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618913-30-7,MFCD31619279
Catalog No.:AA01EOD0

618913-30-7 | AZD5904

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$199.00   $139.00
- +
10mg
≥98%
in stock  
$306.00   $214.00
- +
25mg
≥98%
in stock  
$490.00   $343.00
- +
100mg
95%
in stock  
$1,636.00   $1,145.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EOD0
Chemical Name:
AZD5904
CAS Number:
618913-30-7
Molecular Formula:
C10H12N4O2S
Molecular Weight:
252.2929
MDL Number:
MFCD31619279
SMILES:
O=c1[nH]c(=S)n(c2c1nc[nH]2)C[C@H]1CCCO1
Properties
Computed Properties
 
Complexity:
351  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
0.5  

Literature

Title: 2-thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation.

Journal: The Journal of biological chemistry 20111028

Title: Myeloperoxidase (MPO) inhibitor.

Title: Tidén AK, Sjögren T, Svensson M, et al. 2-thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation. J Biol Chem. 2011;286(43):37578-37589.

Title: Chai W, Aylor K, Liu Z, Gan LM, Michaëlsson E, Barrett E. Inhibiting myeloperoxidase prevents onset and reverses established high-fat diet-induced microvascular insulin resistance. Am J Physiol Endocrinol Metab. 2019;317(6):E1063-E1069.

Title: Ramachandra CJA, Kp MMJ, Chua J, et al. Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes. Cardiovasc Res. 2022;118(2):517-530.

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