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101574-65-6,MFCD00567155
Catalog No.:AA0004QU

101574-65-6 | Benzoic acid, 4-hydroxy-, 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide

Pack Size
Purity
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1mg
98%
in stock  
$15.00   $11.00
- +
5mg
95%
in stock  
$50.00   $35.00
- +
10mg
98%
in stock  
$54.00   $38.00
- +
25mg
98%
in stock  
$90.00   $63.00
- +
50mg
95%
in stock  
$148.00   $103.00
- +
100mg
95%
in stock  
$199.00   $139.00
- +
250mg
95%
in stock  
$336.00   $235.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0004QU
Chemical Name:
Benzoic acid, 4-hydroxy-, 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide
CAS Number:
101574-65-6
Molecular Formula:
C17H18N2O2
Molecular Weight:
282.3370
MDL Number:
MFCD00567155
SMILES:
Oc1ccc(cc1)C(=O)NN=Cc1ccc(cc1)C(C)C
Properties
Properties
 
Form:
Solid  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
352  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
3.3  

Downstream Synthesis Route

[1]Lin,Hua;Doebelin,Christelle;Patouret,Rémi;Garcia-Ordonez,RubenD.;RaChang,Mi;Dharmarajan,Venkatasubramanian;Bayona,ClaudiaRuiz;Cameron,MichaelD.;Griffin,PatrickR.;Kamenecka,TheodoreM.[BioorganicandMedicinalChemistryLetters,2018,vol.28,#8,p.1313-1319]

[1]Lin,Hua;Doebelin,Christelle;Patouret,Rémi;Garcia-Ordonez,RubenD.;RaChang,Mi;Dharmarajan,Venkatasubramanian;Bayona,ClaudiaRuiz;Cameron,MichaelD.;Griffin,PatrickR.;Kamenecka,TheodoreM.[BioorganicandMedicinalChemistryLetters,2018,vol.28,#8,p.1313-1319]

Literature

Title: Neurodevelopmental low-dose bisphenol A exposure leads to early life-stage hyperactivity and learning deficits in adult zebrafish.

Journal: Toxicology 20120127

Title: Identification of pyrido[1,2-α]pyrimidine-4-ones as new molecules improving the transcriptional functions of estrogen-related receptor α.

Journal: Journal of medicinal chemistry 20111110

Title: Estrogen-related receptor gamma is a key regulator of muscle mitochondrial activity and oxidative capacity.

Journal: The Journal of biological chemistry 20100716

Title: An ERRbeta/gamma agonist modulates GRalpha expression, and glucocorticoid responsive gene expression in skeletal muscle cells.

Journal: Molecular and cellular endocrinology 20100205

Title: Accessibility of the extracellular loops of follicle stimulating hormone receptor and their role in hormone-receptor interaction.

Journal: Molecular and cellular endocrinology 20100205

Title: Efficient discovery of selective small molecule agonists of estrogen-related receptor gamma using combinatorial approach.

Journal: Journal of combinatorial chemistry 20090101

Title: X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation.

Journal: The Journal of biological chemistry 20061208

Title: Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma.

Journal: Journal of medicinal chemistry 20050505

Title: Wang SC, et al. An ERRbeta/gamma agonist modulates GRalpha expression, and glucocorticoid responsive gene expression in skeletal muscle cells. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):146-52.

Title: Rangwala SM, et al. Estrogen-related receptor gamma is a key regulator of muscle mitochondrial activity and oxidative capacity. J Biol Chem. 2010 Jul 16;285(29):22619-29.

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SDS
Tags:101574-65-6 Molecular Formula|101574-65-6 MDL|101574-65-6 SMILES|101574-65-6 Benzoic acid, 4-hydroxy-, 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide