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1013101-36-4,MFCD18782794
Catalog No.:AA008TG7

1013101-36-4 | Pf-04691502

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥95%
in stock  
$128.00   $89.00
- +
10mg
≥95%
in stock  
$203.00   $142.00
- +
25mg
≥95%
in stock  
$476.00   $333.00
- +
50mg
≥95%
in stock  
$826.00   $578.00
- +
100mg
95%
in stock  
$976.00   $683.00
- +
500mg
95%
in stock  
$2,828.00   $1,980.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA008TG7
Chemical Name:
Pf-04691502
CAS Number:
1013101-36-4
Molecular Formula:
C22H27N5O4
Molecular Weight:
425.4809
MDL Number:
MFCD18782794
SMILES:
OCCO[C@@H]1CC[C@H](CC1)n1c(=O)c(cc2c1nc(N)nc2C)c1ccc(nc1)OC
Properties
Computed Properties
 
Complexity:
654  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
1.6  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ROCKCREEKADVISORSLLC-WO2018/112176,2018,A1Locationinpatent:Paragraph00394

Literature

Title: p53 Reactivation by PRIMA-1(Met) (APR-246) sensitises (V600E/K)BRAF melanoma to vemurafenib.

Journal: European journal of cancer (Oxford, England : 1990) 20160301

Title: PF-04691502 triggers cell cycle arrest, apoptosis and inhibits the angiogenesis in hepatocellular carcinoma cells.

Journal: Toxicology letters 20130704

Title: Combination of a MEK inhibitor at sub-MTD with a PI3K/mTOR inhibitor significantly suppresses growth of lung adenocarcinoma tumors in Kras(G12D-LSL) mice.

Journal: Cancer chemotherapy and pharmacology 20120801

Title: Highly Selective and Potent Thiophenes as PI3K Inhibitors with Oral Antitumor Activity.

Journal: ACS medicinal chemistry letters 20111110

Title: PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity.

Journal: Molecular cancer therapeutics 20111101

Title: Yuan J, et al. PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity. Mol Cancer Ther. 2011 Nov;10(11):2189-99.

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SDS
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Tags:1013101-36-4 Molecular Formula|1013101-36-4 MDL|1013101-36-4 SMILES|1013101-36-4 Pf-04691502
Catalog No.: AA008TG7
1013101-36-4,MFCD18782794
1013101-36-4 | Pf-04691502
Pack Size： 5mg
Purity： ≥95%
in stock
$128.00 $89.00
Pack Size： 10mg
Purity： ≥95%
in stock
$203.00 $142.00
Pack Size： 25mg
Purity： ≥95%
in stock
$476.00 $333.00
Pack Size： 50mg
Purity： ≥95%
in stock
$826.00 $578.00
Pack Size： 100mg
Purity： 95%
in stock
$976.00 $683.00
Pack Size： 500mg
Purity： 95%
in stock
$2,828.00 $1,980.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA008TG7
Chemical Name: Pf-04691502
CAS Number: 1013101-36-4
Molecular Formula: C22H27N5O4
Molecular Weight: 425.4809
MDL Number: MFCD18782794
SMILES: OCCO[C@@H]1CC[C@H](CC1)n1c(=O)c(cc2c1nc(N)nc2C)c1ccc(nc1)OC
Properties
Complexity: 654  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 31  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 6  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 1.6  
Downstream Synthesis Route
1013101-36-4    1472616-61-7    7693-46-1    2230548-24-8 

[1]CurrentPatentAssignee:ROCKCREEKADVISORSLLC-WO2018/112176,2018,A1Locationinpatent:Paragraph00394

Literature fold

Title: p53 Reactivation by PRIMA-1(Met) (APR-246) sensitises (V600E/K)BRAF melanoma to vemurafenib.

Journal: European journal of cancer (Oxford, England : 1990)20160301

Title: PF-04691502 triggers cell cycle arrest, apoptosis and inhibits the angiogenesis in hepatocellular carcinoma cells.

Journal: Toxicology letters20130704

Title: Combination of a MEK inhibitor at sub-MTD with a PI3K/mTOR inhibitor significantly suppresses growth of lung adenocarcinoma tumors in Kras(G12D-LSL) mice.

Journal: Cancer chemotherapy and pharmacology20120801

Title: Highly Selective and Potent Thiophenes as PI3K Inhibitors with Oral Antitumor Activity.

Journal: ACS medicinal chemistry letters20111110

Title: PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity.

Journal: Molecular cancer therapeutics20111101

Title: Yuan J, et al. PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity. Mol Cancer Ther. 2011 Nov;10(11):2189-99.

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