20070801

Title: Comparison of optical rhinometry and active anterior rhinomanometry using nasal provocation testing.

Journal: Archives of otolaryngology--head & neck surgery 20070401

Title: Drug management in chronic rhinosinusitis: identification of the needs.

Journal: Therapeutics and clinical risk management 20070301

Title: Medication administered to children from 0 to 7.5 years in the Avon Longitudinal Study of Parents and Children (ALSPAC).

Journal: European journal of clinical pharmacology 20070201

Title: Diurnal variation of prescribing pattern of primary care doctors in Bahrain.

Journal: Journal of evaluation in clinical practice 20070201

Title: Efficacy and safety of topical combinations of ipratropium and xylometazoline for the treatment of symptoms of runny nose and nasal congestion associated with acute upper respiratory tract infection.

Journal: American journal of rhinology 20070101

Title: A case series of xylometazoline overdose in children.

Journal: Clinical toxicology (Philadelphia, Pa.) 20070101

Title: Effects on nasal nitric oxide production of 2 mechanisms of vasoconstriction.

Journal: Journal of investigational allergology & clinical immunology 20070101

Title: [Ultrastructural changes in human nasal mucosa in rhinitis medicamentosa].

Journal: HNO 20061001

Title: Immunology and homeopathy. 4. Clinical studies-part 1.

Journal: Evidence-based complementary and alternative medicine : eCAM 20060901

Title: Prevention of nosocomial maxillary sinusitis in the ICU: the effects of topically applied alpha-adrenergic agonists and corticosteroids.

Journal: Intensive care medicine 20060401

Title: Radiofrequency for inferior turbinate hypertrophy: could its long-term effect be predicted with a preoperative topical vasoconstrictor drop test?

Journal: American journal of rhinology 20060101

Title: [Pharmacological and clinical evalutation of nasal obstruction: application to xylometazoline].

Journal: Therapie 20060101

Title: Decongestant effects of nasal xylometazoline and mometasone furoate in persistent allergic rhinitis.

Journal: Rhinology 20051201

Title: The value of Ems Mineral Salts in the treatment of rhinosinusitis in children. Prospective study on the efficacy of mineral salts versus xylometazoline in the topical nasal treatment of children.

Journal: International journal of pediatric otorhinolaryngology 20051001

Title: Comparison of decongestive capacity of xylometazoline and pseudoephedrine with rhinomanometry and MRI.

Journal: Rhinology 20050901

Title: [Treatment of inflammatory diseases of the upper respiratory tract -- comparison of a homeopathic complex remedy with xylometazoline].

Journal: Forschende Komplementarmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine 20050201

Title: Hospital-acquired sinusitis is a common cause of fever of unknown origin in orotracheally intubated critically ill patients.

Journal: Critical care (London, England) 20050101

Title: 2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands.

Journal: Bioorganic & medicinal chemistry letters 20040920

Title: Immediate effect of benzalkonium chloride in decongestant nasal spray on the human nasal mucosal temperature.

Journal: Clinical otolaryngology and allied sciences 20040801

Title: Evaluation of protective and therapeutic effects of dexpanthenol on nasal decongestants and preservatives: results of cytotoxic studies in vitro.

Journal: American journal of rhinology 20040101

Title: The cavernous body of the human efferent tear ducts contributes to regulation of tear outflow.

Journal: Investigative ophthalmology & visual science 20031101

Title: [The tolerability of nasal drugs with special regard to preservatives and physico-chemical parameters].

Journal: Laryngo- rhino- otologie 20031101

Title: [Tolerance and effectiveness of oxymetazoline and xylometazoline in treatment of acute rhinitis].

Journal: HNO 20031001

Title: Assessment of nasal cycle by acoustic rhinometry and rhinomanometry.

Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20030401

Title: [Advance in therapy of acute rhinitis--comparison of efficacy and safety of xylometazoline in combination xylometazoline-dexpanthenol in patients with acute rhinitis].

Journal: Laryngo- rhino- otologie 20030401

Title: [The protective effect of dexpanthenol in nasal sprays. First results of cytotoxic and ciliary-toxic studies in vitro].

Journal: Laryngo- rhino- otologie 20030301

Title: Transdermal penetration of vasoconstrictors--present understanding and assessment of the human epidermal flux and retention of free bases and ion-pairs.

Journal: Pharmaceutical research 20030201

Title: No effect of a nasal decongestant on eustachian tube function in children with ventilation tubes.

Journal: The Laryngoscope 20020601

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: High-performance liquid chromatographic method for the assay of dexamethasone and xylometazoline in nasal drops containing methyl p-hydroxybenzoate.

Journal: Journal of chromatography. A 20020308

Title: Nasal mucociliary transport: new evidence for a key role of ciliary beat frequency.

Journal: The Laryngoscope 20020301

Title: Comparison of the clinical efficacy of standard and mucoadhesive-based nasal decongestants.

Journal: British journal of clinical pharmacology 20020101

Title: Decongestant activity of a new formulation of xylometazoline nasal spray: a double-blind, randomized versus placebo and reference drugs controlled, dose-effect study.

Journal: Drugs under experimental and clinical research 20020101

Title: The effect of topical xylometazoline on the mucosal temperature of the nasal septum.

Journal: American journal of rhinology 20020101

Title: Comparison of cefuroxime with or without intranasal fluticasone for the treatment of rhinosinusitis. The CAFFS Trial: a randomized controlled trial.

Journal: JAMA 20011226

Title: Efficacy and safety of an oral formulation of cetirizine and prolonged-release pseudoephedrine versus xylometazoline nasal spray in nasal congestion.

Journal: Arzneimittel-Forschung 20011101

Title: Detection of particles within the nasal airways before and after nasal decongestion.

Journal: Clinical otolaryngology and allied sciences 20010801

Title: The effect of intranasal budesonide spray on mucosal blood flow measured with laser Doppler flowmetry.

Journal: Rhinology 20010301

Title: The efficacy of topical anaesthesia in flexible nasendoscopy: a double-blind randomised controlled trial.

Journal: Clinical otolaryngology and allied sciences 20010201

Title: Cetirizine/pseudoephedrine.

Journal: Drugs 20010101

Title: Benzylimidazolines as h5-HT1B/1D serotonin receptor ligands: a structure-affinity investigation.

Journal: Journal of medicinal chemistry 19980618

Title: Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes.

Journal: Molecular pharmacology 19941101

Title: Central action of narcotic analgesics. Part IV. Noradrenergic influences on the activity of analgesics in rats.

Journal: Polish journal of pharmacology and pharmacy 19780101

Title: The influence of alpha-adrenergic drugs on catalepsy induced by haloperidol or fluphenazine in rats.

Journal: Polish journal of pharmacology and pharmacy 19780101

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SDS
Tags:526-36-3 Molecular Formula|526-36-3 MDL|526-36-3 SMILES|526-36-3 2-(4-(tert-Butyl)-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole