Home Other Building Blocks 1269662-73-8
1269662-73-8,MFCD31630828
Catalog No.:AA01EO62

1269662-73-8 | Pyrotinib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99%
1 week  
$412.00   $289.00
- +
5mg
99%
1 week  
$1,289.00   $902.00
- +
10mg
99%
1 week  
$1,860.00   $1,302.00
- +
25mg
99%
1 week  
$3,765.00   $2,635.00
- +
50mg
99%
1 week  
$5,670.00   $3,969.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EO62
Chemical Name:
Pyrotinib
CAS Number:
1269662-73-8
Molecular Formula:
C32H31ClN6O3
Molecular Weight:
583.0799
MDL Number:
MFCD31630828
SMILES:
CCOc1cc2ncc(c(c2cc1NC(=O)/C=C/[C@H]1CCCN1C)Nc1ccc(c(c1)Cl)OCc1ccccn1)C#N
Properties
Computed Properties
 
Complexity:
960  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
10  
XLogP3:
5.4  

Literature

Title: Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20171215

Title: Phase I Study and Biomarker Analysis of Pyrotinib, a Novel Irreversible Pan-ErbB Receptor Tyrosine Kinase Inhibitor, in Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20170920

Title: Li X, et al. Discovery and development of Pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer. Eur J Pharm Sci. 2017 Jan 21. pii: S0928-0987(17)30043-X.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:1269662-73-8 Molecular Formula|1269662-73-8 MDL|1269662-73-8 SMILES|1269662-73-8 Pyrotinib