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1020149-73-8,MFCD27937047
Catalog No.:AA000694
1020149-73-8 | SGI-1027
Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$101.00   $71.00
- +
5mg
≥98%
in stock  
$187.00   $131.00
- +
10mg
99.35%
in stock  
$245.00   $171.00
- +
50mg
≥98%
in stock  
$1,016.00   $711.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000694
Chemical Name:
SGI-1027
CAS Number:
1020149-73-8
Molecular Formula:
C27H23N7O
Molecular Weight:
461.5178
MDL Number:
MFCD27937047
IUPAC Name:
N-[4-[(2-amino-6-methylpyrimidin-4-yl)amino]phenyl]-4-(quinolin-4-ylamino)benzamide
InChI:
InChI=1S/C27H23N7O/c1-17-16-25(34-27(28)30-17)32-20-10-12-21(13-11-20)33-26(35)18-6-8-19(9-7-18)31-24-14-15-29-23-5-3-2-4-22(23)24/h2-16H,1H3,(H,29,31)(H,33,35)(H3,28,30,32,34)
InChI Key:
QSYLKMKIVWJAAK-UHFFFAOYSA-N
SMILES:
Cc1cc(Nc2ccc(cc2)NC(=O)c2ccc(cc2)Nc2ccnc3c2cccc3)nc(n1)N
Properties
Computed Properties
 
Complexity:
676  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
461.196g/mol
Formal Charge:
0
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
461.529g/mol
Monoisotopic Mass:
461.196g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
118A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.8  

Synonyms
 
N-(4-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-4-(quinolin-4-ylamino)benzamide 
SGI-1027 
SCHEMBL3655385 
C27H23N7O 
AOB6458 
SGI1027 
HMS3653O06 
BCP09928 
EX-A2160 
BDBM50430056 
FD5030 
MFCD27937047 
SGI-1027 
s7276 
ZINC95591603 
AKOS024458519 
CS-2735 
SB19043 
Benzamide, N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)- 
KS-00000T67 
NCGC00381561-65 
AK175455 
BC600486 
1020149-73-8 
DA-48337 
HY-13962 
FT-0755513 
SGI-1027, >=98% (HPLC) 
SW220204-1 
Y1873 
A14120 
J-000537 
N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide 
B1622 
N-(4-((2-amino-6-methylpyrimidin-4-yl)amino)phenyl)-4-(quinolin-4-ylamino)benzamide 
C581203 
N-(4-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-4-(quinolin-4-ylamino)benzamide 
DNA Methyltransferase Inhibitor II 
SGI 1027 
N-[4-[(2-amino-6-methylpyrimidin-4-yl)amino]phenyl]-4-(quinolin-4-ylamino)benzamide 
CHEMBL2336409 
GTPL8891 
Literature

Title: New insights on the mechanism of quinoline-based DNA Methyltransferase inhibitors.

Journal: The Journal of biological chemistry 20150306

Title: Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells.

Journal: Journal of medicinal chemistry 20140213

Title: Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1.

Journal: The Journal of biological chemistry 20130816

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