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98672-91-4
Catalog No.:AA01EORE

98672-91-4 | [1S-[1α,2α(Z),3α,4α]]-7-[3-[[2-[(phenylamino)carbonyl]hydrazino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoicacid

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1mg
≥98%
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$122.00   $85.00
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5mg
≥98%
in stock  
$548.00   $383.00
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10mg
≥98%
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$972.00   $680.00
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25mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EORE
Chemical Name:
[1S-[1α,2α(Z),3α,4α]]-7-[3-[[2-[(phenylamino)carbonyl]hydrazino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoicacid
CAS Number:
98672-91-4
Molecular Formula:
C21H29N3O4
Molecular Weight:
387.4727
SMILES:
O=C(Nc1ccccc1)NNCC1C2CCC(C1C/C=C\CCCC(=O)O)O2
Properties
Computed Properties
 
Complexity:
548  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
10  
Undefined Atom Stereocenter Count:
4  
Undefined Bond Stereocenter Count:
1  
XLogP3:
0.3  

Literature

Title: Isoprostanes as physiological mediators of transition to newborn life: novel mechanisms regulating patency of the term and preterm ductus arteriosus.

Journal: Pediatric research 20120801

Title: Site-directed mutations and the polymorphic variant Ala160Thr in the human thromboxane receptor uncover a structural role for transmembrane helix 4.

Journal: PloS one 20120101

Title: Acute effects of prostaglandin E1 and E2 on vascular reactivity and blood flow in situ in the chick chorioallantoic membrane.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20120101

Title: EP4 receptor as a new target for bronchodilator therapy.

Journal: Thorax 20111201

Title: Thromboxane and isoprostane share the same prostanoid receptors to increase human placental tone.

Journal: Placenta 20111201

Title: Computational analyses of intravascular tracer washout reveal altered capillary-level flow distributions in obese Zucker rats.

Journal: The Journal of physiology 20110915

Title: Improved functional vasodilation in obese Zucker rats following exercise training.

Journal: American journal of physiology. Heart and circulatory physiology 20110901

Title: Divergence between arterial perfusion and fatigue resistance in skeletal muscle in the metabolic syndrome.

Journal: Experimental physiology 20110301

Title: Central mechanism underlying pressor and bradycardic effect of intracerebroventricularly injected arachidonic acid.

Journal: Canadian journal of physiology and pharmacology 20110201

Title: 4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK) promotes lung cancer cell survival by stimulating thromboxane A2 and its receptor.

Journal: Oncogene 20110106

Title: Effects of pioglitazone and rosiglitazone on vascular function of mesenteric resistance arteries in rat genetic hypertension.

Journal: Pharmacology 20110101

Title: TRA-418, a thromboxane A2 receptor antagonist and prostacyclin receptor agonist, inhibits platelet-leukocyte interaction in human whole blood.

Journal: Thrombosis and haemostasis 20101001

Title: Repurposing an old drug for a new use: glybenclamide exerts antiplatelet activity by interacting with the thromboxane A(2) receptor.

Journal: Acta pharmacologica Sinica 20100201

Title: A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis.

Journal: Blood 20100114

Title: Thromboxane A2 receptor-mediated epidermal growth factor receptor transactivation: involvement of PKC-delta and PKC-epsilon in the shedding of epidermal growth factor receptor ligands.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20091208

Title: Role of prostanoid production and receptors in the regulation of retinal endogenous amino acid neurotransmitters by 8-isoprostaglandin E2, ex vivo.

Journal: Neurochemical research 20091201

Title: Inhibition of thromboxane A2-induced arrhythmias and intracellular calcium changes in cardiac myocytes by blockade of the inositol trisphosphate pathway.

Journal: The Journal of pharmacology and experimental therapeutics 20091201

Title: Ovariectomy increases the formation of prostanoids and modulates their role in acetylcholine-induced relaxation and nitric oxide release in the rat aorta.

