Home Amines 95343-20-7
95343-20-7,MFCD01713157
Catalog No.:AA01DPWC

95343-20-7 | 5,12-Naphthacenedione,10-[[3-amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-

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5mg
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$111.00   $78.00
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10mg
98%
1 week  
$146.00   $102.00
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50mg
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$431.00   $302.00
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100mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01DPWC
Chemical Name:
5,12-Naphthacenedione,10-[[3-amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
CAS Number:
95343-20-7
Molecular Formula:
C32H38ClNO12
Molecular Weight:
664.0966
MDL Number:
MFCD01713157
SMILES:
OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](N)[C@@H]([C@@H](O2)C)O[C@@H]2CCCCO2)c2c(C1)c(O)c1c(c2O)C(=O)c2c(C1=O)cccc2OC.Cl
Properties
Computed Properties
 
Complexity:
1120  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
7  
Heavy Atom Count:
46  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
7  

Literature

Title: Relationship between RFC gene expression and intracellular drug concentration in methotrexate-resistant osteosarcoma cells.

Journal: Genetics and molecular research : GMR 20140724

Title: Comparison on therapeutic effects of RFT and RCTVP regimen in the treatment of patients with indolent B-cell lymphoma in China.

Journal: Medical oncology (Northwood, London, England) 20121201

Title: Influence of coupling bonds on the anti-tumor activity of polymer-pirarubicin conjugates.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120815

Title: Indoleamine 2,3-dioxygenase expression and serum kynurenine concentrations in patients with diffuse large B-cell lymphoma.

Journal: Leukemia & lymphoma 20120601

Title: Pirarubicin inhibits multidrug-resistant osteosarcoma cell proliferation through induction of G2/M phase cell cycle arrest.

Journal: Acta pharmacologica Sinica 20120601

Title: Anthraquinone antitumour agents, doxorubicin, pirarubicin and benzoperimidine BP1, trigger caspase-3/caspase-8-dependent apoptosis of leukaemia sensitive HL60 and resistant HL60/VINC and HL60/DOX cells.

Journal: Anti-cancer drugs 20120401

Title: Delineation of apoptotic genes for synergistic apoptosis of lexatumumab and anthracyclines in human renal cell carcinoma cells by polymerase chain reaction array.

Journal: Anti-cancer drugs 20120401

Title: Small cell osteosarcoma successfully treated by high-dose ifosfamide and methotrexate, combined with carboplatin and pirarubicin.

Journal: Anticancer research 20120301

Title: A phase II study of rituximab combined with pirarubicin-cyclophosphamide, vincristine and prednisolone regimen as first-line therapy for patients with indolent B-cell lymphoma.

Journal: Leukemia & lymphoma 20120201

Title: [Efficacy analysis of THP-containing regimens as neoadjuvant and adjuvant chemotherapy for primary breast cancer].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20120201

Title: Metabonomic study on the cumulative cardiotoxicity of a pirarubicin liposome powder.

Journal: Talanta 20120130

Title: Randomised controlled trial of lipiodol transarterial chemoembolisation with or without amiodarone for unresectable hepatocellular carcinoma.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20111101

Title: Application of high-dose rate (60)Co remote after-loading system for local recurrent neuroblastoma.

Journal: Journal of pediatric surgery 20111101

Title: Additive antitumoral effect of interleukin-12 gene therapy and chemotherapy in the treatment of urothelial bladder cancer in vitro and in vivo.

Journal: International urology and nephrology 20110901

Title: Assessment of late cardiotoxicity of pirarubicin (THP) in children with acute lymphoblastic leukemia.

Journal: Pediatric blood & cancer 20110901

Title: What's up with down syndrome and leukemia-A lot!

Journal: Pediatric blood & cancer 20110715

Title: Continuous and high-dose cytarabine combined chemotherapy in children with down syndrome and acute myeloid leukemia: Report from the Japanese children's cancer and leukemia study group (JCCLSG) AML 9805 down study.

Journal: Pediatric blood & cancer 20110715

Title: [Clinical comparative study of neoadjuvant chemotherapy outcome in locally advanced breast cancer: docetaxel versus paclitaxel plus pirarubicin hydrochloride and cyclophosphamide].

Journal: Zhonghua yi xue za zhi 20110712

Title: [Comparative study of chemosensitivity and efficacy between pirarubicin and epirubicin in breast cancer].

Journal: Zhonghua yi xue za zhi 20110531

Title: Selective ligation of portal vein and hepatic artery for ruptured hepatocellular carcinoma in a 13-year-old boy.

Journal: Journal of pediatric surgery 20110501

Title: Infratentorial brain metastases of pediatric non-epithelial malignant tumors: three case reports.

