Home Other Building Blocks 1513857-77-6
1513857-77-6,MFCD31706227
Catalog No.:AA01EO5B

1513857-77-6 | Pemigatinib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$69.00   $48.00
- +
5mg
≥98%
in stock  
$268.00   $188.00
- +
10mg
≥98%
in stock  
$393.00   $275.00
- +
100mg
95%
in stock  
$1,281.00   $897.00
- +
250mg
95%
in stock  
$2,412.00   $1,689.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01EO5B
Chemical Name:
Pemigatinib
CAS Number:
1513857-77-6
Molecular Formula:
C24H27F2N5O4
Molecular Weight:
487.4991
MDL Number:
MFCD31706227
SMILES:
CCN1C(=O)N(Cc2c1c1cc(nc1[nH]c2)CN1CCOCC1)c1c(F)c(OC)cc(c1F)OC
Properties
Computed Properties
 
Complexity:
731  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
1.8  

Downstream Synthesis Route

[1]CurrentPatentAssignee:INCYTECORP-WO2014/7951,2014,A2

[2]CurrentPatentAssignee:INCYTECORP-US2020/281907,2020,A1

[3]Wu,Liangxing;Zhang,Colin;He,Chunhong;Qian,Dingquan;Lu,Liang;Sun,Yaping;Xu,Meizhong;Zhuo,Jincong;Liu,PhillipC.C.;Klabe,Ronald;Wynn,Richard;Covington,Maryanne;Gallagher,Karen;Leffet,Lynn;Bowman,Kevin;Diamond,Sharon;Koblish,Holly;Zhang,Yue;Soloviev,Maxim;Hollis,Gregory;Burn,TimothyC.;Scherle,Peggy;Yeleswaram,Swamy;Huber,Reid;Yao,Wenqing[JournalofMedicinalChemistry,2021,vol.64,#15,p.10666-10679]

[4]CurrentPatentAssignee:INCYTECORP-US2021/171522,2021,A1

[1]CurrentPatentAssignee:INCYTECORP-WO2014/7951,2014,A2

[2]CurrentPatentAssignee:WILMINGTONPHARMATECHCOMPANYLLC;INCYTECORP-WO2019/213544,2019,A2

[3]CurrentPatentAssignee:INCYTECORP-US2020/281907,2020,A1

[4]Wu,Liangxing;Zhang,Colin;He,Chunhong;Qian,Dingquan;Lu,Liang;Sun,Yaping;Xu,Meizhong;Zhuo,Jincong;Liu,PhillipC.C.;Klabe,Ronald;Wynn,Richard;Covington,Maryanne;Gallagher,Karen;Leffet,Lynn;Bowman,Kevin;Diamond,Sharon;Koblish,Holly;Zhang,Yue;Soloviev,Maxim;Hollis,Gregory;Burn,TimothyC.;Scherle,Peggy;Yeleswaram,Swamy;Huber,Reid;Yao,Wenqing[JournalofMedicinalChemistry,2021,vol.64,#15,p.10666-10679]

[5]CurrentPatentAssignee:INCYTECORP-US2021/171522,2021,A1

[6]CurrentPatentAssignee:INCYTECORP-US2021/171522,2021,A1

[1]CurrentPatentAssignee:INCYTECORP-WO2014/7951,2014,A2

[2]CurrentPatentAssignee:INCYTECORP-US2020/281907,2020,A1

[3]Wu,Liangxing;Zhang,Colin;He,Chunhong;Qian,Dingquan;Lu,Liang;Sun,Yaping;Xu,Meizhong;Zhuo,Jincong;Liu,PhillipC.C.;Klabe,Ronald;Wynn,Richard;Covington,Maryanne;Gallagher,Karen;Leffet,Lynn;Bowman,Kevin;Diamond,Sharon;Koblish,Holly;Zhang,Yue;Soloviev,Maxim;Hollis,Gregory;Burn,TimothyC.;Scherle,Peggy;Yeleswaram,Swamy;Huber,Reid;Yao,Wenqing[JournalofMedicinalChemistry,2021,vol.64,#15,p.10666-10679]

[4]CurrentPatentAssignee:INCYTECORP-US2021/171522,2021,A1

[1]CurrentPatentAssignee:INCYTECORP-WO2014/7951,2014,A2

[2]CurrentPatentAssignee:INCYTECORP-US2020/281907,2020,A1

[3]Wu,Liangxing;Zhang,Colin;He,Chunhong;Qian,Dingquan;Lu,Liang;Sun,Yaping;Xu,Meizhong;Zhuo,Jincong;Liu,PhillipC.C.;Klabe,Ronald;Wynn,Richard;Covington,Maryanne;Gallagher,Karen;Leffet,Lynn;Bowman,Kevin;Diamond,Sharon;Koblish,Holly;Zhang,Yue;Soloviev,Maxim;Hollis,Gregory;Burn,TimothyC.;Scherle,Peggy;Yeleswaram,Swamy;Huber,Reid;Yao,Wenqing[JournalofMedicinalChemistry,2021,vol.64,#15,p.10666-10679]

[4]CurrentPatentAssignee:INCYTECORP-US2021/171522,2021,A1

Literature

Title: Arudra K, et al. Calcinosis cutis dermatologic toxicity associated with fibroblast growth factor receptor inhibitor for the treatment of Wilms tumor. J Cutan Pathol. 2018 Oct;45(10):786-790.

Title: Roskoski R Jr, et al. The role of fibroblast growth factor receptor (FGFR) protein-tyrosine kinase inhibitors in the treatment of cancers including those of the urinary bladder. Pharmacol Res. 2020 Jan;151:104567.

Title: Krook MA, et al. Tumor heterogeneity and acquired drug resistance in FGFR2-fusion-positive cholangiocarcinoma through rapid research autopsy. Cold Spring Harb Mol Case Stud. 2019 Aug 1;5(4).

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