Home Amines 101328-85-2
101328-85-2,MFCD09032921
Catalog No.:AA00045O
101328-85-2 | (R)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
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250mg
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$114.00   $80.00
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1g
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$285.00   $200.00
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5g
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$953.00   $667.00
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  • Technical Information
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  • Technical Information
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Technical Information
Catalog Number:
AA00045O
Chemical Name:
(R)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
CAS Number:
101328-85-2
Molecular Formula:
C11H13N3O
Molecular Weight:
203.2404
MDL Number:
MFCD09032921
IUPAC Name:
(4R)-3-(4-aminophenyl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one
InChI:
InChI=1S/C11H13N3O/c1-7-6-10(15)13-14-11(7)8-2-4-9(12)5-3-8/h2-5,7H,6,12H2,1H3,(H,13,15)/t7-/m1/s1
InChI Key:
GDMRFHZLKNYRRO-SSDOTTSWSA-N
SMILES:
C[C@@H]1CC(=O)NN=C1c1ccc(cc1)N
Properties
Computed Properties
 
Complexity:
280  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
203.106g/mol
Formal Charge:
0
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
203.245g/mol
Monoisotopic Mass:
203.106g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
67.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.8  

Synonyms
 
((4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono)propanedinitrile 
dextrosimendan 
(R)-6-(4-Aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one 
OR-1855 
(r)-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2h)-pyridazinone 
OR 1855 
(R)-6-(4-Aminophenyl)-5-Methylpyridazin-3(2H)One 
3(2H)-Pyridazinone, 6-(4-aminophenyl)-4,5-dihydro-5-methyl-, (R)- 
(4R)-3-(4-Aminophenyl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one 
GDMRFHZLKNYRRO-SSDOTTSWSA-N 
OR1855 
SCHEMBL5681256 
Levosimendan 
3(2H)-Pyridazinone,6-(4-aminophenyl)-4,5-dihydro-5-methyl-, (5R)- 
CTK3J9693 
ZINC5141586 
AC-070 
BBL102299 
CA-590 
MFCD09032921 
STL556098 
AKOS015889656 
AJ-53322 
OR 1259 
BC218833 
CJ-12466 
DS-15085 
AB0070440 
RT-005676 
ST2408178 
TL8000087 
CS-0031338 
FT-0600355 
328A852 
OR 1855 
J-000368 
BRD-K79723649-001-01-3 
6-(4-Aminophenyl)-4,5-dihydro-5-mehtyl-3(2H)-pyridazinone 
(5R)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone 
(5R)-6-(4-aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one 
(R)-6-(4-aminophenyl)-5-methyl-4 5-dihydro-3(2H)-pyridazinone 
(R)-6-(4-aminophenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one 
(R)-6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone 
3(2H)-Pyridazinone, 6-(4-aminophenyl)-4,5-dihydro-5-methyl-, (5R)- 
CID10465484 
OR-1259 
UR6330000 
OR-1855 
Simadax 
simendan 
101328-85-2 
Literature

Title: [Retrospective descriptive study about the use of levosimendan in children undergoing surgical correction for congenital heart disease].

Journal: Revista espanola de anestesiologia y reanimacion 20121101

Title: Beneficial effects of levosimendan in infants with sepsis-associated cardiac dysfunction: report of 2 cases.

Journal: Pediatric emergency care 20121001

Title: Levosimendan infusion improves cardiac output but not blood pressure in a rodent model of severe metoprolol toxicity.

Journal: Human & experimental toxicology 20120901

Title: Levosimendan versus milrinone in neonates and infants after corrective open-heart surgery: a pilot study.

Journal: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20120901

Title: Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan.

Journal: International journal of cardiology 20120823

Title: Levosimendan versus an intra-aortic balloon pump in high-risk cardiac patients.

Journal: Journal of cardiothoracic and vascular anesthesia 20120801

Title: Effects of levosimendan on renal function in patients undergoing coronary artery surgery.

Journal: Journal of cardiothoracic and vascular anesthesia 20120801

Title: Levosimendan protection against kidney ischemia/reperfusion injuries in anesthetized pigs.

Journal: The Journal of pharmacology and experimental therapeutics 20120801

Title: Short-term levosimendan treatment protects rat testes against oxidative stress.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20120801

Title: Continuous levosimendan infusion for refractory cardiogenic shock complicating severe acute dichlorvos poisoning.

Journal: The American journal of the medical sciences 20120801

Title: Levosimendan infusion in newborns after corrective surgery for congenital heart disease: randomized controlled trial.

Journal: Intensive care medicine 20120701

Title: ST-segment elevation during levosimendan infusion.

Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 20120701

Title: Effects of levosimendan on TNF-alpha, BNP and MMP-1 in patients with heart failure with anemia.

Journal: Arquivos brasileiros de cardiologia 20120701

Title: Sepsis-associated takotsubo cardiomyopathy can be reversed with levosimendan.

Journal: The American journal of emergency medicine 20120601

Title: The effects of levosimendan vs dobutamine added to dopamine on liver functions assessed with noninvasive liver function monitoring in patients with septic shock.

Journal: Journal of critical care 20120601

Title: Effects of combined levosimendan and vasopressin on pulmonary function in porcine septic shock.

Journal: Inflammation 20120601

Title: A dose-response study of levosimendan in a porcine model of acute ischaemic heart failure.

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20120601

Title: The predictive value of QRS duration in response to levosimendan therapy in patients with decompensated heart failure.

Journal: Acta cardiologica 20120601

Title: Dobutamine-induced changes of left atrial two-dimensional deformation predict clinical and neurohumoral improvement after levosimendan treatment in patients with acutely decompensated chronic heart failure.

Journal: International journal of cardiology 20120517

Title: Levosimendan attenuates hypoxia-induced pulmonary hypertension in a porcine model.

Journal: Journal of cardiovascular pharmacology 20120501

Title: The antiangiogenic effects of levosimendan in a CAM assay.

Journal: Microvascular research 20120501

Title: The inhibitory in-vitro effect of high-dose levosimendan on platelet function may be mediated through its action as a phosphodiesterase inhibitor.

Journal: Coronary artery disease 20120501

Title: Novel strategies for the management of right ventricular failure with pulmonary hypertension.

Journal: Thorax 20120401

Title: Prolonged antispasmodic effect in isolated radial artery graft and pronounced platelet inhibition induced by the inodilator drug, levosimendan.

Journal: Basic & clinical pharmacology & toxicology 20120301

Title: Milrinone is preferred to levosimendan for mesenteric perfusion in hypoxia-reoxygenated newborn piglets treated with dopamine.

Journal: Pediatric research 20120301

Title: Neonatal blood pressure support: the use of inotropes, lusitropes, and other vasopressor agents.

Journal: Clinics in perinatology 20120301

Title: Levosimendan does not improve cardiac output or blood pressure in a rodent model of propranolol toxicity when administered using various dosing regimens.

Journal: International journal of toxicology 20120301

Title: Beta blocker therapy, decompensated heart failure, and inotropic interactions: current perspectives.

Journal: The Israel Medical Association journal : IMAJ 20120301

Title: [Hemodynamic and efficacies of domestic levosimendan versus dobutamine in patients with acute decompensated heart failure].

Journal: Zhonghua yi xue za zhi 20120227

Title: Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomized controlled studies.

Journal: Critical care medicine 20120201

Title: [The effect of levosimendan and dobutamine treatment on QT dispersion in patients with decompensated heart failure: a prospective study].

Journal: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20120201

Title: How can you mend a broken heart?

Journal: Critical care medicine 20120201

Title: [Comparison on efficacy and safety between domestic levosimendan versus dobutamine for patients with acute decompensated heart failure].

Journal: Zhonghua xin xue guan bing za zhi 20120201

Title: The calcium sensitizer levosimendan improves human diaphragm function.

Journal: American journal of respiratory and critical care medicine 20120101

Title: Levosimendan is superior to epinephrine in improving myocardial function after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats.

Journal: The Journal of thoracic and cardiovascular surgery 20120101

Title: Differential hemodynamic effects of levosimendan in a porcine model of neonatal hypoxia-reoxygenation.

Journal: Neonatology 20120101

Title: Levosimendan in two neonates with ischemic heart failure and pulmonary hypertension.

Journal: Neonatology 20120101

Title: Inotropic support in the NICU: ever more compounds in search of guidance? Commentary on J. Esch et al.: differential hemodynamic effects of levosimendan in a porcine model of neonatal hypoxia-reoxygenation (Neonatology 2012;101:192–200) and M.P. De Carolis et al.: levosimendan in two neonates with ischemic heart failure and pulmonary hypertension (Neonatology 2012;101:201–205).

Journal: Neonatology 20120101

Title: Preoperative treatment with levosimendan in candidates for mechanical circulatory support.

Journal: ASAIO journal (American Society for Artificial Internal Organs : 1992) 20120101

Title: A drug therapy for muscle dysfunction in respiratory disorders?

Journal: American journal of respiratory and critical care medicine 20120101

Title: Hyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts.

Journal: Cardiovascular diabetology 20120101

Title: Pharmacologic interventions to improve splanchnic oxygenation during ventilation with positive end-expiratory pressure.

Journal: Advances in experimental medicine and biology 20120101

Title: Levosimendan produces an additional clinical and hemodynamic benefit in patients with decompensated heart failure successfully submitted to a fluid removal treatment.

Journal: Congestive heart failure (Greenwich, Conn.) 20120101

Title: [Levosimendan reduces mortality in cardiac surgery: a systematic review and meta-analysis].

Journal: Revista espanola de anestesiologia y reanimacion 20120101

Title: Vasoactive compounds in the neonatal period.

Journal: Current medicinal chemistry 20120101

Title: [Possibilities of using levosimendan in patients with idiopathic pulmonary hypertension].

Journal: Terapevticheskii arkhiv 20120101

Title: Levosimendan versus an intra-aortic balloon pump in adult cardiac surgery patients with low cardiac output.

Journal: Journal of cardiothoracic and vascular anesthesia 20111201

Title: Prevention for pediatric low cardiac output syndrome: results from the European survey EuLoCOS-Paed.

Journal: Paediatric anaesthesia 20111201

Title: Effects of levosimendan on cardiac gene expression profile and post-infarct cardiac remodelling in diabetic Goto-Kakizaki rats.

Journal: Basic & clinical pharmacology & toxicology 20111101

Title: Pharmacologic therapy of heart failure in children: part of a special series on paediatric pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo Molteni.

Journal: Pharmacological research 20111101

Title: How mechanical circulatory support helps not to need it--new strategies in pediatric heart failure.

Journal: Artificial organs 20111101

Title: [Levosimendan treatment of severe acute congestive heart failure refractory to dobutamine/milrinone in children].

Journal: Vojnosanitetski pregled 20111101

Title: [Calcium mobilizers and calcium sensitizers].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20111101

Title: Levosimendan decreases intracranial pressure after hypothermic circulatory arrest in a porcine model.

Journal: Scandinavian cardiovascular journal : SCJ 20111001

Title: Levosimendan reduces heart failure after cardiac surgery: a prospective, randomized, placebo-controlled trial.

Journal: Critical care medicine 20111001

Title: Cost-effectiveness of levosimendan in patients with acute heart failure.

Journal: Journal of cardiovascular pharmacology 20111001

Title: Age-dependent effects of milrinone and levosimendan on ventricular function and haemodynamics in newborn and mature pigs.

Journal: Cardiology in the young 20111001

Title: Treatment of acute heart failure using levosimendan for a patient with dilated cardiomyopathy, chronic renal failure, and hypertension.

Journal: Pediatric cardiology 20111001

Title: Levosimendan--an inoprotective drug or much ado about nothing?

Journal: Critical care medicine 20111001

Title: Multiple signalling pathways underlie the protective effect of levosimendan in cardiac myocytes.

Journal: European journal of pharmacology 20110930

Title: Current pharmacologic management of pediatric heart failure in congenital heart disease.

Journal: Current vascular pharmacology 20110901

Title: Management of acute cardiac failure by intracoronary administration of levosimendan.

Journal: Journal of cardiovascular pharmacology 20110901

Title: Value of IGF-I levels in the evaluation of response to treatment with levosimendan in patients with severe heart failure.

Journal: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20110901

Title: Newer inotropes in pediatric heart failure.

Journal: Journal of cardiovascular pharmacology 20110801

Title: Levosimendan versus intra-aortic balloon pump in high-risk cardiac surgery patients.

Journal: Journal of cardiothoracic and vascular anesthesia 20110801

Title: Levosimendan restores the positive force-frequency relation in heart failure.

Journal: American journal of physiology. Heart and circulatory physiology 20110801

Title: No beneficial effects of levosimendan in acute porcine endotoxaemia.

Journal: Acta anaesthesiologica Scandinavica 20110801

Title: Levosimendan attenuates pulmonary vascular remodeling.

Journal: Intensive care medicine 20110801

Title: Is preoperative levosimendan indicated to treat normal left ventricular function and left ventricle outflow obstruction?

Journal: British journal of anaesthesia 20110801

Title: Effect of levosimendan and predictors of recovery in patients with peripartum cardiomyopathy, a randomized clinical trial.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20110701

Title: Levosimendan in congenital cardiac surgery: a randomized, double-blind clinical trial.

Journal: Journal of cardiothoracic and vascular anesthesia 20110601

Title: Combined exogenous and endogenous catecholamine release associated with Tako-Tsubo like syndrome in a patient with atrio-ventricular block undergoing pace-maker implantation.

Journal: Acute cardiac care 20110601

Title: Cardiovascular effects of the combination of levosimendan and valsartan in hypertensive Dahl/Rapp rats.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20110601

Title: Beneficial association of β-blocker therapy on recovery from severe acute heart failure treatment: data from the Survival of Patients With Acute Heart Failure in Need of Intravenous Inotropic Support trial.

Journal: Critical care medicine 20110501

Title: Acetylation status does not affect levosimendan's hemodynamic effects in heart failure patients.

Journal: Scandinavian cardiovascular journal : SCJ 20110401

Title: Intracoronary levosimendan prevents myocardial ischemic damages and activates survival signaling through ATP-sensitive potassium channel and nitric oxide.

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20110401

Title: Oral levosimendan improves filling pressure and systolic function during long-term treatment.

Journal: Scandinavian cardiovascular journal : SCJ 20110401

Title: Levosimendan: from coronary care to intensive care?

Journal: Intensive care medicine 20110401

Title: The effects of levosimendan and glibenclamide on circulatory and metabolic variables in a canine model of acute hypoxia.

Journal: Intensive care medicine 20110401

Title: Levosimendan vs. intra-aortic balloon pump in high-risk cardiac surgery.

Journal: Asian cardiovascular & thoracic annals 20110401

Title: Combined arginine vasopressin and levosimendan: a promising therapy for septic shock.

Journal: Critical care medicine 20110401

Title: Levosimendan preserves the contractile responsiveness of hypoxic human myocardium via mitochondrial K(ATP) channel and potential pERK 1/2 activation.

Journal: European journal of pharmacology 20110325

Title: Levosimendan improves pro/anti-inflammatory cytokines imbalance in male patients with advanced heart failure. A randomized, double-blind, placebo-controlled study.

Journal: International journal of cardiology 20110303

Title: Preoperative levosimendan infusion in combined aortic valve and coronary bypass surgery.

Journal: British journal of anaesthesia 20110301

Title: Mechanism of cardioprotective effect of adenocine and non-glycoside cardiotonic drugs during experimental chronic cardiac insufficiency.

Journal: Bulletin of experimental biology and medicine 20110301

Title: Weaning difficult-to-wean chronic obstructive pulmonary disease patients: a pilot study comparing initial hemodynamic effects of levosimendan and dobutamine.

Journal: Journal of critical care 20110201

Title: Levosimendan improves calcium sensitivity of diaphragm muscle fibres from a rat model of heart failure.

Journal: British journal of pharmacology 20110201

Title: Levosimendan reduces plasma cell-free DNA levels in patients with ischemic cardiomyopathy.

Journal: Journal of thrombosis and thrombolysis 20110201

Title: Levosimendan modulates programmed forms of cell death through K(ATP) channels and nitric oxide.

Journal: Journal of cardiovascular pharmacology 20110201

Title: Rotating inotrope therapy in a pediatric population with decompensated heart failure.

Journal: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20110101

Title: Acute effects of levosimendan on cerebral and systemic perfusion and oxygenation in newborns: an observational study.

Journal: Neonatology 20110101

Title: The protective effects of levosimendan on ischemia/reperfusion injury and apoptosis.

Journal: Recent patents on cardiovascular drug discovery 20110101

Title: Levosimendan: from basic science to clinical trials.

Journal: Recent patents on cardiovascular drug discovery 20110101

Title: Effects of levosimendan/furosemide infusion on plasma brain natriuretic peptide, echocardiographic parameters and cardiac output in end-stage heart failure patients.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20110101

Title: Levosimendan and mortality after coronary revascularisation: a meta-analysis of randomised controlled trials.

Journal: Critical care (London, England) 20110101

Title: Levosimendan inhibits release of reactive oxygen species in polymorphonuclear leukocytes in vitro and in patients with acute heart failure and septic shock: a prospective observational study.

Journal: Critical care (London, England) 20110101

Title: [Efficacy of levosimendan vs dopamine in patients with resistant cardiac failure].

Journal: Terapevticheskii arkhiv 20110101

Title: Levosimendan for primary graft failure after heart transplantation: a 3-year follow-up.

Journal: Transplantation proceedings 20110101

Title: In vivo and in vitro evidence for pleiotropic effects of levosimendan in the intensive care setting.

Journal: Critical care (London, England) 20110101

Title: Effects of levosimendan without loading dose on systolic and diastolic function in patients with end-stage heart failure.

Journal: Cardiology journal 20110101

Title: A structural and functional perspective into the mechanism of Ca2+-sensitizers that target the cardiac troponin complex.

Journal: Journal of molecular and cellular cardiology 20101201

Title: Cardiovascular pharmacology: an update.

Journal: Anesthesiology clinics 20101201

Title: Levosimendan: calcium sensitizer and inodilator.

Journal: Anesthesiology clinics 20101201

Title: Acute effects of levosimendan and dobutamine on QRS duration in patients with heart failure.

Journal: Arquivos brasileiros de cardiologia 20101201

Title: Exploring the ground and excited states structural diversity of levosimendan, a cardiovascular calcium sensitizer.

Journal: The journal of physical chemistry. B 20101118

Title: [Acute early postpartum cardiac failure associated with dilated cardiomyopathy: successful treatment with intra-aortic balloon counter-pulsation and levosimendan].

Journal: Annales francaises d'anesthesie et de reanimation 20101101

Title: Do levosimendan have an adverse effect on platelet function?

Journal: International journal of cardiology 20101029

Title: Effects of combined arginine vasopressin and levosimendan on organ function in ovine septic shock.

Journal: Critical care medicine 20101001

Title: Levosimendan improves cardiac function and survival in rats with angiotensin II-induced hypertensive heart failure.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20101001

Title: Vasopressin, levosimendan, and cardiovascular function in septic shock.

Journal: Critical care medicine 20101001

Title: [Treatment of heart failure patients with inotropic drugs: beyond traditional agents].

Journal: Giornale italiano di cardiologia (2006) 20101001

Title: Levosimendan as a rescue adjunct in amlodipine intoxication--a case report.

Journal: Middle East journal of anaesthesiology 20101001

Title: Levosimendan increases portal blood flow and attenuates intestinal intramucosal acidosis in experimental septic shock.

Journal: Shock (Augusta, Ga.) 20100901

Title: Direct cardiac effects of dobutamine, dopamine, epinephrine, and levosimendan in isolated septic rat hearts.

Journal: Shock (Augusta, Ga.) 20100901

Title: Absence of mitochondrial activation during levosimendan inotropic action in perfused paced guinea pig hearts as demonstrated by modular control analysis.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100901

Title: Acute effects of levosimendan on mitral regurgitation and diastolic function in patients with advanced chronic heart failure.

Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 20100901

Title: Acute heart failure with low cardiac output: can we develop a short-term inotropic agent that does not increase adverse events?

Journal: Current heart failure reports 20100901

Title: Short-term effect of levosimendan on free light chain kappa and lambda levels in patients with decompensated chronic heart failure.

Journal: Heart and vessels 20100901

Title: Levosimendan attenuates reperfusion injury in an isolated perfused rat heart model.

Journal: Journal of cardiothoracic and vascular anesthesia 20100801

Title: Relaxant effect of Levosimendan on human uterine contractility in vitro.

Journal: American journal of obstetrics and gynecology 20100801

Title: Levosimendan in acute decompensated heart failure: systematic review and meta-analysis.

Journal: Arquivos brasileiros de cardiologia 20100801

Title: [Therapeutic strategies in acute decompensated heart failure and cardiogenic shock].

Journal: Der Internist 20100801

Title: Correspondence concerning the article: is levosimendan better than dobutamine in acute heart failure in patients on beta blockade treatment? What is the evidence?

Journal: European journal of heart failure 20100801

Title: How to treat acute decompensated heart failure in the 'beta-blocker era'?

Journal: European journal of heart failure 20100801

Title: Efficacy of levosimendan in patients with chronic heart failure: Does rhythm matter?

Journal: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20100801

Title: Levosimendan in the treatment of cardiogenic shock.

Journal: Minerva cardioangiologica 20100801

Title: Can pulmonary artery hypertension be attributed to levosimendan? A problematic based on a patient's case.

Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 20100701

Title: Mechanical support for postcardiotomy cardiogenic shock: has progress been made?

Journal: Journal of cardiac surgery 20100701

Title: Levosimendan and pulmonary hypertension.

Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 20100701

Title: Levosimendan - a calcium sensitising agent with potential anti-arrhythmic properties.

Journal: International journal of clinical practice 20100701

Title: Levosimendan up-regulates transforming growth factor-beta and smad signaling in the aorta in the early stage of sepsis.

Journal: Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES 20100701

Title: [Levosimendan and dobutamine have a similar profile for potential risk for cardiac arrhythmias during 24-hour infusion in patients with acute decompensated heart failure].

Journal: Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20100701

Title: Levosimendan and platelet function.

Journal: Journal of cardiothoracic and vascular anesthesia 20100601

Title: Comparative hemodynamic effects of levosimendan alone and in conjunction with 4-aminopyridine or calcium chloride in a rodent model of severe verapamil poisoning.

Journal: Journal of medical toxicology : official journal of the American College of Medical Toxicology 20100601

Title: [Efficacy and safety of intravenous levosimendan compared with dobutamine in decompensated heart failure].

Journal: Zhonghua xin xue guan bing za zhi 20100601

Title: Importance of levosimendan on right ventricular function in patients with biventricular heart failure.

Journal: Critical care medicine 20100501

Title: In response to Leppikangas H, et al, Levosimendan as a rescue drug in experimental propranolol-induced myocardial depression: a randomized study.

Journal: Annals of emergency medicine 20100501

Title: Levosimendan in cardiac failure after subarachnoid hemorrhage.

Journal: The Journal of trauma 20100501

Title: Hospital costs for treatment of acute heart failure: economic analysis of the REVIVE II study.

Journal: The European journal of health economics : HEPAC : health economics in prevention and care 20100401

Title: Levosimendan reduces mortality in critically ill patients. A meta-analysis of randomized controlled studies.

Journal: Minerva anestesiologica 20100401

Title: Is levosimendan better than dobutamine in acute heart failure in patients on beta-blockade treatment? What is the evidence?

Journal: European journal of heart failure 20100401

Title: Intravenous levosimendan vs. dobutamine in acute decompensated heart failure patients on beta-blockers.

Journal: European journal of heart failure 20100401

Title: A promising new inotrope: levosimendan.

Journal: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20100401

Title: Postconditioning with levosimendan reduces the infarct size involving the PI3K pathway and KATP-channel activation but is independent of PDE-III inhibition.

