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109826-27-9,MFCD04113002
Catalog No.:AA008Y1C

109826-27-9 | CGS 9343B

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1mg
≥98%
in stock  
$53.00   $37.00
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5mg
≥98%
in stock  
$166.00   $116.00
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10mg
≥98%
in stock  
$279.00   $195.00
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25mg
≥98%
in stock  
$568.00   $397.00
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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA008Y1C
Chemical Name:
CGS 9343B
CAS Number:
109826-27-9
Molecular Formula:
C30H32N4O6
Molecular Weight:
544.5983
MDL Number:
MFCD04113002
SMILES:
O=c1[nH]c2c(n1C1CCN(CC1)CC1(C)OCc3c(n4c1ccc4)cccc3)cccc2.OC(=O)/C=C\C(=O)O
Properties
Computed Properties
 
Complexity:
814  
Covalently-Bonded Unit Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Pleiotropic roles of Ca(+2)/calmodulin-dependent pathways in regulating cadmium-induced toxicity in human osteoblast-like cell lines.

Journal: Toxicology letters 20161017

Title: NCAM-induced neurite outgrowth depends on binding of calmodulin to NCAM and on nuclear import of NCAM and fak fragments.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100811

Title: E6AP and calmodulin reciprocally regulate estrogen receptor stability.

Journal: The Journal of biological chemistry 20060127

Title: Calmodulin regulates the transcriptional activity of estrogen receptors. Selective inhibition of calmodulin function in subcellular compartments.

Journal: The Journal of biological chemistry 20030110

Title: Differential regulation by Ca(2+) of calmodulin- and PKC-dependent contractile pathways in cat lower oesophageal sphincter.

Journal: Autonomic & autacoid pharmacology 20030101

Title: IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin.

Journal: The Journal of biological chemistry 20020301

Title: Traveler's diarrhea.

Journal: Gastroenterology clinics of North America 20010901

Title: Calmodulin enhances the stability of the estrogen receptor.

Journal: The Journal of biological chemistry 20010518

Title: Il-1-related cytokine responses of nonimmune skin cells subjected to CEES exposure with and without potential vesicant antagonists.

Journal: In vitro & molecular toxicology 20000101

Title: Norman JA, et al. CGS 9343B, a novel, potent, and selective inhibitor of calmodulin activity. Mol Pharmacol. 1987 May;31(5):535-40.

Title: Neuhaus R, et al. Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor. Eur J Pharmacol. 1992 Jun 5;226(2):183-5.

Title: Li L, et al. Calmodulin regulates the transcriptional activity of estrogen receptors. Selective inhibition of calmodulin function in subcellular compartments. J Biol Chem. 2003 Jan 10;278(2):1195-200.

Title: Aikawa N, et al. Effects of KW-5617 (zaldaride maleate), a potent and selective calmodulin inhibitor, on secretory diarrhea and on gastrointestinal propulsion in rats. Jpn J Pharmacol. 1998 Feb;76(2):199-206.

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