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147159-51-1,MFCD00926026
Catalog No.:AA001EL6

147159-51-1 | L-Threoninamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-cysteinyl-, cyclic (2→6)-disulfide

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1mg
98%
1 week  
$177.00   $124.00
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5mg
98%
1 week  
$312.00   $219.00
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10mg
98%
1 week  
$479.00   $335.00
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25mg
98%
1 week  
$924.00   $647.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001EL6
Chemical Name:
L-Threoninamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-cysteinyl-, cyclic (2→6)-disulfide
CAS Number:
147159-51-1
Molecular Formula:
C45H58N10O9S2
Molecular Weight:
947.1336
MDL Number:
MFCD00926026
SMILES:
NCCCC[C@@H]1NC(=O)[C@H](NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N[C@H](C(=O)N)[C@H](O)C)NC(=O)[C@@H](Cc1ccccc1)N)Cc1c[nH]c2c1cccc2
Properties
Computed Properties
 
Complexity:
1640  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
66  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
12  
Rotatable Bond Count:
16  
XLogP3:
0.5  

Literature

Title: New cyclic somatostatin analogues containing a pyrazinone ring: importance of Tyr for antiproliferative activity.

Journal: Bioorganic & medicinal chemistry letters 20081201

Title: Synthesis of somatostatin analogues containing C-terminal adamantane and their antiproliferative properties.

Journal: Journal of medicinal chemistry 20080828

Title: Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse.

Journal: European journal of pharmacology 20080114

Title: Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death.

Journal: Cancer research 20070215

Title: Antitumor activity of the somatostatin structural derivative (TT-232), against mouse and human melanoma tumor models.

Journal: Anticancer research 20070101

Title: TT232, a novel signal transduction inhibitory compound in the therapy of cancer and inflammatory diseases.

Journal: Journal of receptor and signal transduction research 20050101

Title: Analgesic effect of TT-232, a heptapeptide somatostatin analogue, in acute pain models of the rat and the mouse and in streptozotocin-induced diabetic mechanical allodynia.

Journal: European journal of pharmacology 20040913

Title: Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund's adjuvant-induced chronic arthritis model in the rat.

Journal: Arthritis and rheumatism 20040501

Title: Pro-apoptotic and anti-apoptotic molecules affecting pathways of signal transduction.

Journal: Annals of the New York Academy of Sciences 20031201

Title: TT-232: a somatostatin structural derivative as a potent antitumor drug candidate.

Journal: Anti-cancer drugs 20030901

Title: Effect of a novel somatostatin analogue combined with cytotoxic drugs on human tumour xenografts and metastasis of B16 melanoma.

Journal: British journal of cancer 20030113

Title: The antitumour effect of the somatostatin analogue TT-232 depends on the treatment regimen.

Journal: Cancer detection and prevention 20030101

Title: The antitumor activity of the somatostatin structural derivative (TT-232) on different human tumor xenografts.

Journal: Anticancer research 20030101

Title: Pharmacological characterisation of the somatostatin analogue TT-232: effects on neurogenic and non-neurogenic inflammation and neuropathic hyperalgesia.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020801

Title: Antiproliferative activity induced by the somatostatin analogue, TT-232, in human pancreatic cancer cells.

Journal: European journal of cancer (Oxford, England : 1990) 20020701

Title: Anti-inflammatory effect of synthetic somatostatin analogues in the rat.

Journal: British journal of pharmacology 20011201

Title: Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta.

Journal: Biochemical and biophysical research communications 20011102

Title: The somatostatin analogue TT-232 induces apoptosis in A431 cells: sustained activation of stress-activated kinases and inhibition of signalling to extracellular signal-regulated kinases.

Journal: Cellular signalling 20011001

Title: The antitumor somatostatin analogue TT-232 induces cell cycle arrest through PKCdelta and c-Src.

Journal: Biochemical and biophysical research communications 20010713

Title: A new strategy for the synthesis of cyclopeptides containing diaminoglutaric acid.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20010501

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SDS
Tags:147159-51-1 Molecular Formula|147159-51-1 MDL|147159-51-1 SMILES|147159-51-1 L-Threoninamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-cysteinyl-, cyclic (2→6)-disulfide