Journal: Basic research in cardiology 20100301

Title: Levosimedan improves hemodynamics functions without sympathetic activation in severe heart failure patients: direct evidence from sympathetic neural recording.

Journal: Acute cardiac care 20100301

Title: Oxygen-wasting effect of inotropy: is there a need for a new evaluation? An experimental large-animal study using dobutamine and levosimendan.

Journal: Circulation. Heart failure 20100301

Title: Concomitant levosimendan and esmolol infusion in ischaemic cardiogenic shock.

Journal: British journal of anaesthesia 20100301

Title: Plasma B-type natriuretic peptide reduction predicts long-term response to levosimendan therapy in acutely decompensated chronic heart failure.

Journal: International journal of cardiology 20100218

Title: Levosimendan for the treatment of acute severe heart failure: a meta-analysis of randomised controlled trials.

Journal: International journal of cardiology 20100204

Title: Levosimendan and cardiac surgery.

Journal: Journal of cardiothoracic and vascular anesthesia 20100201

Title: Calcium sensitisation impairs diastolic relaxation in post-ischaemic myocardium: implications for the use of Ca(2+) sensitising inotropes after cardiac surgery.

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20100201

Title: Reducing mortality in cardiac surgery with levosimendan: a meta-analysis of randomized controlled trials.

Journal: Journal of cardiothoracic and vascular anesthesia 20100201

Title: Ca2+ sensitizers: An emerging class of agents for counterbalancing weakness in skeletal muscle diseases?

Journal: Neuromuscular disorders : NMD 20100201

Title: Rationale and design of the multicentre randomized trial investigating the efficacy and safety of pulsed infusions of levosimendan in outpatients with advanced heart failure (LevoRep study).

Journal: European journal of heart failure 20100201

Title: Modulation of programmed forms of cell death by intracoronary levosimendan during regional myocardial ischemia in anesthetized pigs.

Journal: Cardiovascular drugs and therapy 20100201

Title: Levosimendan cardioprotection in acutely beta-1 adrenergic receptor blocked open chest pigs.

Journal: Acta anaesthesiologica Scandinavica 20100101

Title: Initial experience with levosimendan infusion for preoperative management of hypoplastic left heart syndrome.

Journal: Pediatric cardiology 20100101

Title: Levosimendan in acute and chronic right ventricle failure.

Journal: Acta anaesthesiologica Scandinavica 20100101

Title: Efficacy of levosimendan in Takotsubo-related cardiogenic shock.

Journal: Acta anaesthesiologica Scandinavica 20100101

Title: Superiority of levosimendan over dobutamine in right ventricle failure.

Journal: Critical care medicine 20100101

Title: The effect of levosimendan on bupivacaine-induced severe myocardial depression in anesthetized pigs.

Journal: Regional anesthesia and pain medicine 20100101

Title: Levosimendan and quality of life.

Journal: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20100101

Title: Intravenous levosimendan-norepinephrine combination during off-pump coronary artery bypass grafting in a hemodialysis patient with severe myocardial dysfunction.

Journal: Journal of cardiothoracic surgery 20100101

Title: Effect of levosimendan in experimental verapamil-induced myocardial depression.

Journal: Scandinavian journal of trauma, resuscitation and emergency medicine 20100101

Title: Beneficial effects of levosimendan on cerebral vasospasm induced by subarachnoid haemorrhage: an experimental study.

Journal: Brain injury 20100101

Title: [Use of levosimendan in cardiosurgical patients with chronic heart insufficiency].

Journal: Anesteziologiia i reanimatologiia 20100101

Title: [Study evaluating the impact of a combination of inotropic support and heart rate control on prognosis and stabilization rate in patients with decompensated chronic heart failure (LEGION)].

Journal: Terapevticheskii arkhiv 20100101

Title: Levosimendan neither improves nor worsens mortality in patients with cardiogenic shock due to ST-elevation myocardial infarction.

Journal: Vascular health and risk management 20100101

Title: Neuroprotective properties of levosimendan in an in vitro model of traumatic brain injury.

Journal: BMC neurology 20100101

Title: Levosimendan for resuscitating the microcirculation in patients with septic shock: a randomized controlled study.

Journal: Critical care (London, England) 20100101

Title: [Intensive care for newborns and babies of the first year of life with acute heart failure after cardiosurgical interventions].

Journal: Anesteziologiia i reanimatologiia 20100101

Title: [Inotropic agents for treatment of acute heart failure syndromes in intensive care].

Journal: Revue medicale suisse 20091209

Title: Levosimendan: from basic science to clinical practice.

Journal: Heart failure reviews 20091201

Title: Prophylactic treatment with levosimendan: a retrospective matched-control study of patients with reduced left ventricular function.

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20091201

Title: Right ventricular function in myocardial infarction complicated by cardiogenic shock: Improvement with levosimendan.

Journal: Critical care medicine 20091201

Title: Levosimendan as a rescue drug in experimental propranolol-induced myocardial depression: a randomized study.

Journal: Annals of emergency medicine 20091201

Title: Agents with inotropic properties for the management of acute heart failure syndromes. Traditional agents and beyond.

Journal: Heart failure reviews 20091201

Title: Do it right?

Journal: Critical care medicine 20091201

Title: Influence of temperature on the positive inotropic effect of levosimendan, dobutamine and milrinone.

Journal: European journal of anaesthesiology 20091101

Title: Inotropic support during experimental endotoxemic shock: part I. The effects of levosimendan on splanchnic perfusion.

Journal: Anesthesia and analgesia 20091101

Title: Inotropic support during experimental endotoxemic shock: part II. A comparison of levosimendan with dobutamine.

Journal: Anesthesia and analgesia 20091101

Title: Levosimendan in early sepsis: when good ideas give poor results.

Journal: Anesthesia and analgesia 20091101

Title: Levosimendan may prevent postoperative atrial fibrillation through anti-inflammatory and antioxidant modulation.

Journal: Journal of cardiothoracic and vascular anesthesia 20091001

Title: Oral levosimendan prevents postinfarct heart failure and cardiac remodeling in diabetic Goto-Kakizaki rats.

Journal: Journal of hypertension 20091001

Title: Levosimendan in viral myocarditis: not only an inodilator but also a cardioprotector?

Journal: European journal of clinical investigation 20091001

Title: Effects of levosimendan in experimental acute coxsackievirus myocarditis.

Journal: European journal of clinical investigation 20091001

Title: Effects of levosimendan versus dobutamine on left atrial function in decompensated heart failure.

Journal: The Canadian journal of cardiology 20091001

Title: Comparison of the effects of levosimendan and papaverine on human internal mammary artery and saphenous vein.

Journal: Cardiovascular drugs and therapy 20091001

Title: [Effect of levosimendan on B-type natriuretic peptide levels in patients with advanced heart failure: a meta-analysis].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20091001

Title: Reducing perioperative myocardial infarction with anesthetic drugs and techniques.

Journal: Current drug targets 20090901

Title: Levosimendan vs dobutamine in septic shock.

Journal: Journal of critical care 20090901

Title: Levosimendan is superior to enoximone in refractory cardiogenic shock complicating acute myocardial infarction.

Journal: Critical care medicine 20090901

Title: Levosimendan for calcium channel blocker poisoning in humans.

Journal: Anesthesia and analgesia 20090901

Title: Letter regarding levosimendan in a rat model of severe verapamil poisoning.

Journal: Journal of medical toxicology : official journal of the American College of Medical Toxicology 20090901

Title: Reducing the risk of major elective non-cardiac surgery: is there a role for levosimendan in the preoperative optimization of cardiac function?

Journal: Current drug targets 20090901

Title: The use of Levosimendan for myocardiopathy due to acute Chagas' disease.

Journal: International journal of cardiology 20090814

Title: Levosimendan reduces cardiac troponin release after cardiac surgery: a meta-analysis of randomized controlled studies.

Journal: Journal of cardiothoracic and vascular anesthesia 20090801

Title: Effects of intravenous and inhaled levosimendan in severe rodent sepsis.

Journal: Intensive care medicine 20090801

Title: Anti-ischemic effects of inotropic agents in experimental right ventricular infarction.

Journal: Acta anaesthesiologica Scandinavica 20090801

Title: Levosimendan in perioperative and critical care patients.

Journal: Current opinion in anaesthesiology 20090801

Title: Myocarditis.

Journal: The New England journal of medicine 20090723

Title: Levosimendan.

Journal: Indian pediatrics 20090701

Title: The influence of beta-blockade on the hemodynamic effects of levosimendan in elderly (>or= 70 years) patients with acutely decompensated systolic heart failure.

Journal: International journal of clinical pharmacology and therapeutics 20090701

Title: Combination pharmacotherapy in the treatment of experimental cardiac arrest.

Journal: The American journal of emergency medicine 20090701

Title: [Inotrope therapy in acute heart failure: a critical review of clinical and scientific evidence for levosimendan in the context of traditional treatment].

Journal: Giornale italiano di cardiologia (2006) 20090701

Title: Lowered B-type natriuretic peptide in response to levosimendan or dobutamine treatment is associated with improved survival in patients with severe acutely decompensated heart failure.

Journal: Journal of the American College of Cardiology 20090623

Title: First experiences with intraoperative Levosimendan in pediatric cardiac surgery.

Journal: European journal of pediatrics 20090601

Title: Levosimendan is not effective in reducing pulmonary pressures in patients with idiopathic pulmonary arterial hypertension: report of two cases.

Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 20090601

Title: Clinical outcome benefits of pretreatment with levosimendan.

Journal: British journal of anaesthesia 20090601

Title: Timing of levosimendan in cardiac surgery.

Journal: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20090601

Title: Use of levosimendan for treatment of cardiogenic shock associated with electrical storm.

Journal: Annals of internal medicine 20090519

Title: Levosimendan: a new therapeutic option in the treatment of primary graft dysfunction after heart transplantation.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20090501

Title: The management of severe primary graft failure after cardiac transplantation.

Journal: Journal of cardiothoracic and vascular anesthesia 20090401

Title: Effects of levosimendan on the energy balance: preclinical and clinical evidence.

Journal: Journal of cardiovascular pharmacology 20090401

Title: Comparison of ischemic side effects of levosimendan and dobutamine with integrated backscatter analysis.

Journal: Clinical cardiology 20090401

Title: [Levosimendan, a new inotropic drug: experience in children with acute heart failure].

Journal: Archivos argentinos de pediatria 20090401

Title: Levosimendan vs. dobutamine: outcomes for acute heart failure patients on beta-blockers in SURVIVE.

Journal: European journal of heart failure 20090301

Title: Levosimendan does not improve survival time in a rat model of verapamil toxicity.

Journal: Journal of medical toxicology : official journal of the American College of Medical Toxicology 20090301

Title: Treatment of serious calcium channel blocker overdose with levosimendan, a calcium sensitizer.

Journal: Anesthesia and analgesia 20090301

Title: Evaluation of 30-day mortality of levosimendan versus enoximone.

Journal: Critical care medicine 20090301

Title: Levosimendan or enoximone in refractory cardiogenic shock?

Journal: Critical care medicine 20090301

Title: Weaning failure from mechanical ventilation due to dilated cardiomyopathy: successful use of levosimendan.

Journal: Acta anaesthesiologica Scandinavica 20090301

Title: Levosimendan pre-treatment improves outcomes in patients undergoing coronary artery bypass graft surgery.

Journal: British journal of anaesthesia 20090201

Title: Levosimendan facilitates weaning from cardiopulmonary bypass in patients undergoing coronary artery bypass grafting with impaired left ventricular function.

Journal: The Annals of thoracic surgery 20090201

Title: Intermittent inotropic infusions combined with prophylactic oral amiodarone for patients with decompensated end-stage heart failure.

Journal: Journal of cardiovascular pharmacology 20090201

Title: Levosimendan in heart failure after surgical repair of cardiac rupture.

Journal: Minerva cardioangiologica 20090201

Title: Relationship between the pharmacokinetics of levosimendan and its effects on cardiovascular system.

Journal: Current drug metabolism 20090201

Title: Effectiveness and safety of levosimendan in clinical practice.

