Aldehyde Functional Group

An aldehyde is an organic compound that contains a carbonyl group with the central carbon bonded to a hydrogen and R group (R-CHO). Aldehydes differ from ketones in that the carbonyl is placed at the end of the carbon skeleton rather than between two carbon atoms of the backbone. Like ketones, aldehydes are sp2 hybridized and can exist in the keto or enol tautomer. Aldehydes are named by dropping the suffix of the parent molecule, and adding the suffix “-al.” For instance, a three-carbon chain with an aldehyde group on a terminal carbon would be propanal. If there are higher order functional groups on the compound, the prefix “oxo-” can be used to indicate which carbon atom is part of the aldehyde functional group. If the location of the aldehyde must be specified, a number can be used in between the parent chain and suffix, or at the beginning of the compound name.

 

Both aldehydes and ketones exist in an equilibrium with their enol forms; the enol form is defined as an alkene with a hydroxyl group affixed to one of the carbon atoms composing the double bond. The keto form predominates at equilibrium for most ketones. However, the enol form is important for some reactions because the deprotonated enolate form is a strong nucleophile. The equilibrium is strongly thermodynamically driven, and at room temperature the keto form is favored. The interconversion can be catalyzed by the presence of either an acid or a base.

Both ketones and aldehydes can be identified by spectroscopic methods. They display strong CO absorption bands near 1700 cm-1. In NMR spectroscopy, the carbonyl hydrogen shows a strong absorption peak, and any coupling to protons on the alpha carbon will also show strong signals.

 

Ketones and aldehydes can both be readily reduced to alcohols, usually in the presence of a strong reducing agent such as sodium borohydride. In the presence of strong oxidizing agents, they can be oxidized to carboxylic acids. As electrophiles, they are subject to attack by nucleophiles, meaning they participate in many nucleophilic addition reactions.

 

The following Aldehydes are available from AA Blocks:

