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1052147-86-0,MFCD22690843
Catalog No.:AA01EOAW

1052147-86-0 | LP-211

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$46.00   $32.00
- +
10mg
≥98%
in stock  
$82.00   $57.00
- +
25mg
≥98%
in stock  
$188.00   $131.00
- +
50mg
≥98%
in stock  
$348.00   $243.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA01EOAW
Chemical Name:
LP-211
CAS Number:
1052147-86-0
Molecular Formula:
C30H34N4O
Molecular Weight:
466.6172
MDL Number:
MFCD22690843
SMILES:
N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1
Properties
Computed Properties
 
Complexity:
665  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
10  
XLogP3:
5  

Literature

Title: The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT₇ receptor antagonists.

Journal: European journal of medicinal chemistry 20121001

Title: Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.

Journal: Journal of medicinal chemistry 20120726

Title: Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice.

Journal: Neuropharmacology 20120201

Title: LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor.

Journal: Neuroscience letters 20100830

Title: Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III.

Journal: Journal of medicinal chemistry 20080925

Title: Leopoldo M, et al. Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. J Med Chem. 2008 Sep 25;51(18):5813-22.

Title: Norouzi-Javidan A, et al. Effect of 5-HT7 receptor agonist, LP-211, on micturition following spinal cord injury in male rats. Am J Transl Res. 2016 Jun 15;8(6):2525-33. eCollection 2016.

Title: Beaudet G, et al. LP-211, a selective 5-HT7 receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats. Synapse. 2017 Dec;71(12).

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Tags:1052147-86-0 Molecular Formula|1052147-86-0 MDL|1052147-86-0 SMILES|1052147-86-0 LP-211
Catalog No.: AA01EOAW
1052147-86-0,MFCD22690843
1052147-86-0 | LP-211
Pack Size： 5mg
Purity： ≥98%
in stock
$46.00 $32.00
Pack Size： 10mg
Purity： ≥98%
in stock
$82.00 $57.00
Pack Size： 25mg
Purity： ≥98%
in stock
$188.00 $131.00
Pack Size： 50mg
Purity： ≥98%
in stock
$348.00 $243.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA01EOAW
Chemical Name: LP-211
CAS Number: 1052147-86-0
Molecular Formula: C30H34N4O
Molecular Weight: 466.6172
MDL Number: MFCD22690843
SMILES: N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1
Properties
Complexity: 665  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 35  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 1  
Rotatable Bond Count: 10  
XLogP3: 5  
Literature fold

Title: The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT₇ receptor antagonists.

Journal: European journal of medicinal chemistry20121001

Title: Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.

Journal: Journal of medicinal chemistry20120726

Title: Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice.

Journal: Neuropharmacology20120201

Title: LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor.

Journal: Neuroscience letters20100830

Title: Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III.

Journal: Journal of medicinal chemistry20080925

Title: Leopoldo M, et al. Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. J Med Chem. 2008 Sep 25;51(18):5813-22.

Title: Norouzi-Javidan A, et al. Effect of 5-HT7 receptor agonist, LP-211, on micturition following spinal cord injury in male rats. Am J Transl Res. 2016 Jun 15;8(6):2525-33. eCollection 2016.

Title: Beaudet G, et al. LP-211, a selective 5-HT7 receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats. Synapse. 2017 Dec;71(12).

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