Journal: Cardiovascular research 20091101

Title: Cyclooxygenase and thromboxane/prostaglandin receptor contribute to aortic endothelium-dependent dysfunction in aging female spontaneously hypertensive rats.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20091001

Title: The effect of endothelin-1 on the production of interleukin-6 in cultured human detrusor smooth muscle cells, and the effect of interleukin-6 on the contractile response of bladder smooth muscle strips from rats.

Journal: BJU international 20090901

Title: Thromboxane A(2) contributes to the mediation of flow-induced responses of skeletal muscle venules: role of cyclooxygenases 1 and 2.

Journal: Journal of vascular research 20090801

Title: Involvement of the thromboxane A2 receptor in the regulation of steroidogenic acute regulatory gene expression in murine Leydig cells.

Journal: Endocrinology 20090701

Title: Oxidative stress impairs vasorelaxation induced by the soluble guanylyl cyclase activator BAY 41-2272 in spontaneously hypertensive rats.

Journal: American journal of hypertension 20090501

Title: Cyclooxygenase 2 inhibition suppresses tubuloglomerular feedback: roles of thromboxane receptors and nitric oxide.

Journal: American journal of physiology. Renal physiology 20090401

Title: Equol is more active than soy isoflavone itself to compete for binding to thromboxane A(2) receptor in human platelets.

Journal: Thrombosis research 20090301

Title: Thromboxane A2 receptor antagonism by flavonoids: structure-activity relationships.

Journal: Journal of agricultural and food chemistry 20090225

Title: Developmental changes in the effects of prostaglandin E2 in the chicken ductus arteriosus.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20090201

Title: The Gq and G12 families of heterotrimeric G proteins report functional selectivity.

Journal: Molecular pharmacology 20090101

Title: Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A(2) receptor: a potential link between oxidative stress and impaired angiogenesis.

Journal: Circulation research 20081024

Title: Increased vascular thromboxane generation impairs dilation of skeletal muscle arterioles of obese Zucker rats with reduced oxygen tension.

Journal: American journal of physiology. Heart and circulatory physiology 20081001

Title: Up-regulated thromboxane production in the rat liver with biliary obstruction does not contribute to promote hepatic injury.

Journal: Shock (Augusta, Ga.) 20080601

Title: Apigenin inhibits platelet adhesion and thrombus formation and synergizes with aspirin in the suppression of the arachidonic acid pathway.

Journal: Journal of agricultural and food chemistry 20080514

Title: Alpha-adrenoceptor-mediated vasoconstriction is not involved in impaired functional vasodilation in the obese Zucker rat.

Journal: Clinical and experimental pharmacology & physiology 20080501

Title: Increased myogenic responsiveness of skeletal muscle arterioles with juvenile growth.

Journal: American journal of physiology. Heart and circulatory physiology 20080501

Title: Phospholipase D in human platelets: presence of isoenzymes and participation of autocrine stimulation during thrombin activation.

Journal: Platelets 20080501

Title: The role of prostaglandin E and thromboxane-prostanoid receptors in the response to prostaglandin E2 in the aorta of Wistar Kyoto rats and spontaneously hypertensive rats.

Journal: Cardiovascular research 20080401

Title: Insulin resistance and impaired functional vasodilation in obese Zucker rats.

Journal: American journal of physiology. Heart and circulatory physiology 20080401

Title: Orchidectomy increases the formation of prostanoids and modulates their role in the acetylcholine-induced relaxation in the rat aorta.

Journal: Cardiovascular research 20080201

Title: F2-isoprostane receptors on hepatic stellate cells.

Journal: Laboratory investigation; a journal of technical methods and pathology 20080201

Title: Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho.

Journal: Cancer research 20080101

Title: A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice.

Journal: American journal of physiology. Heart and circulatory physiology 20071001

Title: Piperlongumine, a constituent of Piper longum L., inhibits rabbit platelet aggregation as a thromboxane A(2) receptor antagonist.

Journal: European journal of pharmacology 20070910

Title: Short-term ANG II produces renal vasoconstriction independent of TP receptor activation and TxA2/isoprostane production.

Journal: American journal of physiology. Renal physiology 20070901

Title: Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice.