"4-methyl-2-(thiophen-2-yl)-1,3-thiazole-5-carboxamide" Catalog No.:AA01FMVL CAS No.:1097815-09-2 MDL No.:MFCD11643717 MF:C9H8N2OS2 MW:224.3026	5-Bromo-2-ethoxy-n-methylbenzene-1-sulfonamide Catalog No.:AA01AANF CAS No.:1097815-33-2 MDL No.:MFCD11646539 MF:C9H12BrNO3S MW:294.1655
2-(2H-indazol-3-yl)-1H-1,3-benzodiazole Catalog No.:AA01AB4P CAS No.:1097816-83-5 MDL No.:MFCD11547580 MF:C14H10N4 MW:234.2560	5-(thiophen-3-yl)-10,13-dioxa-4,6-diazatricyclo[7.4.0.0,3,7]trideca-1(9),2,4,7-tetraene Catalog No.:AA01A641 CAS No.:1097819-60-7 MDL No.:MFCD11547590 MF:C13H10N2O2S MW:258.2957
2-(5-Methylthiophen-2-yl)morpholine Catalog No.:AA01DX87 CAS No.:1097820-93-3 MDL No.:MFCD11646239 MF:C9H13NOS MW:183.2706	2-[4-(difluoromethoxy)phenyl]morpholine Catalog No.:AA01A3LB CAS No.:1097820-96-6 MDL No.:MFCD11646247 MF:C11H13F2NO2 MW:229.2232
1-[(2-bromoethyl)sulfanyl]-2,4-difluorobenzene Catalog No.:AA01B56S CAS No.:1097824-30-0 MDL No.:MFCD11642596 MF:C8H7BrF2S MW:253.1070	2-bromo-N-[(4-methoxyphenyl)methyl]-N,3-dimethylbutanamide Catalog No.:AA019KWX CAS No.:1097825-87-0 MDL No.:MFCD11547040 MF:C14H20BrNO2 MW:314.2181
3-(2-Fluorophenoxy)propanamide Catalog No.:AA01AA83 CAS No.:1097829-72-5 MDL No.:MFCD11643184 MF:C9H10FNO2 MW:183.1796	1-tert-butyl 2-methyl 3-bromo-1H-pyrrole-1,2-dicarboxylate Catalog No.:AA00IKXY CAS No.:1097834-88-2 MDL No.:MFCD24469434 MF:C11H14BrNO4 MW:304.1372
5-Methoxy-2-methyl-1H-pyrrolo[2,3-c]pyridine Catalog No.:AA008U8W CAS No.:1097839-70-7 MDL No.:MFCD12400733 MF:C9H10N2O MW:162.1885	lactosyl lysosphingolipid Catalog No.:AA008YV4 CAS No.:109785-20-8 MDL No.:MFCD07374300 MF:C30H57NO12 MW:623.7731
4-Chloro-2,5-difluoroiodobenzene Catalog No.:AA00HBIP CAS No.:1097871-23-2 MDL No.:MFCD18379746 MF:C6H2ClF2I MW:274.4344	2-(4-Cyano-3-fluorophenyl)acetic acid Catalog No.:AA0091FP CAS No.:1097871-99-2 MDL No.:MFCD18072763 MF:C9H6FNO2 MW:179.1478
1-Ethynyl-2,4,5-trifluorobenzene Catalog No.:AA01DRL8 CAS No.:1097874-78-6 MDL No.:MFCD11655774 MF:C8H3F3 MW:156.1046	(S)-tert-Butyl 4-(((tert-butylsulfinyl)imino)methyl)piperidine-1-carboxylate Catalog No.:AA01EFKK CAS No.:1097880-26-6 MDL No.:MFCD18781720 MF:C15H28N2O3S MW:316.4594
4-azido-1-bromo-2-methylbenzene Catalog No.:AA01AI57 CAS No.:1097885-39-6 MDL No.:MFCD11650631 MF:C7H6BrN3 MW:212.0466	Ms-peg7-ms Catalog No.:AA0081TA CAS No.:109789-40-4 MDL No.:MFCD31692182 MF:C14H34O13S2 MW:474.5420
Ms-peg8-ms Catalog No.:AA019EAK CAS No.:109789-41-5 MDL No.:MFCD10699795 MF:C16H34O12S2 MW:482.5640	Potassium (z)-2,3-dibromoprop-1-enyltrifluoroborate Catalog No.:AA008UOZ CAS No.:1097890-24-8 MDL No.:MFCD19982307 MF:C3H3BBr2F3K MW:305.7684
N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine Catalog No.:AA008TAR CAS No.:1097917-15-1 MDL No.:MFCD21609265 MF:C29H40N8O3S MW:580.7447	1-Boc-1,12-diaminododecane Catalog No.:AA00791W CAS No.:109792-60-1 MDL No.:MFCD02094503 MF:C17H36N2O2 MW:300.4799
3-chloro-2-(propane-2-sulfonyl)aniline Catalog No.:AA01B9GQ CAS No.:1097921-24-8 MDL No.:MFCD24063274 MF:C9H12ClNO2S MW:233.7151	2-(cyclopropanesulfonyl)aniline Catalog No.:AA01BKCM CAS No.:1097921-73-7 MDL No.:MFCD24643543 MF:C9H11NO2S MW:197.2541
