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64221-86-9,MFCD09753321
Catalog No.:AA00IB9D

64221-86-9 | Imipenem

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10mg
in stock  
$147.00   $103.00
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50mg
in stock  
$290.00   $203.00
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100mg
≥98%
in stock  
$550.00   $385.00
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250mg
≥98%
in stock  
$734.00   $514.00
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1g
≥98%
in stock  
$2,390.00   $1,673.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00IB9D
Chemical Name:
Imipenem
CAS Number:
64221-86-9
Molecular Formula:
C12H17N3O4S
Molecular Weight:
299.3461
MDL Number:
MFCD09753321
SMILES:
C[C@H]([C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCNC=N)O
Properties
Properties
 
BP:
567.3°C at 760 mmHg  
Form:
Solid  
MP:
106-111°C  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
491  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
-0.7  

Downstream Synthesis Route
3473-63-0    64221-86-9   
CASUnavailable 
 
CASUnavailable 

[1]Smith;Dezeny;Douglas[JournalofPharmaceuticalSciences,1990,vol.79,#8,p.732-740]

64221-86-9   
CASUnavailable 

[1]Smith;Dezeny;Douglas[JournalofPharmaceuticalSciences,1990,vol.79,#8,p.732-740]

64221-86-9   
CASUnavailable 

[1]Smith;Dezeny;Douglas[JournalofPharmaceuticalSciences,1990,vol.79,#8,p.732-740]

64221-86-9   
CASUnavailable 

[1]Smith;Dezeny;Douglas[JournalofPharmaceuticalSciences,1990,vol.79,#8,p.732-740]

[1]Mendez;Alemany;Martin-Villacorta[ChemicalandPharmaceuticalBulletin,1992,vol.40,#12,p.3228-3233]

[2]Gadallah,MohamedI.;Ali,HassanRefatH.;Askal,HassanF.;Saleh,GamalA.[JournalofMolecularLiquids,2019,vol.276,p.705-713]

Literature

Title: Johann Motsch, et al. RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections. Clin Infect Dis. 2020 Apr 15;70(9):1799-1808.

Title: F P Tally, et al. In vitro activity of N-formimidoyl thienamycin (MK0787). Antimicrob Agents Chemother. 1980 Oct;18(4):642-4.

Title: Wang Hengzhuang, et al. In vivo pharmacokinetics/pharmacodynamics of colistin and imipenem in Pseudomonas aeruginosa biofilm infection. Antimicrob Agents Chemother. 2012 May;56(5):2683-90.

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SDS
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