Journal: Brain tumor pathology 20110401

Title: [The study of absorbable sustained-release implants and animal experiments to prevent recurrence of bladder cancer].

Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20110401

Title: Spinal cord compression by epidural involvement over 21 vertebral levels in acute lymphoblastic leukemia.

Journal: Journal of pediatric hematology/oncology 20110301

Title: Reactive tonsillar enlargement with strong 18F-FDG uptake after chemotherapy for tonsillar diffuse large B-cell lymphoma.

Journal: Journal of pediatric hematology/oncology 20110301

Title: A retrospective study of the preoperative treatment of advanced Wilms tumor in children with chemotherapy versus transcatheter arterial chemoembolization alone or combined with short-term systemic chemotherapy.

Journal: Journal of vascular and interventional radiology : JVIR 20110301

Title: Double short-time exposure to pirarubicin produces higher cytotoxicity against T24 bladder cancer cells.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20110201

Title: Outcome of hepatoblastomas treated using the Japanese Study Group for Pediatric Liver Tumor (JPLT) protocol-2: report from the JPLT.

Journal: Pediatric surgery international 20110101

Title: [In vitro synergistic effect of bortezomib and pirarubicin on proliferation and apoptosis of T cell lymphoma cell line Hut-78 cells].

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20110101

Title: Adjuvant therapy of breast cancer with pirarubicin versus epirubicin in combination with cyclophosphamide and 5-fluorouracil.

Journal: The breast journal 20110101

Title: Clinical comparison on the safety and efficacy of fluorouracil/pirarubicin/cyclophosphamide (FPC) with fluorouracil/ epirubicin/cyclophosphamide (FEC) as postoperative adjuvant chemotherapy in breast cancer.

Journal: Asian Pacific journal of cancer prevention : APJCP 20110101

Title: [A case of HER2 overexpressing advanced breast cancer with CTF therapy [cyclophosphamide, pirarubicin (THPADM), fluorouracil] showed long-term effectiveness after paclitaxel shock].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20101201

Title: Improved detection of nonmuscle invasive urothelial carcinoma of the bladder using pirarubicin endoscopy: a prospective, single-center preliminary study.

Journal: Journal of endourology 20101101

Title: Primary malignant bone neoplasm: a case report of dedifferentiated chondrosarcoma in the rib and review of the literature.

Journal: Chinese journal of cancer 20101101

Title: [Clinical investigation on intravesical instillation of high-dose pirarubicin during perioperative period to prevent bladder carcinoma recurrence].

Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] 20101101

Title: Characterization and pharmacokinetics of a novel pirarubicin liposome powder.

Journal: Drug development and industrial pharmacy 20101001

Title: A pilot study of combination chemotherapy with paclitaxel, pirarubicin, and carboplatin (TPC) for endometrial carcinoma.

Journal: International journal of clinical oncology 20101001

Title: [Analysis of the risk factors for vascular pain induced by the administration of pirarubicin].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20101001

Title: [Clinical observation of transarterial chemoembolization combined with sorafenib for advanced hepatocellular carcinoma].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20100901

Title: In vitro and in vivo evaluation of tumor targeting styrene-maleic acid copolymer-pirarubicin micelles: Survival improvement and inhibition of liver metastases.

Journal: Cancer science 20100801

Title: Weekly paclitaxel improved pathologic response of primary chemotherapy compared with standard 3 weeks schedule in primary breast cancer.

Journal: Breast cancer research and treatment 20100801

Title: [Localization diagnosis of carcinoma in situ of bladder cancer by pirarubicin: preliminary clinical experience].

Journal: Zhonghua yi xue za zhi 20100511

Title: [Neuroblastoma LA-N-6 cells express Foxp3 which can be suppressed by chemotherapeutic agents].

Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20100501

Title: Therapeutic effect of pirarubicin-based chemotherapy for osteosarcoma patients with lung metastasis.

Journal: Journal of chemotherapy (Florence, Italy) 20100401

Title: A case of cutaneous B-cell lymphoma showing multiple lipoatrophy-like skin depressions.

Journal: International journal of dermatology 20100301

Title: Structure-activity relationships studies in a series of N,N-bis(alkanol)amine aryl esters as P-glycoprotein (Pgp) dependent multidrug resistance (MDR) inhibitors.

Journal: Journal of medicinal chemistry 20100225

Title: Cerebral lipiodol embolism following transcatheter arterial chemoembolization for hepatocellular carcinoma.

Journal: World journal of gastroenterology 20100121

Title: Phase II study of Rituximab combined with THP-COP as first-line therapy for patients younger than 70 years with diffuse large B cell lymphoma.

Journal: Journal of cancer research and clinical oncology 20100101

Title: Long-term results of pirarubicin versus doxorubicin in combination chemotherapy for aggressive non-Hodgkin's lymphoma: single center, 15-year experience.