1-(6-Amino-7-chloro-3,4-dihydroisoquinolin-2(1h)-yl)-2,2,2-trifluoroethanone Catalog No.:AA00946H CAS No.:1097922-04-7 MDL No.:MFCD20921907 MF:C11H10ClF3N2O MW:278.6581	[1,3]thiazolo[4,5-b]pyridine-7-carboxylic acid Catalog No.:AA01B6DN CAS No.:1097937-02-4 MDL No.:MFCD19690182 MF:C7H4N2O2S MW:180.1839
5-Dimethylaminonaphthalene-1-sulfonyl-l-valine Catalog No.:AA003P5V CAS No.:1098-50-6 MDL No.:MFCD00069524 MF:C17H22N2O4S MW:350.4326	Triflupromazine hydrochloride Catalog No.:AA007WAN CAS No.:1098-60-8 MDL No.:MFCD00058103 MF:C18H20ClF3N2S MW:388.8780
Pyrithioxin Catalog No.:AA00HBIT CAS No.:1098-97-1 MDL No.:MFCD00151477 MF:C16H20N2O4S2 MW:368.4710	1-(3-pyridinyl)- 1H-pyrazole-4-carbaldehyde Catalog No.:AA0095ET CAS No.:1098004-79-5 MDL No.:MFCD18838744 MF:C9H7N3O MW:173.1714
4-(4-bromo-1-methyl-1H-pyrazol-5-yl)butanal Catalog No.:AA01E7I4 CAS No.:109801-19-6 MDL No.:MFCD30724100 MF:C8H11BrN2O MW:231.0897	(2R)-2-[2-(cyclopent-2-en-1-yl)acetamido]propanoic acid Catalog No.:AA01E7E8 CAS No.:1098018-80-4 MDL No.:MFCD16050514 MF:C10H15NO3 MW:197.2310
5-Chloro-4-methoxy-2-methylbenzoic acid Catalog No.:AA01ACY7 CAS No.:109803-47-6 MDL No.:MFCD21882471 MF:C9H9ClO3 MW:200.6190	1-Bromo-2,3-dichloro-4-methoxybenzene Catalog No.:AA00HBIV CAS No.:109803-52-3 MDL No.:MFCD21609662 MF:C7H5BrCl2O MW:255.9240
5-hydroxy-2-methyl-2,3-dihydro-1H-isoindol-1-one Catalog No.:AA01A3WA CAS No.:109803-65-8 MDL No.:MFCD12924811 MF:C9H9NO2 MW:163.1733	4-(p-Chloro-α-phenylbenzyl)-1-piperazineethanol Catalog No.:AA008S2G CAS No.:109806-71-5 MDL No.:MFCD00035326 MF:C19H23ClN2O MW:330.8517
1-carbamoyl-4-hydroxypyrrolidine-2-carboxylic acid Catalog No.:AA01EK55 CAS No.:1098066-21-7 MDL No.:MFCD18896423 MF:C6H10N2O4 MW:174.1546	1-[4-fluoro-3-(trifluoromethyl)phenyl]ethan-1-amine Catalog No.:AA01A2FG CAS No.:1098068-92-8 MDL No.:MFCD18702837 MF:C9H9F4N MW:207.1681
1-(2-CHLORO-4-FLUOROPHENYL)ETHAN-1-AMINE Catalog No.:AA00963M CAS No.:1098070-11-1 MDL No.:MFCD12147965 MF:C8H9ClFN MW:173.6152	2-(3,5-Dibromophenyl)-2,3-dihydro-1h-naphtho[1,8-de][1,3,2]diazaborinine Catalog No.:AA00HBIW CAS No.:1098071-09-0 MDL No.:MFCD20527133 MF:C16H11BBr2N2 MW:401.8909
N-(4-acetylphenyl)-2-(phenylformamido)acetamide Catalog No.:AA00IQS8 CAS No.:109809-55-4 MDL No.:MFCD00140889 MF:C17H16N2O3 MW:296.3205	N-Phenylacetyl-2-(2-chlorophenyl)-d-glycine Catalog No.:AA00HBIX CAS No.:1098100-07-2 MDL No.:MFCD22377974 MF:C16H14ClNO3 MW:303.7403
4,8-Bis(octyloxy)benzo[1,2-b:4,5-b']dithiophene Catalog No.:AA009435 CAS No.:1098102-94-3 MDL No.:MFCD26793498 MF:C26H38O2S2 MW:446.7087	(4,8-Bis(octyloxy)benzo[1,2-b:4,5-b']dithiophene-2,6-diyl)bis(trimethylstannane) Catalog No.:AA009434 CAS No.:1098102-95-4 MDL No.:MFCD27923034 MF:C32H54O2S2Sn2 MW:772.3020
3-(3-bromophenyl)-2,2-dimethylpropan-1-amine hydrochloride Catalog No.:AA01AUEX CAS No.:1098106-78-5 MDL No.:MFCD29034890 MF:C11H17BrClN MW:278.6164	N-Boc-2-(3-bromophenoxy)ethylamine Catalog No.:AA00HBIY CAS No.:1098107-26-6 MDL No.:MFCD24471090 MF:C13H18BrNO3 MW:316.1909
2-(3-BroMo-phenylsulfanyl)-ethanol Catalog No.:AA009LRQ CAS No.:1098108-96-3 MDL No.:MFCD17226068 MF:C8H9BrOS MW:233.1255	α,α-Diphenyl-2-pyridinemethanol Hydrochloride Catalog No.:AA007SDR CAS No.:109812-56-8 MDL No.:MFCD16293830 MF:C18H16ClNO MW:297.7787
