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Home Other Building Blocks 1196541-47-5
1196541-47-5,MFCD29048675
Catalog No.:AA01EOMS

1196541-47-5 | GDC-0575

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$22.00   $15.00
- +
5mg
98+%
in stock  
$52.00   $36.00
- +
25mg
98+%
in stock  
$129.00   $90.00
- +
50mg
98+%
in stock  
$194.00   $136.00
- +
1g
95%
in stock  
$2,133.00   $1,493.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EOMS
Chemical Name:
GDC-0575
CAS Number:
1196541-47-5
Molecular Formula:
C16H20BrN5O
Molecular Weight:
378.2669
MDL Number:
MFCD29048675
SMILES:
N[C@@H]1CCCN(C1)c1c(Br)cnc2c1c(c[nH]2)NC(=O)C1CC1
Properties
Computed Properties
 
Complexity:
460  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
1  
XLogP3:
1.4  

Literature

Title: Oo ZY, et al. Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo. Clin Cancer Res. 2018 Mar 13. doi: 10.1158/1078-0432.CCR-17-2701.

Title: Laroche-Clary A, et al. CHK1 inhibition in soft-tissue sarcomas: biological and clinical implications. Ann Oncol. 2018 Apr 1;29(4):1023-1029.

Title: Di Tullio A, et al. The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia. Nat Commun. 2017 Nov 22;8(1):1679.

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SDS
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Tags:1196541-47-5 Molecular Formula|1196541-47-5 MDL|1196541-47-5 SMILES|1196541-47-5 GDC-0575