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161715-21-5,MFCD00936545
Catalog No.:AA01EAYB

161715-21-5 | Tebipenem

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1mg
98%
in stock  
$6.00   $4.00
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5mg
98%
in stock  
$7.00   $5.00
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10mg
98%
in stock  
$9.00   $7.00
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250mg
95%
in stock  
$144.00   $101.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EAYB
Chemical Name:
Tebipenem
CAS Number:
161715-21-5
Molecular Formula:
C16H21N3O4S2
Molecular Weight:
383.4856
MDL Number:
MFCD00936545
SMILES:
C[C@H]([C@H]1C(=O)N2[C@@H]1[C@@H](C)C(=C2C(=O)O)SC1CN(C1)C1=NCCS1)O
Properties
Computed Properties
 
Complexity:
689  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
0.6  

Literature

Title: In vitro susceptibility of Mycobacterium tuberculosis isolates to an oral carbapenem alone or in combination with β-lactamase inhibitors.

Journal: Antimicrobial agents and chemotherapy 20141101

Title: [Clinical efficacy of tebipenem pivoxil treatment in children with pneumonia, who had no relief despite having administered oral beta-lactam antibiotics].

Journal: The Japanese journal of antibiotics 20110601

Title: Investigation of pneumonia-causing pathogenic organisms in children and the usefulness of tebipenem pivoxil for their treatment.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20100801

Title: [Pharmacokinetics of tebipenem pivoxil, a novel oral carbapenem antibiotic, in experimental animals].

Journal: The Japanese journal of antibiotics 20090601

Title: [Convulsive liability of an oral carbapenem antibiotic, tebipenem pivoxil].

Journal: The Japanese journal of antibiotics 20090601

Title: [Antimicrobial activity of tebipenem against various clinical isolates from various specimen, mainly urinary tract].

Journal: The Japanese journal of antibiotics 20090401

Title: [Tissue and aural discharge distribution of tebipenem pivoxil].

Journal: The Japanese journal of antibiotics 20090401

Title: [Effect of diet on the pharmacokinetics of tebipenem pivoxil fine granules in healthy male volunteers].

Journal: The Japanese journal of antibiotics 20090401

Title: [Clinical efficacy, safety and PK-PD analysis of tebipenem pivoxil in a phase II clinical trial in otolaryngological infections].

Journal: The Japanese journal of antibiotics 20090401

Title: Population pharmacokinetics of tebipenem pivoxil (ME1211), a novel oral carbapenem antibiotic, in pediatric patients with otolaryngological infection or pneumonia.

Journal: Drug metabolism and pharmacokinetics 20080101

Title: Efficacy of a novel oral carbapenem, tebipenem pivoxil (TBM-PI), against experimental otitis media caused by penicillin resistant Streptococcus pneumoniae in chinchilla.

Journal: Vaccine 20070322

Title: Comparative review of the carbapenems.

Journal: Drugs 20070101

Title: [Relationship between protein binding and antimicrobial activities of antibiotics against Streptococcus pneumoniae and Haemophilus influenzae].

Journal: The Japanese journal of antibiotics 20061001

Title: Syntheses and pharmacokinetic studies of prodrug esters for the development of oral carbapenem, L-084.

Journal: The Journal of antibiotics 20060401

Title: Hazra S, et al. Tebipenem, a new carbapenem antibiotic, is a slow substrate that inhibits the β-lactamase from Mycobacterium tuberculosis. Biochemistry. 2014 Jun 10;53(22):3671-8

Title: Seenama C, et al. In vitro activity of tebipenem against Burkholderia pseudomallei. Int J Antimicrob Agents. 2013 Oct;42(4):375.

Title: Li H, et al. In vitro antibacterial activities of two novel oral antibiotics, tebipenem and cefditoren, and other comparators against community-acquired respiratory tract infection-associated bacterial pathogens: A multicentre study in China. Int J Antimicrob Agents. 2014 Jan;43(1):92-3.

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