Journal: Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20090201

Title: Repetitive dosing of intravenous levosimendan improves pulmonary hemodynamics in patients with pulmonary hypertension: results of a pilot study.

Journal: Journal of clinical pharmacology 20090101

Title: Levosimendan enhances force generation of diaphragm muscle from patients with chronic obstructive pulmonary disease.

Journal: American journal of respiratory and critical care medicine 20090101

Title: Effects of levosimendan and dobutamine on experimental acute lung injury in rats.

Journal: Acta histochemica 20090101

Title: Rescuing a failing heart: putting on the squeeze.

Journal: Nature medicine 20090101

Title: Levosimendan for heart-operated patients: what is the state of the art?

Journal: Recent patents on cardiovascular drug discovery 20090101

Title: Levosimendan induces NO production through p38 MAPK, ERK and Akt in porcine coronary endothelial cells: role for mitochondrial K(ATP) channel.

Journal: British journal of pharmacology 20090101

Title: Comparative effects of levosimendan and dobutamine on right ventricular function in patients with biventricular heart failure.

Journal: Heart and vessels 20090101

Title: Hemodynamic effects of levosimendan in acute myocardial infarction complicated by cardiogenic shock and high systemic vascular resistance.

Journal: Acute cardiac care 20090101

Title: Use of levosimendan in patients with ischemic heart disease following mechanical reperfusion.

Journal: Surgery today 20090101

Title: Role of potassium channels in the relaxant effect of levosimendan in guinea pig tracheal preparations.

Journal: Pharmacological reports : PR 20090101

Title: Prophylactic preoperative levosimendan administration in heart failure patients undergoing elective non-cardiac surgery: a preliminary report.

Journal: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20090101

Title: Assessment of quality of life using three activity questionnaires in heart failure patients after monthly, intermittent administration of levosimendan during a six-month period.

Journal: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20090101

Title: [Use of levosimendan in acute heart failure and its effect on renal function].

Journal: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20090101

Title: [Impact of preoperative levosimendan therapy on the volemic status and vascular tone of patients with chronic heart failure during anesthesia].

Journal: Anesteziologiia i reanimatologiia 20090101

Title: Oral levosimendan in patients with severe chronic heart failure --the PERSIST study.

Journal: European journal of heart failure 20081201

Title: Cardiac Ca2+ signaling and Ca2+ sensitizers.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20081201

Title: [Is everything which is feasible also sensible?: coronary artery bypass grafting in conscious patients -- a procedure with a perspective?].

Journal: Der Anaesthesist 20081201

Title: Effects of levosimendan on left atrial functions in patients with ischemic heart failure.

Journal: Clinical cardiology 20081201

Title: Levosimendan and calcium sensitization of the contractile proteins in cardiac muscle: impact on heart failure.

Journal: Journal of cardiovascular pharmacology and therapeutics 20081201

Title: Levosimendan for bridging in a pediatric patient with Alström syndrome awaiting heart-lung transplantation.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20081101

Title: Management of heart failure: a brief review and selected update.

Journal: Cardiology clinics 20081101

Title: Usefulness of dobutamine-induced changes of the two-dimensional longitudinal deformation predict clinical and neurohumoral improvement in men after levosimendan treatment in acutely decompensated chronic heart failure.

Journal: The American journal of cardiology 20081101

Title: [Superiority of levosimendan to dobutamine in postoperative low cardiac output syndrome: is it due to previous beta-blocker treatment?].

Journal: Revista espanola de cardiologia 20081101

Title: Effects of levo- and dextrosimendan on NF-kappaB-mediated transcription, iNOS expression and NO production in response to inflammatory stimuli.

Journal: British journal of pharmacology 20081101

Title: Tricuspid valve replacement and levosimendan.

Journal: General thoracic and cardiovascular surgery 20081101

Title: Levosimendan and severe pulmonary hypertension during open heart surgery.

Journal: General thoracic and cardiovascular surgery 20081101

Title: Inotropic, vasodilating and preconditioning actions of levosimendan in the heart.

Journal: The Thoracic and cardiovascular surgeon 20081001

Title: Levosimendan in aortic valve surgery: cardiac performance and recovery.

Journal: Journal of cardiothoracic and vascular anesthesia 20081001

Title: A randomized trial evaluating different modalities of levosimendan administration in cardiac surgery patients with myocardial dysfunction.

Journal: Journal of cardiothoracic and vascular anesthesia 20081001

Title: [Determination of levosimendan and its main metabolites in human plasma with HPLC-MS/MS method].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20081001

Title: Use of levosimendan for cardiogenic shock in a patient with the apical ballooning syndrome.

Journal: Annals of internal medicine 20080902

Title: Strain rate analysis and levosimendan improve detection of myocardial viability by dobutamine echocardiography in patients with post-infarction left ventricular dysfunction: a pilot study.

Journal: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20080901

Title: The case for levosimendan.

Journal: Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20080901

Title: Prospective observational study of levosimendan and weaning of difficult-to-wean ventilator dependent intensive care patients.

Journal: Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20080901

Title: Effects of levosimendan versus dobutamine on left ventricular diastolic function in patients with cardiogenic shock after primary angioplasty.

Journal: International journal of cardiology 20080818

Title: Rescue peri-operative management of the patient with giant electrical storm and severe left ventricular dysfunction: support by levosimendan and intraaortic balloon counterpulsation.

Journal: Interactive cardiovascular and thoracic surgery 20080801

Title: Levosimendan infusion improves haemodynamics in elderly heart failure patients undergoing urgent hip fracture repair.

Journal: European journal of anaesthesiology 20080801

Title: Natriuretic peptide-guided levosimendan therapy for heart failure: a promising new approach.

Journal: International journal of cardiology 20080801

Title: The prolonged lowering effect of levosimendan on brain natriuretic peptide levels in patients with decompansated heart failure: clinical implications.

Journal: International journal of cardiology 20080801

Title: Ca2+ sensitizer superior to catecholamine during myocardial stunning?

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20080801

Title: Novel biologic mechanisms of levosimendan and its effect on the failing heart.

Journal: Expert opinion on investigational drugs 20080801

Title: Levosimendan is superior to enoximone in refractory cardiogenic shock complicating acute myocardial infarction.

Journal: Critical care medicine 20080801

Title: Levosimendan in cardiogenic shock: better than enoximone!

Journal: Critical care medicine 20080801

Title: BELIEF: believe it or not.

Journal: Arquivos brasileiros de cardiologia 20080801

Title: Levosimendan in patients with decompensated heart failure.

Journal: Arquivos brasileiros de cardiologia 20080801

Title: The hemodynamic and pharmacokinetic interactions between chronic use of oral levosimendan and digoxin in patients with NYHA Classes II-III heart failure.

Journal: International journal of clinical pharmacology and therapeutics 20080801

Title: Both levosimendan and dobutamine treatments result in significant reduction of NT-proBNP levels, but levosimendan has better and prolonged neurohormonal effects than dobutamine.

Journal: International journal of cardiology 20080721

Title: Defining the binding site of levosimendan and its analogues in a regulatory cardiac troponin C-troponin I complex.

Journal: Biochemistry 20080715

Title: Effects of levosimendan versus dobutamine on long-term survival of patients with cardiogenic shock after primary coronary angioplasty.

Journal: International journal of cardiology 20080704

Title: Effects of levosimendan on indocyanine green plasma disappearance rate and the gastric mucosal-arterial pCO2 gradient in abdominal aortic aneurysm surgery.

Journal: Acta anaesthesiologica Scandinavica 20080701

Title: Safety and effectiveness of levosimendan in patients with predominant right heart failure.

Journal: Herz 20080701

Title: Protective effects of levosimendan and iloprost on lung injury induced by limb ischemia-reperfusion: a rabbit model.

Journal: The Journal of surgical research 20080601

Title: Repeated infusions of levosimendan: well tolerated and improves functional capacity in decompensated heart failure - a single-centre experience.

Journal: Heart, lung & circulation 20080601

Title: Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock.

Journal: Critical care medicine 20080601

Title: Inhaled levosimendan reduces mortality and release of proinflammatory mediators in a rat model of experimental ventilator-induced lung injury.

Journal: Critical care medicine 20080601

Title: Inotropic agents improve the peripheral microcirculation of patients with end-stage chronic heart failure.

Journal: Journal of cardiac failure 20080601

Title: Levo is in the air: take a deep breath!

Journal: Critical care medicine 20080601

Title: Calcium sensitizing in sepsis: is levosimendan on the right path?

Journal: Critical care medicine 20080601

Title: Perioperative cardiac evaluation: the importance of cardiac failure management.

Journal: Southern medical journal 20080601

Title: A role for the RISK pathway and K(ATP) channels in pre- and post-conditioning induced by levosimendan in the isolated guinea pig heart.

Journal: British journal of pharmacology 20080501

Title: [Paediatric use of levosimendan in septic shock].

Journal: Anales de pediatria (Barcelona, Spain : 2003) 20080501

Title: [Levosimendan and low cardiac output syndrome. Does mortality really decrease? ].

Journal: Revista espanola de cardiologia 20080501

Title: [The calcium sensitizer levosimendan gives superior results to dobutamine in postoperative low cardiac output syndrome].

Journal: Revista espanola de cardiologia 20080501

Title: [Levosimendan for postoperative ventricular dysfunction following heart transplantation].

Journal: Revista espanola de cardiologia 20080501

Title: [Is there a role for levosimendan in hospital emergency departments?].

Journal: Revista espanola de cardiologia 20080501

Title: Primary graft failure and Ca2+ sensitizers after heart transplantation.

Journal: Transplantation proceedings 20080501

Title: The influence of levosimendan and iloprost on renal ischemia-reperfusion: an experimental study.

Journal: Interactive cardiovascular and thoracic surgery 20080401

Title: Evoked changes in cardiovascular function in rats by infusion of levosimendan, OR-1896 [(R)-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide], OR-1855 [(R)-6-(4-aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one], dobutamine, and milrinone: comparative effects on peripheral resistance, cardiac output, dP/dt, pulse rate, and blood pressure.

Journal: The Journal of pharmacology and experimental therapeutics 20080401

Title: Orally available levosimendan dose-related positive inotropic and lusitropic effect in conscious chronically instrumented normal and heart failure dogs.

Journal: The Journal of pharmacology and experimental therapeutics 20080401

Title: Pharmacokinetics of intravenous levosimendan and its metabolites in subjects with hepatic impairment.

Journal: Journal of clinical pharmacology 20080401

Title: Preoperative levosimendan in heart failure patients undergoing noncardiac surgery.

Journal: The Netherlands journal of medicine 20080401

Title: Role of levosimendan in sepsis and septic shock.

Journal: Current opinion in anaesthesiology 20080401

Title: Improvement in Doppler alternans in patients with severe heart failure: Levosimendan versus dobutamin.

Journal: International journal of cardiology 20080328

Title: Effects of levosimendan on flow-mediated vasodilation and soluble adhesion molecules in patients with advanced chronic heart failure.

Journal: Atherosclerosis 20080301

Title: Levosimendan in patients with acute myocardial ischaemia undergoing emergency surgical revascularization.

Journal: European journal of anaesthesiology 20080301

Title: Levosimendan and ventriculo-arterial coupling.

Journal: Acta anaesthesiologica Scandinavica 20080301

Title: Inoprotection review.

Journal: Anaesthesia and intensive care 20080301

Title: Can we believe in levosimendan?

Journal: Arquivos brasileiros de cardiologia 20080301

Title: Levosimendan in decompensated heart failure patients: efficacy in a Brazilian cohort. Results of the BELIEF study.

Journal: Arquivos brasileiros de cardiologia 20080301

Title: Levosimendan use in several scenarios of acute heart failure.

Journal: Arquivos brasileiros de cardiologia 20080301

Title: Effects of levosimendan on left ventricular relaxation and early filling at maintained preload and afterload conditions after aortic valve replacement for aortic stenosis.

Journal: Circulation 20080226

Title: Effect of levosimendan on right ventricular systolic and diastolic functions in patients with ischaemic heart failure.

Journal: International journal of clinical practice 20080201

Title: Levosimendan: current status and future prospects.