Journal: International journal of hematology 20100101

Title: Molecular mechanism of cell apoptosis by paclitaxel and pirarubicin in a human osteosarcoma cell line.

Journal: Chemotherapy 20100101

Title: [Application of neoadjuvant chemotherapy for operable breast cancer].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20091201

Title: [Mechanism of intravesical instillation of pirarubicin for preventing recurrence of non-muscle invasive bladder cancer].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20091201

Title: Studying the interaction of pirarubicin with DNA and determining pirarubicin in human urine samples: combining excitation-emission fluorescence matrices with second-order calibration methods.

Journal: Journal of fluorescence 20091101

Title: Combined arterial infusion and stent implantation compared with metal stent alone in treatment of malignant gastroduodenal obstruction.

Journal: Cardiovascular and interventional radiology 20090901

Title: Investigation on the interactions between pirarubicin and phospholipids.

Journal: Biophysical chemistry 20090801

Title: Use of intra-arterial chemotherapy and embolization before limb salvage surgery for osteosarcoma of the lower extremity.

Journal: Cardiovascular and interventional radiology 20090701

Title: Pilot study of transarterial chemoembolization with pirarubicin and amiodarone for unresectable hepatocellular carcinoma.

Journal: American journal of clinical oncology 20090601

Title: [Usefulness of FDG-PET/CT for the diagnosis of intravascular large B-cell lymphoma presenting with fever of unknown origin and renal dysfunction].

Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 20090601

Title: Regimen containing perarubicin for the treatment of newly diagnosed young patients with acute myeloid leukemia.

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20090601

Title: [Intra-arterial chemotherapy for bladder preservation in patients with locally advanced bladder cancer].

Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 20090301

Title: N,N-bis(cyclohexanol)amine aryl esters: a new class of highly potent transporter-dependent multidrug resistance inhibitors.

Journal: Journal of medicinal chemistry 20090212

Title: Long-term follow-up of neoadjuvant intraarterial chemotherapy using an original four-lumen double-balloon (4L-DB) catheter for locally advanced uterine cervical cancer.

Journal: International journal of clinical oncology 20090201

Title: [Effects of neoadjuvant chemotherapy of docetaxel combined with and epirubicin or pirarubicin on breast cancer: clinical analysis of 160 cases].

Journal: Zhonghua yi xue za zhi 20090113

Title: Styrene maleic acid-pirarubicin disrupts tumor microcirculation and enhances the permeability of colorectal liver metastases.

Journal: Journal of vascular research 20090101

Title: Autologous peripheral blood stem cell transplantation to treat CHOP-refractory aggressive subcutaneous panniculitis-like T cell lymphoma.

Journal: Acta haematologica 20090101

Title: Prognostic significance of circulating tumor cells and bone marrow micrometastasis in advanced neuroblastoma.

Journal: Journal of pediatric surgery 20081201

Title: Hepatocellular carcinoma presenting as paraneoplastic myasthenia gravis.

Journal: European journal of internal medicine 20081201

Title: [Ureteral cancer occurred in megaureter].

Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 20081101

Title: Treatment-related acute myelomonocytic leukemia with t(11;19) in a child following chemotherapy for hepatoblastoma.

Journal: Pediatric blood & cancer 20080401

Title: Favourable outcomes in children with diffuse large B-cell lymphoma treated by a short-term ALL-like regimen: a report on the NHL960 study from the Japanese Childhood Cancer and Leukemia Study Group.

Journal: Leukemia & lymphoma 20080401

Title: Iodine-131-metaiodobenzylguanidine therapy with reduced-intensity allogeneic stem cell transplantation in recurrent neuroblastoma.

Journal: Pediatric blood & cancer 20080301

Title: Neoadjuvant chemotherapy with vinorelbine-containing regimens in elderly patients with locally advanced breast cancer.

Journal: Anticancer research 20080101

Title: Variation of substituents on pirarubicin for enhancing response to hepatocellular carcinoma and pattern recognition analysis to determine analogy to parent drug.

Journal: Physiological chemistry and physics and medical NMR 20080101

Title: Rituximab with chemotherapy improves survival of non-germinal center type untreated diffuse large B-cell lymphoma.

Journal: Leukemia 20071201

Title: Prospective study of a pirarubicin, intermediate-dose cytarabine, and etoposide regimen in children with Down syndrome and acute myeloid leukemia: the Japanese Childhood AML Cooperative Study Group.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20071201

Title: Continuous remission in an infant with chest wall malignant rhabdoid tumor after relapse.

Journal: Journal of pediatric surgery 20071001

Title: Bladder tumor associated with phenacetin abuse: a case report and a review of the literature.

