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Home Other Building Blocks 1015474-32-4
1015474-32-4,MFCD29919294
Catalog No.:AA008ZRW

1015474-32-4 | CC-122

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
in stock  
$11.00   $8.00
- +
5mg
95%
in stock  
$48.00   $34.00
- +
25mg
95%
in stock  
$58.00   $41.00
- +
250mg
95%
in stock  
$420.00   $294.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008ZRW
Chemical Name:
CC-122
CAS Number:
1015474-32-4
Molecular Formula:
C14H14N4O3
Molecular Weight:
286.2860
MDL Number:
MFCD29919294
SMILES:
O=C1CCC(C(=O)N1)n1c(C)nc2c(c1=O)c(N)ccc2
Properties
Computed Properties
 
Complexity:
530  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
1  

Upstream Synthesis Route

[1]Patent:WO2017/197056,2017,A1,.Locationinpatent:Page/Pagecolumn371-372

[2]Patent:WO2008/39489,2008,A2,.Locationinpatent:Page/Pagecolumn52

[3]Patent:US2012/232100,2012,A1,.Locationinpatent:Page/Pagecolumn24

[4]Patent:WO2014/39960,2014,A1,.Locationinpatent:Page/Pagecolumn58;60

[5]Patent:EP2683384,2015,B1,.Locationinpatent:Paragraph0354;0359

[6]Patent:WO2015/200795,2015,A1,.Locationinpatent:Paragraph00378

[7]Patent:US9365640,2016,B2,.Locationinpatent:Page/Pagecolumn67;68

[8]Patent:WO2017/24019,2017,A1,.Locationinpatent:Paragraph00345

[9]Patent:WO2017/53555,2017,A1,.Locationinpatent:Paragraph00174

[10]Patent:WO2017/96024,2017,A1,.Locationinpatent:Paragraph00206

[11]Patent:WO2017/117118,2017,A1,.Locationinpatent:Paragraph00461

[12]Patent:WO2018/165142,2018,A1,.Locationinpatent:Paragraph00430

[13]Patent:WO2016/60702,2016,A1,.Locationinpatent:Paragraph00466

[1]Patent:US2012/230983,2012,A1,

[1]Patent:US2012/232100,2012,A1,

[2]Patent:EP2683384,2015,B1,

[3]Patent:WO2015/200795,2015,A1,

[4]Patent:US9365640,2016,B2,

[5]Patent:WO2017/24019,2017,A1,

[6]Patent:WO2017/96024,2017,A1,

[7]Patent:WO2017/117118,2017,A1,

[8]Patent:WO2017/197056,2017,A1,

[9]Patent:WO2018/165142,2018,A1,

[1]Patent:US2012/232100,2012,A1,

[2]Patent:WO2014/39960,2014,A1,

[3]Patent:EP2683384,2015,B1,

[4]Patent:WO2015/200795,2015,A1,

[5]Patent:WO2016/60702,2016,A1,

[6]Patent:US9365640,2016,B2,

[7]Patent:WO2017/24019,2017,A1,

[8]Patent:WO2017/53555,2017,A1,

[9]Patent:WO2017/96024,2017,A1,

[10]Patent:WO2017/117118,2017,A1,

[11]Patent:WO2018/165142,2018,A1,

[1]Patent:US2012/232100,2012,A1,

[2]Patent:EP2683384,2015,B1,

[3]Patent:US9365640,2016,B2,

[4]Patent:WO2017/24019,2017,A1,

[5]Patent:WO2017/117118,2017,A1,

Downstream Synthesis Route

[1]Patent:WO2017/197056,2017,A1.Locationinpatent:Page/Pagecolumn371-372

[2]Patent:WO2008/39489,2008,A2.Locationinpatent:Page/Pagecolumn52

[3]Patent:US2012/232100,2012,A1.Locationinpatent:Page/Pagecolumn24

[4]Patent:WO2014/39960,2014,A1.Locationinpatent:Page/Pagecolumn58;60

[5]Patent:EP2683384,2015,B1.Locationinpatent:Paragraph0354;0359

[6]Patent:WO2015/200795,2015,A1.Locationinpatent:Paragraph00378

[7]Patent:US9365640,2016,B2.Locationinpatent:Page/Pagecolumn67;68

[8]Patent:WO2017/24019,2017,A1.Locationinpatent:Paragraph00345

[9]Patent:WO2017/53555,2017,A1.Locationinpatent:Paragraph00174

[10]Patent:WO2017/96024,2017,A1.Locationinpatent:Paragraph00206

[11]Patent:WO2017/117118,2017,A1.Locationinpatent:Paragraph00461

[12]Patent:WO2018/165142,2018,A1.Locationinpatent:Paragraph00430

[13]Patent:WO2016/60702,2016,A1.Locationinpatent:Paragraph00466

1015474-32-4    38870-89-2   
N-3-(2,6-dioxo-piperidin-3-yl)-2-methyl-4-oxo-3,4-dihydro-quinazolin-5-yl-2-methoxy-acetamide 

[1]Patent:WO2008/39489,2008,A2.Locationinpatent:Page/Pagecolumn54

1015474-32-4    75-36-5   
N-3-(2,6-dioxo-piperidin-3-yl)-2-methyl-4-oxo-3,4-dihydro-quinazolin-5-yl-acetamide 

[1]Patent:WO2008/39489,2008,A2.Locationinpatent:Page/Pagecolumn54-55

[1]Patent:WO2008/39489,2008,A2.Locationinpatent:Page/Pagecolumn55

1015474-32-4    2528-61-2   
heptanoicacid3-(2,6-dioxo-piperidin-3-yl)-2-methyl-4-oxo-3,4-dihydro-quinazolin-5-yl-amide 

[1]Patent:WO2008/39489,2008,A2.Locationinpatent:Page/Pagecolumn55-56

Literature

Title: Rasco DW, et al. A First-in-Human Study of Novel Cereblon Modulator Avadomide (CC-122) in Advanced Malignancies. Clin Cancer Res. 2019 Jan 1;25(1):90-98.

Title: Hagner, P.R.et al.CC-122, a pleiotropic pathway modifier, mimics an IFN response and has antitumor activity in DLBCL.Blood.Aug 6;126(6):779-89.

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SDS
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