Journal: Current opinion in anaesthesiology 20080201

Title: Metabolism of OR-1896, a metabolite of levosimendan, in rats and humans.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20080201

Title: Management of pulmonary hypertension in the intensive care unit.

Journal: Critical care medicine 20080201

Title: Overview of emerging pharmacologic agents for acute heart failure syndromes.

Journal: European journal of heart failure 20080201

Title: Peripartum cardiomyopathy: a new successful setting for levosimendan.

Journal: International journal of cardiology 20080124

Title: Effect of levosimendan on E/E' ratio in patients with ischemic heart failure.

Journal: International journal of cardiology 20080111

Title: Levosimendan has an inhibitory effect on platelet function.

Journal: American journal of hematology 20080101

Title: Myocardial stunning following no flow ischaemia is diminished by levosimendan or cariporide, without benefits of combined administration.

Journal: Resuscitation 20080101

Title: Effects of levosimendan on myocardial ischaemia-reperfusion injury.

Journal: European journal of anaesthesiology 20080101

Title: Early and sustained haemodynamic improvement with levosimendan compared to intraaortic balloon counterpulsation (IABP) in cardiogenic shock complicating acute myocardial infarction.

Journal: Acute cardiac care 20080101

Title: Treatment of experimental verapamil poisoning with levosimendan utilizing a rodent model of drug toxicity.

Journal: Clinical toxicology (Philadelphia, Pa.) 20080101

Title: Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O2 consumption in dogs.

Journal: American journal of physiology. Heart and circulatory physiology 20080101

Title: Inotropes in the management of acute heart failure.

Journal: Critical care medicine 20080101

Title: New pharmacologic therapies for acute heart failure.

Journal: Critical care medicine 20080101

Title: Levosimendan effect on spinal cord ischemia-reperfusion injury following aortic clamping.

Journal: Journal of cardiac surgery 20080101

Title: Protection of the spinal cord from ischemia: comparative effects of levosimendan and iloprost.

Journal: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20080101

Title: Levosimendan for ischemic preconditioning in thoracic aortic aneurysm repair.

Journal: Journal of cardiac surgery 20080101

Title: The use of more than one inotrope in acute heart failure is associated with increased mortality: a multi-centre observational study.

Journal: Acute cardiac care 20080101

Title: Levosimendan versus dobutamine in heart failure patients treated chronically with carvedilol.

Journal: Cardiovascular therapeutics 20080101

Title: Levosimendan as rescue therapy in severe cardiogenic shock after ST-elevation myocardial infarction.

Journal: Acute cardiac care 20080101

Title: Design, synthesis and structure-activity relationship studies of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives as cardiotonic agents.

Journal: Arzneimittel-Forschung 20080101

Title: The costs of treating acute heart failure: an economic analysis of the SURVIVE trial.

Journal: Journal of medical economics 20080101

Title: Effects of Levosimendan on circulating markers of oxidative and nitrosative stress in patients with advanced heart failure.

Journal: Atherosclerosis 20071201

Title: Pharmacokinetics and excretion balance of OR-1896, a pharmacologically active metabolite of levosimendan, in healthy men.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20071201

Title: Hemodynamic improvement following levosimendan treatment in patients with acute myocardial infarction and cardiogenic shock.

Journal: Critical care medicine 20071201

Title: Levosimendan improves renal function in patients with acute decompensated heart failure: comparison with dobutamine.

Journal: Cardiovascular drugs and therapy 20071201

Title: Levosimendan improves renal function in acute decompensated heart failure: cause and clinical application. Editorial to: 'Levosimendan improves renal function in patients with acute decompensated heart failure: comparison with dobutamine by Yilmaz et al.'.

Journal: Cardiovascular drugs and therapy 20071201

Title: [New pharmacological treatment approaches to cardiogenic shock].

Journal: Der Internist 20071201

Title: Levosimendan in cardiogenic shock: the magic drug for every patient?

Journal: Critical care medicine 20071201

Title: Is there a place for levosimendan in the intensive care unit?

Journal: Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20071201

Title: Effects of levosimendan on coronary artery flow and cardiac performance in patients with advanced heart failure.

Journal: European journal of heart failure 20071201

Title: Inoprotection: the perioperative role of levosimendan.

Journal: Anaesthesia and intensive care 20071201

Title: Pharmacologic therapy for acute heart failure.

Journal: Cardiology clinics 20071101

Title: Antieosinophilic activity of simendans.

Journal: The Journal of pharmacology and experimental therapeutics 20071001

Title: A struggle to SURVIVE: to abandon or not to abandon levosimendan?

Journal: Cardiovascular drugs and therapy 20071001

Title: Efficacy and safety of perioperative infusion of levosimendan in patients with compromised cardiac function undergoing open-heart surgery: importance of early use.

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20071001

Title: The gender differences in the relaxation to levosimendan of human internal mammary artery.

Journal: Cardiovascular drugs and therapy 20071001

Title: Pharmacological preconditioning by levosimendan is mediated by inducible nitric oxide synthase and mitochondrial KATP channel activation in the in vivo anesthetized rabbit heart model.

Journal: Vascular pharmacology 20071001

Title: Effect of levosimendan on ventriculo-arterial coupling in patients with ischemic cardiomyopathy.

Journal: Acta anaesthesiologica Scandinavica 20071001

Title: New pharmacologic options in the treatment of acute coronary syndromes and myocardial ischemia-reperfusion injury: potential role of levosimendan.

Journal: Minerva cardioangiologica 20071001

Title: Levosimendan in acute pulmonary embolism.

Journal: Anaesthesia and intensive care 20071001

Title: Preconditioning with levosimendan prevents contractile dysfunction due to H2O2-induced oxidative stress in human myocardium.

Journal: Journal of cardiovascular pharmacology 20071001

Title: Letter by Guarracino et al regarding article, 'Direct myocardial effects of levosimendan in humans with left ventricular dysfunction: alteration of force-frequency and relaxation-frequency relationships'.

Journal: Circulation 20070911

Title: Levosimendan allows detection of contractile reserve in patients with chronic ischaemic left ventricular dysfunction and non-diagnostic dobutamine echocardiography.

Journal: European journal of heart failure 20070901

Title: Levosimendan improves the initial outcome of cardiopulmonary resuscitation in a swine model of cardiac arrest.

Journal: Acta anaesthesiologica Scandinavica 20070901

Title: Levosimendan in septic shock: a case series.

Journal: British journal of anaesthesia 20070901

Title: The effects of levosimendan on myocardial function in ropivacaine toxicity in isolated guinea pig heart preparations.

Journal: Anesthesia and analgesia 20070901

Title: Is there a place for levosimendan in the intensive care unit?

Journal: Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20070901

Title: A 6-month follow-up of intermittent levosimendan administration effect on systolic function, specific activity questionnaire, and arrhythmia in advanced heart failure.

Journal: Journal of cardiac failure 20070901

Title: The cardioprotective effects of levosimendan: preclinical and clinical evidence.

Journal: Journal of cardiovascular pharmacology 20070901

Title: Patients with advanced heart failure and the effects of levosimendan.

Journal: The American journal of cardiology 20070815

Title: Effects of levosimendan on acute pulmonary embolism-induced right ventricular failure.

Journal: Critical care medicine 20070801

Title: Effects of levosimendan on quality of life and emotional stress in advanced heart failure patients.

Journal: Cardiovascular drugs and therapy 20070801

Title: The heart rules the head.

Journal: Emergency medicine Australasia : EMA 20070801

Title: Levosimendan: right for the right ventricle?

Journal: Critical care medicine 20070801

Title: Levosimendan improves renal function in patients with advanced chronic heart failure awaiting cardiac transplantation.

Journal: Journal of cardiac failure 20070801

Title: [Clinical experience with levosimendan in the emergency department of a tertiary care hospital].

Journal: Revista espanola de cardiologia 20070801

Title: Therapies for heart failure: a report from the Heart Failure Congress 2007.

Journal: Timely topics in medicine. Cardiovascular diseases 20070713

Title: Cardiovascular effects of levosimendan in the early stages of endotoxemia.

Journal: Shock (Augusta, Ga.) 20070701

Title: Levosimendan in acute decompensation of anthracycline-induced cardiotoxicity.

Journal: International journal of cardiology 20070612

Title: Classical inotropes and new cardiac enhancers.

Journal: Heart failure reviews 20070601

Title: Experiences of levosimendan as an inotropic agent in conjunction with passive containment surgery.

Journal: Scandinavian cardiovascular journal : SCJ 20070601

Title: Myocardial depression associated with pneumococcal septic shock reversed by levosimendan.

Journal: Anaesthesia and intensive care 20070601

Title: Do calcium sensitizers affect right ventricular functions in patients with chronic heart failure?

Journal: International journal of cardiology 20070531

Title: [Calcium sensitizer: characteristics, mechanisms of action, pharmacokinetics, indication, contraindication, clinical data, and side effects].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20070528

Title: [Calcium sensitizer agents in heart failure therapy].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20070528

Title: [Combination therapy with PDE III inhibitor for heart failure].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20070528

Title: [Levosimendan for treatment of heart failure].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20070528

Title: Levosimendan vs dobutamine for patients with acute decompensated heart failure: the SURVIVE Randomized Trial.

Journal: JAMA 20070502

Title: Levosimendan: beyond its simple inotropic effect in heart failure.

Journal: Pharmacology & therapeutics 20070501

Title: Levosimendan restores both systolic and diastolic cardiac performance in lipopolysaccharide-treated rabbits: comparison with dobutamine and milrinone.

Journal: Critical care medicine 20070501

Title: Vasodilating mechanisms of levosimendan: involvement of K+ channels.

Journal: Journal of pharmacological sciences 20070501

Title: Could Ca2+ sensitizers rescue patients from chronic congestive heart failure?

Journal: British journal of pharmacology 20070401

Title: Effects of levosimendan on cardiac remodeling and cardiomyocyte apoptosis in hypertensive Dahl/Rapp rats.

Journal: British journal of pharmacology 20070401

Title: The use of levosimendan in comparison and in combination with dobutamine in the treatment of decompensated heart failure.

Journal: Expert opinion on pharmacotherapy 20070401

Title: Levosimendan in cardiac surgery: a unique drug for the treatment of perioperative left ventricular dysfunction or just another inodilator searching for a clinical application?

Journal: Anesthesia and analgesia 20070401

Title: The effects of levosimendan in cardiac surgery patients with poor left ventricular function.

Journal: Anesthesia and analgesia 20070401

Title: Levosimendan: a new option in acute septic cardiac failure?

Journal: Emergency medicine Australasia : EMA 20070401

Title: Direct myocardial effects of levosimendan in humans with left ventricular dysfunction: alteration of force-frequency and relaxation-frequency relationships.

Journal: Circulation 20070313

Title: Levosimendan improves right ventriculovascular coupling in a porcine model of right ventricular dysfunction.

Journal: Critical care medicine 20070301

Title: Levosimendan in septic shock: another piece in the puzzle, but many pieces are still lacking.

Journal: Intensive care medicine 20070301

Title: Effects of levosimendan and dobutamine in experimental acute endotoxemia: a preliminary controlled study.

Journal: Intensive care medicine 20070301

Title: Dear levosimendan, the right ventricle will thank you!

Journal: Critical care medicine 20070301

Title: Levosimendan and prostaglandin E1 for uptitration of beta-blockade in patients with refractory, advanced chronic heart failure.

Journal: European journal of heart failure 20070201

Title: Levosimendan: perpetuum mobile?

Journal: European heart journal 20070201

Title: Duration of the haemodynamic action of a 24-h infusion of levosimendan in patients with congestive heart failure.

Journal: European journal of heart failure 20070101

Title: Levosimendan cardioprotection reduces the metabolic response during temporary regional coronary occlusion in an open chest pig model.

Journal: Acta anaesthesiologica Scandinavica 20070101

Title: [Role of Levosimendan in intensive care treatment of myocardial insufficiency].

Journal: Der Anaesthesist 20070101

Title: Severe stunned myocardium after lightning strike.