Journal: The Tokai journal of experimental and clinical medicine 20070920

Title: [A case of long-term survival of advanced penile carcinoma treated with combination therapy].

Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 20070901

Title: Repetitive cycles of high-dose cytarabine are effective for childhood acute myeloid leukemia: long-term outcome of the children with AML treated on two consecutive trials of Tokyo Children's Cancer Study Group.

Journal: Pediatric blood & cancer 20070801

Title: [Squamous cell carcinoma of the bladder treated with a new combined chemotherapy regimen, intraarterial nedaplatin and pirarubicin plus intravenous methotrexate and vincristine--second case report in Japan].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20070801

Title: [Clinical features of patients with metastasis in phalanges as first symptom of primary lung cancer].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20070701

Title: Systemic varicella zoster virus reinfection in a case of angioimmunoblastic T-cell lymphoma.

Journal: The Journal of dermatology 20070601

Title: Salvage therapy and late neurotoxicity in patients with recurrent primary CNS lymphoma treated with a modified ProMACE-MOPP hybrid regimen.

Journal: Leukemia & lymphoma 20070601

Title: Immuno-chemotherapy with a combination of rituximab, methotrexate, pirarubicin and procarbazine for patients with primary CNS lymphoma--a preliminary report.

Journal: Leukemia & lymphoma 20070501

Title: Pediatric primary leptomeningeal lymphoma treated without cranial radiotherapy.

Journal: Pediatric blood & cancer 20070401

Title: [Overexpression of PTEN gene inhibits proliferation of bladder transitional carcinoma cell line EJ].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20070401

Title: [Superficial bladder cancer with lung metastasis without local invasion: a case report].

Journal: Hinyokika kiyo. Acta urologica Japonica 20070301

Title: Isomeric N,N-bis(cyclohexanol)amine aryl esters: the discovery of a new class of highly potent P-glycoprotein (Pgp)-dependent multidrug resistance (MDR) inhibitors.

Journal: Journal of medicinal chemistry 20070222

Title: Evaluation of the effect of SMA-pirarubicin micelles on colorectal cancer liver metastases and of hyperbaric oxygen in CBA mice.

Journal: Journal of drug targeting 20070101

Title: Concurrent chemoradiotherapy with cyclophosphamide, pirarubicin, and cisplatin for patients with locally advanced salivary gland carcinoma.

Journal: Acta oto-laryngologica 20061201

Title: In vivo 1H magnetic resonance spectroscopy in evaluation of hepatocellular carcinoma and its early response to transcatheter arterial chemoembolization.

Journal: Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20061201

Title: [Effects of pirarubicin chemotherapy combined with hyperthermia on gastric cancer in vitro].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20061001

Title: Granisetron reduces clinical and histological response to intra-arterial neoadjuvant chemotherapy in oral squamous cell carcinoma.

Journal: International journal of oral and maxillofacial surgery 20060901

Title: [Bladder cancer with skin metastasis: a case report].

Journal: Hinyokika kiyo. Acta urologica Japonica 20060901

Title: The expression of thymidine phosphorylase is a prognostic predictor for the intravesical recurrence of superficial bladder cancer.

Journal: International journal of clinical oncology 20060801

Title: Squamous cell carcinoma of the bladder: a patient treated successfully with a new combined chemotherapy regimen, intraarterial nedaplatin and pirarubicin plus intravenous methotrexate and vincristine.

Journal: International journal of clinical oncology 20060801

Title: [Effects of hyperthermic chemotherapy on gastrointestinal cancer cells in vitro].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20060801

Title: [Effect of modified MAID regimen for patients with advanced soft tissue sarcoma].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20060801

Title: Recurrence pattern for superficial bladder cancer.

Journal: International journal of urology : official journal of the Japanese Urological Association 20060601

Title: [5 years intravesical instillation with mitomycin-C and pirarubicin as a prophylactic treatment for superficial bladder cancer].

Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 20060501

Title: Outcome of preoperative concurrent chemoradiotherapy and surgery for resectable lingual squamous cell carcinoma greater than 3 cm: the possibility of less extensive surgery.

Journal: Oral oncology 20060401

Title: Angiotensin-II combined intra-arterial chemotherapy for locally advanced bladder cancer: a case series study at a single institution.

Journal: Hinyokika kiyo. Acta urologica Japonica 20060201

Title: Apoptosis in cervical cancer after balloon-occluded arterial infusion of anticancer drugs.

Journal: Anticancer research 20060101

Title: Treatment of infantile hepatoblastoma and related complications.

Journal: The Tokai journal of experimental and clinical medicine 20051201

Title: Treatment for HTLV-I associated arthropathy: a case study and synovial tissue culture analysis.

Journal: Rheumatology international 20051101

Title: [Long-term outcomes of 392 non-Hodgkin's lymphoma patients treated with pirarubicin based regimens].

