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1021950-26-4,MFCD17010276
Catalog No.:AA008THM

1021950-26-4 | Cabozantinib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
99%
1 week  
$201.00   $141.00
- +
10mg
99%
1 week  
$281.00   $197.00
- +
25mg
99%
1 week  
$511.00   $358.00
- +
  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008THM
Chemical Name:
Cabozantinib
CAS Number:
1021950-26-4
Molecular Formula:
C31H31FN6O5
Molecular Weight:
586.6134
MDL Number:
MFCD17010276
SMILES:
Fc1ccc(cc1)NC(=O)C1(CC1)C(=O)Nc1ccc(cc1)Oc1ccnc2c1cc([nH]2)C(=O)NCCN1CCOCC1
Properties
Computed Properties
 
Complexity:
978  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
43  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
10  
XLogP3:
3.8  

Literature

Title: Paul MK, et al. Tyrosine kinase - Role and significance in Cancer. Int J Med Sci. 2004;1(2):101-115.

Title: Inoue T, et al.Two cases of gastrointestinal perforation after radiotherapy in patients receiving tyrosine kinase inhibitor for advanced renal cell carcinoma.World J Surg Oncol. 2012 Aug 20;10(1):167.

Title: Bowen JM, et al.Development of a rat model of oral small molecule receptor tyrosine kinase inhibitor-induced diarrhea.Cancer Biol Ther. 2012 Nov 1;13(13).

Title: Sun FK, et al.Multi-targeted tyrosine kinase inhibitor sunitinib: a novel strategy for sporadic malignant pheochromocytoma.Chin Med J (Engl). 2012 Jun;125(12):2231-4.

Title: Thamm DH.Tyrosine kinase inhibitor special issue.Vet Comp Oncol. 2012 Sep;10(3):161-2. doi: 10.1111/j.1476-5829.2012.00339.x.

Title: Eriksson A, et al.The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia.Blood Cancer J. 2012 Aug 3;2:e81. doi: 10.1038/bcj.2012.28.

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SDS
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