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1025065-69-3,MFCD16659064
Catalog No.:AA0007J1
1025065-69-3 | Sgi-1776
Pack Size
Purity
Availability
Price(USD)
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1mg
95%
in stock  
$72.00   $50.00
- +
5mg
95%
in stock  
$143.00   $100.00
- +
25mg
98% by HPLC
in stock  
$691.00   $484.00
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50mg
99.23%
in stock  
$880.00   $616.00
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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA0007J1
Chemical Name:
Sgi-1776
CAS Number:
1025065-69-3
Molecular Formula:
C20H22F3N5O
Molecular Weight:
405.4168
MDL Number:
MFCD16659064
IUPAC Name:
N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine
InChI:
InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26)
InChI Key:
MHXGEROHKGDZGO-UHFFFAOYSA-N
SMILES:
CN1CCC(CC1)CNc1ccc2n(n1)c(cn2)c1cccc(c1)OC(F)(F)F
UNII:
72AUA0603W
Properties
Computed Properties
 
Complexity:
529  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
405.178g/mol
Formal Charge:
0
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
405.425g/mol
Monoisotopic Mass:
405.178g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
54.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.3  

Synonyms
 
SGI 1776 
SGI-1776 
N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine 
CHEMBL1952329 
72AUA0603W 
N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine 
CHEMBL1952141 
Imidazo[1,2-b]pyridazin-6-amine, N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-;Imidazo[1,2-b]pyridazin-6-amine, N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]- 
N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine 
Imidazo(1,2-b)pyridazin-6-amine, N-((1-methyl-4-piperidinyl)methyl)-3-(3-(trifluoromethoxy)phenyl)- 
Imidazo[1,2-b]pyridazin-6-amine, N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]- 
N-((1-Methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo(1,2-b)pyridazin-6-amine 
SGI1776 
Pim-Kinase Inhibitor IX 
SGI 1776 free base 
cc-574 
MLS006011076 
SCHEMBL102498 
GTPL8784 
CHEBI:95061 
KS-00000XIR 
AOB2259 
DTXSID10647329 
SGI-1776 
QCR-216 
HMS3655P08 
BCP02279 
EX-A1373 
ABP000939 
BDBM50364776 
MFCD16659064 
s2198 
ZINC68205235 
AKOS026750649 
1025065-69-3 
CS-0513 
DB12494 
RL00118 
SB19298 
NCGC00263186-01 
NCGC00263186-02 
NCGC00263186-11 
4CA-1156 
AC-28432 
AK474022 
SGI-1776 free base 
AS-16326 
BC660088 
HY-13287 
SMR004702864 
DB-058820 
FT-0702224 
SW218133-2 
X7567 
W-5655 
J-000709 
SGI1776 
J-523286 
1025065-69-3 , SGI 1776 
N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-beta]pyridazin-6-amine 
N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[2,1-f]pyridazin-6-amine 
Resminostat 
C20H22F3N5O 
SYN1193 
MHXGEROHKGDZGO-UHFFFAOYSA-N 
A4192 
A10838 
SGI 1776 
1173928-26-1 
N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine 
UNII-72AUA0603W 
Literature

Title: Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies.

Journal: Journal of medicinal chemistry 20151112

Title: Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.

Journal: ACS medicinal chemistry letters 20131212

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Transcription and translation are primary targets of Pim kinase inhibitor SGI-1776 in mantle cell lymphoma.

Journal: Blood 20121025

Title: Potential use of selective and nonselective Pim kinase inhibitors for cancer therapy.

Journal: Journal of medicinal chemistry 20121011

Title: Targeting PIM kinase activity significantly augments the efficacy of cytarabine.

Journal: British journal of haematology 20120101

Title: The Pim kinases: new targets for drug development.

Journal: Current drug targets 20111201

Title: PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells.

Journal: Oncotarget 20111201

Title: Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma.

Journal: British journal of cancer 20111108

Title: Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia.

Journal: Blood 20110721

Title: Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells.

Journal: Blood 20091105

Title: Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes.

Journal: Molecular cancer therapeutics 20091001

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