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205437-64-5,MFCD00467639
Catalog No.:AA01E3LS

205437-64-5 | BU224Hydrochloride

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10mg
≥99%
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$322.00   $225.00
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50mg
≥99%
in stock  
$957.00   $670.00
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100mg
≥99%
in stock  
$1,679.00   $1,175.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E3LS
Chemical Name:
BU224Hydrochloride
CAS Number:
205437-64-5
Molecular Formula:
C12H12ClN3
Molecular Weight:
233.6968
MDL Number:
MFCD00467639
SMILES:
C1CN=C(N1)C2=NC3=CC=CC=C3C=C2.Cl
Properties
Computed Properties
 
Complexity:
262  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  

Literature

Title: Effects of imidazoline I(2) receptor agonists and morphine on schedule-controlled responding in rats.

Journal: Pharmacology, biochemistry, and behavior 20120501

Title: Synthesis and evaluation of PET probes for the imaging of I2 imidazoline receptors in peripheral tissues.

Journal: Nuclear medicine and biology 20120101

Title: Plasma glucose-lowering action of allantoin is induced by activation of imidazoline I-2 receptors in streptozotocin-induced diabetic rats.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20120101

Title: Dexmedetomidine protects against oxygen-glucose deprivation-induced injury through the I2 imidazoline receptor-PI3K/AKT pathway in rat C6 glioma cells.

Journal: The Journal of pharmacy and pharmacology 20120101

Title: Effects of imidazoline I₂ receptor ligands on morphine- and tramadol-induced antinociception in rats.

Journal: European journal of pharmacology 20111130

Title: Morphine-induced antinociception in the rat: supra-additive interactions with imidazoline I₂ receptor ligands.

Journal: European journal of pharmacology 20111101

Title: Activation of imidazoline I-2B receptor by metformin to increase glucose uptake in skeletal muscle.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20110901

Title: In vivo and in vitro imaging of I₂ imidazoline receptors in the monkey brain.

Journal: Synapse (New York, N.Y.) 20110501

Title: Increase of beta-endorphin secretion by agmatine is induced by activation of imidazoline I(2A) receptors in adrenal gland of rats.

Journal: Neuroscience letters 20100114

Title: Activation of imidazoline I(2B) receptors by guanidine to increase glucose uptake in skeletal muscle of rats.

Journal: Neuroscience letters 20091225

Title: Pharmacological characterization of the inhibition by moxonidine and agmatine on the cardioaccelerator sympathetic outflow in pithed rats.

Journal: European journal of pharmacology 20090815

Title: Activation of I2-imidazoline receptors by agmatine improved insulin sensitivity through two mechanisms in type-2 diabetic rats.

Journal: Neuroscience letters 20090703

Title: The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20090501

Title: Modulation of stress by imidazoline binding sites: implications for psychiatric disorders.

Journal: Stress (Amsterdam, Netherlands) 20090301

Title: Activation of I(2)-imidazoline receptors may ameliorate insulin resistance in fructose-rich chow-fed rats.

Journal: Neuroscience letters 20081219

Title: The imidazoline I2-site ligands BU 224 and 2-BFI inhibit MAO-A and MAO-B activities, hydrogen peroxide production, and lipolysis in rodent and human adipocytes.

Journal: European journal of pharmacology 20061215

Title: Identification of the central imidazoline receptor subtype involved in modulation of halothane-epinephrine arrhythmias in rats.

Journal: Anesthesia and analgesia 20051201

Title: IRAS, a candidate for I1-imidazoline receptor, mediates inhibitory effect of agmatine on cellular morphine dependence.

Journal: Biochemical pharmacology 20051001

Title: Characterisation of imidazoline I2 binding sites in pig brain.

Journal: European journal of pharmacology 20050905

Title: Autoradiographic localisation of [3H]2-BFI imidazoline I2 binding sites in mouse brain.

Journal: European journal of pharmacology 20050601

Title: Activation of imidazoline receptors in adrenal gland to lower plasma glucose in streptozotocin-induced diabetic rats.

Journal: Diabetologia 20050401

Title: Estimation of endogenous noradrenaline release in rat brain in vivo using [3H]RX 821002.

Journal: Synapse (New York, N.Y.) 20050201

Title: Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal pathway.

Journal: British journal of pharmacology 20041201

Title: Imidazoline2 (I2) receptor- and alpha2-adrenoceptor-mediated modulation of hypothalamic-pituitary-adrenal axis activity in control and acute restraint stressed rats.

Journal: Journal of psychopharmacology (Oxford, England) 20040301

Title: Novel ligands for the investigation of imidazoline receptors and their binding proteins.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Relationship between imidazoline(2) sites and monoamine oxidase.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Behavioral, neuroendocrine and neurochemical effects of the imidazoline I2 receptor selective ligand BU224 in naive rats and rats exposed to the stress of the forced swim test.

Journal: Psychopharmacology 20030501

Title: Distribution of [(3)H]BU224, a selective imidazoline I(2) binding site ligand, in rat brain.

Journal: European journal of pharmacology 20020816

Title: Imidazoline(2) (I(2)) binding site- and alpha(2)-adrenoceptor-mediated modulation of central noradrenergic and HPA axis function in control rats and chronically stressed rats with adjuvant-induced arthritis.

Journal: Neuropharmacology 20020601

Title: Imidazoline drugs stabilize lysosomes and inhibit oxidative cytotoxicity in astrocytes.

Journal: Free radical biology & medicine 20020301

Title: Selective imidazoline I2 ligands do not show antidepressant-like activity in the forced swim test in mice.

Journal: Journal of psychopharmacology (Oxford, England) 20010301

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