Home Other Building Blocks 1005168-10-4
1005168-10-4,MFCD28502100
Catalog No.:AA019G91

1005168-10-4 | PAC-14028

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
1 week  
$336.00   $235.00
- +
5mg
95%
1 week  
$717.00   $502.00
- +
10mg
95%
1 week  
$1,003.00   $702.00
- +
50mg
95%
1 week  
$2,908.00   $2,035.00
- +
100mg
95%
1 week  
$4,050.00   $2,835.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA019G91
Chemical Name:
PAC-14028
CAS Number:
1005168-10-4
Molecular Formula:
C21H22F5N3O3S
Molecular Weight:
491.4747
MDL Number:
MFCD28502100
SMILES:
CCCc1nc(ccc1/C=C/C(=O)N[C@@H](c1cc(F)c(c(c1)F)NS(=O)(=O)C)C)C(F)(F)F
Properties
Computed Properties
 
Complexity:
775  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
XLogP3:
3.7  

Literature

Title: Oral and topical pharmacokinetic studies of a novel TRPV1 antagonist, PAC-14028 in rats and minipigs using liquid chromatography/tandem mass spectrometric method.

Journal: Journal of pharmaceutical and biomedical analysis 20120305

Title: Development of PAC-14028, a novel transient receptor potential vanilloid type 1 (TRPV1) channel antagonist as a new drug for refractory skin diseases.

Journal: Archives of pharmacal research 20120301

Title: Antipruritic effects of TRPV1 antagonist in murine atopic dermatitis and itching models.

Journal: The Journal of investigative dermatology 20110701

Title: TRPV1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery.

Journal: Journal of dermatological science 20110401

Title: Park YH, et al. Oral and topical pharmacokinetic studies of a novel TRPV1 antagonist, PAC-14028 in rats and minipigs using liquid chromatography/tandem mass spectrometric method. J Pharm Biomed Anal. 2012 Mar 5;61:8-14.

Title: Lim KM, et al. Development of PAC-14028, a novel transient receptor potential vanilloid type 1 (TRPV1) channel antagonist as a new drug for refractory skin diseases. Arch Pharm Res. 2012 Mar;35(3):393-6.

Title: Yun JW, et al. TRPV1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery. J Dermatol Sci. 2011 Apr;62(1):8-15.

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SDS
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