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103222-11-3,MFCD30489723
Catalog No.:AA01DZBK

103222-11-3 | Vapreotide

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Purity
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5mg
98%
1 week  
$177.00   $124.00
- +
10mg
98%
1 week  
$257.00   $180.00
- +
25mg
98%
1 week  
$447.00   $313.00
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50mg
98%
1 week  
$685.00   $480.00
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100mg
98%
1 week  
$1,082.00   $758.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01DZBK
Chemical Name:
Vapreotide
CAS Number:
103222-11-3
Molecular Formula:
C57H70N12O9S2
Molecular Weight:
1131.3707
MDL Number:
MFCD30489723
SMILES:
NCCCCC1NC(=O)C(NC(=O)C(Cc2ccc(cc2)O)NC(=O)C(CSSCC(NC(=O)C(NC1=O)C(C)C)C(=O)NC(C(=O)N)Cc1c[nH]c2c1cccc2)NC(=O)C(Cc1ccccc1)N)Cc1c[nH]c2c1cccc2
Properties
Computed Properties
 
Complexity:
2080  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
80  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
13  
Rotatable Bond Count:
18  
Undefined Atom Stereocenter Count:
8  
XLogP3:
3.6  

Literature

Title: Meta-analysis: vasoactive medications for the management of acute variceal bleeds.

Journal: Alimentary pharmacology & therapeutics 20120601

Title: Feeding responses to central administration of several somatostatin analogs in chicks.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20110101

Title: Treatment of transplanted tumor of lung adenocarcinoma A549 transfected by human somatostatin receptor subtype 2 (hsstr2) gene with 188Re-RC-160.

Journal: Nuclear medicine and biology 20101101

Title: Combination therapy in A549 cells.

Journal: Nuclear medicine and biology 20100401

Title: Somatostatin analogues for pancreatic surgery.

Journal: The Cochrane database of systematic reviews 20100217

Title: Vapreotide: a somatostatin analog for the treatment of acute variceal bleeding.

Journal: Expert opinion on pharmacotherapy 20091001

Title: Somatostatin and somatostatin receptors: implications for neoplastic growth and cancer biology.

Journal: Expert opinion on investigational drugs 20090901

Title: Somatostatin analogues inhibit cancer cell proliferation in an SSTR2-dependent manner via both cytostatic and cytotoxic pathways.

Journal: Oncology reports 20090201

Title: Vapreotide acetate for the treatment of esophageal variceal bleeding.

Journal: Expert review of gastroenterology & hepatology 20080401

Title: Efficacy of somatostatin and its analogues in prevention of postoperative complications after pancreaticoduodenectomy: a meta-analysis of randomized controlled trials.

Journal: Pancreas 20080101

Title: Dephosphorylation of cancer protein by tyrosine phosphatases in response to analogs of luteinizing hormone-releasing hormone and somatostatin.

Journal: Anticancer research 20080101

Title: Somatostatin analogues in the prevention of pancreas-related complications after pancreatic resection.

Journal: Journal of hepato-biliary-pancreatic surgery 20060101

Title: Transdermal iontophoretic delivery of vapreotide acetate across porcine skin in vitro.

Journal: Pharmaceutical research 20050801

Title: Importance of single or blended polymer types for controlled in vitro release and plasma levels of a somatostatin analogue entrapped in PLA/PLGA microspheres.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20040518

Title: sst2 Somatostatin receptor inhibits cell proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 activation.

Journal: The Journal of biological chemistry 20031010

Title: Response of patients with advanced prostatic cancer to administration of somatostatin analog RC-160 (vapreotide) at the time of relapse.

Journal: The Prostate 20030801

Title: Inhibitory role of the somatostatin receptor SST2 on the intracrine-regulated cell proliferation induced by the 210-amino acid fibroblast growth factor-2 isoform: implication of JAK2.

Journal: The Journal of biological chemistry 20030606

Title: The potent somatostatin analogue vapreotide does not decrease pancreas-specific complications after elective pancreatectomy: a prospective, multicenter, double-blinded, randomized, placebo-controlled trial.

Journal: Journal of the American College of Surgeons 20030401

Title: Hemodynamic effects of acute and chronic administration of vapreotide in rats with cirrhosis.

Journal: Digestive diseases and sciences 20030101

Title: Ultrasonic atomization and subsequent polymer desolvation for peptide and protein microencapsulation into biodegradable polyesters.

Journal: Journal of microencapsulation 20030101

Title: Vapreotide: BMY 41606, RC 160, Sanvar.

Journal: Drugs in R&D 20030101

Title: Inhibition of proliferation of PC-3 human prostate cancer by antagonists of growth hormone-releasing hormone: lack of correlation with the levels of serum IGF-I and expression of tumoral IGF-II and vascular endothelial growth factor.