Journal: Critical care medicine 20070101

Title: Mechanisms of a reduced cardiac output and the effects of milrinone and levosimendan in a model of infant cardiopulmonary bypass.

Journal: Critical care medicine 20070101

Title: Use of levosimendan, a new inodilator, for postoperative myocardial stunning in a premature neonate.

Journal: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20070101

Title: Levosimendan for the treatment of acute heart failure syndromes: time to identify subpopulations of responding patients.

Journal: The American journal of cardiology 20070101

Title: Effect of severe renal failure and haemodialysis on the pharmacokinetics of levosimendan and its metabolites.

Journal: Clinical pharmacokinetics 20070101

Title: Successful use of levosimendan in a patient during cardiopulmonary bypass.

Journal: Journal of cardiac surgery 20070101

Title: The utility of levosimendan in the treatment of heart failure.

Journal: Annals of medicine 20070101

Title: Haemodynamic effects of levosimendan for low cardiac output after cardiac surgery: a case series.

Journal: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20070101

Title: Clinical pharmacology of levosimendan.

Journal: Clinical pharmacokinetics 20070101

Title: Levosimendan: the inotrope of choice in cardiogenic shock secondary to takotsubo cardiomyopathy?

Journal: Heart, lung & circulation 20070101

Title: A strategy for high-throughput analysis of levosimendan and its metabolites in human plasma samples using sequential negative and positive ionization liquid chromatography/tandem mass spectrometric detection.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: Medical support and surgery of the failing heart: levosimendan.

Journal: Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society 20070101

Title: Evaluation of the clinical, hemodynamic and neurohormonal response to levosimendan administration in decompensated heart failure patients. One-month follow-up.

Journal: Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20070101

Title: Synthesis and bioactivity of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives.

Journal: Arzneimittel-Forschung 20070101

Title: Levosimendana.

Journal: Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular 20070101

Title: Effect of levosimendan on ventricular arrhythmias and prognostic autonomic indexes in patients with decompensated advanced heart failure secondary to ischemic or dilated cardiomyopathy.

Journal: The American journal of cardiology 20061215

Title: Long-term effects of levosimendan infusion on inflammatory processes and sFas in patients with severe heart failure.

Journal: European journal of heart failure 20061201

Title: Effects of serial levosimendan infusions on left ventricular performance and plasma biomarkers of myocardial injury and neurohormonal and immune activation in patients with advanced heart failure.

Journal: Heart (British Cardiac Society) 20061201

Title: Effects of levosimendan on right ventricular function in patients with advanced heart failure.

Journal: The American journal of cardiology 20061201

Title: A review of levosimendan in the treatment of heart failure.

Journal: Vascular health and risk management 20061201

Title: Cardiogenic shock after primary percutaneous coronary intervention: Effects of levosimendan compared with dobutamine on haemodynamics.

Journal: European journal of heart failure 20061101

Title: Effects of levosimendan versus dobutamine on pressure load-induced right ventricular failure.

Journal: Critical care medicine 20061101

Title: The vasodilatory effects of levosimendan on the human internal mammary artery.

Journal: Anesthesia and analgesia 20061101

Title: Intracoronary infusion of levosimendan to treat postpericardiotomy heart failure.

Journal: The Annals of thoracic surgery 20061101

Title: Levosimendan treatment after primary organ failure in heart transplantation: a direct way to recovery?

Journal: Transplantation 20061027

Title: Clinical significance of acute neurohormonal response after levosimendan treatment.

Journal: The American journal of cardiology 20061015

Title: Levosimendan for weaning from cardiopulmonary bypass after coronary artery bypass grafting.

Journal: Heart, lung & circulation 20061001

Title: Levosimendan reversing low output syndrome after heart transplantation.

Journal: The Annals of thoracic surgery 20061001

Title: Preconditioning effects of levosimendan in a rabbit cardiac ischemia-reperfusion model.

Journal: Journal of cardiovascular pharmacology 20061001

Title: Effects of levosimendan on myocardial infarct size and hemodynamics in a closed-chest porcine ischemia-reperfusion model.

Journal: Cardiovascular drugs and therapy 20061001

Title: Effects of levosimendan on right ventricular afterload in patients with acute respiratory distress syndrome: a pilot study.

Journal: Critical care medicine 20060901

Title: Early experience with Levosimendan in children with ventricular dysfunction.

Journal: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20060901

Title: The preconditioning effects of levosimendan.

Journal: British journal of anaesthesia 20060901

Title: A new horizon in the treatment of right ventricular failure and pulmonary hypertension associated with acute respiratory distress syndrome?

Journal: Critical care medicine 20060901

Title: Testing new drugs for heart failure in children.

Journal: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20060901

Title: Evidence-based use of levosimendan in different clinical settings.

Journal: European heart journal 20060801

Title: The role of potassium channels in the vasodilatory effect of levosimendan in human internal thoracic arteries.

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060801

Title: Management of acute decompensated heart failure: treatment, controversy, and future directions.

Journal: Pharmacotherapy 20060801

Title: Vasorelaxing effect of levosimendan against 5-hydroxytryptamine-induced contractions in isolated human conduit bypass grafts.

Journal: The Journal of pharmacy and pharmacology 20060801

Title: The calcium sensitizer levosimendan improves carbon monoxide poisoning related stunned myocardium: a cardiac magnetic resonance study.

Journal: Acta anaesthesiologica Scandinavica 20060801

Title: [Effect of levosimendan treatment of myocardial stunning and low-output syndrome after cardiac surgery].

Journal: Revista espanola de cardiologia 20060801

Title: The levosimendan metabolite OR-1896 elicits vasodilation by activating the K(ATP) and BK(Ca) channels in rat isolated arterioles.

Journal: British journal of pharmacology 20060701

Title: Level A in vitro-in vivo correlation (IVIVC) model with Bayesian approach to formulation series.

Journal: Journal of pharmaceutical sciences 20060701

Title: Effects of levosimendan versus dobutamine on inflammatory and apoptotic pathways in acutely decompensated chronic heart failure.

Journal: The American journal of cardiology 20060701

Title: The effect of levosimendan during long-term amiodarone treatment in dogs.

Journal: Basic & clinical pharmacology & toxicology 20060701

Title: Beneficial outcome after prostaglandin-induced post-partum cardiac arrest using levosimendan and extracorporeal membrane oxygenation.

Journal: Acta anaesthesiologica Scandinavica 20060701

Title: Levosimendan protects against experimental endotoxemic acute renal failure.

Journal: American journal of physiology. Renal physiology 20060601

Title: Preconditioning effects of levosimendan in coronary artery bypass grafting--a pilot study.

Journal: British journal of anaesthesia 20060601

Title: Levosimendan or milrinone in the type 2 diabetic patient with low ejection fraction undergoing elective coronary artery surgery.

Journal: Journal of cardiothoracic and vascular anesthesia 20060601

Title: Effect of levosimendan and milrinone on regional myocardial ischemia/reperfusion-induced arrhythmias in dogs.

Journal: Journal of cardiovascular pharmacology and therapeutics 20060601

Title: Levosimendan: a novel agent in heart failure.

Journal: Recent patents on cardiovascular drug discovery 20060601

Title: Effects of levosimendan in normodynamic endotoxaemia: a controlled experimental study.

Journal: Resuscitation 20060501

Title: Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression.

Journal: Intensive care medicine 20060501

Title: Potassium channel-related relaxation by levosimendan in the human internal mammary artery.

Journal: The Annals of thoracic surgery 20060501

Title: Potassium channels in the vasodilating action of levosimendan on the human umbilical artery.

Journal: Journal of the Society for Gynecologic Investigation 20060501

Title: The role of potassium channels in relaxant effect of levosimendan in rat small mesenteric arteries.

Journal: Cardiovascular drugs and therapy 20060401

Title: Levosimendan in cardiac surgery: current best available evidence.

Journal: The Annals of thoracic surgery 20060401

Title: [Levosimendan in acute heart failure: past, present and future].

Journal: Revista espanola de cardiologia 20060401

Title: [Hemodynamic effects of levosimendan compared with dobutamine in patients with low cardiac output after cardiac surgery].

Journal: Revista espanola de cardiologia 20060401

Title: [Therapy of acute decompensated heart failure with levosimendan].

Journal: Medizinische Klinik (Munich, Germany : 1983) 20060322

Title: [Medical and ventilatory treatment of acute heart failure].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20060309

Title: Levosimendan improves cardiopulmonary resuscitation and survival by K(ATP) channel activation.

Journal: Journal of the American College of Cardiology 20060307

Title: Ischemia-reperfusion injury changes the dynamics of Ca2+-contraction coupling due to inotropic drugs in isolated hearts.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20060301

Title: Levosimendan therapy in decompensated chronic heart failure: favourable haemodynamic and neurohormonal effects but for how long?

Journal: European journal of heart failure 20060301

Title: Levosimendan and plasma BNP levels: do inflammatory cytokines regulate BNP in chronic decompensated heart failure?

Journal: European journal of heart failure 20060301

Title: Optimizing outcomes in the patient with acute decompensated heart failure.

Journal: American heart journal 20060301

Title: Levosimendan, a new inotropic and vasodilator agent.

Journal: Anesthesiology 20060301

Title: Effects of levosimendan on left ventricular diastolic function after primary angioplasty for acute anterior myocardial infarction: a Doppler echocardiographic study.

Journal: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20060201

Title: Levosimendan in severe right ventricular failure following mitral valve replacement.

Journal: Journal of cardiothoracic and vascular anesthesia 20060201

Title: Pre-operative use of levosimendan in two patients with severe aortic stenosis and left ventricular dysfunction.

Journal: Heart, lung & circulation 20060201

Title: Successful administration of levosimendan in a patient with low-gradient low-output aortic stenosis.

Journal: Wiener klinische Wochenschrift 20060201

Title: Newer approaches to the pharmacological management of heart failure.

Journal: Current opinion in anaesthesiology 20060201

Title: [On levosimendan in comparison with dobutamine].

Journal: Revista espanola de anestesiologia y reanimacion 20060201

Title: [Levosimendan--an alternative to conventional inotropic treatment of patients with acute heart failure?].

Journal: Ugeskrift for laeger 20060116

Title: Resuscitation from adrenaline resistant electro-mechanical dissociation facilitated by levosimendan in a young man with idiopathic dilated cardiomyopathy.

Journal: Resuscitation 20060101

Title: Levosimendan: a promising treatment for myocardial stunning?

Journal: Anaesthesia 20060101

Title: Levosimendan may improve survival in patients requiring mechanical assist devices for post-cardiotomy heart failure.

Journal: Critical care (London, England) 20060101

Title: Positive inotropic effect of levosimendan is correlated to its stereoselective Ca2+-sensitizing effect but not to stereoselective phosphodiesterase inhibition.

Journal: Basic & clinical pharmacology & toxicology 20060101

Title: The 2005 Scientific Sessions of the American Heart Association (AHA).

Journal: Heart failure monitor 20060101

Title: Pharmacologic treatment of heart failure due to ventricular dysfunction by myocardial stunning: potential role of levosimendan.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20060101

Title: The effects of Levosimendan on global haemodynamics in patients with cardiogenic shock.

Journal: Neuro endocrinology letters 20060101

Title: Levosimendan for low cardiac output: a pediatric experience.

Journal: Journal of intensive care medicine 20060101

Title: Levosimendan: a new option in acute cardiac failure.

Journal: Emergency medicine Australasia : EMA 20060101

Title: Short-term effects of levosimendan and prostaglandin E1 on hemodynamic parameters and B-type natriuretic peptide levels in patients with decompensated chronic heart failure.

Journal: European journal of heart failure 20051201

Title: Duration of the beneficial effects of levosimendan in decompensated heart failure as measured by echocardiographic indices and B-type natriuretic peptide.

Journal: Journal of cardiovascular pharmacology 20051201

Title: Levosimendan for the treatment of acute heart failure syndromes.

Journal: Expert opinion on pharmacotherapy 20051201

Title: Levosimendan: dual mechanisms for acute heart failure...and beyond?