Journal: Journal of pharmacological sciences 20070901

Title: BM-520, an original TXA2 modulator, inhibits the action of thromboxane A2 and 8-iso-prostaglandin F2alphain vitro and in vivo on human and rodent platelets, and aortic vascular smooth muscles from rodents.

Journal: Prostaglandins & other lipid mediators 20070801

Title: Inhibitory effect of ethanol extract of Piper longum L. on rabbit platelet aggregation through antagonizing thromboxane A2 receptor.

Journal: Biological & pharmaceutical bulletin 20070701

Title: Potentiation of adrenaline vasoconstrictor response by sub-threshold concentrations of U-46619 in human umbilical vein: involvement of smooth muscle prostanoid TP(alpha) receptor isoform.

Journal: European journal of pharmacology 20070521

Title: Functional characterization of the mechanisms underlying bradykinin-induced relaxation in the isolated rat carotid artery.

Journal: Life sciences 20070417

Title: Enantiomeric metabolic interactions and stereoselective human methadone metabolism.

Journal: The Journal of pharmacology and experimental therapeutics 20070401

Title: Direct vasoconstrictor effect of prostaglandin E2 on renal interlobular arteries: role of the EP3 receptor.

Journal: American journal of physiology. Renal physiology 20070301

Title: Regulation of thromboxane receptor trafficking through the prostacyclin receptor in vascular smooth muscle cells: role of receptor heterodimerization.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20070201

Title: PAR-2 activating peptide-induced stimulation of pregnant rat myometrium contractile activity partly involves the other membrane receptors.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20070101

Title: Vasoreactivity of chorionic plate arteries in response to vasoconstrictors produced by preeclamptic placentas.

Journal: Placenta 20070101

Title: Distinct effects of z-335, a new thromboxane A2 receptor antagonist, on rabbit platelets and aortic smooth muscle.

Journal: Pharmacology 20070101

Title: Vascular dysfunction in type 2 diabetic TallyHo mice: role for an increase in the contribution of PGH2/TxA2 receptor activation and cytochrome p450 products.

Journal: Canadian journal of physiology and pharmacology 20070101

Title: Activation of the central cholinergic system mediates the reversal of hypotension by centrally administrated U-46619, a thromboxane A2 analog, in hemorrhaged rats.

Journal: Brain research 20061106

Title: Enhanced thromboxane receptor-mediated responses and impaired endothelium-dependent relaxation in human corpus cavernosum from diabetic impotent men: role of protein kinase C activity.

Journal: The Journal of pharmacology and experimental therapeutics 20061101

Title: TP receptor as a therapeutic target in atherosclerosis and related cardiovascular diseases.

Journal: Recent patents on cardiovascular drug discovery 20061101

Title: Evaluation of original dual thromboxane A2 modulators as antiangiogenic agents.

Journal: The Journal of pharmacology and experimental therapeutics 20060901

Title: The role of the central thromboxane A2 in cardiovascular effects of a phospholipase A2 activator melittin administrated intracerebroventricularly in normotensive conscious rats.

Journal: Neuropeptides 20060601

Title: The G12 family of G proteins as a reporter of thromboxane A2 receptor activity.

Journal: Molecular pharmacology 20060401

Title: Physiological significance of thromboxane A(2) receptor dimerization.

Journal: Journal of pharmacological sciences 20060401

Title: Contribution of prostanoid tp receptors to the pressor and intrarenal haemodynamic response to endothelin.

Journal: Clinical and experimental pharmacology & physiology 20060301

Title: Altered arachidonic acid metabolism impairs functional vasodilation in metabolic syndrome.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20060101

Title: Vasoactive responses of U46619, PGF2alpha, latanoprost, and travoprost in isolated porcine ciliary arteries.

Journal: Investigative ophthalmology & visual science 20060101

Title: Hydrogen peroxide is an endothelium-dependent contracting factor in rat renal artery.

Journal: British journal of pharmacology 20051201

Title: Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20051115

Title: CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses.

Journal: European journal of pharmacology 20051107

Title: Involvement of thromboxane receptor in the proatherogenic effect of isoprostane F2alpha-III: evidence from apolipoprotein E- and LDL receptor-deficient mice.