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20051001

Title: [A randomized study of prophylactic intravesical instillation of pirarubicin (THP) prior to transurethral resection of superficial bladder cancer].

Journal: Hinyokika kiyo. Acta urologica Japonica 20050701

Title: Radiation reduces pirarubicin sensitivity in human cervical squamous cell carcinoma cells.

Journal: Oncology reports 20050601

Title: [Therapeutic effects of chemotherapeutic regimens containing pirarubicin on the treatment of high-risk or refractory and relapsed acute leukemia in adults].

Journal: Zhonghua yi xue za zhi 20050511

Title: [A case of advanced breast cancer markedly responding to chemo-endocrine therapy with only slight alopecia].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20050501

Title: Uptake of the anthracycline pirarubicin into mouse M5076 ovarian sarcoma cells via a sodium-dependent nucleoside transport system.

Journal: Cancer chemotherapy and pharmacology 20050301

Title: [Superselective intraarterial chemotherapy using low dose CBDCA and Pirarubicin with concurrent radiotherapy for head and neck cancer].

Journal: Nihon Jibiinkoka Gakkai kaiho 20050301

Title: Obstructive jaundice as a presentation of ganglioneuroblastoma.

Journal: Journal of pediatric hematology/oncology 20050201

Title: [Clinical analysis of 79 cases of cervical cancer].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20050201

Title: Phase I/II study of the rituximab-EPOCT regimen in combination with granulocyte colony-stimulating factor in patients with relapsed or refractory follicular lymphoma including evaluation of its cardiotoxicity using B-type natriuretic peptide and troponin T levels.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050115

Title: Copoly(styrene-maleic acid)-pirarubicin micelles: high tumor-targeting efficiency with little toxicity.

Journal: Bioconjugate chemistry 20050101

Title: Diagnosing the location of carcinoma in situ (CIS) of the urinary bladder using pirarubicin hydrochloride.

Journal: Urologia internationalis 20050101

Title: [Efficacy of selective continuous transarterial infusion chemotherapy on advanced pancreatic cancer].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20041201

Title: [Sustained clinical response of large hepatocellular carcinoma after chemoembolization with pirarubicin, amiodarone and Lipiodol].

Journal: Gastroenterologie clinique et biologique 20041201

Title: Selective intra-arterial chemoembolization of pelvic and spine bone metastases.

Journal: European radiology 20041001

Title: Concurrent chemoradiotherapy with pirarubicin and 5-fluorouracil for resectable oral and maxillary carcinoma.

Journal: Acta oto-laryngologica. Supplementum 20041001

Title: A case of pediatric ovarian dysgerminoma associated with high serum levels and positive immunohistochemical staining of neuron-specific enolase.

Journal: Journal of pediatric surgery 20040901

Title: Thiol oxidation induced by oxidative action of adriamycin.

Journal: Free radical research 20040901

Title: [Neoadjuvant chemotherapy for primary breast cancer].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20040801

Title: [Intravesial instillation of recombination interferon-alpha and pirarubicin in the prophylaxis of local recurrence after resection of the superficial bladder cancer].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20040701

Title: [Therapeutic effects of chemotherapeutic regimen with pirarubicin for adult high-risk acute leukemia].

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20040701

Title: Prevention of peritoneal carcinomatosis from colon cancer cell seeding using a pirarubicin solution in rats and nude mice.

Journal: World journal of surgery 20040501

Title: [Multidisciplinary treatment for advanced bladder cancer--a case report].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20040501

Title: [A case of anaphylactic shock induced by pirarubicin hydrochloride].

Journal: Hinyokika kiyo. Acta urologica Japonica 20040401

Title: [A phase I study of combination chemotherapy using TS-1 and pirarubicin (THP) for advanced gastric cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20040301

Title: First-line hepatic infusion of pirarubicin in patients with isolated liver metastases: is it really promising?

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20040201

Title: Rapid improvement of paraplegia caused by epidural involvements of Burkitt's lymphoma with chemotherapy.

Journal: Spine 20040101

Title: Optimal strategy of preoperative transcatheter arterial chemoembolization for hepatoblastoma.

Journal: Surgery today 20040101

Title: The activity of latent benzoperimidine esters to inhibit P-glycoprotein and multidrug resistance-associated protein 1 dependent efflux of pirarubicin from several lines of multidrug resistant tumor cells.

Journal: Cancer detection and prevention 20040101

Title: Multimodal therapy with intravenous biweekly leucovorin, 5-fluorouracil and irinotecan combined with hepatic arterial infusion pirarubicin in non-resectable hepatic metastases from colorectal cancer (a European Association for Research in Oncology trial).

