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911715-90-7,MFCD28139065
Catalog No.:AA01EOIF

911715-90-7 | Azd8797

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$96.00   $67.00
- +
5mg
≥98%
in stock  
$328.00   $229.00
- +
10mg
≥98%
in stock  
$572.00   $400.00
- +
  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EOIF
Chemical Name:
Azd8797
CAS Number:
911715-90-7
Molecular Formula:
C19H25N5OS2
Molecular Weight:
403.5647
MDL Number:
MFCD28139065
SMILES:
OC[C@H](Nc1nc(S[C@H](c2ccccc2)C)nc2c1sc(n2)N)CC(C)C
Properties
Computed Properties
 
Complexity:
452  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  
XLogP3:
4.8  

Literature

Title: Cederblad L, et al. AZD8797 is an allosteric non-competitive modulator of the human CX3CR1 receptor. Biochem J. 2016 Mar 1;473(5):641-9.

Title: Ridderstad Wollberg A, et al. Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5409-14.

Title: Sofia Karlströ, et al. Substituted 7-amino-5-thio-thiazolo,5-dpyrimidines as potent and selective antagonists of the fractalkine receptor (CX3CR1). J Med Chem. 2013 Apr 25;56(8):3177-90.

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