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586368-06-1,MFCD30738010
Catalog No.:AA01EO7Z

586368-06-1 | Olcegepant hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
99%
1 week  
$355.00   $249.00
- +
10mg
99%
1 week  
$565.00   $395.00
- +
50mg
99%
1 week  
$1,606.00   $1,124.00
- +
100mg
99%
1 week  
$2,527.00   $1,769.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EO7Z
Chemical Name:
Olcegepant hydrochloride
CAS Number:
586368-06-1
Molecular Formula:
C38H48Br2ClN9O5
Molecular Weight:
906.1060
MDL Number:
MFCD30738010
SMILES:
NCCCC[C@@H](C(=O)N1CCN(CC1)c1ccncc1)NC(=O)[C@H](NC(=O)N1CCC(CC1)N1Cc2ccccc2NC1=O)Cc1cc(Br)c(c(c1)Br)O.Cl
Properties
Computed Properties
 
Complexity:
1250  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
55  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
12  

Literature

Title: Rudolf K, et al. Development of human calcitonin gene-related peptide (CGRP) receptor antagonists. 1. Potent and selective small molecule CGRP antagonists. 1-[N2-,5-dibromo-N-[-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinylcarbonyl-D-tyrosyl-l-lysyl-4-(4-pyridinyl)piperazine: the first CGRP antagonist for clinical trials in acute migraine. J Med Chem. 2005 Sep 22;48(19):5921-31.

Title: Edvinsson L, et al. Effect of the CGRP receptor antagonist BIBN4096BS in human cerebral, coronary and omentalarteries and in SK-N-MC cells. Eur J Pharmacol. 2002 Jan 2;434(1-2):49-53.

Title: Doods H, et al. Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist. Br J Pharmacol. 2000 Feb;129(3):420-3.

Title: Sixt ML, et al. Calcitonin gene-related peptide receptor antagonist Olcegepant acts in the spinal trigeminal nucleus. Brain. 2009 Nov;132(Pt 11):3134-41.

Title: Michot B, et al. Differential effects of calcitonin gene-related peptide receptor blockade by Olcegepant on mechanical allodynia induced by ligation of the infraorbital nerve vs the sciatic nerve in the rat. Pain. 2012 Sep;153(9):1939-48.

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Tags:586368-06-1 Molecular Formula|586368-06-1 MDL|586368-06-1 SMILES|586368-06-1 Olcegepant hydrochloride