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244101-03-9
Catalog No.:AA01EPUO

244101-03-9 | (2E)-N-[(5-bromo-2-methoxyphenyl)sulfonyl]-3-[5-chloro-2-(2-naphthalenylmethyl)phenyl]-2-propenamide

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1mg
≥98%
in stock  
$130.00   $91.00
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5mg
≥98%
in stock  
$488.00   $341.00
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10mg
≥98%
in stock  
$845.00   $591.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EPUO
Chemical Name:
(2E)-N-[(5-bromo-2-methoxyphenyl)sulfonyl]-3-[5-chloro-2-(2-naphthalenylmethyl)phenyl]-2-propenamide
CAS Number:
244101-03-9
Molecular Formula:
C27H21BrClNO4S
Molecular Weight:
570.8819
SMILES:
COc1ccc(cc1S(=O)(=O)NC(=O)/C=C/c1cc(Cl)ccc1Cc1ccc2c(c1)cccc2)Br
Properties
Computed Properties
 
Complexity:
847  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  
XLogP3:
7.2  

Literature

Title: Differential reactivity of human mammary artery and saphenous vein to prostaglandin E(2) : implication for cardiovascular grafts.

Journal: British journal of pharmacology 20110601

Title: Roles of affinity and lipophilicity in the slow kinetics of prostanoid receptor antagonists on isolated smooth muscle preparations.

Journal: British journal of pharmacology 20110201

Title: Prostaglandins of the E series inhibit monoamine release via EP3 receptors: proof with the competitive EP3 receptor antagonist L-826,266.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20100101

Title: MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis.

Journal: The Journal of pharmacology and experimental therapeutics 20080501

Title: Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkappaB activity.

Journal: British journal of pharmacology 20080401

Title: Intraplantar PGE2 causes nociceptive behaviour and mechanical allodynia: the role of prostanoid E receptors and protein kinases.

Journal: British journal of pharmacology 20070301

Title: Pharmacological and molecular characterization of the mechanisms involved in prostaglandin E2-induced mouse paw edema.

Journal: The Journal of pharmacology and experimental therapeutics 20060801

Title: Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia.

Journal: European journal of pharmacology 20060113

Title: Structure-activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor.

Journal: Bioorganic & medicinal chemistry 20010801

Title: M S Oliveira, et al. Modulation of pentylenetetrazol-induced seizures by prostaglandin E2 receptors. Neuroscience. 2008 Apr 9;152(4):1110-8.

Title: Mauro Schneider Oliveira, et al. Prostaglandin E2 modulates Na+,K+-ATPase activity in rat hippocampus: implications for neurological diseases. J Neurochem. 2009 Apr;109(2):416-26.

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Tags:244101-03-9 Molecular Formula|244101-03-9 MDL|244101-03-9 SMILES|244101-03-9 (2E)-N-[(5-bromo-2-methoxyphenyl)sulfonyl]-3-[5-chloro-2-(2-naphthalenylmethyl)phenyl]-2-propenamide