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Home Other Building Blocks 259674-19-6
259674-19-6,MFCD31746884
Catalog No.:AA01EOFN

259674-19-6 | TRPM8 Antagonist

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
1 week  
$96.00   $68.00
- +
100mg
98+%
1 week  
$142.00   $99.00
- +
250mg
98+%
1 week  
$283.00   $198.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01EOFN
Chemical Name:
TRPM8 Antagonist
CAS Number:
259674-19-6
Molecular Formula:
C26H26N2O2
Molecular Weight:
398.4968
MDL Number:
MFCD31746884
SMILES:
COC(=O)[C@@H](N(Cc1ccccc1)Cc1ccccc1)Cc1c[nH]c2c1cccc2
Properties
Computed Properties
 
Complexity:
507  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
9  
XLogP3:
5.5  

Downstream Synthesis Route
100-39-0   
(S)-tryptophanmethylesterhydrochloride 
  259674-19-6 

[1]Schkeryantz,JeffreyM.;Woo,JonathanC.G.;Siliphaivanh,Phieng;Depew,KristopherM.;Danishefsky,SamuelJ.[JournaloftheAmericanChemicalSociety,1999,vol.121,#51,p.11964-11975]

7677-24-9    259674-19-6   
3-(2-cyano-3<i>H</i>-indol-3-yl)-2-dibenzylamino-propionicacidmethylester 

[1]Schkeryantz,JeffreyM.;Woo,JonathanC.G.;Siliphaivanh,Phieng;Depew,KristopherM.;Danishefsky,SamuelJ.[JournaloftheAmericanChemicalSociety,1999,vol.121,#51,p.11964-11975]

53911-92-5    259674-19-6   
3-(2-allyl-3<i>H</i>-indol-3-yl)-2-dibenzylamino-propionicacidmethylester 

[1]Schkeryantz,JeffreyM.;Woo,JonathanC.G.;Siliphaivanh,Phieng;Depew,KristopherM.;Danishefsky,SamuelJ.[JournaloftheAmericanChemicalSociety,1999,vol.121,#51,p.11964-11975]

259674-19-6   
9-(3-methylbut-2-enyl)-9-borabicyclo3.3.1.nonane 
 
2-dibenzylamino-3-2-(1,1-dimethyl-allyl)-3<i>H</i>-indol-3-yl-propionicacidmethylester 

[1]Schkeryantz,JeffreyM.;Woo,JonathanC.G.;Siliphaivanh,Phieng;Depew,KristopherM.;Danishefsky,SamuelJ.[JournaloftheAmericanChemicalSociety,1999,vol.121,#51,p.11964-11975]

Tri-tert-butyl-(1-ethoxy-vinyloxy)-silane 
  259674-19-6   
2-dibenzylamino-3-(2-ethoxycarbonylmethyl-3<i>H</i>-indol-3-yl)-propionicacidmethylester 

[1]Schkeryantz,JeffreyM.;Woo,JonathanC.G.;Siliphaivanh,Phieng;Depew,KristopherM.;Danishefsky,SamuelJ.[JournaloftheAmericanChemicalSociety,1999,vol.121,#51,p.11964-11975]

Literature

Title: Bertamino A, et al. Identification of a Potent Tryptophan-Based TRPM8 Antagonist With in Vivo Analgesic Activity. J Med Chem. 2018 Jul 10. doi: 10.1021/acs.jmedchem.8b00545.

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SDS
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Tags:259674-19-6 Molecular Formula|259674-19-6 MDL|259674-19-6 SMILES|259674-19-6 TRPM8 Antagonist