Name: Name:JNJ-39758979
Brand: AABLOCKS
SKU: AA01EN57
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA01EN57

Chemical Name: JNJ-39758979

CAS Number: 1046447-90-8

Molecular Formula: C11H19N5

Molecular Weight: 221.3021

MDL Number: MFCD28502028

SMILES: N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C

Properties

Complexity: 232

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 1

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 16

Hydrogen Bond Acceptor Count: 5

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 2

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 0.7

Downstream Synthesis Route

Literature fold

Title: International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.

Journal: Pharmacological reviews20150701

Title: Phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of a H4 R-antagonist (JNJ-39758979) in Japanese adults with moderate atopic dermatitis.

Journal: The Journal of dermatology20150201

Title: The histamine H₄ receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects.

Journal: The Journal of pharmacology and experimental therapeutics20140701

Title: Clinical and preclinical characterization of the histamine H(4) receptor antagonist JNJ-39758979.

Journal: The Journal of pharmacology and experimental therapeutics20140501

Title: Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists.

Journal: Journal of medicinal chemistry20140327

Title: Savall BM, et al. Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H4 receptor antagonists. J Med Chem. 2014 Mar 27;57(6):2429-39.

Title: Murata Y, et al. Phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of a H4 R-antagonist (JNJ-39758979) in Japanese adults with moderate atopic dermatitis.

1046447-90-8 | JNJ-39758979