Journal: Circulation 20051101

Title: Implications for repetitive application of acetylcholine in the determination of the mechanisms of endothelium-dependent relaxation.

Journal: Vascular pharmacology 20051001

Title: Nitric oxide modulates angiotensin II-induced endothelial vasoconstrictor prostanoid release.

Journal: European journal of pharmacology 20050927

Title: Testosterone treatment increases thromboxane function in rat cerebral arteries.

Journal: American journal of physiology. Heart and circulatory physiology 20050801

Title: The involvement of central cholinergic system in the pressor effect of intracerebroventricularly injected U-46619, a thromboxane A2 analog, in conscious normotensive rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20050701

Title: Differential effects of 20-hydroxyeicosatetraenoic acid on intrarenal blood flow in the rat.

Journal: The Journal of pharmacology and experimental therapeutics 20050601

Title: The isoprostane 8-iso-PGF2alpha suppresses monocyte adhesion to human microvascular endothelial cells via two independent mechanisms.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050301

Title: Thromboxane A2 from Kupffer cells contributes to the hyperresponsiveness of hepatic portal circulation to endothelin-1 in endotoxemic rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20050201

Title: Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation.

Journal: The Journal of biological chemistry 20041217

Title: Gender difference in response to thromboxane A2/prostaglandin H2 receptor antagonism in spontaneously hypertensive rats.

Journal: Gender medicine 20041201

Title: Vasoconstrictor effects of 8-iso-prostaglandin E2 and 8-iso-prostaglandin F(2alpha) on human umbilical vein.

Journal: European journal of pharmacology 20040919

Title: Effect of the statin atorvastatin on intracellular signalling by the prostacyclin receptor in vitro and in vivo.

Journal: British journal of pharmacology 20040901

Title: Thromboxane A2 receptor signaling inhibits vascular endothelial growth factor-induced endothelial cell differentiation and migration.

Journal: Circulation research 20040820

Title: Hypertension alters role of iNOS, COX-2, and oxidative stress in bradykinin relaxation impairment after LPS in rat cerebral arteries.

Journal: American journal of physiology. Heart and circulatory physiology 20040701

Title: In-vitro contraction of the equine aortic valve.

Journal: The Journal of heart valve disease 20040701

Title: Cyclooxygenase involvement in thromboxane-dependent contraction in rat mesenteric resistance arteries.

Journal: Hypertension (Dallas, Tex. : 1979) 20040601

Title: Arachidonic acid metabolites and peroxide-induced inhibition of [3H]D-aspartate release from bovine isolated retinae.

Journal: Current eye research 20040501

Title: Thromboxane A2 receptor agonists antagonize the proangiogenic effects of fibroblast growth factor-2: role of receptor internalization, thrombospondin-1, and alpha(v)beta3.

Journal: Circulation research 20040402

Title: Restoration of blood pressure by centrally injected U-46619, a thromboxane A(2) analog, in hemorrhaged hypotensive rats: investigation of different brain areas.

Journal: Pharmacology 20040401

Title: The mechanism of oxidative stress stabilization of the thromboxane receptor in COS-7 cells.

Journal: The Journal of biological chemistry 20040227

Title: 11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils.

Journal: The Journal of biological chemistry 20040227

Title: Vascular oxygen sensing: detection of novel candidates by proteomics and organ culture.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20040201

Title: Pharmacological characterization and identification of EP3 prostanoid receptor binding sites in hamster uterus homogenates.

Journal: The Journal of pharmacy and pharmacology 20040201

Title: The thromboxane receptor antagonist PBT-3, a hepoxilin stable analog, selectively antagonizes the TPalpha isoform in transfected COS-7 cells.

Journal: The Journal of pharmacology and experimental therapeutics 20031201

Title: Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin.

Journal: Hypertension (Dallas, Tex. : 1979) 20031101

Title: Thromboxane A2-induced inhibition of voltage-gated K+ channels and pulmonary vasoconstriction: role of protein kinase Czeta.

Journal: Circulation research 20031003

Title: Synergism interaction between arachidonic acid by 5-hydroxytryptamine in human platelet aggregation is mediated through multiple signalling pathways.

