Home Other Building Blocks 108852-90-0
108852-90-0,MFCD00871079
Catalog No.:AA008TFR

108852-90-0 | Nemorubicin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
1 week  
$116.00   $81.00
- +
5mg
95%
1 week  
$197.00   $138.00
- +
10mg
95%
1 week  
$283.00   $198.00
- +
25mg
95%
1 week  
$578.00   $404.00
- +
50mg
95%
1 week  
$826.00   $578.00
- +
100mg
95%
1 week  
$1,150.00   $805.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008TFR
Chemical Name:
Nemorubicin
CAS Number:
108852-90-0
Molecular Formula:
C32H37NO13
Molecular Weight:
643.6351
MDL Number:
MFCD00871079
SMILES:
CO[C@H]1OCCN(C1)[C@H]1C[C@@H](O[C@H]([C@H]1O)C)O[C@H]1C[C@@](O)(Cc2c1c(O)c1c(c2O)C(=O)c2c(C1=O)c(OC)ccc2)C(=O)CO
Properties
Computed Properties
 
Complexity:
1160  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Heavy Atom Count:
46  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
7  
XLogP3:
1.7  

Literature

Title: Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor.

Journal: Scientific reports 20140101

Title: MicroRNA gene dosage alterations and drug response in lung cancer.

Journal: Journal of biomedicine & biotechnology 20110101

Title: Interaction between double helix DNA fragments and the new antitumor agent sabarubicin, Men10755.

Journal: Bioorganic & medicinal chemistry 20100215

Title: Down-regulation of the nucleotide excision repair gene XPG as a new mechanism of drug resistance in human and murine cancer cells.

Journal: Molecular cancer 20100101

Title: Potentiation of methoxymorpholinyl doxorubicin antitumor activity by P450 3A4 gene transfer.

Journal: Cancer gene therapy 20090501

Title: In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: a comparison with human liver microsomes.

Journal: Biochemical pharmacology 20080915

Title: Ongoing phase I and II studies of novel anthracyclines.

Journal: Cardiovascular toxicology 20070101

Title: Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050215

Title: Antitumor activity of methoxymorpholinyl doxorubicin: potentiation by cytochrome P450 3A metabolism.

Journal: Molecular pharmacology 20050101

Title: LC-MS-MS determination of nemorubicin (methoxymorpholinyldoxorubicin, PNU-152243A) and its 13-OH metabolite (PNU-155051A) in human plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20021015

Title: Nucleotide-induced conformational changes in the human multidrug resistance protein MRP1 are related to the capacity of chemotherapeutic drugs to accumulate or not in resistant cells.

Journal: FEBS letters 20010323

Title: Quintieri L, et al. Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes. Clin Cancer Res. 2005 Feb 15;11(4):1608-17.

Title: Quintieri L, et al. In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: a comparison with human liver microsomes. Biochem Pharmacol. 2008 Sep 15;76(6):784-95.

Title: Sabatino MA, et al. Down-regulation of the nucleotide excision repair gene XPG as a new mechanism of drug resistance in human and murine cancer cells. Mol Cancer. 2010 Sep 24;9:259.

Title: Lu H, et al. Potentiation of methoxymorpholinyl doxorubicin antitumor activity by P450 3A4 gene transfer. Cancer Gene Ther. 2009 May;16(5):393-404.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:108852-90-0 Molecular Formula|108852-90-0 MDL|108852-90-0 SMILES|108852-90-0 Nemorubicin