Home Other Building Blocks 943540-75-8
943540-75-8,MFCD11977274
Catalog No.:AA01DNQT

943540-75-8 | JNJ-38877605

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$19.00   $14.00
- +
5mg
98+%
in stock  
$46.00   $32.00
- +
10mg
98+%
in stock  
$68.00   $48.00
- +
50mg
98+%
in stock  
$193.00   $135.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01DNQT
Chemical Name:
JNJ-38877605
CAS Number:
943540-75-8
Molecular Formula:
C19H13F2N7
Molecular Weight:
377.3502
MDL Number:
MFCD11977274
SMILES:
Cn1ncc(c1)c1ccc2n(n1)c(nn2)C(c1ccc2c(c1)cccn2)(F)F
Properties
Computed Properties
 
Complexity:
564  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
7  
Rotatable Bond Count:
3  
XLogP3:
2.1  

Downstream Synthesis Route
943541-20-6    943541-39-7   
JNJ-38877605 

[1]Patent:WO2008/155378,2008,A1.Locationinpatent:Page/Pagecolumn73

[2]Patent:WO2007/75567,2007,A1.Locationinpatent:Page/Pagecolumn117;119-120

943540-75-8   
CASUnavailable 

[1]CurrentPatentAssignee:JOHNSON&JOHNSONINC-WO2007/75567,2007,A1Locationinpatent:Page/Pagecolumn120

CASUnavailable 
  943540-75-8 

[1]CurrentPatentAssignee:JOHNSON&JOHNSONINC-WO2008/155378,2008,A1Locationinpatent:Page/Pagecolumn75

943540-75-8   
CASUnavailable 

[1]CurrentPatentAssignee:SOLVIASAG;JOHNSON&JOHNSONINC-WO2016/87586,2016,A1

943540-75-8   
CASUnavailable 

[1]CurrentPatentAssignee:SOLVIASAG;JOHNSON&JOHNSONINC-WO2016/87586,2016,A1Locationinpatent:Page/Pagecolumn14;15

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors.

Journal: Cancer research 20101001

Title: Perera T, et al. JNJ-38877605: a selective Met kinase inhibitor inducing regression of Met-driven tumor models. Presented at the 99th AACR Annual Meeting; 2008 Apr 12-16

Title: De Bacco F, et al. Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer. J Natl Cancer Inst. 2011 Apr, 103(8), 645-661.

Title: Torti D, et al. A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors. Int J Cancer. 2012, 130(6), 1357-1366.

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SDS
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