1H-Pyrrole-3-carboxylicacid, 2-methyl-1,5-diphenyl- Catalog No.:AA007SDQ CAS No.:109812-64-8 MDL No.:MFCD01567220 MF:C18H15NO2 MW:277.3172	Octahydro-4h-pyrido[1,2-a]pyrazin-4-one Catalog No.:AA007SDP CAS No.:109814-50-8 MDL No.:MFCD09878611 MF:C8H14N2O MW:154.2096
2-Fluoro-6-methylpyridine-3-trifluoroborate potassium salt Catalog No.:AA00791Q CAS No.:1098173-30-8 MDL No.:MFCD09260453 MF:C6H5BF4KN MW:217.0135	1-(Trifluoromethyl)cyclobutan-1-ol Catalog No.:AA019YZR CAS No.:1098183-73-3 MDL No.:MFCD16067944 MF:C5H7F3O MW:140.1037
N-Boc-2-(1-trifluoromethylcyclopropyl)-dl-glycine Catalog No.:AA00HBJ0 CAS No.:1098188-08-9 MDL No.:MFCD11053529 MF:C11H16F3NO4 MW:283.2442	3,4-Dihydro-1h-2-benzothiopyran-4-ol Catalog No.:AA01A85E CAS No.:109819-33-2 MDL No.:MFCD02183485 MF:C9H10OS MW:166.2401
1,1-DIOXO-2,3,4,5-TETRAHYDRO-1H-116-BENZO[B]THIEPIN-5-OL Catalog No.:AA009OHN CAS No.:109821-96-7 MDL No.:MFCD09283647 MF:C10H12O3S MW:212.2655	CGS 9343B Catalog No.:AA008Y1C CAS No.:109826-27-9 MDL No.:MFCD04113002 MF:C30H32N4O6 MW:544.5983
1-(2,4-Difluorobenzyl)-5-oxopyrrolidine-3-carboxylic acid Catalog No.:AA00HBJ4 CAS No.:1098340-12-5 MDL No.:MFCD11655668 MF:C12H11F2NO3 MW:255.2174	Methyl 4-(trifluoromethyl)-1h-indole-2-carboxylate Catalog No.:AA0096H4 CAS No.:1098340-27-2 MDL No.:MFCD11655690 MF:C11H8F3NO2 MW:243.1819
2-(4-Bromo-2-fluorophenoxy)acetohydrazide Catalog No.:AA00HBJK CAS No.:1098341-68-4 MDL No.:MFCD11643343 MF:C8H8BrFN2O2 MW:263.0637	3-phenylthiophene-2-carboxamide Catalog No.:AA019VE6 CAS No.:1098342-63-2 MDL No.:MFCD11643464 MF:C11H9NOS MW:203.2603
1-Acetylpiperidine-3-carbohydrazide Catalog No.:AA007EJ5 CAS No.:1098343-82-8 MDL No.:MFCD11643574 MF:C8H15N3O2 MW:185.2236	3-(2-chloropropanamido)-N,N-diethylbenzamide Catalog No.:AA019KO1 CAS No.:1098347-63-7 MDL No.:MFCD12655062 MF:C14H19ClN2O2 MW:282.7659
N-[(4-bromophenyl)methyl]-2-chloro-N-methylpropanamide Catalog No.:AA019KPB CAS No.:1098347-69-3 MDL No.:MFCD11643915 MF:C11H13BrClNO MW:290.5840	4-Aminonicotinaldehyde Catalog No.:AA00375B CAS No.:42373-30-8 MDL No.:MFCD04038972 MF:C6H6N2O MW:122.1246
5-(Trifluoromethyl)-1h-indole-3-carboxaldehyde Catalog No.:AA0039ED CAS No.:468718-16-3 MDL No.:MFCD09954785 MF:C10H6F3NO MW:213.1559	5-Methylpyridine-2-carboxaldehyde Catalog No.:AA0037C2 CAS No.:4985-92-6 MDL No.:MFCD07367942 MF:C7H7NO MW:121.1366
5-Methylpyrazine-2-carbaldehyde Catalog No.:AA0037B3 CAS No.:50866-30-3 MDL No.:MFCD10697792 MF:C6H6N2O MW:122.1246	4-(Bromomethyl)benzaldehyde Catalog No.:AA0037BL CAS No.:51359-78-5 MDL No.:MFCD08271963 MF:C8H7BrO MW:199.0446
2-(3,4-Dimethoxyphenyl)acetaldehyde Catalog No.:AA0037IU CAS No.:5703-21-9 MDL No.:MFCD02261749 MF:C10H12O3 MW:180.2005	Isovaleraldehyde Catalog No.:AA0038JS CAS No.:590-86-3 MDL No.:MFCD00007014 MF:C5H10O MW:86.1323
2,3-dibromobenzaldehyde Catalog No.:AA0037A5 CAS No.:61563-26-6 MDL No.:MFCD11520724 MF:C7H4Br2O MW:263.9141	Pentafluorobenzaldehyde Catalog No.:AA0036US CAS No.:653-37-2 MDL No.:MFCD09032441 MF:C7HF5O MW:196.0743
Oxazole-2-carbaldehyde Catalog No.:AA0036SM CAS No.:65373-52-6 MDL No.:MFCD03412587 MF:C4H3NO2 MW:97.0721	4-(Chloromethyl)benzaldehyde Catalog No.:AA0038E7 CAS No.:73291-09-5 MDL No.:MFCD00191396 MF:C8H7ClO MW:154.5936