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1020149-73-8,MFCD27937047
Catalog No.:AA000694

1020149-73-8 | SGI-1027

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$23.00   $16.00
- +
10mg
98+%
in stock  
$135.00   $95.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000694
Chemical Name:
SGI-1027
CAS Number:
1020149-73-8
Molecular Formula:
C27H23N7O
Molecular Weight:
461.5178
MDL Number:
MFCD27937047
SMILES:
Cc1cc(Nc2ccc(cc2)NC(=O)c2ccc(cc2)Nc2ccnc3c2cccc3)nc(n1)N
Properties
Computed Properties
 
Complexity:
676  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
6  
XLogP3:
4.8  

Literature

Title: New insights on the mechanism of quinoline-based DNA Methyltransferase inhibitors.

Journal: The Journal of biological chemistry 20150306

Title: Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells.

Journal: Journal of medicinal chemistry 20140213

Title: Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1.

Journal: The Journal of biological chemistry 20130816

Title: Datta J, et al. A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation. Cancer Res. 2009 May 15;69(10):4277-85.

Title: Rilova E, et al. Design, synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation. ChemMedChem. 2014 Mar;9(3):590-601.

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SDS
Tags:1020149-73-8 Molecular Formula|1020149-73-8 MDL|1020149-73-8 SMILES|1020149-73-8 SGI-1027