Journal: Minerva cardioangiologica 20051201

Title: Levosimendan as a new strategy during off-pump coronary artery bypass grafting: double-blind randomized placebo-controlled trial.

Journal: Croatian medical journal 20051201

Title: Levosimendan use reduces matrix metalloproteinase-2 in patients with decompensated heart failure.

Journal: Cardiovascular drugs and therapy 20051201

Title: Ca2+-sensitisers--a promising option to treat heart failure?

Journal: Cardiovascular drugs and therapy 20051201

Title: Treatment of cardiogenic shock with levosimendan in combination with beta-adrenergic antagonists.

Journal: British journal of anaesthesia 20051101

Title: Levosimendan: a novel inotropic agent for treatment of acute, decompensated heart failure.

Journal: The Annals of pharmacotherapy 20051101

Title: Levosimendan improves postresuscitation outcomes in a rat model of CPR.

Journal: The Journal of laboratory and clinical medicine 20051101

Title: [Levosimendan].

Journal: Deutsche medizinische Wochenschrift (1946) 20051028

Title: Levosimendan reduces plasma amino terminal proBNP in patients with decompensated heart failure.

Journal: International journal of cardiology 20051010

Title: Effects of levosimendan on restrictive left ventricular filling in severe heart failure: a combined hemodynamic and Doppler echocardiographic study.

Journal: Chest 20051001

Title: [Successful use of levosimendan in a patient with cardiogenic shock complicating acute myocardial infarction].

Journal: La Tunisie medicale 20051001

Title: Cardioprotection: a new paradigm in the management of acute heart failure syndromes.

Journal: The American journal of cardiology 20050919

Title: Pharmacology of new agents for acute heart failure syndromes.

Journal: The American journal of cardiology 20050919

Title: Randomized clinical trials with levosimendan.

Journal: The American journal of cardiology 20050919

Title: European experience on the practical use of levosimendan in patients with acute heart failure syndromes.

Journal: The American journal of cardiology 20050919

Title: Calcium sensitizer agents: a new class of inotropic agents in the treatment of decompensated heart failure.

Journal: International journal of cardiology 20050901

Title: Hemodynamic effect of intracoronary administration of levosimendan in the anesthetized pig.

Journal: Journal of cardiovascular pharmacology 20050901

Title: Two inotropes with different mechanisms of action: contractile, PDE-inhibitory and direct myofibrillar effects of levosimendan and enoximone.

Journal: Journal of cardiovascular pharmacology 20050901

Title: Cardiac and renal effects of levosimendan, arginine vasopressin, and norepinephrine in lipopolysaccharide-treated rabbits.

Journal: Anesthesiology 20050901

Title: Levosimendan improves postresuscitation myocardial dysfunction after beta-adrenergic blockade.

Journal: The Journal of laboratory and clinical medicine 20050901

Title: Levosimendan improves hemodynamics and coronary flow reserve after percutaneous coronary intervention in patients with acute myocardial infarction and left ventricular dysfunction.

Journal: American heart journal 20050901

Title: The Ca2+-sensitizer levosimendan improves oxidative damage, BNP and pro-inflammatory cytokine levels in patients with advanced decompensated heart failure in comparison to dobutamine.

Journal: European journal of heart failure 20050801

Title: Dual regulation of myofilament Ca2+ sensitivity by levosimendan in normal and acidotic conditions in aequorin-loaded canine ventricular myocardium.

Journal: British journal of pharmacology 20050801

Title: Effects of levosimendan on markers of left ventricular diastolic function and neurohormonal activation in patients with advanced heart failure.

Journal: The American journal of cardiology 20050801

Title: What is the in vivo mechanism of action of levosimendan?

Journal: Journal of cardiac failure 20050801

Title: Anti-inflammatory and anti-apoptotic effects of levosimendan in decompensated heart failure: a novel mechanism of drug-induced improvement in contractile performance of the failing heart.

Journal: Current medicinal chemistry. Cardiovascular and hematological agents 20050701

Title: [Cost analysis of the treatment of acute decompensated heart failure. Levosimendan versus dobutamine].

Journal: Arquivos brasileiros de cardiologia 20050701

Title: Utility of levosimendan, a new calcium sensitizing agent, in the treatment of cardiogenic shock due to myocardial stunning in patients with ST-elevation myocardial infarction: a series of cases.

Journal: Journal of clinical pharmacology 20050601

Title: An emerging role for calcium sensitisation in the treatment of heart failure.

Journal: Expert opinion on investigational drugs 20050601

Title: Levosimendan in cardiac surgery.

Journal: Journal of cardiothoracic and vascular anesthesia 20050601

Title: [Levosimendan, a revolution in the world of inotropic agents?].

Journal: Revue medicale suisse 20050525

Title: [Cardiogenic shock-- new therapeutic strategies].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20050519

Title: Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression.

Journal: Intensive care medicine 20050501

Title: The myofilament force-calcium relationship as a target for positive inotropic therapy in congestive heart failure.

Journal: Cardiovascular drugs and therapy 20050501

Title: [If the myofilaments become sensitive: Ca2+-sensitizer for the therapy of heart insufficiency].

Journal: Deutsche medizinische Wochenschrift (1946) 20050415

Title: Anti-inflammatory effects of levosimendan in decompensated heart failure: impact on weight loss and anemia.

Journal: The American journal of cardiology 20050401

Title: Levosimendan reduces plasma B-type natriuretic peptide and interleukin 6, and improves central hemodynamics in severe heart failure patients.

Journal: International journal of cardiology 20050330

Title: Effects of intravenous levosimendan on human coronary vasomotor regulation, left ventricular wall stress, and myocardial oxygen uptake.

Journal: Circulation 20050329

Title: Efficacy and safety of intermittent, long-term, concomitant dobutamine and levosimendan infusions in severe heart failure refractory to dobutamine alone.

Journal: The American journal of cardiology 20050315

Title: Comparison between dobutamine and levosimendan for management of postresuscitation myocardial dysfunction.

Journal: Critical care medicine 20050301

Title: Inotropic options for postresuscitation myocardial dysfunction.

Journal: Critical care medicine 20050301

Title: Levosimendan improves LV systolic and diastolic performance at rest and during exercise after heart failure.

Journal: American journal of physiology. Heart and circulatory physiology 20050201

Title: Contractile action of levosimendan and epinephrine during acidosis.

Journal: European journal of pharmacology 20050110

Title: Levosimendan in septic cardiac failure.

Journal: Intensive care medicine 20050101

Title: Levosimendan is superior to milrinone and dobutamine in selectively increasing microvascular gastric mucosal oxygenation in dogs.

Journal: Critical care medicine 20050101

Title: Levosimendan and gut mucosal blood flow--not all inotropes are created equal.

Journal: Critical care medicine 20050101

Title: Successful reversal of resistent hypodynamic septic shock with levosimendan.

Journal: Acta anaesthesiologica Scandinavica 20050101

Title: Levosimendan: a new inodilatory drug for the treatment of decompensated heart failure.

Journal: Current pharmaceutical design 20050101

Title: Pharmacological mechanisms contributing to the clinical efficacy of levosimendan.

Journal: Cardiovascular drug reviews 20050101

Title: [Use of levosimendan after cardiac arrest by ventricular fibrillation: a case report].

Journal: La Clinica terapeutica 20050101

Title: [The novelty in the treatment of heart failure].

Journal: Medicina (Kaunas, Lithuania) 20050101

Title: Effects of levosimendan on left ventricular functional remodelling and exercise intolerance: a tissue Doppler study.

Journal: The Journal of international medical research 20050101

Title: [Hemodynamic effects of levosimendan following cardiac surgery].

Journal: Revista espanola de anestesiologia y reanimacion 20050101

Title: [Levosimendan in patients with acute cardiac failure].

Journal: Archivos de cardiologia de Mexico 20050101

Title: [Levosimendan: a new strategy in the treatment of heart failure].

Journal: Archivos de cardiologia de Mexico 20050101

Title: [Treatment of cardiogenic shock with the Ca2+ sensitizer levosimendan].

Journal: Medizinische Klinik (Munich, Germany : 1983) 20041215

Title: Enatiomeric analysis of simendan by CE with beta-CD as chiral selector compared with CMPA-HPLC.

Journal: Biomedical chromatography : BMC 20041201

Title: Levosimendan in off-pump coronary artery bypass: a four-times masked controlled study.

Journal: Journal of cardiovascular pharmacology 20041201

Title: Successful treatment of dilative cardiomyopathy in a 12-year-old girl using the calcium sensitizer levosimendan after weaning from mechanical biventricular assist support.

Journal: Journal of cardiothoracic and vascular anesthesia 20041201

Title: Hemodynamic effects of levosimendan added to dobutamine in patients with decompensated advanced heart failure refractory to dobutamine alone.

Journal: The American journal of cardiology 20041115

Title: Pharmacokinetics of levosimendan and its active metabolite OR-1896 in rapid and slow acetylators.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20041101

Title: Comparision of the inotropic effects of levosimendan, rolipram, and dobutamine on human atrial trabeculae.

Journal: Journal of cardiovascular pharmacology 20041101

Title: The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin c.

Journal: Molecular and cellular biochemistry 20041101

Title: Levosimendan in daily intensive care practice--the experience of 15 centers. Background, methods and organization of the PORTLAND study.

Journal: Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20041101

Title: End-stage heart failure with pulmonary hypertension: levosimendan to evaluate for heart transplantation alone versus combined heart-lung transplantation.

Journal: Transplantation 20041027

Title: Impact of levosimendan treatment on chronic heart failure.

Journal: The American journal of cardiology 20041015

Title: Pharmacodynamics and pharmacokinetics of oral levosimendan and its metabolites in patients with severe congestive heart failure: a dosing interval study.

Journal: Journal of clinical pharmacology 20041001

Title: Force-frequency relationship in intact mammalian ventricular myocardium: physiological and pathophysiological relevance.

Journal: European journal of pharmacology 20041001

Title: Levosimendan, a new calcium-sensitizing inotrope for heart failure.

Journal: Pharmacotherapy 20041001

Title: Potassium-specific effects of levosimendan on heart mitochondria.

Journal: Biochemical pharmacology 20040901

Title: Pharmacokinetics of levosimendan in pediatric patients evaluated for cardiac surgery.

Journal: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20040901

Title: Resumption of atrioventricular conduction by levosimendan after radiofrequency ablation of the AV node:

Journal: Pacing and clinical electrophysiology : PACE 20040901

Title: Effect of levosimendan on balance between ATP production and consumption in isolated perfused guinea-pig heart before ischemia or after reperfusion.

Journal: Journal of cardiovascular pharmacology 20040901

Title: Levosimendan: a calcium-sensitizing agent for the treatment of patients with decompensated heart failure.

Journal: Current heart failure reports 20040901

Title: Levosimendan in patients with cardiogenic shock undergoing surgical revascularization: a case series.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20040801

Title: The use of the novel calcium sensitizer levosimendan in critically ill patients.

Journal: Anaesthesia and intensive care 20040801

Title: Treatment of acute heart failure in an infant after cardiac surgery using levosimendan.

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20040701

Title: On the mechanism of levosimendan-induced dopamine release in the striatum of freely moving rats.

Journal: Journal of pharmacological sciences 20040701

Title: Medical therapy in heart failure--is polypharmacy necessary?

Journal: Annals of the Academy of Medicine, Singapore 20040701

Title: The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia.

Journal: Journal of the American College of Cardiology 20040616

Title: New positive inotropic agents in the treatment of left ventricular dysfunction.

Journal: Italian heart journal : official journal of the Italian Federation of Cardiology 20040601

Title: Levosimendan interacts with potassium channel blockers in human saphenous veins.

Journal: Basic & clinical pharmacology & toxicology 20040601

Title: Effects of levosimendan on circulating pro-inflammatory cytokines and soluble apoptosis mediators in patients with decompensated advanced heart failure.

Journal: The American journal of cardiology 20040515

Title: The calcium sensitizer levosimendan and cardiac arrhythmias: an analysis of the safety database of heart failure treatment studies.

