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1218-34-4,MFCD00065976
Catalog No.:AA0015ZF

1218-34-4 | N-Acetyl-L-tryptophan

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1g
>98.0%(HPLC)
in stock  
$20.00   $14.00
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5g
98%(HPLC)
in stock  
$24.00   $17.00
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25g
98%(HPLC)
in stock  
$43.00   $30.00
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100g
98%
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$95.00   $67.00
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500g
98%
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0015ZF
Chemical Name:
N-Acetyl-L-tryptophan
CAS Number:
1218-34-4
Molecular Formula:
C13H14N2O3
Molecular Weight:
246.2619
MDL Number:
MFCD00065976
SMILES:
CC(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2
Properties
Properties
 
BP:
586.6 °C at 760 mmHg  
Form:
Solid  
MP:
86 °C  
Refractive Index:
1.6450 (estimate)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
332  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
1.1  

Literature

Title: Combined tissue plasminogen activator and an NK1 tachykinin receptor antagonist: an effective treatment for reperfusion injury following acute ischemic stroke in rats.

Journal: Neuroscience 20120918

Title: Ultrafast dynamics of nonequilibrium electron transfer in photoinduced redox cycle: solvent mediation and conformation flexibility.

Journal: The journal of physical chemistry. B 20120802

Title: Substance P-induced changes in cell genesis following diffuse traumatic brain injury.

Journal: Neuroscience 20120712

Title: Tachykinin NK₁ receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation.

Journal: European journal of pharmacology 20120605

Title: Treatment with a substance P receptor antagonist is neuroprotective in the intrastriatal 6-hydroxydopamine model of early Parkinson's disease.

Journal: PloS one 20120101

Title: Conjugation of organoruthenium(II) 3-(1H-benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and indolo[3,2-d]benzazepines to recombinant human serum albumin: a strategy to enhance cytotoxicity in cancer cells.

Journal: Inorganic chemistry 20111219

Title: Concerted electron-proton transfer (EPT) in the oxidation of tryptophan with hydroxide as a base.

Journal: Journal of the American Chemical Society 20111214

Title: Characterization of N-acetyltryptophan degradation products in concentrated human serum albumin solutions and development of an automated high performance liquid chromatography-mass spectrometry method for their quantitation.

Journal: Journal of chromatography. A 20111014

Title: A substance P antagonist improves outcome when administered 4 h after onset of ischaemic stroke.

Journal: Brain research 20110601

Title: Industrial stabilizers caprylate and N-acetyltryptophanate reduce the efficacy of albumin in liver patients.

Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20110601

Title: Characterizing the role of the neuropeptide substance P in experimental subarachnoid hemorrhage.

Journal: Brain research 20110510

Title: Involvement of substance P in peripheral neuropathy induced by paclitaxel but not oxaliplatin.

Journal: The Journal of pharmacology and experimental therapeutics 20110401

Title: Role of constituents of Optison in Optison-mediated gene transfection enhancement in skeletal muscle in vivo.

Journal: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 20110301

Title: A substance P antagonist reduces axonal injury and improves neurologic outcome when administered up to 12 hours after traumatic brain injury.

Journal: Journal of neurotrauma 20110201

Title: Reversible exposure of hydrophobic residues on albumin as a novel strategy for formulation of nanodelivery vehicles for taxanes.

Journal: International journal of nanomedicine 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: One-step preparation of S-nitrosated human serum albumin with high biological activities.

Journal: Nitric oxide : biology and chemistry 20100915

Title: Chemical constituents of a marine-derived endophytic fungus Penicillium commune G2M.

Journal: Molecules (Basel, Switzerland) 20100504

Title: Infusions of albumin increase free fraction of naproxen in healthy volunteers: a randomized crossover study.

Journal: Acta anaesthesiologica Scandinavica 20100401

Title: Changes of protein solutions during storage: a study of albumin pharmaceutical preparations.

Journal: Biotechnology and applied biochemistry 20100305

Title: Contractile responses induced by physalaemin, an analogue of substance P, in the rat esophagus.

Journal: European journal of pharmacology 20100225

Title: Transport of benzo[alpha]pyrene in the dually perfused human placenta perfusion model: effect of albumin in the perfusion medium.

Journal: Basic & clinical pharmacology & toxicology 20090901

Title: Capillary electrophoresis with indirect UV detection for the determination of stabilizers and citrates present in human albumin solutions.

Journal: Journal of pharmaceutical and biomedical analysis 20090815

Title: Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090801

Title: Annotating enzymes of uncertain function: the deacylation of D-amino acids by members of the amidohydrolase superfamily.

Journal: Biochemistry 20090714

Title: Effects of uric acid on nitrosation of N-acetylcysteine by diethylamine NONOate and N-acetyl-N-nitrosotryptophan.

Journal: Chemical & pharmaceutical bulletin 20090701

Title: New tryptophanase inhibitors: towards prevention of bacterial biofilm formation.

Journal: Journal of enzyme inhibition and medicinal chemistry 20090401

Title: Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.

Journal: Nature chemical biology 20090101

Title: Tryptophan and kynurenine levels in lenses of Wistar and accelerated-senescence OXYS rats.

Journal: Molecular vision 20090101

Title: Effects of nucleobase metalation on frontier molecular orbitals: potential implications for pi-stacking interactions with tryptophan.