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20031001

Title: Doxorubicin and two of its analogues are preferential inducers of homologous recombination compared with mutational events in somatic cells of Drosophila melanogaster.

Journal: Mutation research 20030805

Title: Functional study of intracellular P-gp- and MRP1-mediated pumping of free cytosolic pirarubicin into acidic organelles in intrinsic resistant SiHa cells.

Journal: Canadian journal of physiology and pharmacology 20030801

Title: [Nephrogenic adenoma of the bladder treated with cystectomy to control severe irritative symptoms: a case report].

Journal: Hinyokika kiyo. Acta urologica Japonica 20030801

Title: Rhodamine B as a mitochondrial probe for measurement and monitoring of mitochondrial membrane potential in drug-sensitive and -resistant cells.

Journal: Journal of biochemical and biophysical methods 20030731

Title: Pirarubicin is taken up by a uridine-transportable sodium-dependent concentrative nucleoside transporter in Ehrlich ascites carcinoma cells.

Journal: Cancer chemotherapy and pharmacology 20030601

Title: Induction chemotherapy for breast carcinoma: predictive markers and relation with outcome.

Journal: International journal of oncology 20030601

Title: Hepatic arterial infusion using pirarubicin combined with systemic chemotherapy: a phase II study in patients with nonresectable liver metastases from colorectal cancer.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20030601

Title: Cloning and functional study of a novel human metallothionein-I isoform induced by paraquat.

Journal: Biochemical and biophysical research communications 20030502

Title: In vitro study of the compatibility of tris-acryl gelatin microspheres with various chemotherapeutic agents.

Journal: Journal of vascular and interventional radiology : JVIR 20030501

Title: [Intravesical instillation of pirarubicin (THP) together with polyvinylpyrrolidone (PVP) in the prevention of postoperative recurrence of superficial bladder cancer].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20030401

Title: Liver metastasis of pancreatic cancer managed by intra-arterial infusion chemotherapy combined with degradable starch microspheres.

Journal: International journal of clinical oncology 20030401

Title: [Severe type of Epstein-Barr virus associated hemophagocytic syndrome successfully treated with T-COP-E and splenectomy].

Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20030401

Title: Regression of refractory rhabdomyosarcoma after allogeneic stem-cell transplantation.

Journal: Pediatric hematology and oncology 20030301

Title: [Preoperative concurrent chemoradiotherapy with intra-arterial infusion of pirarubicin and continuous intravenous instillation of 5-fluorouracil for resectable advanced head and neck squamous cell carcinoma].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20030301

Title: Preparation and pharmacokinetics of pirarubicin loaded dehydration-rehydration vesicles.

Journal: International journal of pharmaceutics 20030218

Title: Prospective comparison of 18F-FDG PET with conventional imaging modalities (MRI, CT, and 67Ga scintigraphy) in assessment of combined intraarterial chemotherapy and radiotherapy for head and neck carcinoma.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20030201

Title: Advanced ureteral cancer with complete remission achieved by taxan containing systemic chemotherapy.

Journal: International journal of urology : official journal of the Japanese Urological Association 20030201

Title: [Paclitaxel and carboplatin with or without pirarubicin (THP-ADR) as first line chemotherapy in elderly patients].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20030201

Title: FDG-PET for prediction of tumour aggressiveness and response to intra-arterial chemotherapy and radiotherapy in head and neck cancer.

Journal: European journal of nuclear medicine and molecular imaging 20030101

Title: Clinical outcome of conservative therapy for stage T1, grade 3 transitional cell carcinoma of the bladder.

Journal: International journal of urology : official journal of the Japanese Urological Association 20030101

Title: [Weekly administration of paclitaxel and pirarubicine for recurrent breast cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20030101

Title: In vitro polyvinylformaldehyde particle compatibility with chemotherapeutic drugs used for chemoembolization therapy.

Journal: Cardiovascular and interventional radiology 20030101

Title: [A case of recurrent breast cancer with carcinomatous pleurisy successfully treated with combined chemoendocrine-therapy of CTF (CPA, THP and 5-FU) and anastrozole following instillation therapy 12 years after radical mastectomy].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20021201

Title: Comparative binding of antitumor drugs to DNA containing the telomere repeat sequence.

Journal: Experimental & molecular medicine 20021130

Title: Correlation between nuclear action of anthracycline anticancer agents and their binding affinity to the proteasome.

Journal: International journal of oncology 20021101

Title: Intensified chemotherapy increases the survival rates in patients with stage 4 neuroblastoma with MYCN amplification.

Journal: Journal of pediatric hematology/oncology 20021101

Title: Relation between MDR1 mRNA levels, resistance factor, and the efficiency of P-glycoprotein-mediated efflux of pirarubicin in multidrug-resistant K562 sublines.