Journal: Acta pharmacologica Sinica 20031001

Title: Interaction between nitric oxide and prostanoids in arterioles of rat cremaster muscle in vivo.

Journal: American journal of physiology. Heart and circulatory physiology 20030901

Title: Pharmacological characterization of prostanoid receptors mediating vasoconstriction in human umbilical vein.

Journal: British journal of pharmacology 20030802

Title: Myogenic constriction is increased in mesenteric resistance arteries from rats with chronic heart failure: instantaneous counteraction by acute AT1 receptor blockade.

Journal: British journal of pharmacology 20030801

Title: TRA-418, a novel compound having both thromboxane A(2) receptor antagonistic and prostaglandin I(2) receptor agonistic activities: its antiplatelet effects in human and animal platelets.

Journal: Journal of thrombosis and haemostasis : JTH 20030801

Title: Solution structure of the third extracellular loop of human thromboxane A2 receptor.

Journal: Archives of biochemistry and biophysics 20030615

Title: The early allergic response in small airways of human precision-cut lung slices.

Journal: The European respiratory journal 20030601

Title: Epidermal-growth-factor receptor and metalloproteinases mediate thromboxane A2-dependent extracellular-signal-regulated kinase activation.

Journal: The Biochemical journal 20030501

Title: The promoting effect of epinephrine on lipopolysaccharide-induced interleukin-8 production in whole blood may be mediated by thromboxane A2.

Journal: Journal of thrombosis and haemostasis : JTH 20030501

Title: Endothelium-derived prostaglandin H2 evokes the stretch-induced contraction of rabbit pulmonary artery.

Journal: European journal of pharmacology 20030425

Title: The stable analog carbocyclic TXA2 but not platelet-released TXA2 induces osteoclast-like cell formation.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20030401

Title: Identification of residues important for ligand binding of thromboxane A2 receptor in the second extracellular loop using the NMR experiment-guided mutagenesis approach.

Journal: The Journal of biological chemistry 20030328

Title: 8-iso-prostaglandin F(2alpha), a product of noise exposure, reduces inner ear blood flow.

Journal: Audiology & neuro-otology 20030101

Title: Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine.

Journal: British journal of pharmacology 20021201

Title: Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle.

Journal: International journal of impotence research 20021201

Title: Beta2 integrin-dependent neutrophil adhesion induced by minimally modified low-density lipoproteins is mainly mediated by F2-isoprostanes.

Journal: Circulation 20021105

Title: Sexual dimorphism in prostanoid-potentiated vascular contraction: roles of endothelium and ovarian steroids.

Journal: American journal of physiology. Heart and circulatory physiology 20021101

Title: Angiotensin II constriction of rat vasa recta is partially thromboxane dependent.

Journal: Hypertension (Dallas, Tex. : 1979) 20021001

Title: Hypertension alters the participation of contractile prostanoids and superoxide anions in lipopolysaccharide effects on small mesenteric arteries.

Journal: Life sciences 20020913

Title: PGD(2) modulates fibroblast-mediated native collagen gel contraction.

Journal: American journal of respiratory cell and molecular biology 20020901

Title: Enhanced thromboxane synthesis during chronic reductions in uterine perfusion pressure in pregnant rats.

Journal: American journal of hypertension 20020901

Title: Inhibition of renin-angiotensin system ameliorates endothelial dysfunction associated with aging in rats.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20020901

Title: Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function.

Journal: Circulation research 20020614

Title: Evaluation of the effects of anti-thromboxane agents in platelet-vessel wall interaction.

Journal: European journal of pharmacology 20020517

Title: The hepoxilin analog PBT-3 inhibits heparin-activated platelet aggregation evoked by ADP.

Journal: FEBS letters 20020327

Title: Involvement of protein kinase C and Na+/K+-ATPase in the contractile response induced by myricetin in rat isolated aorta.

Journal: Planta medica 20020201

Title: Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20020101

Title: Thromboxane receptor signalling in human myometrial cells.

Journal: Prostaglandins & other lipid mediators 20020101

Title: Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets.