Journal: The Prostate 20020801

Title: Radiolabeled peptides in diagnosis and tumor imaging: clinical overview.

Journal: Seminars in nuclear medicine 20020401

Title: Somatostatins and their role in thyroid cancer.

Journal: Clinical otolaryngology and allied sciences 20020401

Title: Endoscopic treatment versus endoscopic plus pharmacologic treatment for acute variceal bleeding: a meta-analysis.

Journal: Hepatology (Baltimore, Md.) 20020301

Title: Early administration of vapreotide for variceal bleeding in patients with cirrhosis.

Journal: Gastrointestinal endoscopy 20020101

Title: Selective alkylation and acylation of alpha and epsilon amino groups with PEG in a somatostatin analogue: tailored chemistry for optimized bioconjugates.

Journal: Bioconjugate chemistry 20020101

Title: [Somatostatin and somatostatin receptors in the prostate].

Journal: Minerva endocrinologica 20010901

Title: Tonic control of peripheral cutaneous nociceptors by somatostatin receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010601

Title: Antagonists of growth hormone-releasing hormone and somatostatin analog RC-160 inhibit the growth of the OV-1063 human epithelial ovarian cancer cell line xenografted into nude mice.

Journal: The Journal of clinical endocrinology and metabolism 20010501

Title: Assessment of value of consensus definitions in acute variceal bleeding.

Journal: Lancet (London, England) 20010414

Title: Synthesis and preliminary evaluation of Tc-99m-labeled somatostatin analog (RC-160) using '3+1' mixed ligand approach.

Journal: Nuclear medicine and biology 20010401

Title: Binding of 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland.

Journal: Journal of endocrinological investigation 20010301

Title: Somatostatin octapeptides (lanreotide, octreotide, vapreotide, and their analogs) share the growth hormone-releasing peptide receptor in the human pituitary gland.

Journal: Endocrine 20010201

Title: Early administration of vapreotide for variceal bleeding in patients with cirrhosis.

Journal: The New England journal of medicine 20010104

Title: Anti-inflammatory effects of somatostatin analogs on zymosan-induced earlobe inflammation in mice: comparison with dexamethasone and ketoprofen.

Journal: Neuroimmunomodulation 20010101

Title: [125I][Tyr3]octreotide labels human somatostatin sst2 and sst5 receptors.

Journal: European journal of pharmacology 19980508

Title: Rhenium-labeled somatostatin analog RC-160. 1H NMR and computer modeling conformational analysis.

Journal: The Journal of biological chemistry 19940429

Title: Evidence for a central long-lasting antinociceptive effect of vapreotide, an analog of somatostatin, involving an opioidergic mechanism.

Journal: The Journal of pharmacology and experimental therapeutics 19940401

Title: Seven-day antinociceptive effect of a sustained release vapreotide formulation.

Journal: Neuroreport 19940131

Title: Vapreotide, a new somatostatin analogue in the palliative management of obstructive ileus in advanced cancer.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 19930101

Title: Vapreotide, a somatostatin analogue, in cryptosporidiosis and other AIDS-related diarrhoeal diseases.

Journal: AIDS (London, England) 19920701

Title: Effect of microcapsules of luteinizing hormone-releasing hormone antagonist SB-75 and somatostatin analog RC-160 on endocrine status and tumor growth in the Dunning R-3327H rat prostate cancer model.

Journal: The Prostate 19920101

Title: Effect of combination treatment with analogs of luteinizing hormone-releasing hormone (LH-RH) or somatostatin and 5-fluorouracil on pancreatic cancer in hamsters.

Journal: International journal of cancer 19910909

Title: Programmed cell death (apoptosis) in pancreatic cancers of hamsters after treatment with analogs of both luteinizing hormone-releasing hormone and somatostatin.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19890301

Title: Somatostatin analogues inhibit growth of pancreatic cancer by stimulating tyrosine phosphatase.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19890301

Title: Radioimmunoassay for octapeptide analogs of somatostatin: measurement of serum levels after administration of long-acting microcapsule formulations.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19880801

Title: Superactive somatostatin analog decreases plasma glucose and glucagon levels in diabetic rats.

Journal: Peptides 19880101

Title: Somatostatin analogs as adjuncts to agonists of luteinizing hormone-releasing hormone in the treatment of experimental prostate cancer.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19871001

Title: Effects of highly potent octapeptide analogs of somatostatin on growth hormone, insulin and glucagon release.

Journal: Life sciences 19870824

Title: Treatment of nitrosamine-induced pancreatic tumors in hamsters with analogs of somatostatin and luteinizing hormone-releasing hormone.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19870201

Title: Spitsin S et al. Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor. Neuroimmunomodulation. 2013;20(5):247-55.

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