Home Other Building Blocks 2134096-03-8
2134096-03-8,MFCD31807629
Catalog No.:AA01EO5J

2134096-03-8 | HS-10296 hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
98+%
1 week  
$139.00   $98.00
- +
50mg
98+%
1 week  
$234.00   $164.00
- +
100mg
98+%
1 week  
$395.00   $277.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01EO5J
Chemical Name:
HS-10296 hydrochloride
CAS Number:
2134096-03-8
Molecular Formula:
C30H36ClN7O2
Molecular Weight:
562.1055
MDL Number:
MFCD31807629
SMILES:
C=CC(=O)Nc1cc(Nc2nccc(n2)c2cn(c3c2cccc3)C2CC2)c(cc1N(CCN(C)C)C)OC.Cl
Properties
Computed Properties
 
Complexity:
823  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
11  

Downstream Synthesis Route

[1]CurrentPatentAssignee:HANSOHPHARMACEUTICALGROUPCOLTD-TW2017/34006,2017,ALocationinpatent:Page/Pagecolumn36;39

Literature

Title: Sullivan I, et al. Next-Generation EGFR Tyrosine Kinase Inhibitors for Treating EGFR-Mutant Lung Cancer beyond First Line. Front Med (Lausanne). 2017 Jan 18;3:76.

Title: Wu SG, et al. Management of acquired resistance to EGFR TKI-targeted therapy in advanced non-small cell lung cancer. Mol Cancer. 2018 Feb 19;17(1):38.

Title: Yang JC, et al. Safety, Efficacy, and Pharmacokinetics of Almonertinib (HS-10296) in Pretreated Patients With EGFR-Mutated Advanced NSCLC: A Multicenter, Open-label, Phase 1 Trial [published online ahead of print, 2020 Sep 9 J Thorac Oncol. 2020;S1556-0864(20)30714-0.

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SDS
Tags:2134096-03-8 Molecular Formula|2134096-03-8 MDL|2134096-03-8 SMILES|2134096-03-8 HS-10296 hydrochloride