Journal: Thrombosis and haemostasis 20020101

Title: The central role of thromboxane and platelet activating factor receptors in ex vivo regulation of endotoxin-induced monocyte tissue factor activity in human whole blood.

Journal: Journal of endotoxin research 20020101

Title: Thromboxane receptor density is increased in human cardiovascular disease with evidence for inhibition at therapeutic concentrations by the AT(1) receptor antagonist losartan.

Journal: British journal of pharmacology 20011201

Title: Hydrogen peroxide induces a greater contraction in mesenteric arteries of spontaneously hypertensive rats through thromboxane A(2) production.

Journal: British journal of pharmacology 20011201

Title: Potentiation of sympathetic neurotransmission in bovine isolated irides by isoprostanes.

Journal: Free radical research 20010901

Title: Simulated microgravity upregulates an endothelial vasoconstrictor prostaglandin.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20010801

Title: Identification and functional characterization of thromboxane A2 receptors in Schwann cells.

Journal: Journal of neurochemistry 20010801

Title: Activity of a novel dual thromboxane A(2)receptor antagonist and thromboxane synthase inhibitor (BM-573) on platelet function and isolated smooth muscles.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20010801

Title: Dietary polyunsaturated fatty acid and antioxidant modulation of vascular dysfunction in the spontaneously hypertensive rat.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20010801

Title: Inhibition of prostanoid-mediated contraction to endothelin-1 after hypoxia in rat aorta.

Journal: European journal of pharmacology 20010629

Title: The interaction of nitric oxide and prostaglandins in the control of corporal smooth muscle tone: evidence for production of a cyclooxygenase-derived endothelium-contracting factor.

Journal: BJU international 20010601

Title: Thromboxane A(2) receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells.

Journal: Biochimica et biophysica acta 20010528

Title: Changes in airway resistance by simultaneous exposure to TNF-alpha and IL-1beta in perfused rat lungs.

Journal: American journal of physiology. Lung cellular and molecular physiology 20010401

Title: L-Arginine improves endothelial function in renal artery of hypertensive Dahl rats.

Journal: Journal of hypertension 20010301

Title: PGH(2)-TxA(2)-receptor blockade restores vasoreactivity in a new rodent model of genetic hypertension.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20000601

Title: Evidence for human thromboxane receptor heterogeneity using a novel series of 9,11-cyclic carbonate derivatives of prostaglandin F2 alpha.

Journal: British journal of pharmacology 19960301

Title: Rat kidney thromboxane receptor: molecular cloning, signal transduction, and intrarenal expression localization.

Journal: The Journal of clinical investigation 19950801

Title: Dose-dependent mediation of leukotriene D4-induced airway microvascular leakage and bronchoconstriction in the guinea pig.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 19950601

Title: Pharmacological profile of BMS 180,291: a potent, long-acting, orally active thromboxane A2/prostaglandin endoperoxide receptor antagonist.

Journal: The Journal of pharmacology and experimental therapeutics 19930201

Title: Effects of KW-3635, a novel dibenzoxepin derivative of a selective thromboxane A2 antagonist, on human, guinea pig and rat platelets.

Journal: Japanese journal of pharmacology 19920701

Title: Differential effect of pH on thromboxane A2/prostaglandin H2 receptor agonist and antagonist binding in human platelets.

Journal: The Journal of biological chemistry 19910725

Title: Angiotensin and thromboxane in the enhanced renal adrenergic nerve sensitivity of acute renal failure.

Journal: The Journal of clinical investigation 19901101

Title: Bradykinin-induced vasoconstriction of rat mesenteric arteries precontracted with noradrenaline.

Journal: British journal of pharmacology 19901001

Title: Characterization of [5,6-3H]SQ 29,548 as a high affinity radioligand, binding to thromboxane A2/prostaglandin H2-receptors in human platelets.

Journal: The Journal of pharmacology and experimental therapeutics 19880601

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Tags:98672-91-4 Molecular Formula|98672-91-4 MDL|98672-91-4 SMILES|98672-91-4 [1S-[1α,2α(Z),3α,4α]]-7-[3-[[2-[(phenylamino)carbonyl]hydrazino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoicacid