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Home Other Building Blocks 1642297-01-5
1642297-01-5,MFCD31631581
Catalog No.:AA01EO46

1642297-01-5 | GDC-0927

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$170.00   $119.00
- +
10mg
98%
in stock  
$253.00   $178.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01EO46
Chemical Name:
GDC-0927
CAS Number:
1642297-01-5
Molecular Formula:
C28H28FNO4
Molecular Weight:
461.5246
MDL Number:
MFCD31631581
SMILES:
FCC1CN(C1)CCOc1ccc(cc1)[C@@H]1Oc2ccc(cc2C(=C1c1cccc(c1)O)C)O
Properties
Computed Properties
 
Complexity:
703  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
4.7  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2014/205138,2014,A1

[2]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2014/205138,2014,A1

[3]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2014/205138,2014,A1

[4]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2014/205138,2014,A1

[1]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2014/205138,2014,A1

[2]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2014/205138,2014,A1

[3]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2014/205138,2014,A1

[4]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2014/205138,2014,A1

[1]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2014/205138,2014,A1

[2]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2014/205138,2014,A1

[3]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2014/205138,2014,A1

[4]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2014/205138,2014,A1

2785-98-0   
(S)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol 

[1]Patent:WO2014/205138,2014,A1

[2]Patent:WO2014/205138,2014,A1

[3]Patent:WO2014/205138,2014,A1

[4]Patent:WO2014/205138,2014,A1

[1]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2014/205138,2014,A1

[2]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2014/205138,2014,A1

Literature

Title: MN Dickler, et al. Abstract PD5-10: A first-in-human phase I study to evaluate the oral selective estrogen receptor degrader (SERD), GDC-0927, in postmenopausal women with estrogen receptor positive (ER+) HER2-negative metastatic breast cancer (BC). AACR; Cancer Res 2018;78(4 Suppl):Abstract nr PD5-10.

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SDS
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Tags:1642297-01-5 Molecular Formula|1642297-01-5 MDL|1642297-01-5 SMILES|1642297-01-5 GDC-0927