Journal: Canadian journal of physiology and pharmacology 20021101

Title: The role of the proteasome in apoptosis induced by anthracycline anticancer agents.

Journal: International journal of oncology 20020601

Title: Pirarubicin-based versus doxorubicin-based osteosarcoma chemotherapy.

Journal: The Annals of pharmacotherapy 20020601

Title: Outcome of hepatoblastoma treated with the JPLT-1 (Japanese Study Group for Pediatric Liver Tumor) Protocol-1: A report from the Japanese Study Group for Pediatric Liver Tumor.

Journal: Journal of pediatric surgery 20020601

Title: Doxorubicin enhances TRAIL-induced apoptosis in prostate cancer.

Journal: International journal of oncology 20020501

Title: Randomized study of single early instillation of (2'R)-4'-O-tetrahydropyranyl-doxorubicin for a single superficial bladder carcinoma.

Journal: Cancer 20020501

Title: Relationships between the in vitro cytotoxicity and transport characteristics of pirarubicin and doxorubicin in M5076 ovarian sarcoma cells, and comparison with those in Ehrlich ascites carcinoma cells.

Journal: Cancer chemotherapy and pharmacology 20020301

Title: High-dose chemotherapy with peripheral blood stem cell transplantation for advanced testicular cancer.

Journal: International journal of urology : official journal of the Japanese Urological Association 20020301

Title: Apoptosis in young rats with adriamycin-induced cardiomyopathy--comparison with pirarubicin, a new anthracycline derivative.

Journal: Pediatric research 20020201

Title: Locally advanced mucinous carcinoma of the breast with sudden growth acceleration: a case report.

Journal: Japanese journal of clinical oncology 20020201

Title: Scintigraphic prediction of response to chemotherapy in patients with breast cancer: Technetium 99m-tetrofosmin and thallium-201 dual single photon emission computed tomography.

Journal: International journal of oncology 20020101

Title: [A 5'-DFUR + CPA + THP therapy that was effective for paclitaxel-refractory pulmonary metastasis of breast cancer--a case report].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20020101

Title: [A case of regionally metastatic pure squamous cell carcinoma of the urinary bladder successfully treated with radical chemoradiotherapy].

Journal: Hinyokika kiyo. Acta urologica Japonica 20020101

Title: Breast-conservation treatment for bilateral breast cancer in five Japanese women.

Journal: Oncology reports 20020101

Title: Circadian chemotherapy for gynecological and genitourinary cancers.

Journal: Chronobiology international 20020101

Title: Interferon-alpha therapy following autologous peripheral blood stem cell transplantation for adult T cell leukemia/lymphoma.

Journal: Acta haematologica 20020101

Title: Docetaxel enhances the cytotoxicity of anthracyclines by increasing intracellular drug accumulation.

Journal: Oncology reports 20020101

Title: Superior outcome of infant acute myeloid leukemia with intensive chemotherapy: results of the Japan Infant Leukemia Study Group.

Journal: Blood 20011215

Title: Increased cytotoxicity and stability of Lipiodol-pirarubicin emulsion compared to classical doxorubicin-Lipiodol: potential advantage for chemoembolization of unresectable hepatocellular carcinoma.

Journal: Anti-cancer drugs 20011101

Title: Myeloid-positive T cell acute leukemia after treatment of infantile neuroblastoma.

Journal: Medical and pediatric oncology 20011101

Title: Spectroscopic studies on iron complexes of different anthracyclines in aprotic solvent systems.

Journal: Inorganic chemistry 20011008

Title: Structure-activity relationships and optimisation of the selective MDR modulator 2-(3,4-dimethoxyphenyl)-5-(9-fluorenylamino)-2-(methylethyl) pentanenitrile and its N-methyl derivative.

Journal: Bioorganic & medicinal chemistry 20011001

Title: [A case of malignant pericardial effusion due to breast cancer successfully controlled by intrapericardial chemotherapy using pirarubicin].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20011001

Title: Improved survival of children with advanced neuroblastoma treated by intensified therapy including myeloablative chemotherapy with stem cell transplantation: a retrospective analysis from the Tohoku Neuroblastoma Study Group.

Journal: The Tohoku journal of experimental medicine 20011001

Title: Fluorescent verapamil analogue for monitoring acidic intracellular organelles in multidrug resistant and sensitive cells.

Journal: Chemico-biological interactions 20010731

Title: Prognostic factors for survival and bladder recurrence in transitional cell carcinoma of the upper urinary tract.

Journal: International journal of urology : official journal of the Japanese Urological Association 20010701

Title: [CHF arising after low dose THP-COP chemotherapy in an elderly patient with malignant lymphoma].