Journal: Inorganic chemistry 20081117

Title: Kinetics of enzyme attack on substrates covalently attached to solid surfaces: influence of spacer chain length, immobilized substrate surface concentration and surface charge.

Journal: Langmuir : the ACS journal of surfaces and colloids 20081021

Title: Quantitative determination of singlet oxygen generated by excited state aromatic amino acids, proteins, and immunoglobulins.

Journal: Journal of the American Chemical Society 20080604

Title: Two L-amino acid oxidase isoenzymes from Russell's viper (Daboia russelli russelli) venom with different mechanisms of inhibition by substrate analogs.

Journal: The FEBS journal 20080501

Title: Electron transfer between guanosine radicals and amino acids in aqueous solution. II. Reduction of guanosine radicals by tryptophan.

Journal: The journal of physical chemistry. B 20080306

Title: Electron transfer from aromatic amino acids to triplet quinones.

Journal: Journal of photochemistry and photobiology. B, Biology 20070925

Title: 15N-CIDNP investigations during tryptophan, N-acetyl-L-tryptophan, and melatonin nitration with reactive nitrogen species.

Journal: Free radical research 20070501

Title: The role of N-acetyl-methioninate as a new stabilizer for albumin products.

Journal: International journal of pharmaceutics 20070201

Title: Nitrosation of N-terminally blocked tryptophan and tryptophan-containing peptides by peroxynitrite.

Journal: Chembiochem : a European journal of chemical biology 20070122

Title: On the mechanism of the ascorbic acid-induced release of nitric oxide from N-nitrosated tryptophan derivatives: scavenging of NO by ascorbyl radicals.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20061124

Title: Preparation and identification of anti-melatonin monoclonal antibodies.

Journal: Journal of pineal research 20060501

Title: Covalent and noncovalent interactions for [metal(dien)nucleobase](2+) complexes with L-tryptophan derivatives: formation of palladium-tryptophan species by nucleobase substitution under biologically relevant conditions.

Journal: Inorganic chemistry 20060220

Title: Catecholamine-induced release of nitric oxide from N-nitrosotryptophan derivatives: a non-enzymatic method for catecholamine oxidation.

Journal: Organic & biomolecular chemistry 20060121

Title: N-Nitroso products from the reaction of indoles with Angeli's salt.

Journal: Chemical research in toxicology 20060101

Title: Substance P promotes sleep in the ventrolateral preoptic area of rats.

Journal: Brain research 20041203

Title: Stabilizing mechanisms in commercial albumin preparations: octanoate and N-acetyl-L-tryptophanate protect human serum albumin against heat and oxidative stress.

Journal: Biochimica et biophysica acta 20041001

Title: A substance P antagonist increases brain intracellular free magnesium concentration after diffuse traumatic brain injury in rats.

Journal: Journal of the American College of Nutrition 20041001

Title: Degradation of N-acetyl tryptophan by low-energy (<12 eV) electrons.

Journal: Journal of the American Chemical Society 20040929

Title: Nitration and nitrosation of N-acetyl-L-tryptophan and tryptophan residues in proteins by various reactive nitrogen species.

Journal: Free radical biology & medicine 20040901

Title: Endogenous and dietary indoles: a class of antioxidants and radical scavengers in the ABTS assay.

Journal: Free radical research 20040301

Title: Synthesis and characterization of carboxymethylated cyclosophoraose, and its inclusion complexation behavior.

Journal: Carbohydrate research 20040225

Title: A mass spectrometric and molecular orbital study of H2O loss from protonated tryptophan and oxidized tryptophan derivatives.

Journal: Rapid communications in mass spectrometry : RCM 20040101

Title: More chemistry of the thaxtomin phytotoxins.

Journal: Phytochemistry 20031101

Title: PAR-2 modulates pepsinogen secretion from gastric-isolated chief cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20030901

Title: Interpretation of fluorescence decays using a power-like model.

Journal: Biophysical journal 20030701

Title: Comparative studies on the properties of the extrinsic manganese-stabilizing protein from higher plants and of a synthetic peptide of its C-terminus.

Journal: Biochimica et biophysica acta 20030605

Title: Regiospecific nitrosation of N-terminal-blocked tryptophan derivatives by N2O3 at physiological pH.

Journal: The Journal of biological chemistry 20030404

Title: Effects of antidepressants in rats trained to discriminate centrally administered isoproterenol.

Journal: The Journal of pharmacology and experimental therapeutics 20020801

Title: Mechanisms of reactions of flavin mononucleotide triplet with aromatic amino acids.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20020701

Title: Albumin, bilirubin, and activated carbon: new edges of an old triangle.

Journal: Artificial cells, blood substitutes, and immobilization biotechnology 20020301

Title: The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location.

Journal: Genomics 20020101

Title: In vitro and in vivo properties of recombinant human serum albumin from Pichia pastoris purified by a method of short processing time.

Journal: Pharmaceutical research 20011201

Title: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.

Journal: The Journal of biological chemistry 20010518

Title: Intra and intermolecular charge effects on the reaction of the superoxide radical anion with semi-oxidized tryptophan in peptides and N-acetyl tryptophan.

Journal: Free radical research 19981101

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