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103404-90-6,MFCD00069573
Catalog No.:AA007XKK

103404-90-6 | (2R)-2-Hydroxypentanedioic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
in stock  
$7.00   $5.00
- +
10mg
95%
in stock  
$9.00   $7.00
- +
25mg
95%
in stock  
$15.00   $11.00
- +
50mg
95%
in stock  
$28.00   $20.00
- +
100mg
95%
in stock  
$45.00   $32.00
- +
250mg
95%
in stock  
$65.00   $46.00
- +
1g
95%
in stock  
$143.00   $100.00
- +
5g
95%
in stock  
$658.00   $461.00
- +
10g
95%
in stock  
$867.00   $607.00
- +
25g
95%
in stock  
$2,140.00   $1,498.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007XKK
Chemical Name:
(2R)-2-Hydroxypentanedioic acid
CAS Number:
103404-90-6
Molecular Formula:
C5H6Na2O5
Molecular Weight:
192.0777
MDL Number:
MFCD00069573
SMILES:
[O-]C(=O)CC[C@H](C(=O)[O-])O.[Na+].[Na+]
Properties
Computed Properties
 
Complexity:
130  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  

Literature

Title: Xu W, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30.

Title: Fu X, et al. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. Cell Metab. 2015 Sep 1;22(3):508-15.

Title: Martijn Kranendijk, et al. Progress in understanding 2-hydroxyglutaric acidurias. J Inherit Metab Dis. 2012 Jul;35(4):571-87.

Title: Martin Böttcher, et al. D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization. Oncoimmunology. 2018 Mar 26;7(7):e1445454.

Title: Alexandra Latini , et al. D-2-hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats. Eur J Neurosci. 2003 May;17(10):2017-22.

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SDS
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Tags:103404-90-6 Molecular Formula|103404-90-6 MDL|103404-90-6 SMILES|103404-90-6 (2R)-2-Hydroxypentanedioic acid