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1026791-61-6,MFCD30738001
Catalog No.:AA01EO9A

1026791-61-6 | Org-26576

Pack Size
Purity
Availability
Price(USD)
Quantity
  
2mg
95%
1 week  
$104.00   $73.00
- +
5mg
95%
1 week  
$134.00   $94.00
- +
10mg
95%
1 week  
$180.00   $126.00
- +
25mg
95%
1 week  
$260.00   $182.00
- +
50mg
95%
1 week  
$350.00   $245.00
- +
100mg
95%
1 week  
$572.00   $400.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EO9A
Chemical Name:
Org-26576
CAS Number:
1026791-61-6
Molecular Formula:
C11H12N2O2
Molecular Weight:
204.2252
MDL Number:
MFCD30738001
SMILES:
O=C1N2CCC[C@H]2COc2c1cccn2
Properties
Computed Properties
 
Complexity:
269  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
3  
XLogP3:
0.9  

Literature

Title: A translational approach to evaluate the efficacy and safety of the novel AMPA receptor positive allosteric modulator org 26576 in adult attention-deficit/hyperactivity disorder.

Journal: Biological psychiatry 20121201

Title: Maximum tolerated dose evaluation of the AMPA modulator Org 26576 in healthy volunteers and depressed patients: a summary and method analysis of bridging research in support of phase II dose selection.

Journal: Drugs in R&D 20120901

Title: Differential effects of AMPA receptor potentiators and glycine reuptake inhibitors on antipsychotic efficacy and prefrontal glutamatergic transmission.

Journal: Psychopharmacology 20120501

Title: The AMPA receptor potentiator Org 26576 modulates stress-induced transcription of BDNF isoforms in rat hippocampus.

Journal: Pharmacological research 20120201

Title: Translational PK-PD modelling of molecular target modulation for the AMPA receptor positive allosteric modulator Org 26576.

Journal: Psychopharmacology 20111201

Title: Chronic treatment with AMPA receptor potentiator Org 26576 increases neuronal cell proliferation and survival in adult rodent hippocampus.

Journal: Psychopharmacology 20091001

Title: The ampakine, Org 26576, bolsters early spatial reference learning and retrieval in the Morris water maze: a subchronic, dose-ranging study in rats.

Journal: Behavioural pharmacology 20091001

Title: Jordan GR, et al. Regionally selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on local cerebral glucose utilisation in the mouse as assessed by 14C-2-deoxyglucose autoradiography. Neuropharmacology. 2005 Aug;49(2):254-64.

Title: Su XW, et al. Chronic treatment with AMPA receptor potentiator Org 26576 increases neuronal cell proliferation and survival in adult rodent hippocampus. Psychopharmacology (Berl). 2009 Oct;206(2):215-22.

Title: Fumagalli F, et al. The AMPA receptor potentiator Org 26576 modulates stress-induced transcription of BDNF isoforms in rat hippocampus. Pharmacol Res. 2012 Feb;65(2):176-81.

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