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Home Other Building Blocks 952021-60-2
952021-60-2,MFCD16038847
Catalog No.:AA01DBL6

952021-60-2 | Pf-477736

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$152.00   $106.00
- +
10mg
≥98%
in stock  
$283.00   $198.00
- +
25mg
≥98%
in stock  
$592.00   $414.00
- +
50mg
in stock  
$861.00   $603.00
- +
500mg
98% by HPLC
in stock  
$7,851.00   $5,496.00
- +
1000mg
98% by HPLC
in stock  
$12,525.00   $8,768.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01DBL6
Chemical Name:
Pf-477736
CAS Number:
952021-60-2
Molecular Formula:
C22H25N7O2
Molecular Weight:
419.4796
MDL Number:
MFCD16038847
SMILES:
Cn1ncc(c1)c1[nH]c2c3c1cn[nH]c(=O)c3cc(c2)NC(=O)[C@@H](C1CCCCC1)N
Properties
Computed Properties
 
Complexity:
725  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  
XLogP3:
1.5  

Downstream Synthesis Route

[1]CurrentPatentAssignee:PFIZERINC-WO2007/113647,2007,A1Locationinpatent:Page/Pagecolumn10;24

[2]CurrentPatentAssignee:PFIZERINC-WO2007/113647,2007,A1Locationinpatent:Page/Pagecolumn25

[1]CurrentPatentAssignee:PFIZERINC-WO2007/113647,2007,A1Locationinpatent:Page/Pagecolumn24

Literature

Title: Checkpoint kinase 1 is activated and promotes cell survival after exposure to sulphur mustard.

Journal: Toxicology letters 20150122

Title: Response of subtype-specific human breast cancer-derived cells to poly(ADP-ribose) polymerase and checkpoint kinase 1 inhibition.

Journal: Cancer science 20111001

Title: Blasina A, et al. Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1. Mol Cancer Ther. 2008 Aug;7(8):2394-404

Title: Ashwell S, et, al. DNA damage detection and repair pathways--recent advances with inhibitors of checkpoint kinases in cancer therapy. Clin Cancer Res. 2008 Jul 1; 14(13): 4032-7.

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SDS
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Tags:952021-60-2 Molecular Formula|952021-60-2 MDL|952021-60-2 SMILES|952021-60-2 Pf-477736