Home Other Building Blocks 1012104-68-5
1012104-68-5,MFCD22124483
Catalog No.:AA008TE8

1012104-68-5 | IRAK inhibitor 4

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5mg
99%
1 week  
$1,327.00   $929.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008TE8
Chemical Name:
IRAK inhibitor 4
CAS Number:
1012104-68-5
Molecular Formula:
C33H35F3N6O3
Molecular Weight:
620.6646
MDL Number:
MFCD22124483
SMILES:
CC(CCNC(=O)c1ccc2c(c1)nc(n2C1CCC(CC1)O)Nc1n[nH]c2c1cc(cc2)c1ccccc1OC(F)(F)F)C
Properties
Computed Properties
 
Complexity:
982  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
9  
XLogP3:
7.6  

Literature

Title: Marinho FV, et al. Lack of IL-1 Receptor-Associated Kinase-4 Leads to Defective Th1 Cell Responses and Renders Mice Susceptible to Mycobacterial Infection. J Immunol. 2016 Sep 1;197(5):1852-63.

Title: Talreja J, et al. Dual Inhibition of Rip2 and IRAK1/4 Regulates IL-1β and IL-6 in Sarcoidosis Alveolar Macrophages and Peripheral Blood Mononuclear Cells. J Immunol. 2016 Aug 15;197(4):1368-78.

Title: Li Z, et al. Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies. J Clin Invest. 2015 Mar 2;125(3):1081-97.

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