Journal: Scandinavian cardiovascular journal : SCJ 20040501

Title: Pharmacokinetics of levosimendan and its circulating metabolites in patients with heart failure after an extended continuous infusion of levosimendan.

Journal: British journal of clinical pharmacology 20040401

Title: Effects of levosimendan and milrinone on oxygen consumption in isolated guinea-pig heart.

Journal: Journal of cardiovascular pharmacology 20040401

Title: Hemodynamic effects of levosimendan in patients with low-output heart failure after cardiac surgery.

Journal: International journal of clinical pharmacology and therapeutics 20040401

Title: Successful use of levosimendan in a patient with peripartum cardiomyopathy.

Journal: Anesthesia and analgesia 20040301

Title: [Levosimendan-long-term inodilation in an infant with myocardial infarction].

Journal: Zeitschrift fur Kardiologie 20040301

Title: New therapies for heart failure.

Journal: RN 20040301

Title: Stereoselective binding of levosimendan to cardiac troponin C causes Ca2+-sensitization.

Journal: European journal of pharmacology 20040213

Title: The effects of levosimendan and OR-1896 on isolated hearts, myocyte-sized preparations and phosphodiesterase enzymes of the guinea pig.

Journal: European journal of pharmacology 20040213

Title: [Levosimendan. Clinical indications of a new vasoactive substance].

Journal: Der Anaesthesist 20040201

Title: Pharmacological therapy of acute cardiogenic pulmonary oedema in the emergency department.

Journal: Emergency medicine Australasia : EMA 20040201

Title: [Levosimendan in cardiology and intensive care medicine].

Journal: Wiener klinische Wochenschrift 20040131

Title: Levosimendan: first in a new class of inodilator for acute and chronic severe heart failure.

Journal: Expert review of cardiovascular therapy 20040101

Title: [Levosimendan in heart failure].

Journal: Recenti progressi in medicina 20040101

Title: [Usefulness of Levosimendan in patients with ventricular dysfunction before surgery].

Journal: Archivos de cardiologia de Mexico 20040101

Title: Levosimendan.

Journal: Intensive & critical care nursing 20031201

Title: Hemodynamic effects of a continuous infusion of levosimendan in critically ill patients with cardiogenic shock requiring catecholamines.

Journal: Acta anaesthesiologica Scandinavica 20031101

Title: New and emerging drug therapies for the management of acute heart failure.

Journal: Internal medicine journal 20031101

Title: The calcium sensitizer levosimendan attenuates endotoxin-evoked myocardial dysfunction in isolated guinea pig hearts.

Journal: Intensive care medicine 20031001

Title: The role of Ca++-sensitizers for the treatment of heart failure.

Journal: Current opinion in critical care 20031001

Title: Levosimendan: implications for clinicians.

Journal: Journal of clinical pharmacology 20031001

Title: Cardiotonic drugs differentially alter cytosolic [Ca2+] to left ventricular relationships before and after ischemia in isolated guinea pig hearts.

Journal: Cardiovascular research 20031001

Title: [Levosimendan as inotropic support during coronary surgery with extracorporeal circulation in a patient with severely depressed ventricular function].

Journal: Revista espanola de anestesiologia y reanimacion 20031001

Title: Molecular mechanism of levosimendan action: an update.

Journal: Journal of molecular and cellular cardiology 20030901

Title: Interaction of levosimendan with cardiac troponin C in the presence of cardiac troponin I peptides.

Journal: Journal of molecular and cellular cardiology 20030901

Title: [Is levosimendan an inoprotective drug in patients with acute coronary syndrome undergoing surgical revascularization?].

Journal: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20030901

Title: Effects of levosimendan on right ventricular function and ventriculovascular coupling in open chest pigs.

Journal: Critical care medicine 20030901

Title: Advances in positive inotropic therapy: levosimendan.

Journal: Critical care medicine 20030901

Title: The cardiotonic effects of levosimendan in guinea pig hearts are modulated by beta-adrenergic stimulation.

Journal: General physiology and biophysics 20030901

Title: Pharmacokinetic-pharmacodynamic interrelationships of intravenous and oral levosimendan in patients with severe congestive heart failure.

Journal: International journal of clinical pharmacology and therapeutics 20030801

Title: Population pharmacokinetics of levosimendan in patients with congestive heart failure.

Journal: British journal of clinical pharmacology 20030601

Title: Levosimendan: a new dual-action drug in the treatment of acute heart failure.

Journal: International journal of clinical practice 20030601

Title: Is calcium sensitization the best strategy to improve myocardial contractility in acute heart failure?

Journal: Italian heart journal : official journal of the Italian Federation of Cardiology 20030501

Title: Levosimendan in patients with low-output heart failure: lessons from the LIDO trial.

Journal: Italian heart journal : official journal of the Italian Federation of Cardiology 20030501

Title: Considerations on the efficacy and safety of levosimendan in ischemic heart failure.

Journal: Italian heart journal : official journal of the Italian Federation of Cardiology 20030501

Title: Preliminary clinical experience with the repetitive administration of levosimendan in patients with end-stage heart failure.

Journal: Italian heart journal : official journal of the Italian Federation of Cardiology 20030501

Title: The clinical experience with levosimendan in anesthesiology and in the intensive care unit.

Journal: Italian heart journal : official journal of the Italian Federation of Cardiology 20030501

Title: Levosimendan compared with dobutamine in low output patients.

Journal: Minerva anestesiologica 20030401

Title: Effect of long-term oral pretreatment with levosimendan on cardiac arrhythmias during coronary artery occlusion in conscious rats.

Journal: European journal of pharmacology 20030319

Title: Functional role of potassium channels in the vasodilating mechanism of levosimendan in porcine isolated coronary artery.

Journal: Cardiovascular drugs and therapy 20030301

Title: Vasodilating mechanisms of levosimendan.

Journal: Cardiovascular drugs and therapy 20030301

Title: Complete structure analysis of OR-1746, a complex product of cyclocondensation of arylhydrazomalononitriles containing clusters of protonated and unprotonated nitrogens, by pulsed-field-gradient heteronuclear NMR.

Journal: Journal of pharmaceutical and biomedical analysis 20030205

Title: Current medical treatment for the exacerbation of chronic heart failure resulting in hospitalization.

Journal: American heart journal 20030201

Title: Dyspnea as an end point in clinical trials of therapies for acute decompensated heart failure.

Journal: American heart journal 20030201

Title: Sustained hemodynamic effects of intravenous levosimendan.

Journal: Circulation 20030107

Title: Pharmacotherapeutic approaches for decompensated heart failure: a role for the calcium sensitiser, levosimendan?

Journal: European journal of heart failure 20030101

Title: Intravenous levosimendan treatment is cost-effective compared with dobutamine in severe low-output heart failure: an analysis based on the international LIDO trial.

Journal: European journal of heart failure 20030101

Title: [The best of clinical pharmacology in 2002].

Journal: Archives des maladies du coeur et des vaisseaux 20030101

Title: 15th Annual Congress of the European Society of Intensive Care Medicine, 29 September-2 October 2002, Barcelona, Spain: clinical research to improve outcome.

Journal: Critical care (London, England) 20030101

Title: [Levosimendan: a new option in the pharmacologic management of cardiac insufficiency].

Journal: Gaceta medica de Mexico 20030101

Title: [Inotropic agents in advanced and refractory heart failure].

Journal: Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology 20030101

Title: Levosimendan: a new approach for the treatment of patients with severe heart failure. A brief summary based on a clinical case.

Journal: Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20030101

Title: Levosimendan: a review of its use in the management of acute decompensated heart failure.

Journal: Drugs 20030101

Title: Pharmacodynamic interactions of levosimendan and felodipine in patients with coronary heart disease.

Journal: Cardiovascular drugs and therapy 20030101

Title: Effects of OR-1896, a metabolite of levosimendan, on force of contraction and Ca2+ transients under acidotic condition in aequorin-loaded canine ventricular myocardium.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20021101

Title: The contractility enhancing effect of the calcium sensitiser levosimendan is not attenuated by carvedilol in healthy subjects.

Journal: European journal of clinical pharmacology 20021001

Title: Pharmacokinetics of levosimendan and its metabolites during and after a 24-hour continuous infusion in patients with severe heart failure.

Journal: International journal of clinical pharmacology and therapeutics 20021001

Title: Positive inotropy for acute heart failure complicating myocardial infarction.

Journal: European heart journal 20020901

Title: Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction. A randomized, placebo-controlled, double-blind study (RUSSLAN).

Journal: European heart journal 20020901

Title: Effect of the calcium sensitizer levosimendan on the performance of ischaemic myocardium in anaesthetised pigs.

Journal: Cardiovascular drugs and therapy 20020901

Title: Levosimendan in regional myocardial ischemia.

Journal: Cardiovascular drugs and therapy 20020901

Title: Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial.

Journal: Lancet (London, England) 20020720

Title: Development of level A, B and C in vitro-in vivo correlations for modified-release levosimendan capsules.

Journal: International journal of pharmaceutics 20020708

Title: An analysis of responses to levosimendan in the pulmonary vascular bed of the cat.

Journal: Anesthesia and analgesia 20020601

Title: Levosimendan: a new era for inodilator therapy for heart failure?

Journal: Current opinion in cardiology 20020501

Title: Levosimendan increases L-type Ca(2+) current via phosphodiesterase-3 inhibition in human cardiac myocytes.

Journal: European journal of pharmacology 20020118

Title: Beneficial effects of the Ca(2+) sensitizer levosimendan in human myocardium.

Journal: American journal of physiology. Heart and circulatory physiology 20020101

Title: Pharmacodynamics and safety of a new calcium sensitizer, levosimendan, and its metabolites during an extended infusion in patients with severe heart failure.

Journal: Journal of clinical pharmacology 20020101

Title: Levosimendan: a unique approach to the treatment of heart failure.

Journal: Heart disease (Hagerstown, Md.) 20020101

Title: Comparison of enoximone, amrinone, or levosimendan enriched St. Thomas' hospital cardioplegic solutions used for myocardial preservation in isolated guinea pig hearts.

Journal: Acta medica (Hradec Kralove) 20020101

Title: The development of new medical treatments for acute decompensated heart failure.

Journal: Heart failure monitor 20020101

Title: Effects of levosimendan, a novel inotropic calcium-sensitizing drug, in experimental septic shock.

Journal: Critical care medicine 20011101

Title: Levosimendan is a mitochondrial K(ATP) channel opener.

Journal: European journal of pharmacology 20011012

Title: Mechanism of action of Ca2+ sensitizers--update 2001.

Journal: Cardiovascular drugs and therapy 20010901

Title: Effect of levosimendan on myocardial contractility, coronary and peripheral blood flow, and arrhythmias during coronary artery ligation and reperfusion in the in vivo pig model.

Journal: Heart (British Cardiac Society) 20010701

Title: New pharmacological strategies for the treatment of heart failure.

Journal: Current opinion in investigational drugs (London, England : 2000) 20010701

Title: Improved survival with simendan after experimental myocardial infarction in rats.

Journal: European journal of pharmacology 20010511

Title: Levosimendan: a parenteral calcium-sensitising drug with additional vasodilatory properties.

Journal: Expert opinion on investigational drugs 20010501

Title: Levosimendan increases diastolic coronary flow in isolated guinea-pig heart by opening ATP-sensitive potassium channels.

Journal: Journal of cardiovascular pharmacology 20010401

Title: Binding of levosimendan, a calcium sensitizer, to cardiac troponin C.

Journal: The Journal of biological chemistry 20010323

Title: [Acute hemodynamic and clinical effects of a new inotropic agent, levosimendan, in patients with severe heart failure].

Journal: Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology 20010201

Title: Levosimendan.

Journal: Drugs 20010101

Title: New therapeutic choices in the management of acute congestive heart failure.

Journal: Reviews in cardiovascular medicine 20010101

Title: Myocardial efficiency during levosimendan infusion in congestive heart failure.

Journal: Clinical pharmacology and therapeutics 20001101

Title: Levosimendan: A promising agent for the treatment of hospitalized patients with decompensated heart failure.

Journal: Current cardiology reports 20000501

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