Journal: Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20010701

Title: [Multi-institutional cooperative study on combination chemotherapy with THP, CDDP and 5-FU for squamous cell carcinoma of the head and neck].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20010601

Title: [Prophylactic effect of pirarubicin (THP) on postoperative recurrence of superficial bladder cancer in terms of intravesical retention time].

Journal: Hinyokika kiyo. Acta urologica Japonica 20010501

Title: [Fundamental study of combination chemotherapy with THP, 5-FU and CDDP for human KB carcinoma cell line and its multidrug resistant cell line KB-C1--usefulness of treatment with 5-FU preceding CDDP].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20010401

Title: Transport of new non-cross-resistant antitumor compounds of the benzoperimidine family in multidrug resistant cells.

Journal: European journal of pharmacology 20010216

Title: Two patients with N3 bladder cancer successfully treated by internal iliac arterial infusion chemotherapy and irradiation: case reports.

Journal: American journal of clinical oncology 20010201

Title: [Therapy-related myeloid leukemia following platinum-based chemotherapy for ovarian cancer].

Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 20010201

Title: Outcome prediction by molecular detection of minimal residual disease in bone marrow for advanced neuroblastoma.

Journal: Medical and pediatric oncology 20010101

Title: Skin rash in the hypogastric region during a regional chemotherapy for bladder carcinoma: CT and scintigraphic demonstration of a potential collateral pathway between the internal iliac and inferior epigastric arteries.

Journal: European radiology 20010101

Title: Docetaxel enhances the cytotoxicity of tetrahydropyranyladriamycin in a sequence-dependent manner.

Journal: Anticancer research 20010101

Title: Resistant mechanisms of anthracyclines--pirarubicin might partly break through the P-glycoprotein-mediated drug-resistance of human breast cancer tissues.

Journal: Breast cancer (Tokyo, Japan) 20010101

Title: In vitro chemosensitivity of human soft tissue sarcoma.

Journal: Anticancer research 20010101

Title: [Combination effect of pirarubicin, ifosfamide, and vincristine sulfate in the treatment of advanced synovial sarcoma--report of a case].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 19950901

Title: Phase II clinical and pharmacological study of pirarubicin in combination with 5-fluorouracil and cyclophosphamide in metastatic breast cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 19950701

Title: [Ischemic hepatitis due to anthracycline-induced cardiac insufficiency in a patient with acute myelocytic leukemia (M0)].

Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 19950101

Title: Comparison of cardiotoxicity of pirarubicin, epirubicin and doxorubicin in the rat.

Journal: Drugs under experimental and clinical research 19940101

Title: [Sciatic nerve paralysis following intraarterial chemotherapy for bladder cancer: reports of two cases].

Journal: Hinyokika kiyo. Acta urologica Japonica 19930801

Title: [Intrapleural administration of pirarubicin in the treatment of malignant pleural effusion].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 19910901

Title: New anthracycline antitumor antibiotics.

Journal: Critical reviews in oncology/hematology 19910101

Title: A phase I study of 4'-0-tetrahydropyranyladriamycin. Clinical pharmacology and pharmacokinetics.

Journal: Cancer 19901115

Title: Phase I-II study on weekly administration of pirarubicin in patients with metastatic breast cancer.

Journal: American journal of clinical oncology 19900101

Title: [THP-adriamycin: status of the clinical development of a new anthracycline in France].

Journal: Pathologie-biologie 19900101

Title: Activity of pirarubicin (4'-0-tetrahydropyranyladriamycin) in malignant mesothelioma.

Journal: Cancer 19890315

Title: An oriented phase II trial of THP-adriamycin in breast carcinoma.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 19860101

Title: [Acute cardiotoxicity of anthracyclines--analysis by using Holter ECG].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 19840401

Title: Takigawa N, et al. Cytotoxic effect of topoisomerase II inhibitors against adriamycin- and etoposide-resistant small cell lung cancer sublines. Gan To Kagaku Ryoho. 1993 May;20(7):929-35.

Title: Nagai K, et al. Relationships between the in vitro cytotoxicity and transport characteristics of pirarubicin and doxorubicin in M5076 ovarian sarcoma cells, and comparison with those in Ehrlich ascites carcinoma cells. Cancer Chemother Pharmacol. 2002 Mar;49(3):244-50. Epub 2002 Jan 8.

Title: Li K, et al. Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of rapamycin signaling pathway in human bladder cancer cells. Biochem Biophys Res Commun. 2015 May 1;460(2):380-5.

Title: Wang YD, et al. Cardioprotective effects of rutin in rats exposed to pirarubicin toxicity. J Asian Nat Prod Res. 2017 Oct 27:1-13.

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Tags:95343-20-7 Molecular Formula|95343-20-7 MDL|95343-20-7 SMILES|95343-20-7 5,12-Naphthacenedione,10-[[3-amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-